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Research Output 1994 2019

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Article
2019
1 Citation (Scopus)

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Tan, S. F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., Doi, K., Conaway, M. R., Amin, S., Claxton, D., Wang, H-G., Kester, M., Cabot, M. C., Feith, D. J. & Loughran, T. P., Jan 1 2019, In : Journal of Lipid Research. 60, 6, p. 1078-1086 9 p.

Research output: Contribution to journalArticle

Acid Ceramidase
P-Glycoprotein
Drug Resistance
Acute Myeloid Leukemia
Up-Regulation

Bif-1 interacts with prohibitin-2 to regulate mitochondrial inner membrane during cell stress and apoptosis

Cho, S. G., Xiao, X., Wang, S., Gao, H., Rafikov, R., Black, S., Huang, S., Ding, H. F., Yoon, Y., Kirken, R. A., Yin, X. M., Wang, H. G. & Dong, Z., Jul 2019, In : Journal of the American Society of Nephrology. 30, 7, p. 1174-1191 18 p.

Research output: Contribution to journalArticle

Mitochondrial Membranes
Apoptosis
Proteolysis
Mitochondrial Dynamics
Kidney
1 Citation (Scopus)
Open Access
Phosphorylation
lung neoplasms
Non-Small Cell Lung Carcinoma
Lung Neoplasms
phosphorylation
8 Citations (Scopus)

Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ

Liu, Z., Wei, Y., Zhang, L., Yee, P. P., Johnson, M., Zhang, X., Gulley, M., Atkinson, J. M., Trebak, M., Wang, H-G. & Li, W., Jan 3 2019, In : Oncogene. 38, 1, p. 120-139 20 p.

Research output: Contribution to journalArticle

Protein Kinase C beta
Glioblastoma
Amlodipine
Calcium
Growth

Pivotal role of mitophagy in response of acute myelogenous leukemia to a ceramide-tamoxifen-containing drug regimen

Morad, S. A. F., MacDougall, M. R., Abdelmageed, N., Kao, L. P., Feith, D. J., Tan, S. F., Kester, M., Loughran, T. P., Wang, H. G. & Cabot, M. C., Aug 15 2019, In : Experimental Cell Research. 381, 2, p. 256-264 9 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Ceramides
Tamoxifen
Acute Myeloid Leukemia
Pharmaceutical Preparations

Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia

Barth, B. M., Wang, W., Toran, P. T., Fox, T. E., Annageldiyev, C., Ondrasik, R. M., Keasey, N. R., Brown, T. J., Devine, V. G., Sullivan, E. C., Cote, A. L., Papakotsi, V., Tan, S. F., Shanmugavelandy, S. S., Deering, T. G., Needle, D. B., Stern, S. T., Zhu, J., Liao, J., Viny, A. D. & 7 others, Feith, D. J., Levine, R. L., Wang, H. G., Loughran, T. P., Sharma, A., Kester, M. & Claxton, D. F., Sep 10 2019, In : Blood Advances. 3, 17, p. 2598-2603 6 p.

Research output: Contribution to journalArticle

Open Access
Sphingolipids
Ceramides
Acute Myeloid Leukemia
Therapeutics

Time-resolved FRET and NMR analyses reveal selective binding of peptides containing the LC3-interacting region to ATG8 family proteins

Atkinson, J. M., Ye, Y., Gebru, M. T., Liu, Q., Zhou, S., Young, M. M., Takahashi, Y., Lin, Q., Tian, F. & Wang, H. G., Jan 1 2019, In : Journal of Biological Chemistry. 294, 38, p. 14033-14042 10 p.

Research output: Contribution to journalArticle

Open Access
Autophagy
Nuclear magnetic resonance
Peptides
Proteins
GABA Receptors
1 Citation (Scopus)

TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion

Tang, Z., Takahashi, Y., He, H., Hattori, T., Chen, C., Liang, X., Chen, H., Young, M. M. & Wang, H. G., Aug 13 2019, In : Cell Reports. 28, 7, p. 1744-1757.e5

Research output: Contribution to journalArticle

Open Access
Mitochondria
Membranes
Fluxes
Mitochondrial Proteins
Autophagy
1 Citation (Scopus)

VPS37A directs ESCRT recruitment for phagophore closure

Takahashi, Y., Liang, X., Hattori, T., Tang, Z., He, H., Chen, H., Liu, X., Abraham, T., Imamura-Kawasawa, Y., Buchkovich, N. J., Young, M. M. & Wang, H. G., Oct 7 2019, In : The Journal of cell biology. 218, 10, p. 3336-3354 19 p.

