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Personal profile

Research interests

Dr. Hong-Gang “H.G.” Wang formerly worked at the H. Lee Moffitt Cancer Center and the University of South Florida in Tampa, beginning as assistant professor in 1998 and advancing to the rank of professor before moving to Penn State College of Medicine in 2008. Research in Dr. Wang’s laboratory aims to better understand the fundamental mechanisms that control apoptosis (self-killing) and autophagy (self-eating) in the context of oncogenesis. In addition, targeting of these two closely related but distinct self-destructive cellular processes for anticancer drug discovery and development is another major interest of his research group. The ultimate goal of Dr. Wang’s research is to translate basic science discoveries to the development of new approaches for the treatment of cancer.

Education/Academic qualification

Postdoctoral Fellowship, Sanford Burnham Prebys Medical Discovery Institute

19931997

PhD, University of Tsukuba

19871992

BS, University of Tsukuba

19831987

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Apoptosis Medicine & Life Sciences
Autophagy Medicine & Life Sciences
Proteins Medicine & Life Sciences
Cell Death Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Caspase 3 Medicine & Life Sciences
Cells Chemical Compounds
Cell death Chemical Compounds

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Projects 1999 2023

Caspase 8
Death Domain Receptor Signaling Adaptor Proteins
Autophagy
Membranes
Neoplasms
Endosomal Sorting Complexes Required for Transport
Autophagy
Membranes
Membrane Fusion
Recycling

Targeted Sphingolipid Metabolism for Treatment of AML

Claxton, D., Wang, H., Wang, H., Amin, S., Liao, J. (., Fox, T., Loughran, T. P., Loughran, T. P., Kester, M., Kester, M. & Cabot, M. C.

National Institutes of Health

9/10/138/31/19

Project: Research project

Acute Myeloid Leukemia
Acid Ceramidase
Sphingolipids
Ceramides
Tamoxifen
Tumor Microenvironment
Autophagy
Neoplasms
Cell Survival
Neoplasm Metastasis
Autophagy
Carcinogenesis
Membranes
src Homology Domains
Neoplasms

Research Output 1994 2019

Bif-1 interacts with prohibitin-2 to regulate mitochondrial inner membrane during cell stress and apoptosis

Cho, S. G., Xiao, X., Wang, S., Gao, H., Rafikov, R., Black, S., Huang, S., Ding, H. F., Yoon, Y., Kirken, R. A., Yin, X. M., Wang, H-G. & Dong, Z., Jul 1 2019, In : Journal of the American Society of Nephrology. 30, 7, p. 1174-1191 18 p.

Research output: Contribution to journalArticle

Mitochondrial Membranes
Mitochondria
Apoptosis
Proteolysis
Mitochondrial Dynamics
4 Citations (Scopus)

Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ

Liu, Z., Wei, Y., Zhang, L., Yee, P. P., Johnson, M., Zhang, X., Gulley, M., Atkinson, J. M., Trebak, M., Wang, H-G. & Li, W., Jan 3 2019, In : Oncogene. 38, 1, p. 120-139 20 p.

Research output: Contribution to journalArticle

Protein Kinase C beta
Glioblastoma
Amlodipine
Calcium
Growth

Pivotal role of mitophagy in response of acute myelogenous leukemia to a ceramide-tamoxifen-containing drug regimen

Morad, S. A. F., MacDougall, M. R., Abdelmageed, N., Kao, L. P., Feith, D. J., Tan, S. F., Kester, M., Loughran, T. P., Wang, H-G. & Cabot, M. C., Aug 15 2019, In : Experimental Cell Research. 381, 2, p. 256-264 9 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Ceramides
Tamoxifen
Acute Myeloid Leukemia
Pharmaceutical Preparations

TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion

Tang, Z., Takahashi, Y., He, H., Hattori, T., Chen, C., Liang, X., Chen, H., Young, M. M. & Wang, H-G., Jan 1 2019, In : Cell Reports.

Research output: Contribution to journalArticle

Open Access
Mitochondria
Membranes
Fluxes
Mitochondrial Proteins
Autophagy
15 Citations (Scopus)

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

Takahashi, Y., He, H., Tang, Z., Hattori, T., Liu, Y., Young, M. M., Serfass, J. M., Chen, L., Gebru, M., Chen, C., Wills, C. A., Atkinson, J. M., Chen, H., Abraham, T. & Wang, H-G., Dec 1 2018, In : Nature communications. 9, 1, 2855.

Research output: Contribution to journalArticle

Endosomal Sorting Complexes Required for Transport
regulators
Autophagy
classifying
closures