• 9956 Citations
  • 55 h-Index
1976 …2019
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Research Output 1976 2019

  • 9956 Citations
  • 55 h-Index
  • 128 Article
  • 5 Review article
  • 3 Chapter
  • 1 Letter
2019
9 Citations (Scopus)

Endothelial cells are critical regulators of iron transport in a model of the human blood–brain barrier

Chiou, B., Neal, E. H., Bowman, A. B., Lippmann, E. S., Simpson, I. A. & Connor, J. R., Nov 1 2019, In : Journal of Cerebral Blood Flow and Metabolism. 39, 11, p. 2117-2131 15 p.

Research output: Contribution to journalArticle

Iron
Endothelial Cells
Brain
Apoferritins
Transferrin

Transferrin and H-ferritin involvement in brain iron acquisition during postnatal development: impact of sex and genotype

Chiou, B., Neely, E. B., Mcdevitt, D. S., Simpson, I. & Connor, J., Jan 1 2019, (Accepted/In press) In : Journal of neurochemistry.

Research output: Contribution to journalArticle

Apoferritins
Sexual Development
Transferrin
Brain
Iron
2018
6 Citations (Scopus)

A role for sex and a common HFE gene variant in brain iron uptake

Duck, K. A., Neely, E. B., Simpson, I. A. & Connor, J. R., Mar 1 2018, In : Journal of Cerebral Blood Flow and Metabolism. 38, 3, p. 540-548 9 p.

Research output: Contribution to journalArticle

Iron
Brain
Genes
Mutation
Genotype
6 Citations (Scopus)

Pharmaceutical iron formulations do not cross a model of the human blood-brain barrier

Chiou, B., Neal, E. H., Bowman, A. B., Lippmann, E. S., Simpson, I. A. & Connor, J. R., Jun 2018, In : PloS one. 13, 6, e0198775.

Research output: Contribution to journalArticle

Drug Compounding
blood-brain barrier
Blood-Brain Barrier
Iron
iron
2 Citations (Scopus)

The role of HFE genotype in macrophage phenotype

Nixon, A. M., Neely, E., Simpson, I. A. & Connor, J. R., Feb 1 2018, In : Journal of Neuroinflammation. 15, 1, 30.

Research output: Contribution to journalArticle

Iron
Macrophages
Genotype
Phenotype
Homeostasis
2017
13 Citations (Scopus)

Regulatory mechanisms for iron transport across the blood-brain barrier

Duck, K. A., Simpson, I. A. & Connor, J. R., Dec 9 2017, In : Biochemical and Biophysical Research Communications. 494, 1-2, p. 70-75 6 p.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Iron
Brain
Endothelial cells
Endothelial Cells
2015
60 Citations (Scopus)

A novel model for brain iron uptake: Introducing the concept of regulation

Simpson, I. A., Ponnuru, P., Klinger, M. E., Myers, R. L., Devraj, K., Coe, C. L., Lubach, G. R., Carruthers, A. & Connor, J. R., Jan 10 2015, In : Journal of Cerebral Blood Flow and Metabolism. 35, 1, p. 48-57 10 p.

Research output: Contribution to journalArticle

Iron
Brain
Blood-Brain Barrier
Endothelial Cells
Transferrin
2013

Carbohydrate Metabolism in the Central Nervous System

Simpson, I. & Vannucci, S. J., Feb 15 2013, Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., p. 368-373 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Carbohydrate Metabolism
Neurology
Brain
Central Nervous System
Metabolism
2011
2 Citations (Scopus)

Amino acid transport across each side of the blood-brain barrier

Hawkins, R. A., Viña, J. R., Peterson, D. R., O'Kane, R., Mokashi, A. & Simpson, I., Nov 24 2011, Amino Acids in Human Nutrition and Health. CABI Publishing, p. 189-214 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

blood-brain barrier
Blood-Brain Barrier
Brain
Amino Acids
amino acids
36 Citations (Scopus)