Research output: Contribution to journalArticle

Open Access
Endosomal Sorting Complexes Required for Transport
Clustered Regularly Interspaced Short Palindromic Repeats
Multivesicular Bodies
Ubiquitin
Epidermal Growth Factor Receptor
2018
25 Citations (Scopus)

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

Takahashi, Y., He, H., Tang, Z., Hattori, T., Liu, Y., Young, M. M., Serfass, J. M., Chen, L., Gebru, M., Chen, C., Wills, C. A., Atkinson, J. M., Chen, H., Abraham, T. & Wang, H-G., Dec 1 2018, In : Nature communications. 9, 1, 2855.

Research output: Contribution to journalArticle

Endosomal Sorting Complexes Required for Transport
regulators
Autophagy
classifying
closures
8 Citations (Scopus)

Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells

Clements, K. E., Thakar, T., Nicolae, C. M., Liang, X., Wang, H. G. & Moldovan, G. L., Jan 1 2018, In : Nucleic acids research. 46, 17, p. 8898-8907 10 p.

Research output: Contribution to journalArticle

Recombinational DNA Repair
Therapeutics
Neoplasms
Tumor Biomarkers
DNA Replication
9 Citations (Scopus)

Targeted inhibition of ULK1 promotes apoptosis and suppresses tumor growth and metastasis in neuroblastoma

Dower, C. M., Bhat, N., Gebru, M. T., Chen, L., Wills, C. A., Miller, B. A. & Wang, H. G., Nov 2018, In : Molecular cancer therapeutics. 17, 11, p. 2365-2376 12 p.

Research output: Contribution to journalArticle

Autophagy
Neuroblastoma
Apoptosis
Neoplasm Metastasis
Growth
11 Citations (Scopus)

TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition

Lima, S., Takabe, K., Newton, J., Saurabh, K., Young, M. M., Leopoldino, A. M., Hait, N. C., Roberts, J. L., Wang, H-G., Dent, P., Milstien, S., Booth, L. & Spiegel, S., Jun 3 2018, In : Autophagy. 14, 6, p. 942-957 16 p.

Research output: Contribution to journalArticle

Cell Death
Null Lymphocytes
Autophagy
Vacuoles
Neoplasms
2017
22 Citations (Scopus)

Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis

Tang, Z., Takahashi, Y., Chen, C., Liu, Y., He, H., Tsotakos, N., Serfass, J. M., Gebru, M. T., Chen, H., Young, M. M. & Wang, H. G., Dec 1 2017, In : Cell Death and Differentiation. 24, 12, p. 2127-2138 12 p.

Research output: Contribution to journalArticle

Death Domain Receptor Signaling Adaptor Proteins
Caspase 8
Autophagy
Apoptosis
Membranes
3 Citations (Scopus)

Bif-1 promotes tumor cell migration and metastasis via Cdc42 expression and activity

Zhang, C., Liu, F., Chen, H., Li, N., Luo, Z., Guo, W., Huang, D., Tang, S., Wang, H., Cheng, S., Li, Z. & Wang, H., Jan 1 2017, In : Clinical and Experimental Metastasis. 34, 1, p. 11-23 13 p.

Research output: Contribution to journalArticle

Cell Movement
Hepatocellular Carcinoma
Neoplasm Metastasis
Neoplasms
Rho Factor
5 Citations (Scopus)

Endophilin B2 facilitates endosome maturation in response to growth factor stimulation, autophagy induction, and influenza A virus infection

Serfass, J. M., Takahashi, Y., Zhou, Z., Kawasawa, Y. I., Liu, Y., Tsotakos, N., Young, M. M., Tang, Z., Yang, L., Atkinson, J. M., Chroneos, Z. C. & Wang, H. G., Jun 16 2017, In : Journal of Biological Chemistry. 292, 24, p. 10097-10111 15 p.

Research output: Contribution to journalArticle

Endosomes
Influenza A virus
Autophagy
Virus Diseases
Viruses
1 Citation (Scopus)

PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features

Teye, E. K., Sido, A., Xin, P., Finnberg, N. K., Gokare, P., Kawasawa, Y. I., Salzberg, A. C., Shimko, S., Bayerl, M., Ehmann, W. C., Claxton, D. F., Rybka, W. B., Drabick, J. J., Wang, H. G., Abraham, T., El-Deiry, W. S., Brodsky, R. A., J.Hohl, R. & Pu, J. J., Jan 1 2017, In : Oncotarget. 8, 18, p. 29887-29905 19 p.

