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Research Output 2002 2019

  • 542 Citations
  • 14 h-Index
  • 30 Article
  • 3 Review article
  • 1 Comment/debate
2019
2 Citations (Scopus)

Brain cholesterol metabolism and Parkinson's disease

Huang, X., Sterling, N. W., Du, G., Sun, D., Stetter, C., Kong, L., Zhu, Y., Neighbors, J., Lewis, M., Chen, H., Hohl, R. & Mailman, R., Mar 1 2019, In : Movement Disorders. 34, 3, p. 386-395 10 p.

Research output: Contribution to journalArticle

Parkinson Disease
Cholesterol
Brain
Odds Ratio
Logistic Models
1 Citation (Scopus)

Cancer and the dopamine D2 receptor: A pharmacological perspective

Weissenrieder, J. S., Neighbors, J., Mailman, R. & Hohl, R., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 1, p. 111-126 16 p.

Research output: Contribution to journalReview article

Dopamine D2 Receptors
Pharmacology
Neoplasms
Ligands
Drug Therapy

Inhibiting geranylgeranyl diphosphate synthesis reduces nuclear androgen receptor signaling and neuroendocrine differentiation in prostate cancer cell models

Weissenrieder, J. S., Reilly, J. E., Neighbors, J. & Hohl, R., Jan 1 2019, In : Prostate. 79, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

Androgen Receptors
Cytoplasmic and Nuclear Receptors
Prostatic Neoplasms
Androgens
Prenylation

Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity

Kokolus, K. M., Haley, J. S., Koubek, E. J., Gowda, R., Dinavahi, S. S., Sharma, A., Claxton, D., Helm, K., Drabick, J., Robertson, G., Neighbors, J., Hohl, R. & Schell, T., Feb 1 2019, In : OncoImmunology. 8, 2, e1539614.

Research output: Contribution to journalArticle

Biological Products
Immunity
Melanoma
Immunotherapy
Neoplasms
2018
2 Citations (Scopus)

5′-methylschweinfurthin G reduces chondrosarcoma tumor growth

Stevens, J. W., Meyerholz, D. K., Neighbors, J. & Morcuende, J. A., Apr 1 2018, In : Journal of Orthopaedic Research. 36, 4, p. 1283-1293 11 p.

Research output: Contribution to journalArticle

Chondrosarcoma
Growth
Hyaline Cartilage
Neoplasms
Phenotype
1 Citation (Scopus)

Schweinfurthins: Lipid Modulators with Promising Anticancer Activity

Koubek, E. J., Weissenrieder, J. S., Neighbors, J. & Hohl, R., Aug 1 2018, In : Lipids. 53, 8, p. 767-784 18 p.

Research output: Contribution to journalReview article

Modulators
Lipids
Neoplasms
Cells
trans-Golgi Network
1 Citation (Scopus)

The Mevalonate Pathway and Terpenes: a Diversity of Chemopreventatives

Neighbors, J., Apr 1 2018, In : Current Pharmacology Reports. 4, 2, p. 157-169 13 p.

Research output: Contribution to journalReview article

Mevalonic Acid
Terpenes
Chemoprevention
Biological Products
Carbon
2017
24 Citations (Scopus)

Design, Synthesis, and Antimicrobial Evaluation of a Novel Bone-Targeting Bisphosphonate-Ciprofloxacin Conjugate for the Treatment of Osteomyelitis Biofilms

Sedghizadeh, P. P., Sun, S., Junka, A. F., Richard, E., Sadrerafi, K., Mahabady, S., Bakhshalian, N., Tjokro, N., Bartoszewicz, M., Oleksy, M., Szymczyk, P., Lundy, M. W., Neighbors, J., Russell, R. G. G., McKenna, C. E. & Ebetino, F. H., Mar 23 2017, In : Journal of Medicinal Chemistry. 60, 6, p. 2326-2343 18 p.

Research output: Contribution to journalArticle

Diphosphonates
Osteomyelitis
Ciprofloxacin
Biofilms
Bone and Bones

Selective opioid growth factor receptor antagonists based on a stilbene isostere

Stockdale, D. P., Titunick, M. B., Biegler, J. M., Reed, J. L., Hartung, A. M., Wiemer, D. F., McLaughlin, P. & Neighbors, J., Jan 1 2017, In : Bioorganic and Medicinal Chemistry. 25, 16, p. 4464-4474 11 p.

Research output: Contribution to journalArticle

Stilbenes
Amides
Isomers
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
5 Citations (Scopus)

Targeting protein geranylgeranylation slows tumor development in a murine model of prostate cancer metastasis

Reilly, J. E., Neighbors, J. & Hohl, R., Nov 2 2017, In : Cancer Biology and Therapy. 18, 11, p. 872-882 11 p.

