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Research Output 2002 2019

  • 4191 Citations
  • 15 h-Index
  • 24 Article
  • 4 Review article
  • 3 Comment/debate
  • 3 Short survey
2019

Error-prone replication of a 5-formylcytosine-mediated DNA-peptide cross-link in human cells

Naldiga, S., Ji, S., Thomforde, J., Nicolae, C., Lee, M., Zhang, Z., Moldovan, G-L., Tretyakova, N. Y. & Basu, A. K., Jan 1 2019, In : Journal of Biological Chemistry. 294, 27, p. 10619-10627 9 p.

Research output: Contribution to journalArticle

Cells
Peptides
Mutation
DNA
Plasmids

Heterozygous RNF13 Gain-of-Function Variants Are Associated with Congenital Microcephaly, Epileptic Encephalopathy, Blindness, and Failure to Thrive

Edvardson, S., Nicolae, C., Noh, G. J., Burton, J. E., Punzi, G., Shaag, A., Bischetsrieder, J., De Grassi, A., Pierri, C. L., Elpeleg, O. & Moldovan, G-L., Jan 3 2019, In : American Journal of Human Genetics. 104, 1, p. 179-185 7 p.

Research output: Contribution to journalArticle

Failure to Thrive
Microcephaly
Brain Diseases
Blindness
Protein Unfolding
5 Citations (Scopus)

Mechanisms of DNA damage tolerance: post-translational regulation of PCNA

Leung, W., Baxley, R. M., Moldovan, G-L. & Bielinsky, A. K., Jan 1 2019, In : Genes. 10, 1, 10.

Research output: Contribution to journalReview article

Proliferating Cell Nuclear Antigen
DNA Damage
Post Translational Protein Processing
Ubiquitin
Genetic Recombination

PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells

Nicolae, C., O’Connor, M. J., Schleicher, E. M., Song, C., Gowda, R., Robertson, G., Dovat, S. & Moldovan, G-L., Jul 4 2019, In : Oncogene. 38, 27, p. 5530-5540 11 p.

Research output: Contribution to journalArticle

Myeloid Leukemia
Leukemia
DNA Damage
Myeloid Cells
Differentiation Antigens
3 Citations (Scopus)

STING promotes homeostasis via regulation of cell proliferation and chromosomal stability

Ranoa, D. R. E., Widau, R. C., Mallon, S., Parekh, A. D., Nicolae, C., Huang, X., Bolt, M. J., Arina, A., Parry, R., Kron, S. J., Moldovan, G-L., Khodarev, N. N. & Weichselbaum, R. R., Apr 1 2019, In : Cancer Research. 79, 7, p. 1465-1479 15 p.

Research output: Contribution to journalArticle

Chromosomal Instability
Homeostasis
Cell Proliferation
Cell Cycle
Neoplasms
2018
3 Citations (Scopus)

DNA polymerase eta prevents tumor cell-cycle arrest and cell death during recovery from replication stress

Barnes, R. P., Tsao, W. C., Moldovan, G-L. & Eckert, K., Dec 1 2018, In : Cancer Research. 78, 23, p. 6549-6560 12 p.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Cell Death
Neoplasms
Genomic Instability
Cell Survival
5 Citations (Scopus)

Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells

Clements, K. E., Thakar, T., Nicolae, C., Liang, X., Wang, H-G. & Moldovan, G-L., Jan 1 2018, In : Nucleic acids research. 46, 17, p. 8898-8907 10 p.

Research output: Contribution to journalArticle

Recombinational DNA Repair
Therapeutics
Neoplasms
Tumor Biomarkers
DNA Replication
3 Citations (Scopus)

NFκB regulates p21 expression and controls DNA damage-induced leukemic differentiation

Nicolae, C., O'connor, M. J., Constantin, D. & Moldovan, G-L., Jul 5 2018, In : Oncogene. 37, 27, p. 3647-3656 10 p.

