• 1967 Citations
  • 24 h-Index
19992019
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Research Output 1999 2019

  • 1967 Citations
  • 24 h-Index
  • 39 Article
  • 4 Review article
  • 2 Chapter
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Article
2019
Agaricus
Aryl Hydrocarbon Receptors
Agaricus bisporus
Agaricales
Hydrocarbons
2 Citations (Scopus)

Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline

Hubbard, T. D., Liu, Q., Murray, I. A., Dong, F., Miller, C., Smith, P. B., Gowda, K., Lin, J. M., Amin, S., Patterson, A. D. & Perdew, G. H., Apr 5 2019, In : Journal of Proteome Research. 18, 4, p. 1715-1724 10 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Microbiota
Metabolism
Hydroxyquinolines
Chemical activation

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

Muku, G. E., Kusnadi, A., Kuzu, G., Tanos, R., Murray, I. A., Gowda, K., Amin, S. & Perdew, G. H., Jan 1 2019, (Accepted/In press) In : Laboratory Investigation.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 2
Aryl Hydrocarbon Receptors
Cholesterol
Ligands
Genes
2018
2 Citations (Scopus)

Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice

Smith, K. J., Murray, I. A., Boyer, J. A. & Perdew, G. H., Feb 1 2018, In : Toxicology. 394, p. 27-34 8 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Skin
Gene expression
Chemical activation
Alleles

Structural and Functional Analysis of the Gut Microbiome for Toxicologists

Nichols, R. G., Cai, J., Murray, I. A., Koo, I., Smith, P. B., Perdew, G. H. & Patterson, A. D., Nov 1 2018, In : Current Protocols in Toxicology. 78, 1, e54.

Research output: Contribution to journalArticle

Functional analysis
Structural analysis
Metabolomics
Poisons
Metabolites
3 Citations (Scopus)

Urolithin a is a dietary microbiota-derived human aryl hydrocarbon receptor antagonist

Muku, G. E., Murray, I. A., Espín, J. C. & Perdew, G. H., Dec 1 2018, In : Metabolites. 8, 4

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Microbiota
Ligands
Competitive Binding
Caco-2 Cells
2017
8 Citations (Scopus)

Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin

Smith, K. J., Boyer, J. A., Muku, G. E., Murray, I. A., Gowda, K., Desai, D., Amin, S. G., Glick, A. B. & Perdew, G. H., Jan 1 2017, In : Toxicological Sciences. 160, 1, p. 83-94 12 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Neutrophil Activation
Chemotactic Factors
Keratinocytes
Skin
17 Citations (Scopus)

Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner

Hubbard, T. D., Murray, I. A., Nichols, R. G., Cassel, K., Podolsky, M., Kuzu, G., Tian, Y., Smith, P. B., Kennett, M. J., Patterson, A. D. & Perdew, G. H., Oct 1 2017, In : Journal of Functional Foods. 37, p. 685-698 14 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Brassica
colitis
broccoli
Colitis
10 Citations (Scopus)

Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor

Moyer, B. J., Rojas, I. Y., Murray, I. A., Lee, S., Hazlett, H. F., Perdew, G. H. & Tomlinson, C. R., May 15 2017, In : Toxicology and Applied Pharmacology. 323, p. 74-80 7 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Aryl Hydrocarbon Receptors
Tryptophan
Assays
Clinical Trials
3 Citations (Scopus)

Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses

Muku, G. E., Lahoti, T. S., Murray, I. A., Podolsky, M. A., Smith, K. J., Hubbard, T. D., Kuzu, G., Gowda, K., Amin, S. G. & Perdew, G. H., Dec 1 2017, In : Laboratory Investigation. 97, 12, p. 1471-1487 17 p.

