Iwona Hirschler-Laszkiewicz, MSc, PhD

    • 856 Citations
    • 18 h-Index
    1983 …2019
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    Fingerprint Dive into the research topics where Iwona Hirschler-Laszkiewicz is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

    • 9 Similar Profiles
    Myelin-Associated Glycoprotein Medicine & Life Sciences
    Transient Receptor Potential Channels Medicine & Life Sciences
    Ion Channels Medicine & Life Sciences
    Oligodendroglia Medicine & Life Sciences
    Proteolipids Medicine & Life Sciences
    RNA Polymerase I Medicine & Life Sciences
    Erythropoietin Medicine & Life Sciences
    Ribosomal DNA Medicine & Life Sciences

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    Research Output 1983 2019

    • 856 Citations
    • 18 h-Index
    • 30 Article

    The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2

    Bao, L., Festa, F., Freet, C. S., Lee, J. P., Hirschler-Laszkiewicz, I. M., Chen, S. J., Keefer, K. A., Wang, H. G., Patterson, A. D., Cheung, J. Y. & Miller, B. A., Dec 1 2019, In : Scientific reports. 9, 1, 14132.

    Research output: Contribution to journalArticle

    Open Access
    Transient Receptor Potential Channels
    Ion Channels
    Cell Survival
    NADP
    NAD

    Trpm2 enhances physiological bioenergetics and protects against pathological oxidative cardiac injury: Role of Pyk2 phosphorylation

    Miller, B., Wang, J. F., Song, J., Zhang, X. Q., Hirschler-Laszkiewicz, I., Santhanam, S., Tomar, D., Rajan, S., Feldman, A. M., Madesh, M., Sheu, S. S. & Cheung, J. Y., Sep 1 2019, In : Journal of Cellular Physiology. 234, 9, p. 15048-15060 13 p.

    Research output: Contribution to journalArticle

    Focal Adhesion Kinase 2
    Phosphorylation
    Energy Metabolism
    Muscle Cells
    Wounds and Injuries
    6 Citations (Scopus)

    The human ion channel TRPM2 modulates neuroblastoma cell survival and mitochondrial function through Pyk2, CREB, and MCU activation

    Hirschler-Laszkiewicz, I., Chen, S., Bao, L., Wang, J., Zhang, X. Q., Santhanam, S., Keefer, K., Madesh, M., Cheung, J. Y. & Miller, B., Oct 6 2018, In : American Journal of Physiology - Cell Physiology. 315, 4, p. C571-C586

    Research output: Contribution to journalArticle

    Focal Adhesion Kinase 2
    Transient Receptor Potential Channels
    Neuroblastoma
    Ion Channels
    Cell Survival
    20 Citations (Scopus)

    Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics

    Bao, L., Chen, S. J., Conrad, K., Keefer, K., Abraham, T., Lee, J. P., Wang, J. F., Zhang, X. Q., Hirschler-Laszkiewicz, I., Wang, H. G., Dovat, S., Gans, B., Madesh, M., Cheung, J. Y. & Miller, B. A., Nov 18 2016, In : Journal of Biological Chemistry. 291, 47, p. 24449-24464 16 p.

    Research output: Contribution to journalArticle

    Neuroblastoma
    Ion Channels
    Energy Metabolism
    Reactive Oxygen Species
    Cell Survival
    27 Citations (Scopus)

    Ca2+ entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance

    Hoffman, N. E., Miller, B. A., Wang, J. F., Elrod, J. W., Rajan, S., Gao, E., Song, J., Zhang, X. Q., Hirschler-Laszkiewicz, I., Shanmughapriya, S., Koch, W. J., Feldman, A. M., Madesh, M. & Cheung, J. Y., Mar 15 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 308, 6, p. H637-H650

    Research output: Contribution to journalArticle

    Cardiac Myocytes
    Energy Metabolism
    Maintenance
    Green Fluorescent Proteins
    Muscle Cells