• 807 Citations
  • 14 h-Index
20042019
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Research Output 2004 2019

  • 807 Citations
  • 14 h-Index
  • 41 Article
  • 2 Conference contribution
  • 1 Conference article
  • 1 Review article
2019
4 Citations (Scopus)

Brain cholesterol metabolism and Parkinson's disease

Huang, X., Sterling, N. W., Du, G., Sun, D., Stetter, C., Kong, L., Zhu, Y., Neighbors, J., Lewis, M. M., Chen, H., Hohl, R. J. & Mailman, R. B., Mar 2019, In : Movement Disorders. 34, 3, p. 386-395 10 p.

Research output: Contribution to journalArticle

Parkinson Disease
Cholesterol
Brain
Odds Ratio
Logistic Models
1 Citation (Scopus)

Development and validation of the automated imaging differentiation in parkinsonism (AID-P): a multicentre machine learning study

Archer, D. B., Bricker, J. T., Chu, W. T., Burciu, R. G., McCracken, J. L., Lai, S., Coombes, S. A., Fang, R., Barmpoutis, A., Corcos, D. M., Kurani, A. S., Mitchell, T., Black, M. L., Herschel, E., Simuni, T., Parrish, T. B., Comella, C., Xie, T., Seppi, K., Bohnen, N. I. & 11 others, Müller, M. LTM., Albin, R. L., Krismer, F., Du, G., Lewis, M. M., Huang, X., Li, H., Pasternak, O., McFarland, N. R., Okun, M. S. & Vaillancourt, D. E., Sep 2019, In : The Lancet Digital Health. 1, 5, p. e222-e231

Research output: Contribution to journalArticle

Open Access
Parkinsonian Disorders
Diffusion Magnetic Resonance Imaging
Progressive Supranuclear Palsy
Multiple System Atrophy
Area Under Curve
1 Citation (Scopus)

Higher Hippocampal Mean Diffusivity Values in Asymptomatic Welders

Lee, E. Y., Flynn, M. R., Du, G., Lewis, M. M., Kong, L., Yanosky, J. D., Mailman, R. B. & Huang, X., Apr 1 2019, In : Toxicological Sciences. 168, 2, p. 486-496 11 p.

Research output: Contribution to journalArticle

Manganese
Alzheimer Disease
Hippocampus
Brain
Diffusion tensor imaging
5 Citations (Scopus)

Magnetic resonance T1w/T2w ratio: A parsimonious marker for Parkinson disease

Du, G., Lewis, M. M., Sica, C., Kong, L. & Huang, X., Jan 2019, In : Annals of Neurology. 85, 1, p. 96-104 9 p.

Research output: Contribution to journalArticle

Parkinson Disease
Magnetic Resonance Spectroscopy
Sensitivity and Specificity
Area Under Curve
Magnetic Resonance Imaging

Multimodal MRI evaluation of parkinsonian limbic pathologies

Wang, E. W., Du, G., Lewis, M. M., Lee, E. Y., De Jesus, S., Kanekar, S., Kong, L. & Huang, X., Apr 2019, In : Neurobiology of Aging. 76, p. 194-200 7 p.

Research output: Contribution to journalArticle

Hippocampus
Nucleus Accumbens
Amygdala
Magnetic Resonance Imaging
Pathology
2018
14 Citations (Scopus)

Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients

Du, G., Lewis, M., Sica, C., He, L., Connor, J., Kong, L., Mailman, R. & Huang, X., Sep 1 2018, In : Movement Disorders. 33, 9, p. 1423-1431 9 p.

Research output: Contribution to journalArticle

Substantia Nigra
Control Groups
Parkinson Disease
Longitudinal Studies
Pars Reticulata
13 Citations (Scopus)

Susceptibility MRI captures nigral pathology in patients with parkinsonian syndromes

Lewis, M., Du, G., Baccon, J., Snyder, A., Murie, B., Cooper, F., Stetter, C., Kong, L., Sica, C., Mailman, R., Connor, J. & Huang, X., Sep 1 2018, In : Movement Disorders. 33, 9, p. 1432-1439 8 p.

Research output: Contribution to journalArticle

Synucleins
Parkinsonian Disorders
Substantia Nigra
Pathology
Iron
2017
6 Citations (Scopus)

Association of neurobehavioral performance with R2* in the caudate nucleus of asymptomatic welders

Lee, E. Y., Eslinger, P. J., Flynn, M. R., Wagner, D., Du, G., Lewis, M. M., Kong, L., Mailman, R. B. & Huang, X., Jan 1 2017, In : NeuroToxicology. 58, p. 66-74 9 p.