Research output: Contribution to journalArticle

Genomic Instability
Acute Myeloid Leukemia
Gene Expression
Protein Deficiency
M Phase Cell Cycle Checkpoints
6 Citations (Scopus)

Selective Reversible Inhibition of Autophagy in Hypoxic Breast Cancer Cells Promotes Pulmonary Metastasis

Dower, C. M., Bhat, N., Wang, E. W. & Wang, H. G., Feb 1 2017, In : Cancer Research. 77, 3, p. 646-657 12 p.

Research output: Contribution to journalArticle

Autophagy
Breast Neoplasms
Neoplasm Metastasis
Lung
Tumor Microenvironment
3 Citations (Scopus)

SH3GLB2/endophilin B2 regulates lung homeostasis and recovery from severe influenza A virus infection

Fino, K. K., Yang, L., Silveyra, P., Hu, S., Umstead, T. M., Diangelo, S., Halstead, E. S., Cooper, T. K., Abraham, T., Takahashi, Y., Zhou, Z., Wang, H-G. & Chroneos, Z., Dec 1 2017, In : Scientific reports. 7, 1, 7262.

Research output: Contribution to journalArticle

Influenza A virus
Virus Diseases
Homeostasis
Human Influenza
Lung

SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models

Hengst, J., Dick, T. E., Sharma, A., Doi, K., Hegde, S., Tan, S. F., Geffert, L., Fox, T. E., Sharma, A. K., Desai, D., Amin, S., Kester, M., Loughran, T. P., Paulson, R., Claxton, D., Wang, H-G. & Yun, J., 2017, In : Cancer Translational Medicine. 3, 4, p. 109-121

Research output: Contribution to journalArticle

2016
27 Citations (Scopus)

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

Tan, S. F., Liu, X., Fox, T. E., Barth, B. M., Sharma, A., Turner, S. D., Awwad, A., Dewey, A., Doi, K., Spitzer, B., Shah, M. V., Morad, S. A. F., Desai, D., Amin, S., Zhu, J., Liao, J., Yun, J., Kester, M., Claxton, D. F., Wang, H. G. & 5 others, Cabot, M. C., Schuchman, E. H., Levine, R. L., Feith, D. J. & Loughran, T. P., Jan 1 2016, In : Oncotarget. 7, 50, p. 83208-83222 15 p.

Research output: Contribution to journalArticle

Acid Ceramidase
Acute Myeloid Leukemia
Ceramides
Sphingolipids
Myeloid Cells
18 Citations (Scopus)

Atg5-dependent autophagy contributes to the development of acute myeloid leukemia in an MLL-AF9-driven mouse model

Liu, Q., Chen, L., Atkinson, J. M., Claxton, D. F. & Wang, H. G., Jan 1 2016, In : Cell Death and Disease. 7, 9, e2361.

Research output: Contribution to journalArticle

Autophagy
Acute Myeloid Leukemia
Myeloid Cells
Oncogene Fusion
Stem Cells
12 Citations (Scopus)

Bif-1 deficiency impairs lipid homeostasis and causes obesity accompanied by insulin resistance

Liu, Y., Takahashi, Y., Desai, N., Zhang, J., Serfass, J. M., Shi, Y. G., Lynch, C. J. & Wang, H. G., Feb 9 2016, In : Scientific reports. 6, 20453.

Research output: Contribution to journalArticle

Insulin Resistance
Adipose Tissue
Homeostasis
Obesity
Lipids
21 Citations (Scopus)

Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics

Bao, L., Chen, S. J., Conrad, K., Keefer, K., Abraham, T., Lee, J. P., Wang, J. F., Zhang, X. Q., Hirschler-Laszkiewicz, I., Wang, H. G., Dovat, S., Gans, B., Madesh, M., Cheung, J. Y. & Miller, B. A., Nov 18 2016, In : Journal of Biological Chemistry. 291, 47, p. 24449-24464 16 p.

Research output: Contribution to journalArticle

Neuroblastoma
Ion Channels
Energy Metabolism
Reactive Oxygen Species
Cell Survival
12 Citations (Scopus)

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

Young, M. M., Takahashi, Y., Fox, T. E., Yun, J. K., Kester, M. & Wang, H. G., Nov 1 2016, In : Cell Reports. 17, 6, p. 1532-1545 14 p.