Research output: Contribution to journalArticle

DNA Damage
Myeloid Leukemia
Myeloid Cells
Clustered Regularly Interspaced Short Palindromic Repeats
Binding Sites
5 Citations (Scopus)

PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress

Schleicher, E. M., Galvan, A. M., Imamura, Y., Moldovan, G-L. & Nicolae, C., Jan 1 2018, In : Nucleic acids research. 46, 17, p. 8908-8916 9 p.

Research output: Contribution to journalArticle

Carcinogenesis
Cell Proliferation
HeLa Cells
Neoplasms
Clustered Regularly Interspaced Short Palindromic Repeats
2017

Erratum to: PARP10 deficiency manifests by severe developmental delay and DNA repair defect (Neurogenetics, (2016), 17, (227-232), 10.1007/s10048-016-0493-1)

Shahrour, M. A., Nicolae, C., Edvardson, S., Ashhab, M., Galvan, A. M., Constantin, D., Abu-Libdeh, B., Moldovan, G-L. & Elpeleg, O., Jan 1 2017, In : Neurogenetics. 18, 1, 1 p.

Research output: Contribution to journalComment/debate

DNA Repair

Erratum to: PARP10 deficiency manifests by severe developmental delay and DNA repair defect (neurogenetics, (2016), 17, 4, (227-232), 10.1007/s10048-016-0493-1)

Shahrour, M. A., Nicolae, C., Edvardson, S., Ashhab, M., Galvan, A. M., Constantin, D., Abu-Libdeh, B., Moldovan, G-L. & Elpeleg, O., Apr 1 2017, In : Neurogenetics. 18, 2, 1 p.

Research output: Contribution to journalComment/debate

Organized Financing
DNA Repair
Financial Management
48 Citations (Scopus)

Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork

Choe, K. N. & Moldovan, G-L., Feb 2 2017, In : Molecular cell. 65, 3, p. 380-392 13 p.

Research output: Contribution to journalReview article

Darkness
Proliferating Cell Nuclear Antigen
DNA-Directed DNA Polymerase
Post Translational Protein Processing
Molecular Structure
7 Citations (Scopus)

Heterozygous De Novo UBTF Gain-of-Function Variant Is Associated with Neurodegeneration in Childhood

Edvardson, S., Nicolae, C., Agrawal, P. B., Mignot, C., Payne, K., Prasad, A. N., Prasad, C., Sadler, L., Nava, C., Mullen, T. E., Begtrup, A., Baskin, B., Powis, Z., Shaag, A., Keren, B., Moldovan, G-L. & Elpeleg, O., Aug 3 2017, In : American Journal of Human Genetics. 101, 2, p. 267-273 7 p.

Research output: Contribution to journalArticle

Transcription Factors
Ribosomal DNA
5.8S Ribosomal RNA
28S Ribosomal RNA
18S Ribosomal RNA
2016

ERKing Trypanosoma: PCNA phosphorylation as novel target

Nicolae, C. & Moldovan, G-L., Dec 1 2016, In : Cell Cycle. 15, 23, p. 3167-3168 2 p.

Research output: Contribution to journalComment/debate

Trypanosoma
Trypanosoma brucei brucei
Proliferating Cell Nuclear Antigen
Phosphorylation
18 Citations (Scopus)

HUWE1 interacts with PCNA to alleviate replication stress

Choe, K. N., Nicolae, C., Constantin, D., Imamura, Y., Delgado-Diaz, M. R., De, S., Freire, R., Smits, V. A. & Moldovan, G-L., Jun 1 2016, In : EMBO Reports. 17, 6, p. 874-886 13 p.

Research output: Contribution to journalArticle

Proliferating Cell Nuclear Antigen
DNA Replication
DNA
Ligases
Ubiquitin
5 Citations (Scopus)

PARP10 deficiency manifests by severe developmental delay and DNA repair defect

Shahrour, M. A., Nicolae, C., Edvardson, S., Ashhab, M., Galvan, A. M., Constantin, D., Abu-Libdeh, B., Moldovan, G-L. & Elpeleg, O., Oct 1 2016, In : Neurogenetics. 17, 4, p. 227-232 6 p.