GLUT-1 glucose transporters in the blood-brain barrier: Differential phosphorylation

Devraj, K., Klinger, M. E., Myers, R. L., Mokashi, A., Hawkins, R. A. & Simpson, I. A., Dec 1 2011, In : Journal of Neuroscience Research. 89, 12, p. 1913-1925 13 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Blood-Brain Barrier
Phosphorylation
Brain
Glucose
39 Citations (Scopus)

Increased cerebral matrix metalloprotease-9 activity is associated with compromised recovery in the diabetic db/db mouse following a stroke

Kumari, R., Willing, L. B., Patel, S. D., Baskerville, K. A. & Simpson, I., Dec 1 2011, In : Journal of neurochemistry. 119, 5, p. 1029-1040 12 p.

Research output: Contribution to journalArticle

Metalloproteases
Stroke
Recovery
Blood-Brain Barrier
Tissue
21 Citations (Scopus)
Mifepristone
Glucocorticoid Receptors
Biomarkers
DNA Damage
Muscle
68 Citations (Scopus)

Response to comment on recent modeling studies of astrocyte-neuron metabolic interactions: Much ado about nothing

Mangia, S., Dinuzzo, M., Giove, F., Carruthers, A., Simpson, I. & Vannucci, S. J., Jun 1 2011, In : Journal of Cerebral Blood Flow and Metabolism. 31, 6, p. 1346-1353 8 p.

Research output: Contribution to journalReview article

Astrocytes
Lactic Acid
Neurons
Glucose
Synaptic Transmission
9 Citations (Scopus)

Temporal changes in mRNA expression of the brain nutrient transporters in the lithium-pilocarpine model of epilepsy in the immature and adult rat

Leroy, C., Pierre, K., Simpson, I. A., Pellerin, L., Vannucci, S. J. & Nehlig, A., Sep 1 2011, In : Neurobiology of Disease. 43, 3, p. 588-597 10 p.

Research output: Contribution to journalArticle

Pilocarpine
Lithium
Epilepsy
Status Epilepticus
Food
2010
36 Citations (Scopus)

The PPAR-γ agonist, darglitazone, restores acute inflammatory responses to cerebral hypoxia-ischemia in the diabetic ob/ob mouse

Kumari, R., Willing, L. B., Patel, S. D., Krady, J. K., Zavadoski, W. J., Gibbs, E. M., Vannucci, S. J. & Simpson, I. A., Feb 1 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 2, p. 352-360 9 p.

Research output: Contribution to journalArticle

Brain Hypoxia-Ischemia
Peroxisome Proliferator-Activated Receptors
darglitazone
Glial Fibrillary Acidic Protein
Corticosterone
2009
10 Citations (Scopus)

Improved membrane protein solubilization and clean-up for optimum two-dimensional electrophoresis utilizing GLUT-1 as a classic integral membrane protein

Devraj, K., Geguchadze, R., Klinger, M. E., Freeman, W. M., Mokashi, A., Hawkins, R. A. & Simpson, I., Oct 30 2009, In : Journal of Neuroscience Methods. 184, 1, p. 119-123 5 p.

Research output: Contribution to journalArticle

Electrophoresis
Membrane Proteins
Facilitative Glucose Transport Proteins
Isoelectric Point
Proteins
120 Citations (Scopus)

The in vivo neuron-to-astrocyte lactate shuttle in human brain: Evidence from modeling of measured lactate levels during visual stimulation

Mangia, S., Simpson, I., Vannucci, S. J. & Carruthers, A., May 1 2009, In : Journal of neurochemistry. 109, SUPPL. 1, p. 55-62 8 p.

Research output: Contribution to journalArticle

Photic Stimulation
Astrocytes
Neurons
Magnetic resonance spectroscopy
Lactic Acid
6 Citations (Scopus)

The ketogenic diet has no effect on the expression of spike-and-wave discharges and nutrient transporters in genetic absence epilepsy rats from Strasbourg

Nehlig, A., Dufour, F., Klinger, M., Willing, L. B., Simpson, I. A. & Vannucci, S. J., May 1 2009, In : Journal of neurochemistry. 109, SUPPL. 1, p. 207-213 7 p.

