• 575 Citations
  • 15 h-Index
20022020

Research output per year

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Personal profile

Research interests

Dr. Jeffrey Neighbors’ lab is focused on drug development. One current research project is centered on the development of novel agents which inhibit steps in the mevalonate (cholesterol synthesis) pathway to reduce transcription of genes targeted by the Hippo pathway transcription factor TAZ as potential treatments for osteosarcoma.

Additionally, the lab is studying the potential for statin drugs that inhibit this same pathway as treatment for neuroblastoma and other cancers.

A completely different project looks at a family of natural products, pawhuskins, isolated from a prairie plant, that have antagonist activity at several opioid receptors and are under investigation for the potential to increase wound healing by inhibiting opioid growth factor activity.

Before coming to Penn State, Dr. Neighbors worked for a small biotech company driving the drug development efforts and has experience integrating development activity across disciplines from chemical synthesis to pharmacokinetics and ADME/DMPK studies.

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Projects

  • Research Output

    • 575 Citations
    • 15 h-Index
    • 32 Article
    • 3 Review article
    • 1 Comment/debate

    The Dopamine D2 Receptor Contributes to the Spheroid Formation Behavior of U87 Glioblastoma Cells

    Weissenrieder, J. S., Reed, J. L., Green, M. V., Moldovan, G. L., Koubek, E. J., Neighbors, J. D. & Hohl, R. J., Jan 1 2020, In : Pharmacology. 105, 1-2, p. 19-27 9 p.

    Research output: Contribution to journalArticle

    Open Access
  • Brain cholesterol metabolism and Parkinson's disease

    Huang, X., Sterling, N. W., Du, G., Sun, D., Stetter, C., Kong, L., Zhu, Y., Neighbors, J., Lewis, M. M., Chen, H., Hohl, R. J. & Mailman, R. B., Mar 2019, In : Movement Disorders. 34, 3, p. 386-395 10 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations

    Cancer and the dopamine D2 receptor: A pharmacological perspective

    Weissenrieder, J. S., Neighbors, J. D., Mailman, R. B. & Hohl, R. J., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 1, p. 111-126 16 p.

    Research output: Contribution to journalReview article

  • 2 Scopus citations

    Increased flux through the mevalonate pathway mediates fibrotic repair without injury

    Larson-Casey, J. L., Vaid, M., Gu, L., He, C., Cai, G. Q., Ding, Q., Davis, D., Berryhill, T. F., Wilson, L. S., Barnes, S., Neighbors, J. D., Hohl, R. J., Zimmerman, K. A., Yoder, B. K., Longhini, A. L. F., Hanumanthu, V. S., Surolia, R., Antony, V. B. & Brent Carter, A., Nov 1 2019, In : Journal of Clinical Investigation. 129, 11, p. 4962-4978 17 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Inhibiting geranylgeranyl diphosphate synthesis reduces nuclear androgen receptor signaling and neuroendocrine differentiation in prostate cancer cell models

    Weissenrieder, J. S., Reilly, J. E., Neighbors, J. D. & Hohl, R. J., Jan 1 2019, In : Prostate. 79, 1, p. 21-30 10 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations