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Personal profile

Research interests

Dr. Hong-Gang “H.G.” Wang formerly worked at the H. Lee Moffitt Cancer Center and the University of South Florida in Tampa, beginning as assistant professor in 1998 and advancing to the rank of professor before moving to Penn State College of Medicine in 2008. Research in Dr. Wang’s laboratory aims to better understand the fundamental mechanisms that control apoptosis (self-killing) and autophagy (self-eating) in the context of oncogenesis. In addition, targeting of these two closely related but distinct self-destructive cellular processes for anticancer drug discovery and development is another major interest of his research group. The ultimate goal of Dr. Wang’s research is to translate basic science discoveries to the development of new approaches for the treatment of cancer.

Education/Academic qualification

Postdoctoral Fellowship, Sanford Burnham Prebys Medical Discovery Institute


PhD, University of Tsukuba


BS, University of Tsukuba


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Research Output

A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission

Flower, T. G., Takahashi, Y., Hudait, A., Rose, K., Tjahjono, N., Pak, A. J., Yokom, A. L., Liang, X., Wang, H. G., Bouamr, F., Voth, G. A. & Hurley, J. H., Jun 1 2020, In : Nature Structural and Molecular Biology. 27, 6, p. 570-580 11 p.

Research output: Contribution to journalArticle

  • Ceramide analogue SACLAC modulates sphingolipid levels and MCL-1 splicing to induce apoptosis in acute myeloid leukemia

    Pearson, J. M., Tan, S. F., Sharma, A., Annageldiyev, C., Fox, T. E., Abad, J. L., Fabrias, G., Desai, D., Amin, S., Wang, H. G., Cabot, M. C., Claxton, D. F., Kester, M., Feith, D. J. & Loughran, T. P., 2020, In : Molecular Cancer Research. 18, 3, p. 352-363 12 p.

    Research output: Contribution to journalArticle

  • Expression of R345W-Fibulin-3 Induces Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells

    Zhou, M., Weber, S. R., Zhao, Y., Chen, H., Barber, A. J., Grillo, S. L., Wills, C. A., Wang, H-G., Hulleman, J. D. & Sundstrom, J., Jun 19 2020, In : Frontiers in Cell and Developmental Biology. 8, 469.

    Research output: Contribution to journalArticle

    Open Access
  • Expression patterns of immune genes reveal heterogeneous subtypes of high-risk neuroblastoma

    Liu, Z., Grant, C. N., Sun, L., Miller, B. A., Spiegelman, V. S. & Wang, H. G., 2020, In : Cancers. 12, 7, p. 1-16 16 p., 1739.

    Research output: Contribution to journalArticle

    Open Access
  • Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy

    Chen, S. J., Bao, L., Keefer, K., Shanmughapriya, S., Chen, L., Lee, J., Wang, J. F., Zhang, X. Q., Hirschler-Laszkiewicz, I., Merali, S., Merali, C., Imamura, Y., Dovat, S., Madesh, M., Cheung, J. Y., Wang, H. G. & Miller, B. A., Apr 1 2020, In : Cell Death and Disease. 11, 4, 247.

    Research output: Contribution to journalArticle

    Open Access