Research output: Contribution to journalArticle

Macrophages
Ligands
Uric Acid
Lipopolysaccharides
Inflammation
2016
22 Citations (Scopus)

Divergent Ah Receptor Ligand Selectivity during Hominin Evolution

Hubbard, T. D., Murray, I. A., Bisson, W. H., Sullivan, A. P., Sebastian, A., Perry, G. H., Jablonski, N. G. & Perdew, G. H., Oct 1 2016, In : Molecular Biology and Evolution. 33, 10, p. 2648-2658 11 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Hominidae
ligand
hydrocarbons
Neanderthals
20 Citations (Scopus)
Aryl Hydrocarbon Receptors
Verrucomicrobia
Metagenomics
Metabolomics
Microbiota
19 Citations (Scopus)

Hepatic aryl hydrocarbon receptor attenuates fibroblast growth factor 21 expression

Girer, N. G., Murray, I. A., Omiecinski, C. J. & Perdew, G. H., Jul 15 2016, In : Journal of Biological Chemistry. 291, 29, p. 15378-15387 10 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Liver
Peroxisome Proliferator-Activated Receptors
Hepatocytes
Cyclic AMP Response Element-Binding Protein
4 Citations (Scopus)

Ligand activation of peroxisome proliferator-activated receptor-β/δ suppresses liver tumorigenesis in hepatitis B transgenic mice

Balandaram, G., Kramer, L. R., Kang, B. H., Murray, I. A., Perdew, G. H., Gonzalez, F. J. & Peters, J. M., Jul 1 2016, In : Toxicology. 363-364, p. 1-9 9 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Hepatitis B
Liver
Transgenic Mice
Carcinogenesis
4 Citations (Scopus)

Regulation of cytochrome P450 2B10 (CYP2B10) expression in liver by peroxisome proliferator-activated receptor-β/δ modulation of SP1 promoter occupancy

Koga, T., Yao, P. L., Goudarzi, M., Murray, I. A., Balandaram, G., Gonzalez, F. J., Perdew, G. H., Fornace, A. J. & Peters, J. M., Nov 25 2016, In : Journal of Biological Chemistry. 291, 48, p. 25255-25263 9 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Liver
Cytochrome P-450 Enzyme System
Modulation
Ethanol
2015
82 Citations (Scopus)

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Hubbard, T. D., Murray, I. A., Bisson, W. H., Lahoti, T. S., Gowda, K., Amin, S., Patterson, A. D. & Perdew, G. H., Aug 3 2015, In : Scientific reports. 5, 12689.

Research output: Contribution to journalArticle

Indoles
Microbiota
Hydrocarbons
Ligands
Gastrointestinal Tract
16 Citations (Scopus)

Aryl hydrocarbon receptor activation synergistically induces lipopolysaccharide-mediated expression of proinflammatory chemokine (c-c motif) ligand 20

Lahoti, T. S., Boyer, J. A., Kusnadi, A., Muku, G. E., Murray, I. A. & Perdew, G. H., Nov 1 2015, In : Toxicological Sciences. 148, 1, p. 229-240 12 p., kfv178.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Chemokines
Lipopolysaccharides
Macrophages
Chemical activation
104 Citations (Scopus)

Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

Zhang, L., Nichols, R. G., Correll, J., Murray, I. A., Tanaka, N., Smith, P. B., Hubbard, T. D., Sebastian, A., Albert, I., Hatzakis, E., Gonzalez, F. J., Perdew, G. H. & Patterson, A. D., Jul 6 2015, In : Environmental health perspectives. 123, 7, p. 679-688 10 p.

Research output: Contribution to journalArticle

Homeostasis
Diet
Butyrivibrio
Bacteroidetes
Metabolomics
2014
28 Citations (Scopus)
Aryl Hydrocarbon Receptors
Rheumatoid Arthritis
Intercellular Signaling Peptides and Proteins
Fibroblasts
Cytokines
2013
23 Citations (Scopus)

Aryl hydrocarbon receptor antagonism mitigates cytokine-mediated inflammatory signalling in primary human fibroblast-like synoviocytes

Lahoti, T. S., John, K., Hughes, J. M., Kusnadi, A., Murray, I. A., Krishnegowda, G., Amin, S. & Perdew, G. H., Oct 1 2013, In : Annals of the Rheumatic Diseases. 72, 10, p. 1708-1716 9 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Fibroblasts
Cytokines
Rheumatoid Arthritis
Interleukin-6
2012
42 Citations (Scopus)

Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element-independent manner

Tanos, R., Patel, R. D., Murray, I. A., Smith, P. B., Patterson, A. D. & Perdew, G. H., Jun 1 2012, In : Hepatology. 55, 6, p. 1994-2004 11 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Dioxins
Biosynthetic Pathways
Response Elements
Cholesterol
39 Citations (Scopus)

Role of the Ah receptor in homeostatic control of fatty acid synthesis in the liver

Tanos, R., Murray, I. A., Smith, P. B., Patterson, A. D. & Perdew, G. H., Oct 1 2012, In : Toxicological Sciences. 129, 2, p. 372-379 8 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Liver
Fatty Acids
Genes
Response Elements
10 Citations (Scopus)
Aryl Hydrocarbon Receptors
Cytokines
Response Elements
Complement C3-C5 Convertases
Complement Membrane Attack Complex
2011
51 Citations (Scopus)

Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism

Smith, K. J., Murray, I. A., Tanos, R., Tellew, J., Boitano, A. E., Bisson, W. H., Kolluri, S. K., Cooke, M. P. & Perdew, G. H., Jul 1 2011, In : Journal of Pharmacology and Experimental Therapeutics. 338, 1, p. 318-327 10 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Dioxins
Response Elements
Ligands
Indazoles
36 Citations (Scopus)

Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3′,4′-dimethoxy- α-naphthoflavone

Murray, I. A., Flaveny, C. A., Chiaro, C. R., Sharma, A., Tanos, R. S., Schroeder, J. C., Amin, S., Bisson, W. H., Kolluri, S. K. & Perdew, G. H., Mar 1 2011, In : Molecular pharmacology. 79, 3, p. 508-519 12 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Response Elements
Cytokines
Gene Expression
Dioxins
2010
42 Citations (Scopus)

Antagonism of aryl hydrocarbon receptor signaling by 6,2′,4′- trimethoxyflavone

Murray, I. A., Flaveny, C. A., DiNatale, B. C., Chairo, C. R., Schroeder, J. C., Kusnadi, A. & Perdew, G. H., Jan 1 2010, In : Journal of Pharmacology and Experimental Therapeutics. 332, 1, p. 135-144 10 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Flavonoids
Physiological Phenomena
Ligands
Environmental Pollutants
35 Citations (Scopus)

Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-β/δ antagonist GSK3787

Palkar, P. S., Borland, M. G., Naruhn, S., Ferry, C. H., Lee, C., Sk, U. H., Sharma, A., Amin, S., Murray, I. A., Anderson, C. R., Perdew, G. H., Gonzalez, F. J., Müller, R. & Peters, J. M., Jan 1 2010, In : Molecular pharmacology. 78, 3, p. 419-430 12 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Pharmacology
4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide
Colon
Cell Line
54 Citations (Scopus)

Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties

Murray, I. A., Gowda, K., Dinatale, B. C., Flaveny, C., Chiaro, C., Lin, J. M., Sharma, A., Amin, S. & Perdew, G. H., May 17 2010, In : Chemical Research in Toxicology. 23, 5, p. 955-966 12 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Modulators
Anti-Inflammatory Agents
Tetradecanoylphorbol Acetate
Gene expression
61 Citations (Scopus)

Evidence for ligand-mediated selective modulation of aryl hydrocarbon receptor activity

Murray, I. A., Morales, J. L., Flaveny, C. A., DiNatale, B. C., Chiaro, C., Gowda, K., Amin, S. & Perdew, G. H., Feb 1 2010, In : Molecular Pharmacology. 77, 2, p. 247-254 8 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Ligands
Response Elements
Dioxins
Selective Estrogen Receptor Modulators
229 Citations (Scopus)

Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling

DiNatale, B. C., Murray, I. A., Schroeder, J. C., Flaveny, C. A., Lahoti, T. S., Laurenzana, E. M., Omiecinski, C. J. & Perdew, G. H., May 1 2010, In : Toxicological Sciences. 115, 1, p. 89-97 9 p.

