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Personal profile

Research interests

Dr. Hong-Gang “H.G.” Wang formerly worked at the H. Lee Moffitt Cancer Center and the University of South Florida in Tampa, beginning as assistant professor in 1998 and advancing to the rank of professor before moving to Penn State College of Medicine in 2008. Research in Dr. Wang’s laboratory aims to better understand the fundamental mechanisms that control apoptosis (self-killing) and autophagy (self-eating) in the context of oncogenesis. In addition, targeting of these two closely related but distinct self-destructive cellular processes for anticancer drug discovery and development is another major interest of his research group. The ultimate goal of Dr. Wang’s research is to translate basic science discoveries to the development of new approaches for the treatment of cancer.

Education/Academic qualification

Postdoctoral Fellowship, Sanford Burnham Prebys Medical Discovery Institute

19931997

PhD, University of Tsukuba

19871992

BS, University of Tsukuba

19831987

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Projects

  • Targeted Sphingolipid Metabolism for Treatment of AML

    Claxton, D., Wang, H., Wang, H., Amin, S., Liao, J. (., Fox, T., Loughran, T. P., Kester, M., Cabot, M. C., Loughran, T. P. & Kester, M.

    National Institutes of Health

    9/10/138/31/19

    Project: Research project

  • Research Output

    Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

    Tan, S. F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., Doi, K., Conaway, M. R., Amin, S., Claxton, D. F., Wang, H. G., Kester, M., Cabot, M. C., Feith, D. J. & Loughran, T. P., Jan 1 2019, In : Journal of Lipid Research. 60, 6, p. 1078-1086 9 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    ATG2 regulation of phagophore expansion at mitochondria-associated ER membranes

    Tang, Z., Takahashi, Y. & Wang, H. G., Dec 2 2019, In : Autophagy. 15, 12, p. 2165-2166 2 p.

    Research output: Contribution to journalComment/debate

  • 1 Scopus citations

    Bif-1 interacts with prohibitin-2 to regulate mitochondrial inner membrane during cell stress and apoptosis

    Cho, S. G., Xiao, X., Wang, S., Gao, H., Rafikov, R., Black, S., Huang, S., Ding, H. F., Yoon, Y., Kirken, R. A., Yin, X. M., Wang, H. G. & Dong, Z., Jul 2019, In : Journal of the American Society of Nephrology. 30, 7, p. 1174-1191 18 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations
    Open Access
  • 1 Scopus citations

    Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ

    Liu, Z., Wei, Y., Zhang, L., Yee, P. P., Johnson, M., Zhang, X., Gulley, M., Atkinson, J. M., Trebak, M., Wang, H-G. & Li, W., Jan 3 2019, In : Oncogene. 38, 1, p. 120-139 20 p.

    Research output: Contribution to journalArticle

  • 9 Scopus citations