Projects per year
Personal profile
Research interests
Dr. Gavin Robertson's research program focuses on malignant melanoma, the most deadly form of skin cancer. The central goal of his program is to unravel the biology and signaling pathways involved in melanoma tumor development in order to develop the next generation of therapeutic agents to treat this disease. Specifically, it involves identification and validation of novel therapeutic targets, discovery and development of new therapies and clinical evaluation of these drugs in patients.
Generally,the types of studies occurring the Robertson laboratory are:
Genetic and cell culture studies using animal and human models are used to identify and validate the involvement of candidate melanoma-causing genes. A recent example is the discovery of Akt3 involvement in approximately 70 percent of human melanomas.
Drug screens and medicinal chemistry are used to identify and develop new therapeutic agents. A recent example is the melanoma-treating drug ISC-4, which targets Akt3 signaling.
Nanotechnology and bioengineering are used to better deliver experimental agents into cancer cells. A recent example of this is the use of nanoliposomes and ultrasound that deliver therapeutic siRNA into melanoma cells.
Finally, agents are tested in the clinic for toxicity and tumor inhibitory efficacy. A recent example is a killed mycobacterium called CADI-5 that is being evaluated in clinical trials.
The ultimate goal of Dr. Robertson's translational research program is to develop better therapeutics for the treatment of melanoma based on the biology of the disease.
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Network
Projects
- 5 Finished
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Targeted Chemoprevention for Melanoma
Robertson, G., ROBERTSON, G., Robertson, G. P. & Robertson, G. P.
3/12/10 → 12/31/15
Project: Research project
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Synergistically Acting Targeted Therapeutics for Melanoma
Robertson, G., ROBERTSON, G., Robertson, G. P., Robertson, G. P. & Robertson, G. P.
1/1/10 → 12/31/15
Project: Research project
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Akt3 Signaling as a Therapeutic Target
Robertson, G. & Robertson, G. P.
12/17/07 → 11/30/13
Project: Research project
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Targeted Chemoprevention Through Inhibition of Akt3 Signaling
Robertson, G. & Robertson, G. P.
9/1/07 → 8/31/10
Project: Research project
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Melanoma Chemoprevention by Targeting Mutant (V600E) B-Raf
Robertson, G. & Robertson, G. P.
9/22/06 → 7/31/09
Project: Research project
Research Output
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Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents
Dinavahi, S. S., Gowda, R., Bazewicz, C. G., Battu, M. B., Lin, J. M., Chitren, R. J., Pandey, M. K., Amin, S., Robertson, G. P. & Gowda, K., Feb 1 2020, In: European Journal of Medicinal Chemistry. 187, 111962.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Development of a Novel Multi-Isoform ALDH Inhibitor Effective as an Antimelanoma Agent
Dinavahi, S. S., Gowda, R., Gowda, K., Bazewicz, C. G., Chirasani, V. R., Battu, M. B., Berg, A., Dokholyan, N. V., Amin, S. & Robertson, G. P., Feb 1 2020, In: Molecular cancer therapeutics. 19, 2, p. 447-459 13 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia
Song, C., Ge, Z., Ding, Y., Tan, B. H., Desai, D., Gowda, K., Amin, S., Gowda, R., Robertson, G. P., Yue, F., Huang, S., Spiegelman, V., Payne, J. L., Reeves, M. E., Gurel, Z., Iyer, S., Dhanyamraju, P. K., Xiang, M., Kawasawa, Y. I., Cury, N. M. & 11 others, , Sep 24 2020, In: Blood. 136, 13, p. 1520-1534 15 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Salubrinal in Combination With 4E1RCat Synergistically Impairs Melanoma Development by Disrupting the Protein Synthetic Machinery
Kardos, G. R., Gowda, R., Dinavahi, S. S., Kimball, S. & Robertson, G. P., Jun 19 2020, In: Frontiers in Oncology. 10, 834.Research output: Contribution to journal › Article › peer-review
Open Access -
The role of exosomes in metastasis and progression of melanoma
Gowda, R., Robertson, B. M., Iyer, S., Barry, J., Dinavahi, S. S. & Robertson, G. P., Apr 2020, In: Cancer Treatment Reviews. 85, 101975.Research output: Contribution to journal › Review article › peer-review
11 Scopus citations