Research output: Contribution to journalArticle

Protein Prenylation
Prostatic Neoplasms
Neoplasm Metastasis
Tumor Burden
Farnesyltranstransferase
2016
Stilbenes
delta Opioid Receptor
Narcotic Antagonists
Pharmaceutical Chemistry
corrigendum
2015
4 Citations (Scopus)

3-Deoxyschweinfurthin B Lowers Cholesterol Levels by Decreasing Synthesis and Increasing Export in Cultured Cancer Cell Lines

Kuder, C. H., Weivoda, M. M., Zhang, Y., Zhu, J., Neighbors, J., Wiemer, D. F. & Hohl, R., Dec 1 2015, In : Lipids. 50, 12, p. 1195-1207 13 p.

Research output: Contribution to journalArticle

Cultured Cells
Cholesterol
Cells
Cell Line
Liver
2 Citations (Scopus)

A selective delta opioid receptor antagonist based on a stilbene core

Hartung, A. M., Navarro, H. A., Wiemer, D. F. & Neighbors, J., Dec 1 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 23, p. 5532-5535 4 p.

Research output: Contribution to journalArticle

naltrindole
Stilbenes
delta Opioid Receptor
Narcotic Antagonists
Conformations
9 Citations (Scopus)

Targeting geranylgeranylation reduces adrenal gland tumor burden in a murine model of prostate cancer metastasis

Reilly, J. E., Neighbors, J., Tong, H., Henry, M. D. & Hohl, R., Aug 25 2015, In : Clinical and Experimental Metastasis. 32, 6, p. 555-566 12 p.

Research output: Contribution to journalArticle

Prenylation
Adrenal Glands
Tumor Burden
Terpenes
Prostatic Neoplasms
9 Citations (Scopus)

Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis

Osborn-Heaford, H. L., Murthy, S., Gu, L., Larson-Casey, J. L., Ryan, A. J., Shi, L., Glogauer, M., Neighbors, J., Hohl, R. & Carter, A. B., Jun 27 2015, In : Free Radical Biology and Medicine. 86, p. 47-56 10 p.

Research output: Contribution to journalArticle

Prenylation
Oxidative stress
Pulmonary Fibrosis
Terpenes
rac1 GTP-Binding Protein
2014
8 Citations (Scopus)

Stilbenes as κ-selective, non-nitrogenous opioid receptor antagonists

Hartung, A. M., Beutler, J. A., Navarro, H. A., Wiemer, D. F. & Neighbors, J., Feb 28 2014, In : Journal of Natural Products. 77, 2, p. 311-319 9 p.

Research output: Contribution to journalArticle

Stilbenes
Narcotic Antagonists
Opioid Receptors
Assays
pawhuskin A
2012
6 Citations (Scopus)

Functional evaluation of a fluorescent schweinfurthin: Mechanism of cytotoxicity and intracellular quantification

Kuder, C. H., Sheehy, R. M., Neighbors, J., Wiemer, D. F. & Hohl, R., Jul 1 2012, In : Molecular Pharmacology. 82, 1, p. 9-16 8 p.

Research output: Contribution to journalArticle

Stilbenes
Poly(ADP-ribose) Polymerases
Caspase 9
Eukaryotic Initiation Factor-2
Apoptosis
2010
10 Citations (Scopus)

Fluorescent schweinfurthin B and F analogs with anti-proliferative activity

Topczewski, J. J., Kuder, C. H., Neighbors, J., Hohl, R. & Wiemer, D. F., Sep 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 18, p. 6734-6741 8 p.

Research output: Contribution to journalArticle

Growth Inhibitors
National Cancer Institute (U.S.)
Poisons
Fluorescence microscopy
Fluorescence Microscopy
2009
32 Citations (Scopus)

A tandem cascade cyclization-electrophilic aromatic substitution: Application in the total synthesis of (+)-angelichalcone

Topczewski, J. J., Callahan, M. P., Neighbors, J. & Wiemer, D. F., Oct 21 2009, In : Journal of the American Chemical Society. 131, 41, p. 14630-14631 2 p.

Research output: Contribution to journalArticle

Lewis Acids
Cyclization
Epoxy Compounds
Phenol
Phenols
40 Citations (Scopus)

Hypericum in infection: Identification of anti-viral and anti-inflammatory constituents

Birt, D. F., Widrlechner, M. P., Hammer, K. D. P., Hillwig, M. L., Wei, J., Kraus, G. A., Murphy, P. A., McCoy, J. A., Wurtele, E. S., Neighbors, J., Wiemer, D. F., Maury, W. J. & Price, J. P., Aug 1 2009, In : Pharmaceutical Biology. 47, 8, p. 774-782 9 p.