Research output: Contribution to journalArticle

Sphingosine
Autophagy
Membranes
Membrane Fusion
Fusion reactions
25 Citations (Scopus)

The Bif-1-Dynamin 2 membrane fission machinery regulates Atg9-containing vesicle generation at the Rab11-positive reservoirs

Takahashi, Y., Tsotakos, N., Liu, Y., Young, M. M., Serfass, J., Tang, Z., Abraham, T. & Wang, H. G., Apr 12 2016, In : Oncotarget. 7, 15, p. 20855-20868 14 p.

Research output: Contribution to journalArticle

Dynamin II
Autophagy
Starvation
Membranes
Food
2015
40 Citations (Scopus)

Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy

Hsu, P., Liu, X., Zhang, J., Wang, H-G., Ye, J. M. & Shi, Y., Jan 1 2015, In : Autophagy. 11, 4, p. 643-652 10 p.

Research output: Contribution to journalArticle

Barth Syndrome
Mitochondrial Degradation
Cardiolipins
Oxidative Phosphorylation
Phospholipids
26 Citations (Scopus)

HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains

Ren, T., Takahashi, Y., Liu, X., Loughran, T. P., Sun, S. C., Wang, H-G. & Cheng, H., Jan 15 2015, In : Oncogene. 34, 3, p. 373-384 12 p.

Research output: Contribution to journalArticle

Deltaretrovirus
Autophagy
T-Lymphocytes
Lipids
Phosphotransferases
10 Citations (Scopus)

Loss of endophilin-B1 exacerbates Alzheimer's disease pathology

Wang, D. B., Kinoshita, Y., Kinoshita, C., Uo, T., Sopher, B. L., Cudaback, E., Keene, C. D., Bilousova, T., Gylys, K., Case, A., Jayadev, S., Wang, H-G., Garden, G. A. & Morrison, R. S., Jul 1 2015, In : Brain. 138, 7, p. 2005-2019 15 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Amyloid
Pathology
Neurons
Protein Isoforms
25 Citations (Scopus)

Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner

Varadarajan, S., Poornima, P., Milani, M., Gowda, K., Amin, S., Wang, H. G. & Cohen, G. M., Jan 1 2015, In : Oncotarget. 6, 14, p. 12668-12681 14 p.

Research output: Contribution to journalArticle

Apoptosis
Reactive Oxygen Species
Down-Regulation
Electron Transport Complex I
Caspase 9
6 Citations (Scopus)

Suberoylanilide hydroxamic acid (SAHA) and cladribine synergistically induce apoptosis in NK-LGL leukaemia

Sun, X., Hasanali, Z. S., Chen, A., Zhang, D., Liu, X., Wang, H. G., Feith, D. J., Loughran, T. P. & Xu, K., Feb 1 2015, In : British Journal of Haematology. 168, 3, p. 371-383 13 p.

Research output: Contribution to journalArticle

Large Granular Lymphocytic Leukemia
Cladribine
Histone Deacetylases
Apoptosis
Natural Killer Cells
19 Citations (Scopus)

The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines

Dick, T. E., Hengst, J. A., Fox, T. E., Colledge, A. L., Kale, V. P., Sung, S. S., Sharma, A., Amin, S., Loughran, T. P., Kester, M., Wang, H. G. & Yun, J. K., Mar 1 2015, In : Journal of Pharmacology and Experimental Therapeutics. 352, 3, p. 494-508 15 p.

Research output: Contribution to journalArticle

Myeloid Cells
Acute Myeloid Leukemia
Cell Line
CDC2 Protein Kinase
Cyclin-Dependent Kinases
7 Citations (Scopus)

Tid1, the mammalian homologue of Drosophila tumor suppressor Tid56, mediates macroautophagy by interacting with beclin1-containing autophagy protein complex

Niu, G., Zhang, H., Liu, D., Chen, L., Belani, C., Wang, H. G. & Cheng, H., Jul 17 2015, In : Journal of Biological Chemistry. 290, 29, p. 18102-18110 9 p.

