• 574 Citations
  • 15 h-Index
20022020

Research output per year

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Research Output

  • 574 Citations
  • 15 h-Index
  • 32 Article
  • 3 Review article
  • 1 Comment/debate
2020

The Dopamine D2 Receptor Contributes to the Spheroid Formation Behavior of U87 Glioblastoma Cells

Weissenrieder, J. S., Reed, J. L., Green, M. V., Moldovan, G. L., Koubek, E. J., Neighbors, J. D. & Hohl, R. J., Jan 1 2020, In : Pharmacology. 105, 1-2, p. 19-27 9 p.

Research output: Contribution to journalArticle

Open Access
2019

Brain cholesterol metabolism and Parkinson's disease

Huang, X., Sterling, N. W., Du, G., Sun, D., Stetter, C., Kong, L., Zhu, Y., Neighbors, J., Lewis, M. M., Chen, H., Hohl, R. J. & Mailman, R. B., Mar 2019, In : Movement Disorders. 34, 3, p. 386-395 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Cancer and the dopamine D2 receptor: A pharmacological perspective

Weissenrieder, J. S., Neighbors, J. D., Mailman, R. B. & Hohl, R. J., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 1, p. 111-126 16 p.

Research output: Contribution to journalReview article

2 Scopus citations

Increased flux through the mevalonate pathway mediates fibrotic repair without injury

Larson-Casey, J. L., Vaid, M., Gu, L., He, C., Cai, G. Q., Ding, Q., Davis, D., Berryhill, T. F., Wilson, L. S., Barnes, S., Neighbors, J. D., Hohl, R. J., Zimmerman, K. A., Yoder, B. K., Longhini, A. L. F., Hanumanthu, V. S., Surolia, R., Antony, V. B. & Brent Carter, A., Nov 1 2019, In : Journal of Clinical Investigation. 129, 11, p. 4962-4978 17 p.

Research output: Contribution to journalArticle

1 Scopus citations

Inhibiting geranylgeranyl diphosphate synthesis reduces nuclear androgen receptor signaling and neuroendocrine differentiation in prostate cancer cell models

Weissenrieder, J. S., Reilly, J. E., Neighbors, J. D. & Hohl, R. J., Jan 1 2019, In : Prostate. 79, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity

Kokolus, K. M., Haley, J. S., Koubek, E. J., Gowda, R., Dinavahi, S. S., Sharma, A., Claxton, D. F., Helm, K. F., Drabick, J. J., Robertson, G. P., Neighbors, J. D., Hohl, R. J. & Schell, T. D., Feb 1 2019, In : OncoImmunology. 8, 2, e1539614.

Research output: Contribution to journalArticle

2018

5′-methylschweinfurthin G reduces chondrosarcoma tumor growth

Stevens, J. W., Meyerholz, D. K., Neighbors, J. D. & Morcuende, J. A., Apr 2018, In : Journal of Orthopaedic Research. 36, 4, p. 1283-1293 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Schweinfurthins: Lipid Modulators with Promising Anticancer Activity

Koubek, E. J., Weissenrieder, J. S., Neighbors, J. D. & Hohl, R. J., Aug 2018, In : Lipids. 53, 8, p. 767-784 18 p.

Research output: Contribution to journalReview article

1 Scopus citations

The Mevalonate Pathway and Terpenes: a Diversity of Chemopreventatives

Neighbors, J., Apr 1 2018, In : Current Pharmacology Reports. 4, 2, p. 157-169 13 p.

Research output: Contribution to journalReview article

1 Scopus citations
2017

Design, Synthesis, and Antimicrobial Evaluation of a Novel Bone-Targeting Bisphosphonate-Ciprofloxacin Conjugate for the Treatment of Osteomyelitis Biofilms

Sedghizadeh, P. P., Sun, S., Junka, A. F., Richard, E., Sadrerafi, K., Mahabady, S., Bakhshalian, N., Tjokro, N., Bartoszewicz, M., Oleksy, M., Szymczyk, P., Lundy, M. W., Neighbors, J. D., Russell, R. G. G., McKenna, C. E. & Ebetino, F. H., Mar 23 2017, In : Journal of Medicinal Chemistry. 60, 6, p. 2326-2343 18 p.

