Guangwei Du, MD, PhD

    • 748 Citations
    • 13 h-Index
    20042019
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    Research Output 2004 2019

    • 748 Citations
    • 13 h-Index
    • 40 Article
    • 2 Conference contribution
    • 1 Conference article
    • 1 Review article
    2019
    2 Citations (Scopus)

    Brain cholesterol metabolism and Parkinson's disease

    Huang, X., Sterling, N. W., Du, G., Sun, D., Stetter, C., Kong, L., Zhu, Y., Neighbors, J., Lewis, M., Chen, H., Hohl, R. & Mailman, R., Mar 1 2019, In : Movement Disorders. 34, 3, p. 386-395 10 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Cholesterol
    Brain
    Odds Ratio
    Logistic Models

    Higher Hippocampal Mean Diffusivity Values in Asymptomatic Welders

    Lee, E. Y., Flynn, M. R., Du, G., Lewis, M., Kong, L., Yanosky, J., Mailman, R. & Huang, X., Apr 1 2019, In : Toxicological Sciences. 168, 2, p. 486-496 11 p.

    Research output: Contribution to journalArticle

    Manganese
    Alzheimer Disease
    Hippocampus
    Brain
    Diffusion tensor imaging
    4 Citations (Scopus)

    Magnetic resonance T1w/T2w ratio: A parsimonious marker for Parkinson disease

    Du, G., Lewis, M., Sica, C., Kong, L. & Huang, X., Jan 1 2019, In : Annals of Neurology. 85, 1, p. 96-104 9 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Magnetic Resonance Spectroscopy
    Sensitivity and Specificity
    Area Under Curve
    Magnetic Resonance Imaging

    Multimodal MRI evaluation of parkinsonian limbic pathologies

    Wang, E. W., Du, G., Lewis, M., Lee, E. Y., De Jesus, S., Kanekar, S., Kong, L. & Huang, X., Apr 1 2019, In : Neurobiology of Aging. 76, p. 194-200 7 p.

    Research output: Contribution to journalArticle

    Hippocampus
    Nucleus Accumbens
    Amygdala
    Magnetic Resonance Imaging
    Pathology
    2018
    11 Citations (Scopus)

    Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients

    Du, G., Lewis, M., Sica, C., He, L., Connor, J., Kong, L., Mailman, R. & Huang, X., Sep 1 2018, In : Movement Disorders. 33, 9, p. 1423-1431 9 p.

    Research output: Contribution to journalArticle

    Substantia Nigra
    Control Groups
    Parkinson Disease
    Longitudinal Studies
    Pars Reticulata
    11 Citations (Scopus)

    Susceptibility MRI captures nigral pathology in patients with parkinsonian syndromes

    Lewis, M., Du, G., Baccon, J., Snyder, A., Murie, B., Cooper, F., Stetter, C., Kong, L., Sica, C., Mailman, R., Connor, J. & Huang, X., Sep 1 2018, In : Movement Disorders. 33, 9, p. 1432-1439 8 p.

    Research output: Contribution to journalArticle

    Synucleins
    Parkinsonian Disorders
    Substantia Nigra
    Pathology
    Iron
    2017
    6 Citations (Scopus)

    Association of neurobehavioral performance with R2* in the caudate nucleus of asymptomatic welders

    Lee, E. Y., Eslinger, P., Flynn, M. R., Wagner, D., Du, G., Lewis, M., Kong, L., Mailman, R. & Huang, X., Jan 1 2017, In : NeuroToxicology. 58, p. 66-74 9 p.

    Research output: Contribution to journalArticle

    Welding
    Caudate Nucleus
    Manganese
    Brain
    Neuropsychological Tests
    2 Citations (Scopus)

    Circulating cholesterol levels may link to the factors influencing Parkinson's Risk

    Zhang, L., Wang, X., Wang, M., Sterling, N. W., Du, G., Lewis, M., Yao, T., Mailman, R., Li, R. & Huang, X., Sep 27 2017, In : Frontiers in Neurology. 8, SEP, 501.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Cholesterol
    LDL Cholesterol
    Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Propensity Score
    5 Citations (Scopus)
    Progressive Supranuclear Palsy
    Multiple System Atrophy
    Diffusion Tensor Imaging
    Parkinsonian Disorders
    Parkinson Disease
    4 Citations (Scopus)

    Cortical gray and subcortical white matter associations in Parkinson's disease

    Sterling, N. W., Du, G., Lewis, M., Swavely, S., Kong, L., Styner, M. & Huang, X., Jan 1 2017, In : Neurobiology of Aging. 49, p. 100-108 9 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Anisotropy
    Atrophy
    White Matter
    12 Citations (Scopus)

    Free water improves detection of changes in the substantia nigra in parkinsonism: A multisite study

    Ofori, E., Krismer, F., Burciu, R. G., Pasternak, O., McCracken, J. L., Lewis, M., Du, G., McFarland, N. R., Okun, M. S., Poewe, W., Mueller, C., Gizewski, E. R., Schocke, M., Kremser, C., Li, H., Huang, X., Seppi, K. & Vaillancourt, D. E., Oct 1 2017, In : Movement Disorders. 32, 10, p. 1457-1464 8 p.

    Research output: Contribution to journalArticle

    Parkinsonian Disorders
    Substantia Nigra
    Water
    Anisotropy
    Diffusion Magnetic Resonance Imaging
    2 Citations (Scopus)

    Lateralized basal ganglia vulnerability to pesticide exposure in asymptomatic agricultural workers

    Lewis, M., Sterling, N. W., Du, G., Lee, E. Y., Shyu, G., Goldenberg, M., Allen, T., Stetter, C., Kong, L., Snipes, S. A., Jones, B. C., Chen, H., Mailman, R. & Huang, X., Jan 1 2017, In : Toxicological Sciences. 159, 1, p. 170-178 9 p.

    Research output: Contribution to journalArticle

    Diffusion tensor imaging
    Basal Ganglia
    Pesticides
    Corpus Striatum
    Globus Pallidus

    Predicting the multi-domain progression of Parkinson's disease: A Bayesian multivariate generalized linear mixed-effect model

    Wang, M., Li, Z., Lee, E. Y., Lewis, M., Zhang, L., Sterling, N. W., Wagner, D., Eslinger, P., Du, G. & Huang, X., Sep 25 2017, In : BMC Medical Research Methodology. 17, 1, 147.

    Research output: Contribution to journalArticle

    Parkinson Disease
    National Institute of Neurological Disorders and Stroke
    Organized Financing
    Statistical Models
    ROC Curve
    2016
    5 Citations (Scopus)

    Folded concave penalized learning in identifying multimodal MRI marker for Parkinson's disease

    Liu, H., Du, G., Zhang, L., Lewis, M., Wang, X., Yao, T., Li, R. & Huang, X., Aug 1 2016, In : Journal of Neuroscience Methods. 268, p. 1-6 6 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Learning
    Biomarkers
    Passive Cutaneous Anaphylaxis
    Logistic Models
    7 Citations (Scopus)

    Higher plasma LDL-cholesterol is associated with preserved executive and fine motor functions in Parkinson’s disease

    Sterling, N. W., Lichtenstein, M., Lee, E. Y., Lewis, M., Evans, A., Eslinger, P., Du, G., Gao, X., Chen, H., Kong, L. & Huang, X., Jan 1 2016, In : Aging and Disease. 7, 3, p. 237-245 9 p.

    Research output: Contribution to journalArticle

    Open Access
    LDL Cholesterol
    Parkinson Disease
    Cholesterol
    Executive Function
    Cognition
    10 Citations (Scopus)

    Increased R2* in the caudate nucleus of asymptomatic welders

    Lee, E. Y., Flynn, M. R., Du, G., Li, Y., Lewis, M., Herring, A. H., Buren, E. V., Buren, S. V., Kong, L., Fry, R. C., Snyder, A., Connor, J., Yang, Q., Mailman, R. & Huang, X., Apr 1 2016, In : Toxicological Sciences. 150, 2, p. 369-377 9 p., kfv331.

    Research output: Contribution to journalArticle

    Welding
    Caudate Nucleus
    Manganese
    Basal Ganglia
    Blood
    6 Citations (Scopus)

    Longitudinal T1 relaxation rate (R1) captures changes in short-term Mn exposure in welders

    Lewis, M., Flynn, M. R., Lee, E. Y., Van Buren, S., Van Buren, E., Du, G., Fry, R. C., Herring, A. H., Kong, L., Mailman, R. & Huang, X., Dec 1 2016, In : NeuroToxicology. 57, p. 39-44 6 p.

