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Research interests

The Dr. James Broach lab has studied a variety of biological processes using the yeast Saccharomyces as a model system.  These studies have focused primarily on the interaction of cells with their environment, exploring the nature of signaling pathways that cells use to perceive their nutritional state - such as the Ras/protein kinase A pathway and the Target of Rapamycin Complex – and the transcriptional and metabolic responses of those cells to changes in nutritional state.  More recently, the lab has focused on the cell’s stress response, using single cell imaging and genome sequencing-based studies of chromatin structure and transcriptional remodeling.  These studies yielded the remarkable finding that genetically identical cells in the same environment mount quite different responses to an applied stress, allowing the population as a whole to hedge its bets regarding the best survival strategy in the face of an uncertain future.

 

More recently, the lab has expanded its interest to the application of genomic tools to issues of disease onset and treatment. The work is conducted through the Institute for Personalized Medicine, comprising a biorepository, in which biological samples from all consented patients of the Milton S. Hershey Medical Center are stored; a genomics core, in which state of the art genotyping and NextGen sequencing is applied to the biological samples; and a bioinformatics core, in which patient outcome data obtained from electronic medical records are correlated with genomic profiling and sequencing results. The lab works closely with clinicians at the Milton S. Hershey Medical Center to identify patients whose disorder or response to treatment shows a familial pattern of inheritance, as well as cohorts of patients that have phenotypically distinct disease presentations or responses to treatment.  The lab has successfully pursued studies in a variety of diseases, including various cancers, ALS, multiple sclerosis, inflammatory bowel disease, epilepsy and osteoporosis.

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  • 8 Similar Profiles
Yeasts Medicine & Life Sciences
Saccharomyces cerevisiae Medicine & Life Sciences
Yeast Chemical Compounds
Genes Medicine & Life Sciences
Plasmids Medicine & Life Sciences
Saccharomyces Medicine & Life Sciences
Proteins Medicine & Life Sciences
ras Proteins Medicine & Life Sciences

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Projects 1984 2020

Ras and Tor Signaling in Yeast

Broach, J.

National Institutes of Health

4/1/071/31/20

Project: Research projectResearch Project

Yeasts
Food
Transcription Factors
Metabolome
Chromatin

MATING TYPE SILENCING AND SWITCHING IN YEAST

Broach, J.

National Institutes of Health

1/1/936/30/10

Project: Research projectResearch Project

yeasts
loci
Heterochromatin
chromatin
Yeasts
Chromosome Segregation
Eukaryotic Cells
Cell Cycle
Plasmids
Research

VIRAL AND CELLULAR ONCOGENES--MECHANISM OF ACTION

Broach, J., Levine, A., Shenk, T., Zakian, V. A., Schupbach, G. M., Schwarzbauer, J. & Wieschaus, E.

National Institutes of Health

7/1/862/28/07

Project: Research projectResearch Program Projects

Ceramides
Yeasts
Signal Transduction
Growth
nutrient availability

AUTOMATED PEPTIDE SYNTHESIS AND PURIFICATION

Broach, J. & Carlson, G. A.

National Institutes of Health

6/1/868/31/94

Project: Research projectBiomedical Research Support Shared Instrumentation Grants

peptides
synthesis
Escherichia coli
antigens
microbial genetics

Research Output 1975 2018

A possible role for platelet-activating factor receptor in amyotrophic lateral sclerosis treatment

Briones, M. R. S., Snyder, A. M., Ferreira, R. C., Neely, E. B., Connor, J. R. & Broach, J. R., Feb 6 2018, In : Frontiers in Neurology. 9, FEB, 39

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Platelet Activating Factor
ginkgolide B
Interleukin-18
WEB 2086
8 Citations

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

ITALSGEN Consortium, Genomic Translation for ALS Care (GTAC) Consortium, ALS Sequencing Consortium, NYGC ALS Consortium, Answer ALS Foundation, Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, SLAGEN Consortium, French ALS Consortium & Project MinE ALS Sequencing Consortium, Mar 21 2018, In : Neuron. 97, 6, p. 1268-1283.e6

Research output: Contribution to journalArticle

Kinesin
Genome
Mutation
Genes
Genome-Wide Association Study

Altered molecular profile in thyroid cancers from patients affected by the Three Mile Island nuclear accident

Goldenberg, D., Russo, M., Houser, K., Crist, H., Derr, J. B., Walter, V., Warrick, J. I., Sheldon, K. E., Broach, J. & Bann, D. V., Jul 1 2017, In : Laryngoscope. 127, p. S1-S9

Research output: Contribution to journalArticle

Radioactive Hazard Release
Thyroid Neoplasms
Islands
Gene Fusion
Radiation-Induced Neoplasms
1 Citations

Clonal evolution in paired endometrial intraepithelial neoplasia/atypical hyperplasia and endometrioid adenocarcinoma

Russo, M., Broach, J., Sheldon, K., Houser, K. R., Liu, D. J., Kesterson, J., Phaeton, R., Hossler, C., Hempel, N., Baker, M., Newell, J. M., Zaino, R. & Warrick, J. I., Sep 1 2017, In : Human Pathology. 67, p. 69-77 9 p.

Research output: Contribution to journalArticle

Clonal Evolution
Endometrioid Carcinoma
Endometrial Hyperplasia
Hyperplasia
Endometrial Neoplasms
Brain-Computer Interfaces
Amyotrophic Lateral Sclerosis
Evoked Potentials
Neurodegenerative Diseases
Alleles