Research output: Contribution to journalArticle

Ketogenic Diet
Absence Epilepsy
Nutrition
Nutrients
Rats
2008
218 Citations (Scopus)

The facilitative glucose transporter GLUT3: 20 Years of distinction

Simpson, I. A., Dwyer, D., Malide, D., Moley, K. H., Travis, A. & Vannucci, S. J., Aug 1 2008, In : American Journal of Physiology - Endocrinology and Metabolism. 295, 2, p. E242-E253

Research output: Contribution to journalReview article

Facilitative Glucose Transport Proteins
Glucose
Neurons
Membrane Transport Proteins
Blastocyst
2007
120 Citations (Scopus)

Ferritin: A novel mechanism for delivery of iron to the brain and other organs

Fisher, J., Devraj, K., Ingram, J., Slagle-Webb, B., Madhankumar, A. B., Liu, X., Klinger, M., Simpson, I. A. & Connor, J. R., Aug 1 2007, In : American Journal of Physiology - Cell Physiology. 293, 2, p. C641-C649

Research output: Contribution to journalArticle

Apoferritins
Ferritins
Iron
Brain
Endothelial Cells
41 Citations (Scopus)

Impaired wound healing after cerebral hypoxia-ischemia in the diabetic mouse

Kumari, R., Willing, L. B., Krady, J. K., Vannucci, S. J. & Simpson, I. A., Apr 26 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, 4, p. 710-718 9 p.

Research output: Contribution to journalArticle

Brain Hypoxia-Ischemia
Wound Healing
Interleukin-1
Glial Fibrillary Acidic Protein
Reperfusion
73 Citations (Scopus)

Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I

Zinnanti, W. J., Lazovic, J., Housman, C., Lanoue, K., O'Callaghan, J. P., Simpson, I., Woontner, M., Goodman, S. I., Connor, J. R., Jacobs, R. E. & Cheng, K. C., Nov 1 2007, In : Journal of Clinical Investigation. 117, 11, p. 3258-3270 13 p.

Research output: Contribution to journalArticle

Brain Injuries
Lysine
Brain
Magnetic Resonance Spectroscopy
Corpus Striatum
456 Citations (Scopus)

Supply and demand in cerebral energy metabolism: The role of nutrient transporters

Simpson, I. A., Carruthers, A. & Vannucci, S. J., Nov 1 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, 11, p. 1766-1791 26 p.

Research output: Contribution to journalReview article

Energy Metabolism
Glucose
Food
Lactic Acid
Astrocytes
2006
67 Citations (Scopus)

Analysis of glucose metabolism in diabetic rat retinas

Ola, M. S., Berkich, D. A., Xu, Y., King, M. T., Gardner, T. W., Simpson, I. & LaNoue, K. F., Jun 14 2006, In : American Journal of Physiology - Endocrinology and Metabolism. 290, 6, p. E1057-E1067

Research output: Contribution to journalArticle

Hyperglycemia
Retina
Glucose
NAD
Citric Acid Cycle
53 Citations (Scopus)

Cationic amino acid transport across the blood-brain barrier is mediated exclusively by system y+

O'Kane, R. L., Viña, J. R., Simpson, I., Zaragozá, R., Mokashi, A. & Hawkins, R. A., Jul 17 2006, In : American Journal of Physiology - Endocrinology and Metabolism. 291, 2, p. E412-E419

Research output: Contribution to journalArticle

Blood-Brain Barrier
Basic Amino Acid Transport Systems
Amino Acids
Arginine
Endothelial Cells
486 Citations (Scopus)

Diabetic retinopathy: Seeing beyond glucose-induced microvascular disease

Antonetti, D. A., Barber, A. J., Bronson, S. K., Freeman, W. M., Gardner, T. W., Jefferson, L. S., Kester, M., Kimball, S. R., Krady, J. K., LaNoue, K. F., Norbury, C. C., Quinn, P. G., Sandirasegarane, L. & Simpson, I. A., Sep 1 2006, In : Diabetes. 55, 9, p. 2401-2411 11 p.