Research output: Contribution to journalArticle

Welding
Caudate Nucleus
Manganese
Brain
Neuropsychological Tests
3 Citations (Scopus)

Circulating cholesterol levels may link to the factors influencing Parkinson's Risk

Zhang, L., Wang, X., Wang, M., Sterling, N. W., Du, G., Lewis, M. M., Yao, T., Mailman, R. B., Li, R. & Huang, X., Sep 27 2017, In : Frontiers in Neurology. 8, SEP, 501.

Research output: Contribution to journalArticle

Parkinson Disease
Cholesterol
LDL Cholesterol
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Propensity Score
6 Citations (Scopus)
Progressive Supranuclear Palsy
Multiple System Atrophy
Diffusion Tensor Imaging
Parkinsonian Disorders
Parkinson Disease
4 Citations (Scopus)

Cortical gray and subcortical white matter associations in Parkinson's disease

Sterling, N. W., Du, G., Lewis, M. M., Swavely, S., Kong, L., Styner, M. & Huang, X., Jan 1 2017, In : Neurobiology of Aging. 49, p. 100-108 9 p.

Research output: Contribution to journalArticle

Parkinson Disease
Anisotropy
Atrophy
White Matter
15 Citations (Scopus)

Free water improves detection of changes in the substantia nigra in parkinsonism: A multisite study

Ofori, E., Krismer, F., Burciu, R. G., Pasternak, O., McCracken, J. L., Lewis, M. M., Du, G., McFarland, N. R., Okun, M. S., Poewe, W., Mueller, C., Gizewski, E. R., Schocke, M., Kremser, C., Li, H., Huang, X., Seppi, K. & Vaillancourt, D. E., Oct 2017, In : Movement Disorders. 32, 10, p. 1457-1464 8 p.

Research output: Contribution to journalArticle

Parkinsonian Disorders
Substantia Nigra
Water
Anisotropy
Diffusion Magnetic Resonance Imaging
2 Citations (Scopus)

Lateralized basal ganglia vulnerability to pesticide exposure in asymptomatic agricultural workers

Lewis, M., Sterling, N. W., Du, G., Lee, E. Y., Shyu, G., Goldenberg, M., Allen, T., Stetter, C., Kong, L., Snipes, S. A., Jones, B. C., Chen, H., Mailman, R. & Huang, X., Jan 1 2017, In : Toxicological Sciences. 159, 1, p. 170-178 9 p.

Research output: Contribution to journalArticle

Diffusion tensor imaging
Basal Ganglia
Pesticides
Corpus Striatum
Globus Pallidus

Predicting the multi-domain progression of Parkinson's disease: A Bayesian multivariate generalized linear mixed-effect model

Wang, M., Li, Z., Lee, E. Y., Lewis, M. M., Zhang, L., Sterling, N. W., Wagner, D., Eslinger, P., Du, G. & Huang, X., Sep 25 2017, In : BMC Medical Research Methodology. 17, 1, 147.

Research output: Contribution to journalArticle

Parkinson Disease
National Institute of Neurological Disorders and Stroke
Organized Financing
Statistical Models
ROC Curve
2016
5 Citations (Scopus)

Folded concave penalized learning in identifying multimodal MRI marker for Parkinson's disease

Liu, H., Du, G., Zhang, L., Lewis, M., Wang, X., Yao, T., Li, R. & Huang, X., Aug 1 2016, In : Journal of Neuroscience Methods. 268, p. 1-6 6 p.

Research output: Contribution to journalArticle

Parkinson Disease
Learning
Biomarkers
Passive Cutaneous Anaphylaxis
Logistic Models
8 Citations (Scopus)

Higher plasma LDL-cholesterol is associated with preserved executive and fine motor functions in Parkinson’s disease

Sterling, N. W., Lichtenstein, M., Lee, E. Y., Lewis, M. M., Evans, A., Eslinger, P. J., Du, G., Gao, X., Chen, H., Kong, L. & Huang, X., Jan 1 2016, In : Aging and Disease. 7, 3, p. 237-245 9 p.