    Research output: Contribution to journalArticle

    Welding
    Blood
    Globus Pallidus
    Biomarkers
    Brain
    7 Citations (Scopus)

    Lower fractional anisotropy in the globus pallidus of asymptomatic welders, a marker for long-term welding exposure

    Lee, E. Y., Flynn, M. R., Du, G., Lewis, M., Herring, A. H., Van Buren, E., Van Buren, S., Kong, L., Mailman, R. & Huang, X., Sep 1 2016, In : Toxicological Sciences. 153, 1, p. 165-173 9 p., kfw116.

    Research output: Contribution to journalArticle

    Welding
    Globus Pallidus
    Anisotropy
    Manganese
    Basal Ganglia
    6 Citations (Scopus)

    Parkinson's disease biomarkers program brain imaging repository

    Ofori, E., Du, G., Babcock, D., Huang, X. & Vaillancourt, D. E., Jan 1 2016, In : NeuroImage. 124, p. 1120-1124 5 p.

    Research output: Contribution to journalArticle

    Neuroimaging
    Parkinson Disease
    Biomarkers
    Essential Tremor
    Information Dissemination
    66 Citations (Scopus)

    Quantitative susceptibility mapping of the midbrain in Parkinson's disease

    Du, G., Liu, T., Lewis, M., Kong, L., Wang, Y., Connor, J., Mailman, R. & Huang, X., Mar 1 2016, In : Movement Disorders. 31, 3, p. 317-324 8 p.

    Research output: Contribution to journalArticle

    Mesencephalon
    Parkinson Disease
    Iron
    Levodopa
    Magnetic Resonance Imaging
    8 Citations (Scopus)

    Stage-dependent loss of cortical gyrification as Parkinson disease "unfolds"

    Sterling, N. W., Wang, M., Zhang, L., Lee, E. Y., Du, G., Lewis, M., Styner, M. & Huang, X., Mar 22 2016, In : Neurology. 86, 12, p. 1143-1151 9 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Dementia
    Disease Progression
    Linear Models
    Pathology
    10 Citations (Scopus)

    Structural imaging and Parkinson's disease: Moving toward quantitative markers of disease progression

    Sterling, N. W., Lewis, M., Du, G. & Huang, X., Jan 1 2016, In : Journal of Parkinson's Disease. 6, 3, p. 557-567 11 p.

    Research output: Contribution to journalReview article

    Parkinson Disease
    Disease Progression
    Pathology
    Brain Diseases
    Interneurons
    12 Citations (Scopus)

    Synergy as a new and sensitive marker of basal ganglia dysfunction: A study of asymptomatic welders

    Lewis, M., Lee, E. Y., Jo, H. J., Du, G., Park, J., Flynn, M. R., Kong, L., Latash, M. & Huang, X., Sep 1 2016, In : NeuroToxicology. 56, p. 76-85 10 p.

    Research output: Contribution to journalArticle

    Manganese
    Basal Ganglia
    Iron
    Anisotropy
    Neurodegenerative diseases
    8 Citations (Scopus)

    The key determinants to quality of life in Parkinson's disease patients: Results from the Parkinson's disease biomarker program (PDBP)

    He, L., Lee, E. Y., Sterling, N. W., Kong, L., Lewis, M., Du, G., Eslinger, P. & Huang, X., Jan 1 2016, In : Journal of Parkinson's Disease. 6, 3, p. 523-532 10 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Biomarkers
    Quality of Life
    Linear Models
    Regression Analysis
    18 Citations (Scopus)

    The pattern of gray matter atrophy in Parkinson’s disease differs in cortical and subcortical regions

    Lewis, M., Du, G., Lee, E. Y., Nasralah, Z., Sterling, N. W., Zhang, L., Wagner, D., Kong, L., Tröster, A. I., Styner, M., Eslinger, P., Mailman, R. & Huang, X., Jan 1 2016, In : Journal of Neurology. 263, 1, p. 68-75 8 p.

    Research output: Contribution to journalArticle

    Atrophy
    Parkinson Disease
    Corpus Striatum
    Putamen
    Gray Matter
    2015
    2 Citations (Scopus)

    Cortical thinning and cognitive impairment in Parkinson's disease without dementia

    Zhang, L., Wang, M., Sterling, N. W., Lee, E. Y., Eslinger, P. J., Wagner, D., Du, G., Lewis, M. M., Truong, Y., Bowman, F. D. & Huang, X., 2015, In : IEEE/ACM Transactions on Computational Biology and Bioinformatics. PP, 99, 2465951.

