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Personal profile
Research interests
Dr. Gregory Lewis' research program focuses on orthopaedic biomechanics, with an emphasis on bone, joints and surgical procedures including fracture fixation and shoulder replacement. A major program area is the development of surgeon-targeted software platforms for education and preoperative planning.
The lab has built large simulation libraries of fracture fixation constructs having different implant types, geometries, materials, fracture geometries and bone quality. Computational finite element simulations are used to predict clinically important biomechanics that influence fracture healing and postoperative complications. An innovative, interactive software is being developed for visualizing these biomechanics.
For surgical education, these efforts are currently funded by an NIH R01. For preoperative planning, the group is modifying its approaches to include patient-specific models derived from CT imaging.
Experimental validation using cadaver specimens, and rigorous software testing with surgeons, are also important parts of the research.
Dr. Lewis’s lab has strong collaborations with orthopaedic surgeons, musculoskeletal biologists and other engineers. He is a co-investigator on several NIH R01 projects studying bone biology and regeneration. He provides expertise in bone quality assessment through micro-computed tomography imaging and mechanical testing. He also provides expertise related to in vivo mechanical loading in animal models.
In the area of shoulder replacement biomechanics, Dr. Lewis and collaborators are investigating the multiscale mechanics of glenoid component fixation. The lab has had industry support for several other biomechanical projects.
Dr. Lewis is director of the micro-CT core and the research thrust leader for Penn State Center for Biodevices.
Teaching and educational interests
Dr. Gregory Lewis directs the Center for Orthopaedic Research and Translational Science's basic science curriculum for orthopaedic residents.
Dr. Lewis also serves as an adviser for medical student research projects, is an instructor for the senior undergraduate capstone design course in mechanical engineering at Penn State Harrisburg and provides other lectures to students at three campuses.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Fracture Fixation Biomechanics Simulator with Adaptive Virtual Coaching
National Institute of Biomedical Imaging and Bioengineering
5/1/20 → 1/31/24
Project: Research project
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Comparison of in-situ versus ex-situ delivery of polyethylenimine-BMP-2 polyplexes for rat calvarial defect repair via intraoperative bioprinting
Moncal, K. K., Yeo, M., Celik, N., Acri, T. M., Rizk, E., Wee, H., Lewis, G., Salem, A. K. & Ozbolat, I. T., Jan 1 2023, In: Biofabrication. 15, 1, 015011.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Assessment of Bone Fracture Healing Using Micro-Computed Tomography
Wee, H., Khajuria, D. K., Kamal, F., Lewis, G. & Elbarbary, R. A., Dec 2022, In: Journal of Visualized Experiments. 2022, 190, e64262.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Automated Fractured Femur Segmentation using CNN
Vicory, J., Sahu, P., Wee, H., Nam, H., Chopra, A., Reid, J. S., Lewis, G. S. & Arikatla, V. S., 2022, Medical Imaging 2022: Image Processing. Colliot, O., Isgum, I., Landman, B. A. & Loew, M. H. (eds.). SPIE, 120322Z. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 12032).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
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Biomechanical Comparison of Fiber Tape Device Versus Transarticular Screws for Ligamentous Lisfranc Injury in a Cadaveric Model
Koroneos, Z. A., Manto, K. M., Martinazzi, B. J., Stauch, C., Bifano, S. M., Kunselman, A. R., Lewis, G. S. & Aynardi, M., Oct 2022, In: American Journal of Sports Medicine. 50, 12, p. 3299-3307 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Controlled Co-delivery of pPDGF-B and pBMP-2 from intraoperatively bioprinted bone constructs improves the repair of calvarial defects in rats
Moncal, K. K., Tigli Aydın, R. S., Godzik, K. P., Acri, T. M., Heo, D. N., Rizk, E., Wee, H., Lewis, G. S., Salem, A. K. & Ozbolat, I. T., Feb 2022, In: Biomaterials. 281, 121333.Research output: Contribution to journal › Article › peer-review
17 Scopus citations