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Personal profile

Research interests

Dr. Iryna Pinchuk's research focuses on the mechanisms responsible for the dysregulation of mucosal immune responses, in particular those that are involved in inflammatory bowel disease (IBD) and cancer.

Dr. Pinchuk has pioneered the understanding of the immune function of CD90+ stromal cells (CMFs) in colonic mucosa and demonstrated that in normal gastrointestinal mucosa, CMFs play an immunosuppressive role, contributing to the maintenance of the mucosal tolerance. Dr. Pinchuk also reported that IBD- and gastrointestinal-cancer-derived CMFs have altered tolerogenic function.

Her major study focus is to understand both the interplay between innate and adaptive cells during IBD and cancer development and progression as well as how microbiota modulate these interactions.

Dr. Pinchuk has substantial expertise in the area of human and rodent gastrointestinal mucosal immune responses and more than 15 years of experience in the areas of immunology, cell biology, microbiology and gastrointestinal research.

She holds a patent and has published numerous peer-reviewed articles and two book chapters in the field of immunology, cell biology and microbiology. 

Fingerprint Dive into the research topics where Iryna Pinchuk is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Projects 2014 2019

Stromal Cells
Crohn Disease
CD274 Antigen
Toll-Like Receptors
Antigen-Presenting Cells

Research Output 2001 2018

  • 1959 Citations
  • 26 h-Index
  • 40 Article
  • 5 Review article
  • 1 Chapter
8 Citations (Scopus)

Expression of programmed death-ligand 1 by human colonic CD90+ stromal cells differs between ulcerative colitis and Crohn's disease and determines their capacity to suppress Th1 cells

Beswick, E. J., Grim, C., Singh, A., Aguirre, J. E., Tafoya, M., Qiu, S., Rogler, G., McKee, R., Samedi, V., Ma, T., Reyes, V. E., Powell, D. W. & Pinchuk, I., May 30 2018, In : Frontiers in immunology. 9, MAY, 1125.

Research output: Contribution to journalArticle

Th1 Cells
Stromal Cells
Ulcerative Colitis
Crohn Disease
Fibroblasts

Immunosuppression by intestinal stromal cells

Pinchuk, I. & Powell, D. W., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 115-129 15 p. (Advances in Experimental Medicine and Biology; vol. 1060).

Research output: Chapter in Book/Report/Conference proceedingChapter

Stromal Cells
Stem cells
Mesenchymal Stromal Cells
Immunosuppression
Myofibroblasts
3 Citations (Scopus)

Lactobacillus rhamnosus GG increases cyclooxygenase-2 expression and prostaglandin E2 secretion in colonic myofibroblasts via a MyD88-dependent mechanism during homeostasis

Uribe, G., Villéger, R., Bressollier, P., Dillard, R. N., Worthley, D. L., Wang, T. C., Powell, D. W., Urdaci, M. C. & Pinchuk, I., Nov 1 2018, In : Cellular Microbiology. 20, 11, e12871.

Research output: Contribution to journalArticle

Lactobacillus rhamnosus
Myofibroblasts
Cyclooxygenase 2
Dinoprostone
Homeostasis

MK2 regulates macrophage chemokine activity and recruitment to promote colon tumor growth

Phinney, B. B., Ray, A. L., Peretti, A. S., Jerman, S. J., Grim, C., Pinchuk, I. & Beswick, E. J., Sep 21 2018, In : Frontiers in immunology. 9, SEP, 1857.

Research output: Contribution to journalArticle

Open Access
Personnel Selection
Chemokines
Protein Kinases
Colon
Macrophages
10 Citations (Scopus)

Deletion of NF-κB/RelA in angiotensin II-sensitive mesenchymal cells blocks aortic vascular inflammation and abdominal aortic aneurysm formation

Ijaz, T., Sun, H., Pinchuk, I., Milewicz, D. M., Tilton, R. G. & Brasier, A. R., Jan 1 2017, In : Arteriosclerosis, thrombosis, and vascular biology. 37, 10, p. 1881-1890 10 p.

Research output: Contribution to journalArticle

Open Access
Abdominal Aortic Aneurysm
Angiotensin II
Blood Vessels
Inflammation
Tamoxifen