Research output: Contribution to journalArticle

Open Access
LDL Cholesterol
Parkinson Disease
Cholesterol
Executive Function
Cognition
10 Citations (Scopus)

Increased R2* in the caudate nucleus of asymptomatic welders

Lee, E. Y., Flynn, M. R., Du, G., Li, Y., Lewis, M. M., Herring, A. H., Buren, E. V., Buren, S. V., Kong, L., Fry, R. C., Snyder, A. M., Connor, J. R., Yang, Q. X., Mailman, R. B. & Huang, X., Apr 1 2016, In : Toxicological Sciences. 150, 2, p. 369-377 9 p., kfv331.

Research output: Contribution to journalArticle

Welding
Caudate Nucleus
Manganese
Basal Ganglia
Blood
6 Citations (Scopus)

Longitudinal T1 relaxation rate (R1) captures changes in short-term Mn exposure in welders

Lewis, M. M., Flynn, M. R., Lee, E. Y., Van Buren, S., Van Buren, E., Du, G., Fry, R. C., Herring, A. H., Kong, L., Mailman, R. B. & Huang, X., Dec 1 2016, In : NeuroToxicology. 57, p. 39-44 6 p.

Research output: Contribution to journalArticle

Welding
Blood
Globus Pallidus
Biomarkers
Brain
7 Citations (Scopus)

Lower fractional anisotropy in the globus pallidus of asymptomatic welders, a marker for long-term welding exposure

Lee, E. Y., Flynn, M. R., Du, G., Lewis, M., Herring, A. H., Van Buren, E., Van Buren, S., Kong, L., Mailman, R. & Huang, X., Sep 1 2016, In : Toxicological Sciences. 153, 1, p. 165-173 9 p., kfw116.

Research output: Contribution to journalArticle

Welding
Globus Pallidus
Anisotropy
Manganese
Basal Ganglia
7 Citations (Scopus)

Parkinson's disease biomarkers program brain imaging repository

Ofori, E., Du, G., Babcock, D., Huang, X. & Vaillancourt, D. E., Jan 1 2016, In : NeuroImage. 124, p. 1120-1124 5 p.

Research output: Contribution to journalArticle

Neuroimaging
Parkinson Disease
Biomarkers
Essential Tremor
Information Dissemination
69 Citations (Scopus)

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

Du, G., Liu, T., Lewis, M. M., Kong, L., Wang, Y., Connor, J., Mailman, R. B. & Huang, X., Mar 1 2016, In : Movement Disorders. 31, 3, p. 317-324 8 p.

Research output: Contribution to journalArticle

Mesencephalon
Parkinson Disease
Iron
Levodopa
Magnetic Resonance Imaging
9 Citations (Scopus)

Stage-dependent loss of cortical gyrification as Parkinson disease "unfolds"

Sterling, N. W., Wang, M., Zhang, L., Lee, E. Y., Du, G., Lewis, M. M., Styner, M. & Huang, X., Mar 22 2016, In : Neurology. 86, 12, p. 1143-1151 9 p.

Research output: Contribution to journalArticle

Parkinson Disease
Dementia
Disease Progression
Linear Models
Pathology
12 Citations (Scopus)

Structural imaging and Parkinson's disease: Moving toward quantitative markers of disease progression

Sterling, N. W., Lewis, M. M., Du, G. & Huang, X., Jan 1 2016, In : Journal of Parkinson's Disease. 6, 3, p. 557-567 11 p.

Research output: Contribution to journalReview article

Parkinson Disease
Disease Progression
Pathology
Brain Diseases
Interneurons
13 Citations (Scopus)

Synergy as a new and sensitive marker of basal ganglia dysfunction: A study of asymptomatic welders

Lewis, M. M., Lee, E. Y., Jo, H. J., Du, G., Park, J., Flynn, M. R., Kong, L., Latash, M. L. & Huang, X., Sep 1 2016, In : NeuroToxicology. 56, p. 76-85 10 p.

Research output: Contribution to journalArticle

Manganese
Basal Ganglia
Iron
Anisotropy
Neurodegenerative diseases
8 Citations (Scopus)
Parkinson Disease
Biomarkers
Quality of Life
Linear Models
Regression Analysis
21 Citations (Scopus)

The pattern of gray matter atrophy in Parkinson’s disease differs in cortical and subcortical regions

Lewis, M. M., Du, G., Lee, E. Y., Nasralah, Z., Sterling, N. W., Zhang, L., Wagner, D., Kong, L., Tröster, A. I., Styner, M., Eslinger, P. J., Mailman, R. B. & Huang, X., Jan 1 2016, In : Journal of Neurology. 263, 1, p. 68-75 8 p.