Research output: Contribution to journalReview article

Diabetic Retinopathy
Glucose
Retina
Physiological Stress
Light Coagulation
18 Citations (Scopus)

Paralemmin interacts with D3 dopamine receptors: Implications for membrane localization and cAMP signaling

Basile, M., Lin, R., Kabbani, N., Karpa, K., Kilimann, M., Simpson, I. & Kester, M., Feb 1 2006, In : Archives of Biochemistry and Biophysics. 446, 1, p. 60-68 9 p.

Research output: Contribution to journalArticle

Dopamine D3 Receptors
Cell membranes
Adenylyl Cyclases
Lipid-Linked Proteins
Dopamine D4 Receptors
11 Citations (Scopus)

Pentylenetetrazol-induced status epilepticus up-regulates the expression of glucose transporter mRNAs but not proteins in the immature rat brain

Nehlig, A., Rudolf, G., Leroy, C., Rigoulot, M. A., Simpson, I. & Vannucci, S. J., Apr 12 2006, In : Brain research. 1082, 1, p. 32-42 11 p.

Research output: Contribution to journalArticle

Pentylenetetrazole
Facilitative Glucose Transport Proteins
Status Epilepticus
Seizures
Up-Regulation
10 Citations (Scopus)

Pyroglutamate stimulates Na+-dependent glutamate transport across the blood-brain barrier

Hawkins, R. A., Simpson, I., Mokashi, A. & Viña, J. R., Aug 7 2006, In : FEBS Letters. 580, 18, p. 4382-4386 5 p.

Research output: Contribution to journalArticle

Pyrrolidonecarboxylic Acid
Blood-Brain Barrier
Glutamic Acid
Membranes
Amino Acid Transport System X-AG
260 Citations (Scopus)

Structure of the blood-brain barrier and its role in the transport of amino acids

Hawkins, R. A., O'Kane, R. L., Simpson, I. A. & Viña, J. R., Jan 1 2006, In : Journal of Nutrition. 136, 1, p. 218S-226S

Research output: Contribution to journalArticle

Blood-Brain Barrier
Amino Acids
Brain
Membranes
Neutral Amino Acid Transport Systems
2005
28 Citations (Scopus)

An active transport system in the blood-brain barrier may reduce levodopa availability

Hawkins, R. A., Mokashi, A. & Simpson, I., Sep 1 2005, In : Experimental Neurology. 195, 1, p. 267-271 5 p.

Research output: Contribution to journalArticle

Active Biological Transport
Levodopa
Blood-Brain Barrier
Brain
Amino Acid Transport Systems
37 Citations (Scopus)

Monocarboxylate transporter expression in the spontaneous hypertensive rat: Effect of stroke

Zhang, F., Vannucci, S. J., Philp, N. J. & Simpson, I. A., Jan 15 2005, In : Journal of Neuroscience Research. 79, 1-2, p. 139-145 7 p.

Research output: Contribution to journalArticle

Stroke
Messenger RNA
Astrocytes
Cicatrix
Cell Death
2004
59 Citations (Scopus)

Estrogen stimulates microglia and brain recovery from hypoxia-ischemia in normoglycemic but not diabetic female mice

Zhang, L., Nair, A., Krady, K., Corpe, C., Bonneau, R. H., Simpson, I. A. & Vannucci, S. J., Jan 1 2004, In : Journal of Clinical Investigation. 113, 1, p. 85-95 11 p.

