• 942 Citations
  • 16 h-Index
1991 …2018

Research output per year

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Personal profile

Research interests

Dr. Jacek Krzeminski’s expertise and research is centered on the design and synthesis of novel small, pharmacologically active molecules that could be potentially developed into therapeutic agents.

His related interest in chemoprevention and investigation of active metabolites led to several publications in the field.

Recently, a nanoformulation project that encompasses design and synthesis of cationic bolaamphiphiles as a self-assembling vehicles for delivery of antisense oligos into C. difficile cells is being developed with the prospect of developing an innovative therapy. Synthesis of derivatives of certain natural products exhibiting antiproliferating potential, as well as analogs of some plant-derived opioid receptor modulators, are also currently of interest to Dr. Krzeminski.

As a practitioner of medicinal and bioorganic chemistry, Dr. Krzeminski synthesized more than 800 compounds belonging to many diverse areas, including modified nucleosides, polyaromatic hydrocarbons, nitrosamines, various heterocycles and natural products’ derivatives.

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Research Output

  • 942 Citations
  • 16 h-Index
  • 51 Article

Cationic amphiphilic bolaamphiphile-based delivery of antisense oligonucleotides provides a potentially microbiome sparing treatment for C. difficile

Sharma, A. K., Krzeminski, J., Weissig, V., Hegarty, J. P. & Stewart, D., Aug 1 2018, In : Journal of Antibiotics. 71, 8, p. 713-721 9 p.

Research output: Contribution to journalArticle

  • 2 Scopus citations

    Monoclonal Antibodies for the Detection of a Specific Cyclic DNA Adduct Derived from ω-6 Polyunsaturated Fatty Acids

    Dyba, M., Da Silva, B., Coia, H., Hou, Y., Noguchi, S., Pan, J., Berry, D., Creswell, K., Krzeminski, J., Desai, D., Amin, S., Yang, D. & Chung, F. L., Aug 20 2018, In : Chemical research in toxicology. 31, 8, p. 772-783 12 p.

    Research output: Contribution to journalArticle

  • Identifying the structure-activity relationship of leelamine necessary for inhibiting intracellular cholesterol transport

    Gowda, R., Inamdar, G. S., Kuzu, O., Dinavahi, S. S., Krzeminski, J., Battu, M. B., Voleti, S. R., Amin, S. & Robertson, G. P., Jan 1 2017, In : Oncotarget. 8, 17, p. 28260-28277 18 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations
  • 1 Scopus citations

    Bolaamphiphile-based nanocomplex delivery of phosphorothioate gapmer antisense oligonucleotides as a treatment for Clostridium difficile

    Hegarty, J. P., Krzeminski, J., Sharma, A. K., Guzman-Villanueva, D., Weissig, V. & Stewart, D. B., Aug 1 2016, In : International Journal of Nanomedicine. 11, p. 3607-3619 13 p.

    Research output: Contribution to journalArticle

  • 12 Scopus citations