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2019

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Tan, S. F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., Doi, K., Conaway, M. R., Amin, S., Claxton, D. F., Wang, H. G., Kester, M., Cabot, M. C., Feith, D. J. & Loughran, T. P., Jan 1 2019, In : Journal of Lipid Research. 60, 6, p. 1078-1086 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Bif-1 interacts with prohibitin-2 to regulate mitochondrial inner membrane during cell stress and apoptosis

Cho, S. G., Xiao, X., Wang, S., Gao, H., Rafikov, R., Black, S., Huang, S., Ding, H. F., Yoon, Y., Kirken, R. A., Yin, X. M., Wang, H. G. & Dong, Z., Jul 2019, In : Journal of the American Society of Nephrology. 30, 7, p. 1174-1191 18 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
1 Scopus citations

Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ

Liu, Z., Wei, Y., Zhang, L., Yee, P. P., Johnson, M., Zhang, X., Gulley, M., Atkinson, J. M., Trebak, M., Wang, H-G. & Li, W., Jan 3 2019, In : Oncogene. 38, 1, p. 120-139 20 p.

Research output: Contribution to journalArticle

9 Scopus citations

Pivotal role of mitophagy in response of acute myelogenous leukemia to a ceramide-tamoxifen-containing drug regimen

Morad, S. A. F., MacDougall, M. R., Abdelmageed, N., Kao, L. P., Feith, D. J., Tan, S. F., Kester, M., Loughran, T. P., Wang, H. G. & Cabot, M. C., Aug 15 2019, In : Experimental Cell Research. 381, 2, p. 256-264 9 p.

Research output: Contribution to journalArticle

Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia

Barth, B. M., Wang, W., Toran, P. T., Fox, T. E., Annageldiyev, C., Ondrasik, R. M., Keasey, N. R., Brown, T. J., Devine, V. G., Sullivan, E. C., Cote, A. L., Papakotsi, V., Tan, S. F., Shanmugavelandy, S. S., Deering, T. G., Needle, D. B., Stern, S. T., Zhu, J., Liao, J., Viny, A. D. & 7 others, Feith, D. J., Levine, R. L., Wang, H. G., Loughran, T. P., Sharma, A., Kester, M. & Claxton, D. F., Sep 10 2019, In : Blood Advances. 3, 17, p. 2598-2603 6 p.

Research output: Contribution to journalArticle

Open Access

Time-resolved FRET and NMR analyses reveal selective binding of peptides containing the LC3-interacting region to ATG8 family proteins

Atkinson, J. M., Ye, Y., Gebru, M. T., Liu, Q., Zhou, S., Young, M. M., Takahashi, Y., Lin, Q., Tian, F. & Wang, H. G., Jan 1 2019, In : Journal of Biological Chemistry. 294, 38, p. 14033-14042 10 p.

Research output: Contribution to journalArticle

Open Access

TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion

Tang, Z., Takahashi, Y., He, H., Hattori, T., Chen, C., Liang, X., Chen, H., Young, M. M. & Wang, H. G., Aug 13 2019, In : Cell Reports. 28, 7, p. 1744-1757.e5

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

VPS37A directs ESCRT recruitment for phagophore closure

Takahashi, Y., Liang, X., Hattori, T., Tang, Z., He, H., Chen, H., Liu, X., Abraham, T., Imamura-Kawasawa, Y., Buchkovich, N. J., Young, M. M. & Wang, H. G., Oct 7 2019, In : The Journal of cell biology. 218, 10, p. 3336-3354 19 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

Takahashi, Y., He, H., Tang, Z., Hattori, T., Liu, Y., Young, M. M., Serfass, J. M., Chen, L., Gebru, M., Chen, C., Wills, C. A., Atkinson, J. M., Chen, H., Abraham, T. & Wang, H. G., Dec 1 2018, In : Nature communications. 9, 1, 2855.