Research output: Contribution to journalArticle

Atrophy
Parkinson Disease
Corpus Striatum
Putamen
Gray Matter
2015
3 Citations (Scopus)

Cortical thinning and cognitive impairment in Parkinson's disease without dementia

Zhang, L., Wang, M., Sterling, N. W., Lee, E. Y., Eslinger, P. J., Wagner, D., Du, G., Lewis, M. M., Truong, Y., Bowman, F. D. & Huang, X., 2015, In : IEEE/ACM Transactions on Computational Biology and Bioinformatics. PP, 99, 2465951.

Research output: Contribution to journalArticle

Parkinson's Disease
Dementia
Thinning
Parkinson Disease
Brain
11 Citations (Scopus)

Dopaminergic modulation of arm swing during gait among Parkinson's disease patients

Sterling, N. W., Cusumano, J. P., Shaham, N., Piazza, S. J., Liu, G., Kong, L., Du, G., Lewis, M. M. & Huang, X., Jan 1 2015, In : Journal of Parkinson's Disease. 5, 1, p. 141-150 10 p.

Research output: Contribution to journalArticle

Gait
Parkinson Disease
Arm
Dopamine Agents
Forearm
11 Citations (Scopus)
Parkinson Disease
Parietal Lobe
Brain
Neurodegenerative Diseases
Magnetic Resonance Spectroscopy
23 Citations (Scopus)

T1 relaxation rate (R1) indicates nonlinear mn accumulation in brain tissue of welders with low-level exposure

Lee, E. Y., Flynn, M. R., Du, G., Lewis, M. M., Fry, R., Herring, A. H., Van Buren, E., Van Buren, S., Smeester, L., Kong, L., Yang, Q., Mailman, R. B. & Huang, X., Aug 1 2015, In : Toxicological Sciences. 146, 2, p. 281-289 9 p.

Research output: Contribution to journalArticle

Manganese
Brain
Tissue
Welding
Globus Pallidus
2014
13 Citations (Scopus)

Microstructural changes in the substantia nigra of asymptomatic agricultural workers

Du, G., Lewis, M., Sterling, N. W., Kong, L., Chen, H., Mailman, R. & Huang, X., Jan 1 2014, In : Neurotoxicology and Teratology. 41, p. 60-64 5 p.

Research output: Contribution to journalArticle

Substantia Nigra
Pesticides
Parkinson Disease
Anisotropy
Magnetic resonance
41 Citations (Scopus)

Multi-atlas segmentation of subcortical brain structures via the AutoSeg software pipeline

Wang, J., Vachet, C., Rumple, A., Gouttard, S., Ouziel, C., Perrot, E., Du, G., Huang, X., Gerig, G. & Styner, M., Feb 6 2014, In : Frontiers in Neuroinformatics. 8, FEB, 7.

Research output: Contribution to journalArticle

Atlases
Brain
Software
Pipelines
Tissue
24 Citations (Scopus)

Olfactory-related cortical atrophy is associated with olfactory dysfunction in Parkinson's disease

Lee, E. Y., Eslinger, P., Du, G., Kong, L., Lewis, M. & Huang, X., Jan 1 2014, In : Movement Disorders. 29, 9, p. 1205-1208 4 p.

Research output: Contribution to journalArticle

Atrophy
Parkinson Disease
Prefrontal Cortex
Brain
Smell
2013
37 Citations (Scopus)

Early cortical gray matter loss and cognitive correlates in non-demented Parkinson's patients

Lee, E. Y., Sen, S., Eslinger, P. J., Wagner, D., Shaffer, M. L., Kong, L., Lewis, M. M., Du, G. & Huang, X., Dec 1 2013, In : Parkinsonism and Related Disorders. 19, 12, p. 1088-1093 6 p.

Research output: Contribution to journalArticle

Parkinson Disease
Occipital Lobe
Frontal Lobe
Gray Matter
Corpus Striatum
28 Citations (Scopus)

Higher iron in the red nucleus marks Parkinson's dyskinesia

Lewis, M., Du, G., Kidacki, M., Patel, N., Shaffer, M. L., Mailman, R. & Huang, X., May 1 2013, In : Neurobiology of Aging. 34, 5, p. 1497-1503 7 p.

Research output: Contribution to journalArticle

Red Nucleus
Dyskinesias
Parkinson Disease
Iron
Levodopa
39 Citations (Scopus)

Striatal shape in Parkinson's disease

Sterling, N. W., Du, G., Lewis, M. M., Dimaio, C., Kong, L., Eslinger, P. J., Styner, M. & Huang, X., Nov 1 2013, In : Neurobiology of Aging. 34, 11, p. 2510-2516 7 p.

