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Personal profile

Research interests

Dr. Jacek Krzeminski’s expertise and research is centered on the design and synthesis of novel small, pharmacologically active molecules that could be potentially developed into therapeutic agents.

His related interest in chemoprevention and investigation of active metabolites led to several publications in the field.

Recently, a nanoformulation project that encompasses design and synthesis of cationic bolaamphiphiles as a self-assembling vehicles for delivery of antisense oligos into C. difficile cells is being developed with the prospect of developing an innovative therapy. Synthesis of derivatives of certain natural products exhibiting antiproliferating potential, as well as analogs of some plant-derived opioid receptor modulators, are also currently of interest to Dr. Krzeminski.

As a practitioner of medicinal and bioorganic chemistry, Dr. Krzeminski synthesized more than 800 compounds belonging to many diverse areas, including modified nucleosides, polyaromatic hydrocarbons, nitrosamines, various heterocycles and natural products’ derivatives.

Fingerprint Dive into the research topics where Jacek Krzeminski is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Epoxy Compounds Medicine & Life Sciences
Metabolites Chemical Compounds
DNA Adducts Medicine & Life Sciences
Carcinogens Medicine & Life Sciences
Rats Chemical Compounds
Benzo(a)pyrene Medicine & Life Sciences
Estuaries Medicine & Life Sciences
Breast Medicine & Life Sciences

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Research Output 1991 2018

  • 914 Citations
  • 16 h-Index
  • 51 Article
2 Citations (Scopus)

Cationic amphiphilic bolaamphiphile-based delivery of antisense oligonucleotides provides a potentially microbiome sparing treatment for C. difficile

Sharma, A., Krzeminski, J., Weissig, V., Hegarty, J. P. & Stewart, D. B., Aug 1 2018, In : Journal of Antibiotics. 71, 8, p. 713-721 9 p.

Research output: Contribution to journalArticle

Antisense Oligonucleotides
Microbiota
Escherichia coli
Infection
Dysbiosis

Monoclonal Antibodies for the Detection of a Specific Cyclic DNA Adduct Derived from ω-6 Polyunsaturated Fatty Acids

Dyba, M., Da Silva, B., Coia, H., Hou, Y., Noguchi, S., Pan, J., Berry, D., Creswell, K., Krzeminski, J., Desai, D., Amin, S., Yang, D. & Chung, F. L., Aug 20 2018, In : Chemical research in toxicology. 31, 8, p. 772-783 12 p.

Research output: Contribution to journalArticle

DNA Adducts
Unsaturated Fatty Acids
Monoclonal Antibodies
Deoxyguanosine
Tissue
8 Citations (Scopus)

Identifying the structure-activity relationship of leelamine necessary for inhibiting intracellular cholesterol transport

Gowda, R., Inamdar, G. S., Kuzu, O., Dinavahi, S. S., Krzeminski, J., Battu, M. B., Voleti, S. R., Amin, S. & Robertson, G. P., Jan 1 2017, In : Oncotarget. 8, 17, p. 28260-28277 18 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Cholesterol
Lysosomes
Neoplasms
Computer Simulation
1 Citation (Scopus)
Sulfolobus solfataricus
DNA Polymerase beta
Deoxyguanosine
Benzo(a)pyrene
DNA-Directed DNA Polymerase
10 Citations (Scopus)

Bolaamphiphile-based nanocomplex delivery of phosphorothioate gapmer antisense oligonucleotides as a treatment for Clostridium difficile

Hegarty, J. P., Krzeminski, J., Sharma, A. K., Guzman-Villanueva, D., Weissig, V. & Stewart, D. B., Aug 1 2016, In : International Journal of Nanomedicine. 11, p. 3607-3619 13 p.

Research output: Contribution to journalArticle

Clostridium
Clostridium difficile
Antisense Oligonucleotides
Oligonucleotides
Dequalinium