    Research output: Contribution to journalArticle

    Parkinson's Disease
    Dementia
    Thinning
    Parkinson Disease
    Brain
    9 Citations (Scopus)

    Dopaminergic modulation of arm swing during gait among Parkinson's disease patients

    Sterling, N. W., Cusumano, J. P., Shaham, N., Piazza, S. J., Liu, G., Kong, L., Du, G., Lewis, M. & Huang, X., Jan 1 2015, In : Journal of Parkinson's Disease. 5, 1, p. 141-150 10 p.

    Research output: Contribution to journalArticle

    Gait
    Parkinson Disease
    Arm
    Dopamine Agents
    Forearm
    11 Citations (Scopus)
    Parkinson Disease
    Parietal Lobe
    Brain
    Neurodegenerative Diseases
    Magnetic Resonance Spectroscopy
    22 Citations (Scopus)

    T1 relaxation rate (R1) indicates nonlinear mn accumulation in brain tissue of welders with low-level exposure

    Lee, E. Y., Flynn, M. R., Du, G., Lewis, M., Fry, R., Herring, A. H., Van Buren, E., Van Buren, S., Smeester, L., Kong, L., Yang, Q., Mailman, R. & Huang, X., Aug 1 2015, In : Toxicological Sciences. 146, 2, p. 281-289 9 p.

    Research output: Contribution to journalArticle

    Manganese
    Brain
    Tissue
    Welding
    Globus Pallidus
    2014
    13 Citations (Scopus)

    Microstructural changes in the substantia nigra of asymptomatic agricultural workers

    Du, G., Lewis, M., Sterling, N. W., Kong, L., Chen, H., Mailman, R. & Huang, X., Jan 1 2014, In : Neurotoxicology and Teratology. 41, p. 60-64 5 p.

    Research output: Contribution to journalArticle

    Substantia Nigra
    Pesticides
    Parkinson Disease
    Anisotropy
    Magnetic resonance
    39 Citations (Scopus)

    Multi-atlas segmentation of subcortical brain structures via the AutoSeg software pipeline

    Wang, J., Vachet, C., Rumple, A., Gouttard, S., Ouziel, C., Perrot, E., Du, G., Huang, X., Gerig, G. & Styner, M., Feb 6 2014, In : Frontiers in Neuroinformatics. 8, FEB, 7.

    Research output: Contribution to journalArticle

    Atlases
    Brain
    Software
    Pipelines
    Tissue
    19 Citations (Scopus)

    Olfactory-related cortical atrophy is associated with olfactory dysfunction in Parkinson's disease

    Lee, E. Y., Eslinger, P., Du, G., Kong, L., Lewis, M. & Huang, X., Jan 1 2014, In : Movement Disorders. 29, 9, p. 1205-1208 4 p.

    Research output: Contribution to journalArticle

    Atrophy
    Parkinson Disease
    Prefrontal Cortex
    Brain
    Smell
    2013
    35 Citations (Scopus)

    Early cortical gray matter loss and cognitive correlates in non-demented Parkinson's patients

    Lee, E. Y., Sen, S., Eslinger, P., Wagner, D., Shaffer, M. L., Kong, L., Lewis, M., Du, G. & Huang, X., Dec 1 2013, In : Parkinsonism and Related Disorders. 19, 12, p. 1088-1093 6 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Occipital Lobe
    Frontal Lobe
    Gray Matter
    Corpus Striatum
    27 Citations (Scopus)

    Higher iron in the red nucleus marks Parkinson's dyskinesia

    Lewis, M., Du, G., Kidacki, M., Patel, N., Shaffer, M. L., Mailman, R. & Huang, X., May 1 2013, In : Neurobiology of Aging. 34, 5, p. 1497-1503 7 p.

    Research output: Contribution to journalArticle

    Red Nucleus
    Dyskinesias
    Parkinson Disease
    Iron
    Levodopa
    37 Citations (Scopus)

    Striatal shape in Parkinson's disease

    Sterling, N. W., Du, G., Lewis, M., Dimaio, C., Kong, L., Eslinger, P., Styner, M. & Huang, X., Nov 1 2013, In : Neurobiology of Aging. 34, 11, p. 2510-2516 7 p.