Research output: Contribution to journalArticle

Corpus Striatum
Putamen
Parkinson Disease
Atrophy
Head
2012
68 Citations (Scopus)

Imaging nigral pathology and clinical progression in Parkinson's disease

Du, G., Lewis, M. M., Sen, S., Wang, J., Shaffer, M. L., Styner, M., Yang, Q. X. & Huang, X., Nov 1 2012, In : Movement Disorders. 27, 13, p. 1636-1643 8 p.

Research output: Contribution to journalArticle

Clinical Pathology
Substantia Nigra
Parkinson Disease
Anisotropy
Diffusion Tensor Imaging
10 Citations (Scopus)

Serum cholesterol and nigrostriatal R2* values in Parkinson's disease

Du, G., Lewis, M. M., Shaffer, M. L., Chen, H., Yang, Q. X., Mailman, R. B. & Huang, X., Apr 17 2012, In : PloS one. 7, 4, e35397.

Research output: Contribution to journalArticle

Parkinson disease
Parkinson Disease
Cholesterol
cholesterol
Iron
2011
112 Citations (Scopus)

Combined R2* and Diffusion Tensor Imaging Changes in the Substantia Nigra in Parkinson's Disease

Du, G., Lewis, M. M., Styner, M., Shaffer, M. L., Sen, S., Yang, Q. X. & Huang, X., Aug 1 2011, In : Movement Disorders. 26, 9, p. 1627-1632 6 p.

Research output: Contribution to journalArticle

Diffusion Tensor Imaging
Anisotropy
Substantia Nigra
Parkinson Disease
Magnetic Resonance Imaging
80 Citations (Scopus)

Differential involvement of striato- and cerebello-thalamo-cortical pathways in tremor- and akinetic/rigid-predominant Parkinson's disease

Lewis, M. M., Du, G., Sen, S., Kawaguchi, A., Truong, Y., Lee, S., Mailman, R. B. & Huang, X., Mar 17 2011, In : Neuroscience. 177, p. 230-239 10 p.

Research output: Contribution to journalArticle

Tremor
Parkinson Disease
Corpus Striatum
Hypokinesia
Basal Ganglia Diseases
36 Citations (Scopus)

Manganese accumulation in the olfactory bulbs and other brain regions of "asymptomatic" welders

Sen, S., Flynn, M. R., Du, G., Tröster, A. I., An, H. & Huang, X., May 2 2011, In : Toxicological Sciences. 121, 1, p. 160-167 8 p.

Research output: Contribution to journalArticle

Olfactory Bulb
Manganese
Brain
Magnetic resonance
Hand
2008
2 Citations (Scopus)

Comprehensive evaluation of an image segmentation technique for measuring tumor volume from CT images

Deng, X., Huang, H., Zhu, L., Du, G., Xu, X., Sun, Y., Xu, C., Jolly, M. P., Chen, J., Xiao, J., Merges, R., Suehling, M., Rinck, D., Song, L., Jin, Z., Jiang, Z., Wu, B., Wang, X., Zhang, S. & Peng, W., Jun 18 2008, Medical Imaging 2008 - Image Perception, Observer Performance, and Technology Assessment. 691705. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 6917).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cone-Beam Computed Tomography
Tumor Burden
Image segmentation
Tumors
tumors
2007

Reconstruction of the digital Chinese human

Qi, L., Zhou, G., Han, X., Du, G., Cao, H., Chai, H., Zhong, Q., Dong, S. & Luo, S., Dec 1 2007, 2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007. p. 140-146 7 p. 4381709. (2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Acupuncture
Neurosurgery
Image registration
Macros
Data acquisition
2005
1 Citation (Scopus)

Automatic segmentation and visualization of brain MRA images for image-guided neurosurgery

Du, G. W., Cao, H. Z. & Luo, S. Q., Aug 1 2005, In : Chinese Journal of Biomedical Engineering. 24, 4, p. 438-442 5 p.

Research output: Contribution to journalArticle

Neurosurgery
Brain
Visualization
2004
3 Citations (Scopus)

High resolution visualization of VCH-female dataset

Du, G., Chai, H., Cao, H. & Luo, S., Jun 1 2004, In : Proceedings of SPIE - The International Society for Optical Engineering. 5444, p. 453-458 6 p.

Research output: Contribution to journalConference article

parallel computers
preprocessing
Computer systems
High Resolution
Visualization