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Personal profile

Research interests

Dr. Iryna Pinchuk's research focuses on the mechanisms responsible for the dysregulation of mucosal immune responses, in particular those that are involved in inflammatory bowel disease (IBD) and cancer.

Dr. Pinchuk has pioneered the understanding of the immune function of CD90+ stromal cells (CMFs) in colonic mucosa and demonstrated that in normal gastrointestinal mucosa, CMFs play an immunosuppressive role, contributing to the maintenance of the mucosal tolerance. Dr. Pinchuk also reported that IBD- and gastrointestinal-cancer-derived CMFs have altered tolerogenic function.

Her major study focus is to understand both the interplay between innate and adaptive cells during IBD and cancer development and progression as well as how microbiota modulate these interactions.

Dr. Pinchuk has substantial expertise in the area of human and rodent gastrointestinal mucosal immune responses and more than 15 years of experience in the areas of immunology, cell biology, microbiology and gastrointestinal research.

She holds a patent and has published numerous peer-reviewed articles and two book chapters in the field of immunology, cell biology and microbiology. 

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Projects

  • Research Output

    • 2104 Citations
    • 27 h-Index
    • 40 Article
    • 5 Review article
    • 1 Chapter

    Expression of programmed death-ligand 1 by human colonic CD90+ stromal cells differs between ulcerative colitis and Crohn's disease and determines their capacity to suppress Th1 cells

    Beswick, E. J., Grim, C., Singh, A., Aguirre, J. E., Tafoya, M., Qiu, S., Rogler, G., McKee, R., Samedi, V., Ma, T. Y., Reyes, V. E., Powell, D. W. & Pinchuk, I. V., May 30 2018, In : Frontiers in immunology. 9, MAY, 1125.

    Research output: Contribution to journalArticle

  • 9 Scopus citations

    Immunosuppression by intestinal stromal cells

    Pinchuk, I. & Powell, D. W., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 115-129 15 p. (Advances in Experimental Medicine and Biology; vol. 1060).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • Lactobacillus rhamnosus GG increases cyclooxygenase-2 expression and prostaglandin E2 secretion in colonic myofibroblasts via a MyD88-dependent mechanism during homeostasis

    Uribe, G., Villéger, R., Bressollier, P., Dillard, R. N., Worthley, D. L., Wang, T. C., Powell, D. W., Urdaci, M. C. & Pinchuk, I. V., Nov 2018, In : Cellular Microbiology. 20, 11, e12871.

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    MK2 regulates macrophage chemokine activity and recruitment to promote colon tumor growth

    Phinney, B. B., Ray, A. L., Peretti, A. S., Jerman, S. J., Grim, C., Pinchuk, I. V. & Beswick, E. J., Sep 21 2018, In : Frontiers in immunology. 9, SEP, 1857.

    Research output: Contribution to journalArticle

    Open Access
  • Deletion of NF-κB/RelA in angiotensin II-sensitive mesenchymal cells blocks aortic vascular inflammation and abdominal aortic aneurysm formation

    Ijaz, T., Sun, H., Pinchuk, I. V., Milewicz, D. M., Tilton, R. G. & Brasier, A. R., Jan 1 2017, In : Arteriosclerosis, thrombosis, and vascular biology. 37, 10, p. 1881-1890 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • 13 Scopus citations