Research output: Contribution to journalArticle

29 Scopus citations

Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells

Clements, K. E., Thakar, T., Nicolae, C. M., Liang, X., Wang, H. G. & Moldovan, G. L., Jan 1 2018, In : Nucleic acids research. 46, 17, p. 8898-8907 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Targeted inhibition of ULK1 promotes apoptosis and suppresses tumor growth and metastasis in neuroblastoma

Dower, C. M., Bhat, N., Gebru, M. T., Chen, L., Wills, C. A., Miller, B. A. & Wang, H. G., Nov 2018, In : Molecular cancer therapeutics. 17, 11, p. 2365-2376 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition

Lima, S., Takabe, K., Newton, J., Saurabh, K., Young, M. M., Leopoldino, A. M., Hait, N. C., Roberts, J. L., Wang, H. G., Dent, P., Milstien, S., Booth, L. & Spiegel, S., Jun 3 2018, In : Autophagy. 14, 6, p. 942-957 16 p.

Research output: Contribution to journalArticle

12 Scopus citations
2017

Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis

Tang, Z., Takahashi, Y., Chen, C., Liu, Y., He, H., Tsotakos, N., Serfass, J. M., Gebru, M. T., Chen, H., Young, M. M. & Wang, H. G., Dec 1 2017, In : Cell Death and Differentiation. 24, 12, p. 2127-2138 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Bif-1 promotes tumor cell migration and metastasis via Cdc42 expression and activity

Zhang, C., Liu, F., Chen, H., Li, N., Luo, Z., Guo, W., Huang, D., Tang, S., Wang, H., Cheng, S., Li, Z. & Wang, H., Jan 1 2017, In : Clinical and Experimental Metastasis. 34, 1, p. 11-23 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Endophilin B2 facilitates endosome maturation in response to growth factor stimulation, autophagy induction, and influenza A virus infection

Serfass, J. M., Takahashi, Y., Zhou, Z., Kawasawa, Y. I., Liu, Y., Tsotakos, N., Young, M. M., Tang, Z., Yang, L., Atkinson, J. M., Chroneos, Z. C. & Wang, H. G., Jun 16 2017, In : Journal of Biological Chemistry. 292, 24, p. 10097-10111 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features

Teye, E. K., Sido, A., Xin, P., Finnberg, N. K., Gokare, P., Kawasawa, Y. I., Salzberg, A. C., Shimko, S., Bayerl, M., Ehmann, W. C., Claxton, D. F., Rybka, W. B., Drabick, J. J., Wang, H. G., Abraham, T., El-Deiry, W. S., Brodsky, R. A., J.Hohl, R. & Pu, J. J., Jan 1 2017, In : Oncotarget. 8, 18, p. 29887-29905 19 p.

Research output: Contribution to journalArticle

1 Scopus citations

Selective Reversible Inhibition of Autophagy in Hypoxic Breast Cancer Cells Promotes Pulmonary Metastasis

Dower, C. M., Bhat, N., Wang, E. W. & Wang, H. G., Feb 1 2017, In : Cancer Research. 77, 3, p. 646-657 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

SH3GLB2/endophilin B2 regulates lung homeostasis and recovery from severe influenza A virus infection

Fino, K. K., Yang, L., Silveyra, P., Hu, S., Umstead, T. M., Diangelo, S., Halstead, E. S., Cooper, T. K., Abraham, T., Takahashi, Y., Zhou, Z., Wang, H. G. & Chroneos, Z. C., Dec 1 2017, In : Scientific reports. 7, 1, 7262.