    Research output: Contribution to journalArticle

    Corpus Striatum
    Putamen
    Parkinson Disease
    Atrophy
    Head
    2012
    68 Citations (Scopus)

    Imaging nigral pathology and clinical progression in Parkinson's disease

    Du, G., Lewis, M., Sen, S., Wang, J., Shaffer, M. L., Styner, M., Yang, Q. & Huang, X., Nov 1 2012, In : Movement Disorders. 27, 13, p. 1636-1643 8 p.

    Research output: Contribution to journalArticle

    Clinical Pathology
    Substantia Nigra
    Parkinson Disease
    Anisotropy
    Diffusion Tensor Imaging
    9 Citations (Scopus)

    Serum cholesterol and nigrostriatal R2* values in Parkinson's disease

    Du, G., Lewis, M., Shaffer, M. L., Chen, H., Yang, Q., Mailman, R. & Huang, X., Apr 17 2012, In : PloS one. 7, 4, e35397.

    Research output: Contribution to journalArticle

    Parkinson disease
    Parkinson Disease
    Cholesterol
    cholesterol
    Iron
    2011
    106 Citations (Scopus)

    Combined R2* and Diffusion Tensor Imaging Changes in the Substantia Nigra in Parkinson's Disease

    Du, G., Lewis, M., Styner, M., Shaffer, M. L., Sen, S., Yang, Q. & Huang, X., Aug 1 2011, In : Movement Disorders. 26, 9, p. 1627-1632 6 p.

    Research output: Contribution to journalArticle

    Diffusion Tensor Imaging
    Anisotropy
    Substantia Nigra
    Parkinson Disease
    Magnetic Resonance Imaging
    78 Citations (Scopus)

    Differential involvement of striato- and cerebello-thalamo-cortical pathways in tremor- and akinetic/rigid-predominant Parkinson's disease

    Lewis, M., Du, G., Sen, S., Kawaguchi, A., Truong, Y., Lee, S., Mailman, R. & Huang, X., Mar 17 2011, In : Neuroscience. 177, p. 230-239 10 p.

    Research output: Contribution to journalArticle

    Tremor
    Parkinson Disease
    Corpus Striatum
    Hypokinesia
    Basal Ganglia Diseases
    35 Citations (Scopus)

    Manganese accumulation in the olfactory bulbs and other brain regions of "asymptomatic" welders

    Sen, S., Flynn, M. R., Du, G., Tröster, A. I., An, H. & Huang, X., May 2 2011, In : Toxicological Sciences. 121, 1, p. 160-167 8 p.

    Research output: Contribution to journalArticle

    Olfactory Bulb
    Manganese
    Brain
    Magnetic resonance
    Hand
    2008
    2 Citations (Scopus)

    Comprehensive evaluation of an image segmentation technique for measuring tumor volume from CT images

    Deng, X., Huang, H., Zhu, L., Du, G., Xu, X., Sun, Y., Xu, C., Jolly, M. P., Chen, J., Xiao, J., Merges, R., Suehling, M., Rinck, D., Song, L., Jin, Z., Jiang, Z., Wu, B., Wang, X., Zhang, S. & Peng, W., Jun 18 2008, Medical Imaging 2008 - Image Perception, Observer Performance, and Technology Assessment. 691705. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 6917).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Cone-Beam Computed Tomography
    Tumor Burden
    Image segmentation
    Tumors
    tumors
    2007

    Reconstruction of the digital Chinese human

    Qi, L., Zhou, G., Han, X., Du, G., Cao, H., Chai, H., Zhong, Q., Dong, S. & Luo, S., Dec 1 2007, 2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007. p. 140-146 7 p. 4381709. (2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Acupuncture
    Neurosurgery
    Image registration
    Macros
    Data acquisition
    2005
    1 Citation (Scopus)

    Automatic segmentation and visualization of brain MRA images for image-guided neurosurgery

    Du, G., Cao, H. Z. & Luo, S. Q., Aug 1 2005, In : Chinese Journal of Biomedical Engineering. 24, 4, p. 438-442 5 p.

    Research output: Contribution to journalArticle

    Neurosurgery
    Brain
    Visualization
    2004
    3 Citations (Scopus)

    High resolution visualization of VCH-female dataset

    Du, G., Chai, H., Cao, H. & Luo, S., Jun 1 2004, In : Proceedings of SPIE - The International Society for Optical Engineering. 5444, p. 453-458 6 p.

    Research output: Contribution to journalConference article

    parallel computers
    preprocessing
    Computer systems
    High Resolution
    Visualization