Research output: Contribution to journalArticle

Kynurenic Acid
Aryl Hydrocarbon Receptors
Interleukin-6
Ligands
Tumors
132 Citations (Scopus)

The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor

Schroeder, J. C., DiNatale, B. C., Murray, I. A., Flaveny, C. A., Liu, Q., Laurenzana, E. M., Lin, J. M., Strom, S. C., Omiecinski, C. J., Amin, S. & Perdew, G. H., Jan 19 2010, In : Biochemistry. 49, 2, p. 393-400 8 p.

Research output: Contribution to journalArticle

Indican
Aryl Hydrocarbon Receptors
Sulfates
Ligands
Chemical activation
2009
73 Citations (Scopus)

Ah receptor represses acute-phase response gene expression without binding to its cognate response element

Patel, R. D., Murray, I. A., Flaveny, C. A., Kusnadi, A. & Perdew, G. H., Jun 1 2009, In : Laboratory Investigation. 89, 6, p. 695-707 13 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Acute-Phase Reaction
Response Elements
Gene Expression
Serum Amyloid A Protein
57 Citations (Scopus)

Differential gene regulation by the human and mouse aryl hydrocarbon receptor

Flaveny, C. A., Murray, I. A. & Perdew, G. H., Dec 31 2009, In : Toxicological Sciences. 114, 2, p. 217-225 9 p.

Research output: Contribution to journalArticle

Gene expression
Genes
Hepatocytes
Transcriptional Activation
Ligands
89 Citations (Scopus)

Ligand selectivity and gene regulation by the human aryl hydrocarbon receptor in transgenic mice

Flaveny, C. A., Murray, I. A., Chiaro, C. R. & Perdew, G. H., Jun 1 2009, In : Molecular Pharmacology. 75, 6, p. 1412-1420 9 p.

Research output: Contribution to journalArticle

Transgenic Mice
Ligands
Genes
Aryl Hydrocarbon Receptors
Hepatocytes
2008
53 Citations (Scopus)

Ligand activation of peroxisome proliferator - Activated receptor β/ δ (PPARβ/δ) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression

Shan, W., Palkar, P. S., Murray, I. A., Mcdevitt, E. I., Kennett, M. J., Kang, B. H., Isom, H. C., Perdew, G. H., Gonzalez, F. J. & Peters, J. M., Sep 22 2008, In : Toxicological Sciences. 105, 2, p. 418-428 11 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Carbon Tetrachloride
Gene expression
Down-Regulation
Chemical activation
30 Citations (Scopus)
Aryl Hydrocarbon Receptors
Omeprazole
Hep G2 Cells
Insulin-Like Growth Factor Binding Protein 1
Dioxins
2005
31 Citations (Scopus)

Evidence that ligand binding is a key determinant of Ah receptor-mediated transcriptional activity

Murray, I. A., Reen, R. K., Leathery, N., Ramadoss, P., Bonati, L., Gonzalez, F. J., Peters, J. M. & Perdew, G. H., Oct 1 2005, In : Archives of Biochemistry and Biophysics. 442, 1, p. 59-71 13 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Ligands
Simian virus 40
Bioactivity
Viruses
73 Citations (Scopus)

Peroxisome proliferator-activated receptor-β/δ inhibits epidermal cell proliferation by down-regulation of kinase activity

Kim, D. J., Murray, I. A., Burns, A. M., Gonzalez, F. J., Perdew, G. H. & Peters, J. M., Mar 11 2005, In : Journal of Biological Chemistry. 280, 10, p. 9519-9527 9 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Cell proliferation
Protein Kinase C
Phosphotransferases
Down-Regulation
1999
67 Citations (Scopus)

Interaction of glucocorticoid receptor isoforms with transcription factors AP-1 and NF-κB: Lack of effect of glucocorticoid receptor β

Brogan, I. J., Murray, I. A., Cerillo, G., Needham, M., White, A. & Davis, J. R. E., Nov 25 1999, In : Molecular and Cellular Endocrinology. 157, 1-2, p. 95-104 10 p.

Research output: Contribution to journalArticle

Glucocorticoid Receptors
Transcription Factor AP-1
Transcriptional Activation
Protein Isoforms
Genes