If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research interests

Dr. Hong-Gang “H.G.” Wang formerly worked at the H. Lee Moffitt Cancer Center and the University of South Florida in Tampa, beginning as assistant professor in 1998 and advancing to the rank of professor before moving to Penn State College of Medicine in 2008. Research in Dr. Wang’s laboratory aims to better understand the fundamental mechanisms that control apoptosis (self-killing) and autophagy (self-eating) in the context of oncogenesis. In addition, targeting of these two closely related but distinct self-destructive cellular processes for anticancer drug discovery and development is another major interest of his research group. The ultimate goal of Dr. Wang’s research is to translate basic science discoveries to the development of new approaches for the treatment of cancer.

Education/Academic qualification

Postdoctoral Fellowship, Sanford Burnham Prebys Medical Discovery Institute

19931997

PhD, University of Tsukuba

19871992

BS, University of Tsukuba

19831987

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 15 Similar Profiles
Apoptosis Medicine & Life Sciences
Autophagy Medicine & Life Sciences
Proteins Medicine & Life Sciences
Cell Death Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Caspase 3 Medicine & Life Sciences
Cells Chemical Compounds
Cell death Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 1999 2023

Caspase 8
Death Domain Receptor Signaling Adaptor Proteins
Autophagy
Membranes
Neoplasms

Autophagosome closure by the ESCRT machinery

Wang, H.

National Institutes of Health

7/1/183/31/22

Project: Research projectResearch Project

Endosomal Sorting Complexes Required for Transport
Autophagy
Membranes
Membrane Fusion
Recycling

Targeted Sphingolipid Metabolism for Treatment of AML

Claxton, D., Wang, H., Wang, H., Amin, S., Liao, J. (., Fox, T., Loughran, T. P., Loughran, T. P., Kester, M., Kester, M. & Cabot, M. C.

National Institutes of Health

9/10/138/31/18

Project: Research projectResearch Program Projects

Acute Myeloid Leukemia
Acid Ceramidase
Sphingolipids
Ceramides
Tamoxifen

Targeting autophagy in the TME

Wang, H.

National Institutes of Health

7/1/126/30/15

Project: Research projectExploratory/Developmental Grants

Tumor Microenvironment
Autophagy
Neoplasms
Cell Survival
Neoplasm Metastasis

Regulation of Autophagy and Tumorigenesis by Bif-1

Wang, H.

National Institutes of Health

4/1/091/31/15

Project: Research projectResearch Project

Autophagy
Carcinogenesis
Membranes
src Homology Domains
Neoplasms

Research Output 1994 2018

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

Takahashi, Y., He, H., Tang, Z., Hattori, T., Liu, Y., Young, M. M., Serfass, J. M., Chen, L., Gebru, M., Chen, C., Wills, C. A., Atkinson, J. M., Chen, H., Abraham, T. & Wang, H. G., Dec 1 2018, In : Nature Communications. 9, 1, 2855.

Research output: Contribution to journalArticle

Endosomal Sorting Complexes Required for Transport
regulators
Autophagy
classifying
closures
2 Citations

Mechanisms and context underlying the role of autophagy in cancer metastasis

Dower, C. M., Wills, C. A., Frisch, S. M. & Wang, H. G., Jul 3 2018, In : Autophagy. 14, 7, p. 1110-1128 19 p.

Research output: Contribution to journalReview article

Autophagy
Neoplasm Metastasis
Neoplasms
Cell Survival
Anoikis

Sphingolipids as Regulators of Autophagy and Endocytic Trafficking

Young, M. M. & Wang, H. G., Jan 1 2018, Advances in Cancer Research. Academic Press Inc., p. 27-60 34 p. (Advances in Cancer Research; vol. 140).

Research output: Chapter in Book/Report/Conference proceedingChapter

Sphingolipids
Autophagy
Neoplasms
Organelles
Ceramides
1 Citations

Targeted Inhibition of ULK1 Promotes Apoptosis and Suppresses Tumor Growth and Metastasis in Neuroblastoma

Dower, C. M., Bhat, N., Gebru, M. T., Chen, L., Wills, C. A., Miller, B. A. & Wang, H-G., Nov 1 2018, In : Molecular cancer therapeutics. 17, 11, p. 2365-2376 12 p.

Research output: Contribution to journalArticle

Autophagy
Neuroblastoma
Apoptosis
Neoplasm Metastasis
Growth
5 Citations

TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition

Lima, S., Takabe, K., Newton, J., Saurabh, K., Young, M. M., Leopoldino, A. M., Hait, N. C., Roberts, J. L., Wang, H-G., Dent, P., Milstien, S., Booth, L. & Spiegel, S., Jun 3 2018, In : Autophagy. 14, 6, p. 942-957 16 p.

Research output: Contribution to journalArticle

Cell Death
Null Lymphocytes
Autophagy
Vacuoles
Neoplasms