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Personal profile

Research interests

Dr. Hong-Gang “H.G.” Wang formerly worked at the H. Lee Moffitt Cancer Center and the University of South Florida in Tampa, beginning as assistant professor in 1998 and advancing to the rank of professor before moving to Penn State College of Medicine in 2008. Research in Dr. Wang’s laboratory aims to better understand the fundamental mechanisms that control apoptosis (self-killing) and autophagy (self-eating) in the context of oncogenesis. In addition, targeting of these two closely related but distinct self-destructive cellular processes for anticancer drug discovery and development is another major interest of his research group. The ultimate goal of Dr. Wang’s research is to translate basic science discoveries to the development of new approaches for the treatment of cancer.

Education/Academic qualification

Postdoctoral Fellowship, Sanford Burnham Prebys Medical Discovery Institute


PhD, University of Tsukuba


BS, University of Tsukuba


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Apoptosis Medicine & Life Sciences
Autophagy Medicine & Life Sciences
Proteins Medicine & Life Sciences
Cell Death Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Cells Chemical Compounds
Caspase 3 Medicine & Life Sciences
Cell death Chemical Compounds

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Projects 1999 2023

Caspase 8
Death Domain Receptor Signaling Adaptor Proteins
Endosomal Sorting Complexes Required for Transport
Membrane Fusion

Targeted Sphingolipid Metabolism for Treatment of AML

Claxton, D., Wang, H., Wang, H., Amin, S., Liao, J. (., Fox, T., Loughran, T. P., Loughran, T. P., Kester, M., Kester, M. & Cabot, M. C.

National Institutes of Health


Project: Research project

Acute Myeloid Leukemia
Acid Ceramidase
Tumor Microenvironment
Cell Survival
Neoplasm Metastasis
src Homology Domains

Research Output 1994 2019

1 Citation (Scopus)

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Tan, S. F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., Doi, K., Conaway, M. R., Amin, S., Claxton, D., Wang, H-G., Kester, M., Cabot, M. C., Feith, D. J. & Loughran, T. P., Jan 1 2019, In : Journal of Lipid Research. 60, 6, p. 1078-1086 9 p.

Research output: Contribution to journalArticle

Acid Ceramidase
Drug Resistance
Acute Myeloid Leukemia

Bif-1 interacts with prohibitin-2 to regulate mitochondrial inner membrane during cell stress and apoptosis

Cho, S. G., Xiao, X., Wang, S., Gao, H., Rafikov, R., Black, S., Huang, S., Ding, H. F., Yoon, Y., Kirken, R. A., Yin, X. M., Wang, H-G. & Dong, Z., Jul 1 2019, In : Journal of the American Society of Nephrology. 30, 7, p. 1174-1191 18 p.

Research output: Contribution to journalArticle

Mitochondrial Membranes
Mitochondrial Dynamics
1 Citation (Scopus)

EGFR mutations and AKT phosphorylation are markers for sensitivity to combined MCL-1 and BCL-2/xL inhibition in non-small cell lung cancer

Rice, S. J., Liu, X., Wang, H-G. & Belani, C., May 1 2019, In : PloS one. 14, 5, e0217657.

Research output: Contribution to journalArticle

Open Access
lung neoplasms
Non-Small Cell Lung Carcinoma
Lung Neoplasms
6 Citations (Scopus)

Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ

Liu, Z., Wei, Y., Zhang, L., Yee, P. P., Johnson, M., Zhang, X., Gulley, M., Atkinson, J. M., Trebak, M., Wang, H-G. & Li, W., Jan 3 2019, In : Oncogene. 38, 1, p. 120-139 20 p.

Research output: Contribution to journalArticle

Protein Kinase C beta

Pivotal role of mitophagy in response of acute myelogenous leukemia to a ceramide-tamoxifen-containing drug regimen

Morad, S. A. F., MacDougall, M. R., Abdelmageed, N., Kao, L. P., Feith, D. J., Tan, S. F., Kester, M., Loughran, T. P., Wang, H-G. & Cabot, M. C., Aug 15 2019, In : Experimental Cell Research. 381, 2, p. 256-264 9 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Acute Myeloid Leukemia
Pharmaceutical Preparations