Research output: Contribution to journalArticle

3 Scopus citations

SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models

Hengst, J., Dick, T. E., Sharma, A., Doi, K., Hegde, S., Tan, S. F., Geffert, L., Fox, T. E., Sharma, A. K., Desai, D., Amin, S., Kester, M., Loughran, T. P., Paulson, R., Claxton, D., Wang, H-G. & Yun, J., 2017, In : Cancer Translational Medicine. 3, 4, p. 109-121

Research output: Contribution to journalArticle

2016

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

Tan, S. F., Liu, X., Fox, T. E., Barth, B. M., Sharma, A., Turner, S. D., Awwad, A., Dewey, A., Doi, K., Spitzer, B., Shah, M. V., Morad, S. A. F., Desai, D., Amin, S., Zhu, J., Liao, J., Yun, J., Kester, M., Claxton, D. F., Wang, H. G. & 5 others, Cabot, M. C., Schuchman, E. H., Levine, R. L., Feith, D. J. & Loughran, T. P., Jan 1 2016, In : Oncotarget. 7, 50, p. 83208-83222 15 p.

Research output: Contribution to journalArticle

28 Scopus citations

Atg5-dependent autophagy contributes to the development of acute myeloid leukemia in an MLL-AF9-driven mouse model

Liu, Q., Chen, L., Atkinson, J. M., Claxton, D. F. & Wang, H. G., Jan 1 2016, In : Cell Death and Disease. 7, 9, e2361.

Research output: Contribution to journalArticle

19 Scopus citations

Bif-1 deficiency impairs lipid homeostasis and causes obesity accompanied by insulin resistance

Liu, Y., Takahashi, Y., Desai, N., Zhang, J., Serfass, J. M., Shi, Y. G., Lynch, C. J. & Wang, H. G., Feb 9 2016, In : Scientific reports. 6, 20453.

Research output: Contribution to journalArticle

12 Scopus citations

Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics

Bao, L., Chen, S. J., Conrad, K., Keefer, K., Abraham, T., Lee, J. P., Wang, J. F., Zhang, X. Q., Hirschler-Laszkiewicz, I., Wang, H. G., Dovat, S., Gans, B., Madesh, M., Cheung, J. Y. & Miller, B. A., Nov 18 2016, In : Journal of Biological Chemistry. 291, 47, p. 24449-24464 16 p.

Research output: Contribution to journalArticle

21 Scopus citations

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

Young, M. M., Takahashi, Y., Fox, T. E., Yun, J. K., Kester, M. & Wang, H. G., Nov 1 2016, In : Cell Reports. 17, 6, p. 1532-1545 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

The Bif-1-Dynamin 2 membrane fission machinery regulates Atg9-containing vesicle generation at the Rab11-positive reservoirs

Takahashi, Y., Tsotakos, N., Liu, Y., Young, M. M., Serfass, J., Tang, Z., Abraham, T. & Wang, H. G., Apr 12 2016, In : Oncotarget. 7, 15, p. 20855-20868 14 p.

Research output: Contribution to journalArticle

26 Scopus citations
2015

Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy

Hsu, P., Liu, X., Zhang, J., Wang, H-G., Ye, J. M. & Shi, Y., Jan 1 2015, In : Autophagy. 11, 4, p. 643-652 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains

Ren, T., Takahashi, Y., Liu, X., Loughran, T. P., Sun, S. C., Wang, H-G. & Cheng, H., Jan 15 2015, In : Oncogene. 34, 3, p. 373-384 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Loss of endophilin-B1 exacerbates Alzheimer's disease pathology

Wang, D. B., Kinoshita, Y., Kinoshita, C., Uo, T., Sopher, B. L., Cudaback, E., Keene, C. D., Bilousova, T., Gylys, K., Case, A., Jayadev, S., Wang, H-G., Garden, G. A. & Morrison, R. S., Jul 1 2015, In : Brain. 138, 7, p. 2005-2019 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner

Varadarajan, S., Poornima, P., Milani, M., Gowda, K., Amin, S., Wang, H. G. & Cohen, G. M., Jan 1 2015, In : Oncotarget. 6, 14, p. 12668-12681 14 p.