Research output: Contribution to journalArticle

26 Scopus citations

Selective opioid growth factor receptor antagonists based on a stilbene isostere

Stockdale, D. P., Titunick, M. B., Biegler, J. M., Reed, J. L., Hartung, A. M., Wiemer, D. F., McLaughlin, P. J. & Neighbors, J. D., Jan 1 2017, In : Bioorganic and Medicinal Chemistry. 25, 16, p. 4464-4474 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Targeting protein geranylgeranylation slows tumor development in a murine model of prostate cancer metastasis

Reilly, J. E., Neighbors, J. D. & Hohl, R. J., Nov 2 2017, In : Cancer Biology and Therapy. 18, 11, p. 872-882 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016
2015

3-Deoxyschweinfurthin B Lowers Cholesterol Levels by Decreasing Synthesis and Increasing Export in Cultured Cancer Cell Lines

Kuder, C. H., Weivoda, M. M., Zhang, Y., Zhu, J., Neighbors, J. D., Wiemer, D. F. & Hohl, R. J., Dec 1 2015, In : Lipids. 50, 12, p. 1195-1207 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

A selective delta opioid receptor antagonist based on a stilbene core

Hartung, A. M., Navarro, H. A., Wiemer, D. F. & Neighbors, J. D., Dec 1 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 23, p. 5532-5535 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Targeting geranylgeranylation reduces adrenal gland tumor burden in a murine model of prostate cancer metastasis

Reilly, J. E., Neighbors, J., Tong, H., Henry, M. D. & Hohl, R., Aug 25 2015, In : Clinical and Experimental Metastasis. 32, 6, p. 555-566 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis

Osborn-Heaford, H. L., Murthy, S., Gu, L., Larson-Casey, J. L., Ryan, A. J., Shi, L., Glogauer, M., Neighbors, J. D., Hohl, R. & Carter, A. B., Jun 27 2015, In : Free Radical Biology and Medicine. 86, p. 47-56 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Stilbenes as κ-selective, non-nitrogenous opioid receptor antagonists

Hartung, A. M., Beutler, J. A., Navarro, H. A., Wiemer, D. F. & Neighbors, J. D., Feb 28 2014, In : Journal of Natural Products. 77, 2, p. 311-319 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2012

Functional evaluation of a fluorescent schweinfurthin: Mechanism of cytotoxicity and intracellular quantification

Kuder, C. H., Sheehy, R. M., Neighbors, J. D., Wiemer, D. F. & Hohl, R. J., Jul 1 2012, In : Molecular pharmacology. 82, 1, p. 9-16 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2010

Fluorescent schweinfurthin B and F analogs with anti-proliferative activity

Topczewski, J. J., Kuder, C. H., Neighbors, J. D., Hohl, R. J. & Wiemer, D. F., Sep 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 18, p. 6734-6741 8 p.

Research output: Contribution to journalArticle

10 Scopus citations
2009

A tandem cascade cyclization-electrophilic aromatic substitution: Application in the total synthesis of (+)-angelichalcone

Topczewski, J. J., Callahan, M. P., Neighbors, J. & Wiemer, D. F., Oct 21 2009, In : Journal of the American Chemical Society. 131, 41, p. 14630-14631 2 p.

Research output: Contribution to journalArticle

33 Scopus citations

Hypericum in infection: Identification of anti-viral and anti-inflammatory constituents

Birt, D. F., Widrlechner, M. P., Hammer, K. D. P., Hillwig, M. L., Wei, J., Kraus, G. A., Murphy, P. A., McCoy, J. A., Wurtele, E. S., Neighbors, J. D., Wiemer, D. F., Maury, W. J. & Price, J. P., Aug 1 2009, In : Pharmaceutical Biology. 47, 8, p. 774-782 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Identification of light-independent inhibition of human immunodeficiency virus-1 infection through bioguided fractionation of Hypericum perforatum

Maury, W., Price, J. P., Brindley, M. A., Oh, C., Neighbors, J. D., Wiemer, D. F., Wills, N., Carpenter, S., Hauck, C., Murphy, P., Widrlechner, M. P., Delate, K., Kumar, G., Kraus, G. A., Rizshsky, L. & Nikolau, B., Aug 20 2009, In : Virology Journal. 6, 101.