Research output: Contribution to journalArticle

Autophagy
Drosophila
Tumors
Nutrients
Neoplasms
2014
42 Citations (Scopus)

A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α

Chen, S. J., Hoffman, N. E., Shanmughapriy, S., Bao, L., Keefer, K., Conrad, K., Merali, S., Takahashi, Y., Abraham, T., Hirschler-Laszkiewicz, I., Wang, J. F., Zhang, X. Q., Song, J., Barrero, C., Shi, Y., Kawasawa, Y. I., Bayerl, M., Sun, T., Barbour, M., Wang, H. G. & 3 others, Madesh, M., Cheung, J. Y. & Miller, B. A., Jan 1 2014, In : Journal of Biological Chemistry. 289, 52, p. 36284-36302 19 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Neuroblastoma
Ion Channels
Tumors
Growth
23 Citations (Scopus)

Bax interacting factor-1 promotes survival and mitochondrial elongation in neurons

Wang, D. B., Uo, T., Kinoshita, C., Sopher, B. L., Lee, R. J., Murphy, S. P., Kinoshita, Y., Garden, G. A., Wang, H. G. & Morrison, R. S., Feb 14 2014, In : Journal of Neuroscience. 34, 7, p. 2674-2683 10 p.

Research output: Contribution to journalArticle

Neurons
Mitochondria
Stroke
Mitochondrial Dynamics
Apoptosis
21 Citations (Scopus)

Maritoclax induces apoptosis in acute myeloid leukemia cells with elevated Mcl-1 expression

Doi, K., Liu, Q., Gowda, K., Barth, B. M., Claxton, D., Amin, S., Loughran, T. P. & Wang, H. G., Aug 2014, In : Cancer Biology and Therapy. 15, 8, p. 1077-1086 10 p.

Research output: Contribution to journalArticle

Myeloid Cells
Acute Myeloid Leukemia
Apoptosis
Daunorubicin
Nude Mice
5 Citations (Scopus)

Pyoluteorin derivatives induce Mcl-1 degradation and apoptosis in hematological cancer cells

Doi, K., Gowda, K., Liu, Q., Lin, J. M., Sung, S., Dower, C., Claxton, D., Loughran, T. P., Amin, S. & Wang, H-G., Dec 1 2014, In : Cancer Biology and Therapy. 15, 12, p. 1688-1699 12 p.

Research output: Contribution to journalArticle

Apoptosis
Neoplasms
K562 Cells
Structure-Activity Relationship
Biological Products
15 Citations (Scopus)

Synthesis of cell-permeable stapled BH3 peptide-based Mcl-1 inhibitors containing simple aryl and vinylaryl cross-linkers

Muppidi, A., Doi, K., Ramil, C. P., Wang, H. G. & Lin, Q., Oct 21 2014, In : Tetrahedron. 70, 42, p. 7740-7745 6 p.

Research output: Contribution to journalArticle

Peptides
Noxae
Hydrophobicity
Hydrophobic and Hydrophilic Interactions
Cysteine
8 Citations (Scopus)

Targeted delivery of ubiquitin-conjugated BH3 peptide-based Mcl-1 inhibitors into cancer cells

Muppidi, A., Doi, K., Edwardraja, S., Pulavarti, S. V. S. R. K., Szyperski, T., Wang, H. G. & Lin, Q., Feb 19 2014, In : Bioconjugate Chemistry. 25, 2, p. 424-432 9 p.

Research output: Contribution to journalArticle

Ubiquitin
Peptides
Cells
Neoplasms
Chemokine Receptors
2013
97 Citations (Scopus)

Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy

Yang, Y., Fiskus, W., Yong, B., Atadja, P., Takahashi, Y., Pandita, T. K., Wang, H. G. & Bhalla, K. N., Apr 23 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 17, p. 6841-6846 6 p.

Research output: Contribution to journalArticle

Sumoylation
Autophagy
Proteins
Class III Phosphatidylinositol 3-Kinases
Histone Deacetylase Inhibitors
45 Citations (Scopus)

Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphomagenesis via suppression of mitophagy

Takahashi, Y., Hori, T., Cooper, T. K., Liao, J., Desai, N., Serfass, J. M., Young, M. M., Park, S., Izu, Y. & Wang, H. G., Feb 28 2013, In : Blood. 121, 9, p. 1622-1632 11 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Haploinsufficiency
Chromosomal Instability
Loss of Heterozygosity
Apoptosis
23 Citations (Scopus)

C6-ceramide nanoliposomes target the warburg effect in chronic lymphocytic leukemia

Ryland, L. K., Doshi, U. A., Shanmugavelandy, S. S., Fox, T. E., Aliaga, C., Broeg, K., Baab, K. T., Young, M., Khan, O., Haakenson, J. K., Jarbadan, N. R., Liao, J., Wang, H. G., Feith, D. J., Loughran, T. P., Liu, X. & Kester, M., Dec 19 2013, In : PloS one. 8, 12, e84648.