Research output: Contribution to journalArticle

DNA Repair
Proliferating Cell Nuclear Antigen
DNA Damage
Mutation
Cockayne Syndrome
7 Citations (Scopus)

The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repair

Cukras, S., Lee, E., Palumbo, E., Benavidez, P., Moldovan, G-L. & Kee, Y., Oct 1 2016, In : Cell Cycle. 15, 19, p. 2636-2646 11 p.

Research output: Contribution to journalArticle

Recombinational DNA Repair
Protein Interaction Mapping
Rad51 Recombinase
Mitomycin
Chromosome Aberrations
2015
20 Citations (Scopus)

A novel role for the mono-ADP-ribosyltransferase PARP14/ARTD8 in promoting homologous recombination and protecting against replication stress

Nicolae, C., Aho, E. R., Choe, K. N., Constantin, D., Hu, H. J., Lee, D., Myung, K. & Moldovan, G-L., Jan 1 2015, In : Nucleic acids research. 43, 6, p. 3143-3153 11 p.

Research output: Contribution to journalArticle

ADP Ribose Transferases
Homologous Recombination
DNA Repair
Genomic Instability
Post Translational Protein Processing
8 Citations (Scopus)

Human DNA polymerase ν catalyzes correct and incorrect DNA synthesis with high catalytic efficiency

Gowda, A. S. P., Moldovan, G-L. & Spratt, T., Jun 26 2015, In : Journal of Biological Chemistry. 290, 26, p. 16292-16303 12 p.

Research output: Contribution to journalArticle

DNA-Directed DNA Polymerase
Rate constants
Base Pairing
DNA
Recombinational DNA Repair
2014
28 Citations (Scopus)

The ADP-ribosyltransferase PARP10/ARTD10 interacts with proliferating cell nuclear antigen (PCNA) and is required for DNA damage tolerance

Nicolae, C., Aho, E. R., Vlahos, A. H. S., Choe, K. N., De, S., Karras, G. I. & Moldovan, G-L., Jan 1 2014, In : Journal of Biological Chemistry. 289, 19, p. 13627-13637 11 p.

Research output: Contribution to journalArticle

ADP Ribose Transferases
Damage tolerance
Proliferating Cell Nuclear Antigen
DNA Damage
Genomic Instability
2013
16 Citations (Scopus)

PARI overexpression promotes genomic instability and pancreatic tumorigenesis

O'Connor, K. W., Dejsuphong, D., Park, E., Nicolae, C., Kimmelman, A. C., D'Andrea, A. D. & Moldovan, G-L., Apr 15 2013, In : Cancer Research. 73, 8, p. 2529-2539 11 p.

Research output: Contribution to journalArticle

Genomic Instability
Pancreatic Neoplasms
Carcinogenesis
DNA Damage
DNA Replication
2012
129 Citations (Scopus)

Inhibition of homologous recombination by the PCNA-interacting protein PARI

Moldovan, G-L., Dejsuphong, D., Petalcorin, M. I. R., Hofmann, K., Takeda, S., Boulton, S. J. & D'Andrea, A. D., Jan 13 2012, In : Molecular cell. 45, 1, p. 75-86 12 p.

Research output: Contribution to journalArticle

Homologous Recombination
Proliferating Cell Nuclear Antigen
Genomic Instability
Genetic Recombination
Proteins
14 Citations (Scopus)

To the Rescue: The Fanconi Anemia Genome Stability Pathway Salvages Replication Forks

Moldovan, G-L. & D'Andrea, A. D., Jul 10 2012, In : Cancer Cell. 22, 1, p. 5-6 2 p.

Research output: Contribution to journalShort survey

Fanconi Anemia
Genomic Instability
S Phase
DNA Damage
Neoplasms
2011
4 Citations (Scopus)

DNA Damage Discrimination at Stalled Replication Forks by the Rad5 Homologs HLTF and SHPRH

Moldovan, G-L. & D'Andrea, A. D., Apr 22 2011, In : Molecular Cell. 42, 2, p. 141-143 3 p.