Research output: Contribution to journalArticle

15 Scopus citations

Synthesis and biological activity of a fluorescent schweinfurthin analogue

Kuder, C. H., Neighbors, J. D., Hohl, R. J. & Wiemer, D. F., Jul 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 13, p. 4718-4723 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Synthesis of the cis-fused hexahydroxanthene system via cationic cascade cyclization

Neighbors, J. D., Topczewski, J. J., Swenson, D. C. & Wiemer, D. F., Jul 8 2009, In : Tetrahedron Letters. 50, 27, p. 3881-3884 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Total synthesis of (+)-schweinfurthins B and E

Topczewski, J. J., Neighbors, J. D. & Wiemer, D. F., Sep 18 2009, In : Journal of Organic Chemistry. 74, 18, p. 6965-6972 8 p.

Research output: Contribution to journalArticle

45 Scopus citations
2008

A concise synthesis of Pawhuskin A

Neighbors, J. D., Buller, M. J., Boss, K. D. & Wiemer, D. F., Nov 1 2008, In : Journal of Natural Products. 71, 11, p. 1949-1952 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

BF3·Et2O-mediated cascade cyclizations: Synthesis of schweinfurthins F and G

Mente, N. R., Neighbors, J. D. & Wiemer, D. F., Oct 17 2008, In : Journal of Organic Chemistry. 73, 20, p. 7963-7970 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Pseudohypericin is necessary for the light-activated inhibition of prostaglandin E2 pathways by a 4 component system mimicking an Hypericum perforatum fraction

Hammer, K. D. P., Hillwig, M. L., Neighbors, J. D., Sim, Y. J., Kohut, M. L., Wiemer, D. F., Wurtele, E. S. & Birt, D. F., Sep 1 2008, In : Phytochemistry. 69, 12, p. 2354-2362 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Quantitative determination of farnesyl and geranylgeranyl diphosphate levels in mammalian tissue

Tong, H., Wiemer, A. J., Neighbors, J. D. & Hohl, R. J., Jul 15 2008, In : Analytical Biochemistry. 378, 2, p. 138-143 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Synthesis of the schweinfurthin hexahydroxanthene core through Shi epoxidation

Neighbors, J., Mente, N. R., Boss, K. D., Zehnder, D. W. & Wiemer, D. F., Jan 14 2008, In : Tetrahedron Letters. 49, 3, p. 516-519 4 p.

Research output: Contribution to journalArticle

20 Scopus citations
2007

Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: Differences of bioactivity in the enantiomeric series

Mente, N. R., Wiemer, A. J., Neighbors, J. D., Beutler, J. A., Hohl, R. J. & Wiemer, D. F., Feb 15 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 4, p. 911-915 5 p.

Research output: Contribution to journalArticle

33 Scopus citations
2006
31 Scopus citations
2005

Synthesis of nonracemic 3-deoxyschweinfurthin B

Neighbors, J. D., Beutler, J. A. & Wiemer, D. F., Feb 4 2005, In : Journal of Organic Chemistry. 70, 3, p. 925-931 7 p.

Research output: Contribution to journalArticle

53 Scopus citations

Total synthesis of pawhuskin C: A directed ortho metalation approach

Neighbors, J. D., Salnikova, M. S. & Wiemer, D. F., Feb 21 2005, In : Tetrahedron Letters. 46, 8, p. 1321-1324 4 p.

Research output: Contribution to journalArticle

23 Scopus citations
2002

A cascade cyclization approach to schweinfurthin B

Treadwell, E. M., Neighbors, J. & Wiemer, D. F., Oct 17 2002, In : Organic Letters. 4, 21, p. 3639-3642 4 p.

Research output: Contribution to journalArticle

25 Scopus citations