Research output: Contribution to journalArticle

26 Scopus citations

Suberoylanilide hydroxamic acid (SAHA) and cladribine synergistically induce apoptosis in NK-LGL leukaemia

Sun, X., Hasanali, Z. S., Chen, A., Zhang, D., Liu, X., Wang, H. G., Feith, D. J., Loughran, T. P. & Xu, K., Feb 1 2015, In : British Journal of Haematology. 168, 3, p. 371-383 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines

Dick, T. E., Hengst, J. A., Fox, T. E., Colledge, A. L., Kale, V. P., Sung, S. S., Sharma, A., Amin, S., Loughran, T. P., Kester, M., Wang, H. G. & Yun, J. K., Mar 1 2015, In : Journal of Pharmacology and Experimental Therapeutics. 352, 3, p. 494-508 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

Tid1, the mammalian homologue of Drosophila tumor suppressor Tid56, mediates macroautophagy by interacting with beclin1-containing autophagy protein complex

Niu, G., Zhang, H., Liu, D., Chen, L., Belani, C., Wang, H. G. & Cheng, H., Jul 17 2015, In : Journal of Biological Chemistry. 290, 29, p. 18102-18110 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α

Chen, S. J., Hoffman, N. E., Shanmughapriy, S., Bao, L., Keefer, K., Conrad, K., Merali, S., Takahashi, Y., Abraham, T., Hirschler-Laszkiewicz, I., Wang, J. F., Zhang, X. Q., Song, J., Barrero, C., Shi, Y., Kawasawa, Y. I., Bayerl, M., Sun, T., Barbour, M., Wang, H. G. & 3 others, Madesh, M., Cheung, J. Y. & Miller, B. A., Jan 1 2014, In : Journal of Biological Chemistry. 289, 52, p. 36284-36302 19 p.

Research output: Contribution to journalArticle

43 Scopus citations

Bax interacting factor-1 promotes survival and mitochondrial elongation in neurons

Wang, D. B., Uo, T., Kinoshita, C., Sopher, B. L., Lee, R. J., Murphy, S. P., Kinoshita, Y., Garden, G. A., Wang, H. G. & Morrison, R. S., Feb 14 2014, In : Journal of Neuroscience. 34, 7, p. 2674-2683 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Maritoclax induces apoptosis in acute myeloid leukemia cells with elevated Mcl-1 expression

Doi, K., Liu, Q., Gowda, K., Barth, B. M., Claxton, D., Amin, S., Loughran, T. P. & Wang, H. G., Aug 2014, In : Cancer Biology and Therapy. 15, 8, p. 1077-1086 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Pyoluteorin derivatives induce Mcl-1 degradation and apoptosis in hematological cancer cells

Doi, K., Gowda, K., Liu, Q., Lin, J. M., Sung, S., Dower, C., Claxton, D., Loughran, T. P., Amin, S. & Wang, H-G., Dec 1 2014, In : Cancer Biology and Therapy. 15, 12, p. 1688-1699 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Synthesis of cell-permeable stapled BH3 peptide-based Mcl-1 inhibitors containing simple aryl and vinylaryl cross-linkers

Muppidi, A., Doi, K., Ramil, C. P., Wang, H. G. & Lin, Q., Oct 21 2014, In : Tetrahedron. 70, 42, p. 7740-7745 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Targeted delivery of ubiquitin-conjugated BH3 peptide-based Mcl-1 inhibitors into cancer cells

Muppidi, A., Doi, K., Edwardraja, S., Pulavarti, S. V. S. R. K., Szyperski, T., Wang, H. G. & Lin, Q., Feb 19 2014, In : Bioconjugate Chemistry. 25, 2, p. 424-432 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2013

Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy

Yang, Y., Fiskus, W., Yong, B., Atadja, P., Takahashi, Y., Pandita, T. K., Wang, H. G. & Bhalla, K. N., Apr 23 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 17, p. 6841-6846 6 p.

