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Personal profile

Research interests

The ongoing projects in Dr. Jacek Krzeminski's laboratory are closely related to research on several aspects of chemical carcinogenesis as well as chemoprevention and drug discovery.

The lab is involved in structure elucidation and syntheses in the areas of polyaromatic hydrocarbons (PAHs), nitro-PAHs, nitrosoamines and their metabolites.

Among Dr. Krzeminski's interests are also structurally modified/ adducted oligonucleotides and nucleoside analogues of potential anticancer activity. Other projects include structure-based design approaches to the optimization of leads/small molecules for drug-like properties introduction.

Fingerprint Dive into the research topics where Jacek Krzeminski is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 10 Similar Profiles
Epoxy Compounds Medicine & Life Sciences
Metabolites Chemical Compounds
DNA Adducts Medicine & Life Sciences
Carcinogens Medicine & Life Sciences
Rats Chemical Compounds
Benzo(a)pyrene Medicine & Life Sciences
Estuaries Medicine & Life Sciences
Breast Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1991 2018

  • 896 Citations
  • 16 h-Index
  • 51 Article
2 Citations (Scopus)

Cationic amphiphilic bolaamphiphile-based delivery of antisense oligonucleotides provides a potentially microbiome sparing treatment for C. difficile

Sharma, A., Krzeminski, J., Weissig, V., Hegarty, J. P. & Stewart, D. B., Aug 1 2018, In : Journal of Antibiotics. 71, 8, p. 713-721 9 p.

Research output: Contribution to journalArticle

Antisense Oligonucleotides
Microbiota
Escherichia coli
Infection
Dysbiosis

Monoclonal Antibodies for the Detection of a Specific Cyclic DNA Adduct Derived from ω-6 Polyunsaturated Fatty Acids

Dyba, M., Da Silva, B., Coia, H., Hou, Y., Noguchi, S., Pan, J., Berry, D., Creswell, K., Krzeminski, J., Desai, D., Amin, S., Yang, D. & Chung, F. L., Aug 20 2018, In : Chemical Research in Toxicology. 31, 8, p. 772-783 12 p.

Research output: Contribution to journalArticle

DNA Adducts
Unsaturated Fatty Acids
Monoclonal Antibodies
Deoxyguanosine
Tissue
8 Citations (Scopus)

Identifying the structure-activity relationship of leelamine necessary for inhibiting intracellular cholesterol transport

Gowda, R., Inamdar, G. S., Kuzu, O., Dinavahi, S. S., Krzeminski, J., Battu, M. B., Voleti, S. R., Amin, S. & Robertson, G., Jan 1 2017, In : Oncotarget. 8, 17, p. 28260-28277 18 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Cholesterol
Lysosomes
Neoplasms
Computer Simulation
1 Citation (Scopus)
Sulfolobus solfataricus
DNA Polymerase beta
Deoxyguanosine
Benzo(a)pyrene
DNA-Directed DNA Polymerase
9 Citations (Scopus)

Bolaamphiphile-based nanocomplex delivery of phosphorothioate gapmer antisense oligonucleotides as a treatment for Clostridium difficile

Hegarty, J. P., Krzeminski, J., Sharma, A., Guzman-Villanueva, D., Weissig, V. & Stewart, D., Aug 1 2016, In : International Journal of Nanomedicine. 11, p. 3607-3619 13 p.

Research output: Contribution to journalArticle

Clostridium
Clostridium difficile
Antisense Oligonucleotides
Oligonucleotides
Dequalinium