Research output: Contribution to journalShort survey

Genomic Instability
Mutagenesis
DNA Damage
Yeasts
Maintenance
65 Citations (Scopus)

Regulation of the Fanconi anemia pathway by a SUMO-like delivery network

Yang, K., Moldovan, G-L., Vinciguerra, P., Murai, J., Takeda, S. & D'Andrea, A. D., Sep 1 2011, In : Genes and Development. 25, 17, p. 1847-1858 12 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Proliferating Cell Nuclear Antigen
Homologous Recombination
DNA Repair
Fanconi Anemia Complementation Group Proteins
2010
65 Citations (Scopus)

DNA polymerase POLN participates in cross-link repair and homologous recombination

Moldovan, G-L., Madhavan, M. V., Mirchandani, K. D., McCaffrey, R. M., Vinciguerra, P. & D'Andrea, A. D., Feb 1 2010, In : Molecular and cellular biology. 30, 4, p. 1088-1096 9 p.

Research output: Contribution to journalArticle

Recombinational DNA Repair
DNA-Directed DNA Polymerase
DNA Repair
Homologous Recombination
DNA
38 Citations (Scopus)

RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger

Yang, K., Moldovan, G-L. & D'Andrea, A. D., Jun 18 2010, In : Journal of Biological Chemistry. 285, 25, p. 19085-19091 7 p.

Research output: Contribution to journalArticle

Zinc Fingers
Proliferating Cell Nuclear Antigen
Ubiquitin
DNA Repair
Zinc
2009
14 Citations (Scopus)

FANCD2 Hurdles the DNA Interstrand Crosslink

Moldovan, G-L. & D'Andrea, A. D., Dec 24 2009, In : Cell. 139, 7, p. 1222-1224 3 p.

Research output: Contribution to journalShort survey

Fanconi Anemia Complementation Group Proteins
DNA Replication
DNA
Enzymes
Repair
382 Citations (Scopus)

How the fanconi anemia pathway guards the genome

Moldovan, G-L. & D'Andrea, A. D., Dec 1 2009, In : Annual review of genetics. 43, p. 223-249 27 p.

Research output: Contribution to journalReview article

Fanconi Anemia
DNA Repair
Genome
Nimodipine
Genomic Instability
2007
1055 Citations (Scopus)

PCNA, the Maestro of the Replication Fork

Moldovan, G-L., Pfander, B. & Jentsch, S., May 18 2007, In : Cell. 129, 4, p. 665-679 15 p.

Research output: Contribution to journalReview article

Proliferating Cell Nuclear Antigen
Genes
Genome
Proteolysis
Phosphorylation
2006
104 Citations (Scopus)

A role for PCNA ubiquitination in immunoglobulin hypermutation

Arakawa, H., Moldovan, G-L., Saribasak, H., Saribasak, N. N., Jentsch, S. & Buerstedde, J. M., Nov 1 2006, In : PLoS biology. 4, 11, p. 1947-1956 10 p.

Research output: Contribution to journalArticle

proliferating cell nuclear antigen
Ubiquitination
Proliferating Cell Nuclear Antigen
immunoglobulins
Immunoglobulins
180 Citations (Scopus)

PCNA Controls Establishment of Sister Chromatid Cohesion during S Phase

Moldovan, G-L., Pfander, B. & Jentsch, S., Sep 1 2006, In : Molecular Cell. 23, 5, p. 723-732 10 p.

Research output: Contribution to journalArticle

Chromatids
Proliferating Cell Nuclear Antigen
S Phase
Yeasts
Anaphase
2005
438 Citations (Scopus)

SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase

Pfander, B., Moldovan, G-L., Sacher, M., Hoege, C. & Jentsch, S., Jul 21 2005, In : Nature. 436, 7049, p. 428-433 6 p.

Research output: Contribution to journalArticle

Proliferating Cell Nuclear Antigen
S Phase
Genetic Recombination
Ubiquitin
Lysine
2002
1522 Citations (Scopus)

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

Hoege, C., Pfander, B., Moldovan, G-L., Pyrowolakis, G. & Jentsch, S., Sep 12 2002, In : Nature. 419, 6903, p. 135-141 7 p.

Research output: Contribution to journalArticle

Proliferating Cell Nuclear Antigen
Ubiquitin
DNA Repair
Ubiquitination
Lysine