Research output: Contribution to journalArticle

lymphocytic leukemia
ceramides
Ceramides
B-Cell Chronic Lymphocytic Leukemia
long term effects
61 Citations (Scopus)

Lenalidomide promotes p53 degradation by inhibiting MDM2 auto-ubiquitination in myelodysplastic syndrome with chromosome 5q deletion

Wei, S., Chen, X., McGraw, K., Zhang, L., Komrokji, R., Clark, J., Caceres, G., Billingsley, D., Sokol, L., Lancet, J., Fortenbery, N., Zhou, J., Eksioglu, E. A., Sallman, D., Wang, H., Epling-Burnette, P. K., Djeu, J., Sekeres, M., Maciejewski, J. P. & List, A., Feb 28 2013, In : Oncogene. 32, 9, p. 1110-1120 11 p.

Research output: Contribution to journalArticle

Open Access
Chromosome Deletion
Ubiquitination
Myelodysplastic Syndromes
Protein Phosphatase 2
Catalytic Domain
26 Citations (Scopus)

Proteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the efficacy of ABT-737 in melanoma cells

Pandey, M. K., Gowda, K., Doi, K., Sharma, A. K., Wang, H. G. & Amin, S., Nov 4 2013, In : PloS one. 8, 11, e78570.

Research output: Contribution to journalArticle

melanoma
Melanoma
apoptosis
Apoptosis
Degradation
54 Citations (Scopus)

PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex

He, S., Ni, D., Ma, B., Lee, J. H., Zhang, T., Ghozalli, I., Pirooz, S. D., Zhao, Z., Bharatham, N., Li, B., Oh, S., Lee, W. H., Takahashi, Y., Wang, H-G., Minassian, A., Feng, P., Deretic, V., Pepperkok, R., Tagaya, M., Yoon, H. S. & 1 others, Liang, C., Oct 1 2013, In : Nature Cell Biology. 15, 10, p. 1206-1219 14 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Autophagy
Coat Protein Complex I
Phosphatidylinositols
Phosphate-Binding Proteins
8 Citations (Scopus)

Sh3glb1/Bif-1 and mitophagy: Acquisition of apoptosis resistance during Myc-driven lymphomagenesis

Takahashi, Y., Young, M. M., Serfass, J. M., Hori, T. & Wang, H-G., Jan 1 2013, In : Autophagy. 9, 7, p. 1107-1109 3 p.

Research output: Contribution to journalArticle

Signal Transducing Adaptor Proteins
Mitochondrial Degradation
Proto-Oncogene Proteins c-myc
Biological Models
Chromosomal Instability
2012
29 Citations (Scopus)

Anti-cancer drug discovery and development bcl-2 family small molecule inhibitors

Liu, Q. & Wang, H. G., Nov 1 2012, In : Communicative and Integrative Biology. 5, 6, p. 557-565 9 p.

Research output: Contribution to journalArticle

antineoplastic agents
B-Cell Lymphoma
Drug Discovery
lymphoma
B-lymphocytes
186 Citations (Scopus)

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

Young, M. M., Takahashi, Y., Khan, O., Park, S., Hori, T., Yun, J., Sharma, A. K., Amin, S., Hu, C. D., Zhang, J., Kester, M. & Wang, H. G., Apr 6 2012, In : Journal of Biological Chemistry. 287, 15, p. 12455-12468 14 p.

Research output: Contribution to journalArticle

Death Domain Receptor Signaling Adaptor Proteins
Caspase 8
Chemical activation
Apoptosis
Membranes
23 Citations (Scopus)

Bif-1 suppresses breast cancer cell migration by promoting EGFR Endocytic degradation

Runkle, K. B., Meyerkord, C. L., Desai, N. V., Takahashi, Y. & Wang, H. G., Aug 1 2012, In : Cancer Biology and Therapy. 13, 10, p. 956-966 11 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor
Cell Movement
Breast Neoplasms
Endosomes
Lysosomes
102 Citations (Scopus)

Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation

Doi, K., Li, R., Sung, S. S., Wu, H., Liu, Y., Manieri, W., Krishnegowda, G., Awwad, A., Dewey, A., Liu, X., Amin, S., Cheng, C., Qin, Y., Schonbrunn, E., Daughdrill, G., Loughran, T. P., Sebti, S. & Wang, H. G., Mar 23 2012, In : Journal of Biological Chemistry. 287, 13, p. 10224-10235 12 p.

Research output: Contribution to journalArticle

Degradation
Videocassette recorders
Oncology
Hematologic Neoplasms
Proteasome Endopeptidase Complex