Research output: Contribution to journalArticle

Brain Hypoxia-Ischemia
Microglia
Estrogens
Brain
Gene Expression
39 Citations (Scopus)

Na+-dependent neutral amino acid transporters A, ASC, and N of the blood-brain barrier: Mechanisms for neutral amino acid removal

O'Kane, R. L., Viña, J. R., Simpson, I. & Hawkins, R. A., Oct 1 2004, In : American Journal of Physiology - Endocrinology and Metabolism. 287, 4 50-4, p. E622-E629

Research output: Contribution to journalArticle

Amino Acid Transport System ASC
Amino Acid Transport System A
Neutral Amino Acid Transport Systems
Neutral Amino Acids
Blood-Brain Barrier
43 Citations (Scopus)

Regulation of the Profile of Iron-Management Proteins in Brain Microvasculature

Burdo, J. R., Simpson, I., Menzies, S., Beard, J. & Connor, J., Jan 1 2004, In : Journal of Cerebral Blood Flow and Metabolism. 24, 1, p. 67-74 8 p.

Research output: Contribution to journalArticle

Microvessels
Iron
Brain
Proteins
Ferritins
2003
83 Citations (Scopus)

Characterization of insulin signaling in rat retina in vivo and ex vivo

Reiter, C. E. N., Sandirasegarane, L., Wolpert, E. B., Klinger, M., Simpson, I., Barber, A., Antonetti, D. A., Kester, M. & Gardner, T. W., Oct 1 2003, In : American Journal of Physiology - Endocrinology and Metabolism. 285, 4 48-4

Research output: Contribution to journalArticle

Insulin Receptor
Retina
Insulin
Phosphotransferases
Phosphorylation
164 Citations (Scopus)

Developmental switch in brain nutrient transporter expression in the rat

Vannucci, S. J. & Simpson, I. A., Nov 1 2003, In : American Journal of Physiology - Endocrinology and Metabolism. 285, 5 48-5, p. E1127-E1134

Research output: Contribution to journalArticle

Food
Brain
Monocarboxylic Acid Transporters
Glucose
Blood-Brain Barrier
2002
46 Citations (Scopus)

Cloning and functional characterization of the mouse fructose transporter, GLUT5

Corpe, C. P., Bovelander, F. J., Munoz, C. M., Hoekstra, J. H., Simpson, I., Kwon, O., Levine, M. & Burant, C. F., Jun 7 2002, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1576, 1-2, p. 191-197 7 p.

Research output: Contribution to journalArticle

Cloning
Fructose
Organism Cloning
Complementary DNA
5' Flanking Region
54 Citations (Scopus)

Expression, regulation, and functional role of glucose transporters (GLUTs) in brain

Dwyer, D. S., Vannucci, S. J. & Simpson, I. A., Dec 1 2002, Glucose Metabolism in the Brain. p. 159-188 30 p. (International Review of Neurobiology; vol. 51).

Research output: Chapter in Book/Report/Conference proceedingChapter

Monosaccharide Transport Proteins
Facilitative Glucose Transport Proteins
Tissue Distribution
Hypoglycemia
Hyperglycemia
7 Citations (Scopus)

Glucose transport into brain: Effects of hypoglycemia

Simpson, I. & Vannucci, S. J., Oct 1 2002, In : Diabetes, Nutrition and Metabolism - Clinical and Experimental. 15, 5, p. 281-284 4 p.

Research output: Contribution to journalArticle

hypoglycemia
Hypoglycemia
brain
Glucose
glucose
2001
227 Citations (Scopus)

Distribution of Divalent Metal Transporter 1 and Metal Transport Protein 1 in the normal and Belgrade rat

Burdo, J. R., Menzies, S. L., Simpson, I., Garrick, L. M., Garrick, M. D., Dolan, K. G., Haile, D. J., Beard, J. L. & Connor, J., Dec 15 2001, In : Journal of Neuroscience Research. 66, 6, p. 1198-1207 10 p.

