• 1238 Citations
  • 22 h-Index
1986 …2024
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Personal profile

Research interests

Dr. Gregory Holmes' overarching area of research interest employs a systems neuroscience approach to addressing two key pathophysiological changes in autonomic nervous system (e.g., gastrointestinal) functions following spinal cord injury (SCI).

First, Dr. Holmes' ongoing studies of post-SCI gastrointestinal (GI) dysfunction are revealing that substantial pathophysiological remodeling of GI reflex circuits occurs following injury. Specifically, vagal afferents form the intrinsic circuitry necessary for the gastric reflexes during digestion. The sensitivity of these afferents is diminished after SCI even though vagal innervation remains anatomically intact. One emerging mechanism leading to vagal afferent hyposensitivity appears to involve voltage-gated channelopathy that reduces the initiation and propagation of digestion-associated action potentials within vagal afferents following SCI.

The Holmes lab's data support the emerging notion that the profound changes to the entire physiology following SCI merits focused investigation, and that SCI is a systemic injury beyond the spinal tissue.

Dr. Holmes' second area of research addresses a vastly understudied co-morbidity following SCI that is referred to as neurogenic bowel. Neurogenic bowel is a persistent challenge to the well-being and social reintegration of individuals with SCI. Insights from other fields of GI dysfunction (e.g., irritable bowel) suggests that pathophysiological remodeling of enteric neural circuitry is one mechanism contributing to the reduced colonic transit reported after SCI. The Holmes lab has identified anatomical and functional remodeling of the colonic neuromuscular interface in response to SCI. The enteric nervous system circuit is the final common pathway to the smooth muscle, and remodeling of this circuit will profoundly affect any extrinsic input from spinal autonomic motor neurons.

Addressing the changes in enteric and central nervous system neurocircuitry is critical to better understand the neural mechanisms leading to neurogenic bowel in the SCI population.

Fingerprint Dive into the research topics where Gregory Holmes is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 5 Similar Profiles
Spinal Cord Injuries Medicine & Life Sciences
Stomach Medicine & Life Sciences
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Anal Canal Medicine & Life Sciences
Copulation Medicine & Life Sciences
Sexual Behavior Medicine & Life Sciences
Thyrotropin-Releasing Hormone Medicine & Life Sciences

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Projects 2004 2024

Spinal Cord Injuries
Enteric Nervous System
Neurogenic Bowel
Smooth Muscle
Reactive Oxygen Species
Spinal Cord Injuries
Stomach
Gastroparesis
Solitary Nucleus
Reflex

Research Output 1986 2019

  • 1238 Citations
  • 22 h-Index
  • 43 Article
  • 4 Review article
  • 1 Chapter
  • 1 Comment/debate

Gastrointestinal dysfunction after spinal cord injury

Holmes, G. & Blanke, E. N., Oct 1 2019, In : Experimental Neurology. 320, 113009.

Research output: Contribution to journalReview article

Spinal Cord Injuries
Gastrointestinal Tract
Neurophysiology
Caregivers
Brain Stem
1 Citation (Scopus)

Investigating neurogenic bowel in experimental spinal cord injury: Where to begin?

White, A. & Holmes, G., Feb 1 2019, In : Neural Regeneration Research. 14, 2, p. 222-226 5 p.

Research output: Contribution to journalReview article

Neurogenic Bowel
Spinal Cord Injuries
Caregivers
Colon
Fecal Incontinence

Purinergic receptor expression and function in rat vagal sensory neurons innervating the stomach

Blanke, E. N., Stella, S., Ruiz-Velasco, V. & Holmes, G., Jul 27 2019, In : Neuroscience letters. 706, p. 182-188 7 p.

Research output: Contribution to journalArticle

Nodose Ganglion
Purinergic Receptors
Sensory Receptor Cells
Stomach
Neurons
4 Citations (Scopus)

Anatomical and Functional Changes to the Colonic Neuromuscular Compartment after Experimental Spinal Cord Injury

White, A. R. & Holmes, G., May 1 2018, In : Journal of Neurotrauma. 35, 9, p. 1079-1090 12 p.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Colon
Smooth Muscle
Myelitis
Inflammation
1 Citation (Scopus)

Diminished gastric prokinetic response to ghrelin in a rat model of spinal cord injury

Besecker, E. M., White, A. R. & Holmes, G., Apr 1 2018, In : Neurogastroenterology and Motility. 30, 4, e13258.

Research output: Contribution to journalArticle

Ghrelin
Spinal Cord Injuries
Stomach
Thoracic Injuries
Fasting