Research output: Contribution to journalArticle

100 Scopus citations

Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphomagenesis via suppression of mitophagy

Takahashi, Y., Hori, T., Cooper, T. K., Liao, J., Desai, N., Serfass, J. M., Young, M. M., Park, S., Izu, Y. & Wang, H. G., Feb 28 2013, In : Blood. 121, 9, p. 1622-1632 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

C6-ceramide nanoliposomes target the warburg effect in chronic lymphocytic leukemia

Ryland, L. K., Doshi, U. A., Shanmugavelandy, S. S., Fox, T. E., Aliaga, C., Broeg, K., Baab, K. T., Young, M., Khan, O., Haakenson, J. K., Jarbadan, N. R., Liao, J., Wang, H. G., Feith, D. J., Loughran, T. P., Liu, X. & Kester, M., Dec 19 2013, In : PloS one. 8, 12, e84648.

Research output: Contribution to journalArticle

24 Scopus citations

Lenalidomide promotes p53 degradation by inhibiting MDM2 auto-ubiquitination in myelodysplastic syndrome with chromosome 5q deletion

Wei, S., Chen, X., McGraw, K., Zhang, L., Komrokji, R., Clark, J., Caceres, G., Billingsley, D., Sokol, L., Lancet, J., Fortenbery, N., Zhou, J., Eksioglu, E. A., Sallman, D., Wang, H., Epling-Burnette, P. K., Djeu, J., Sekeres, M., Maciejewski, J. P. & List, A., Feb 28 2013, In : Oncogene. 32, 9, p. 1110-1120 11 p.

Research output: Contribution to journalArticle

Open Access
61 Scopus citations

Proteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the efficacy of ABT-737 in melanoma cells

Pandey, M. K., Gowda, K., Doi, K., Sharma, A. K., Wang, H. G. & Amin, S., Nov 4 2013, In : PloS one. 8, 11, e78570.

Research output: Contribution to journalArticle

27 Scopus citations

PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex

He, S., Ni, D., Ma, B., Lee, J. H., Zhang, T., Ghozalli, I., Pirooz, S. D., Zhao, Z., Bharatham, N., Li, B., Oh, S., Lee, W. H., Takahashi, Y., Wang, H-G., Minassian, A., Feng, P., Deretic, V., Pepperkok, R., Tagaya, M., Yoon, H. S. & 1 others, Liang, C., Oct 1 2013, In : Nature Cell Biology. 15, 10, p. 1206-1219 14 p.

Research output: Contribution to journalArticle

55 Scopus citations

Sh3glb1/Bif-1 and mitophagy: Acquisition of apoptosis resistance during Myc-driven lymphomagenesis

Takahashi, Y., Young, M. M., Serfass, J. M., Hori, T. & Wang, H-G., Jan 1 2013, In : Autophagy. 9, 7, p. 1107-1109 3 p.

Research output: Contribution to journalArticle

8 Scopus citations
2012

Anti-cancer drug discovery and development bcl-2 family small molecule inhibitors

Liu, Q. & Wang, H. G., Nov 1 2012, In : Communicative and Integrative Biology. 5, 6, p. 557-565 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

Young, M. M., Takahashi, Y., Khan, O., Park, S., Hori, T., Yun, J., Sharma, A. K., Amin, S., Hu, C. D., Zhang, J., Kester, M. & Wang, H. G., Apr 6 2012, In : Journal of Biological Chemistry. 287, 15, p. 12455-12468 14 p.

Research output: Contribution to journalArticle

193 Scopus citations

Bif-1 suppresses breast cancer cell migration by promoting EGFR Endocytic degradation

Runkle, K. B., Meyerkord, C. L., Desai, N. V., Takahashi, Y. & Wang, H. G., Aug 1 2012, In : Cancer Biology and Therapy. 13, 10, p. 956-966 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation

Doi, K., Li, R., Sung, S. S., Wu, H., Liu, Y., Manieri, W., Krishnegowda, G., Awwad, A., Dewey, A., Liu, X., Amin, S., Cheng, C., Qin, Y., Schonbrunn, E., Daughdrill, G., Loughran, T. P., Sebti, S. & Wang, H. G., Mar 23 2012, In : Journal of Biological Chemistry. 287, 13, p. 10224-10235 12 p.

Research output: Contribution to journalArticle

103 Scopus citations