Research output: Contribution to journalArticle

Carrier Proteins
Iron
Metals
Brain
Staining and Labeling
115 Citations (Scopus)

Experimental stroke in the female diabetic, db/db, mouse

Vannucci, S. J., Willing, L. B., Goto, S., Alkayed, N. J., Brucklacher, R. M., Wood, T. L., Towfighi, J., Hurn, P. D. & Simpson, I., Jan 1 2001, In : Journal of Cerebral Blood Flow and Metabolism. 21, 1, p. 52-60 9 p.

Research output: Contribution to journalArticle

Stroke
Cerebrovascular Circulation
Common Carotid Artery
Brain
Ligation
73 Citations (Scopus)

Glucose Transporter Asymmetries in the Bovine Blood-Brain Barrier

Simpson, I., Vannucci, S. J., DeJoseph, M. R. & Hawkins, R. A., Apr 20 2001, In : Journal of Biological Chemistry. 276, 16, p. 12725-12729 5 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Blood-Brain Barrier
Membranes
Endothelial cells
Photoaffinity Labels
6 Citations (Scopus)
Citric Acid Cycle
Glycolysis
Norway
Glutamic Acid
Lactic Acid
2000
6 Citations (Scopus)

Cerebral glucose utilization and glucose transporter expression: Response to water deprivation and restoration

Koehler-Stec, E. M., Li, K., Maher, F., Vannucci, S. J., Smith, C. B. & Simpson, I., Jan 1 2000, In : Journal of Cerebral Blood Flow and Metabolism. 20, 1, p. 192-200 9 p.

Research output: Contribution to journalArticle

Water Deprivation
Posterior Pituitary Gland
Facilitative Glucose Transport Proteins
Glucose
Messenger RNA
138 Citations (Scopus)

Dehydroascorbic acid transport by GLUT4 xenopus oocytes and isolated rat adipocytes

Rumsey, S. C., Daruwala, R., Al-Hasani, H., Zarnowski, M. J., Simpson, I. & Levine, M., Sep 8 2000, In : Journal of Biological Chemistry. 275, 36, p. 28246-28253 8 p.

Research output: Contribution to journalArticle

Dehydroascorbic Acid
Xenopus
Adipocytes
Oocytes
Rats
22 Citations (Scopus)

Prenatal expression of the GLUT4 glucose transporter in the mouse

Vannucci, S. J., Rutherford, T., Wilkie, M. B., Simpson, I. A. & Lauder, J. M., Aug 2000, In : Developmental Neuroscience. 22, 4, p. 274-282 9 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Glucose Transporter Type 4
Cerebellum
Cartilage
Brain
1999
30 Citations (Scopus)

Alterations in blood-brain barrier glucose transport in SIV-infected macaques

Mankowski, J. L., Queen, S. E., Kirstein, L. M., Spelman, J. P., Laterra, J., Simpson, I. A., Adams, R. J., Clements, J. E. & Zink, M. C., Dec 1999, In : Journal of neurovirology. 5, 6, p. 695-702 8 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Macaca
Blood-Brain Barrier
Glucose
Encephalitis
150 Citations (Scopus)

Astrocytic demise precedes delayed neuronal death in focal ischemic rat brain

Liu, D., Smith, C. L., Barone, F. C., Ellison, J. A., Lysko, P. G., Li, K. & Simpson, I. A., May 7 1999, In : Molecular Brain Research. 68, 1-2, p. 29-41 13 p.

Research output: Contribution to journalArticle

Neuroglia
Messenger RNA
Brain
Proteins
Middle Cerebral Artery Infarction
218 Citations (Scopus)

Blood-brain barrier glucose transporter: Effects of hypo- and hyperglycemia revisited

Simpson, I. A., Appel, N. M., Hokari, M., Oki, J., Holman, G. D., Maher, F., Koehler-Stec, E. M., Vannucci, S. J. & Smith, Q. R., Jan 11 1999, In : Journal of neurochemistry. 72, 1, p. 238-247 10 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Blood-Brain Barrier
Hypoglycemia
Hyperglycemia
Glucose