Research output: Contribution to journalArticle

Hypericum
Anti-Inflammatory Agents
Infection
Light
Insurance Benefits
14 Citations (Scopus)

Identification of light-independent inhibition of human immunodeficiency virus-1 infection through bioguided fractionation of Hypericum perforatum

Maury, W., Price, J. P., Brindley, M. A., Oh, C., Neighbors, J., Wiemer, D. F., Wills, N., Carpenter, S., Hauck, C., Murphy, P., Widrlechner, M. P., Delate, K., Kumar, G., Kraus, G. A., Rizshsky, L. & Nikolau, B., Aug 20 2009, In : Virology Journal. 6, 101.

Research output: Contribution to journalArticle

Hypericum
Virus Diseases
Hydroxy Acids
Antiviral Agents
HIV-1
19 Citations (Scopus)

Synthesis and biological activity of a fluorescent schweinfurthin analogue

Kuder, C. H., Neighbors, J., Hohl, R. & Wiemer, D. F., Jul 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 13, p. 4718-4723 6 p.

Research output: Contribution to journalArticle

Bioactivity
Biological Products
Growth Inhibitors
National Cancer Institute (U.S.)
Structure-Activity Relationship
13 Citations (Scopus)

Synthesis of the cis-fused hexahydroxanthene system via cationic cascade cyclization

Neighbors, J., Topczewski, J. J., Swenson, D. C. & Wiemer, D. F., Jul 8 2009, In : Tetrahedron Letters. 50, 27, p. 3881-3884 4 p.

Research output: Contribution to journalArticle

Lewis Acids
Stereochemistry
Cyclization
Epoxy Compounds
Phenol
45 Citations (Scopus)

Total synthesis of (+)-schweinfurthins B and E

Topczewski, J. J., Neighbors, J. & Wiemer, D. F., Sep 18 2009, In : Journal of Organic Chemistry. 74, 18, p. 6965-6972 8 p.

Research output: Contribution to journalArticle

Stereochemistry
Methyl Ethers
Epoxidation
Cyclization
Epoxy Compounds
2008
11 Citations (Scopus)

A concise synthesis of Pawhuskin A

Neighbors, J., Buller, M. J., Boss, K. D. & Wiemer, D. F., Nov 1 2008, In : Journal of Natural Products. 71, 11, p. 1949-1952 4 p.

Research output: Contribution to journalArticle

Stilbenes
Organophosphonates
Alkenes
Opioid Receptors
Bioactivity
49 Citations (Scopus)

BF3·Et2O-mediated cascade cyclizations: Synthesis of schweinfurthins F and G

Mente, N. R., Neighbors, J. & Wiemer, D. F., Oct 17 2008, In : Journal of Organic Chemistry. 73, 20, p. 7963-7970 8 p.

Research output: Contribution to journalArticle

Organophosphonates
Cyclization
Lewis Acids
Alcohols
Aldehydes
16 Citations (Scopus)

Pseudohypericin is necessary for the light-activated inhibition of prostaglandin E2 pathways by a 4 component system mimicking an Hypericum perforatum fraction

Hammer, K. D. P., Hillwig, M. L., Neighbors, J., Sim, Y. J., Kohut, M. L., Wiemer, D. F., Wurtele, E. S. & Birt, D. F., Sep 1 2008, In : Phytochemistry. 69, 12, p. 2354-2362 9 p.

Research output: Contribution to journalArticle

Hypericum
Hypericum perforatum
Dinoprostone
prostaglandins
Light
33 Citations (Scopus)

Quantitative determination of farnesyl and geranylgeranyl diphosphate levels in mammalian tissue

Tong, H., Wiemer, A. J., Neighbors, J. & Hohl, R., Jul 15 2008, In : Analytical Biochemistry. 378, 2, p. 138-143 6 p.

Research output: Contribution to journalArticle

Tissue
Terpenes
Biosynthesis
Transferases
Hydroxymethylglutaryl-CoA Reductase Inhibitors
20 Citations (Scopus)

Synthesis of the schweinfurthin hexahydroxanthene core through Shi epoxidation

Neighbors, J., Mente, N. R., Boss, K. D., Zehnder, D. W. & Wiemer, D. F., Jan 14 2008, In : Tetrahedron Letters. 49, 3, p. 516-519 4 p.

Research output: Contribution to journalArticle

Epoxidation
Chirality
Epoxy Compounds
schweinfurthin F
3-deoxyschweinfurthin B
2007
33 Citations (Scopus)

Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: Differences of bioactivity in the enantiomeric series

Mente, N. R., Wiemer, A. J., Neighbors, J., Beutler, J. A., Hohl, R. & Wiemer, D. F., Feb 15 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 4, p. 911-915 5 p.

Research output: Contribution to journalArticle

Bioactivity
Biological Products
Optical rotation
Optical Rotation
Enantiomers
2006
31 Citations (Scopus)

Synthesis and structure-activity studies of schweinfurthin B analogs: Evidence for the importance of a D-ring hydrogen bond donor in expression of differential cytotoxicity

Neighbors, J., Salnikova, M. S., Beutler, J. A. & Wiemer, D. F., Mar 15 2006, In : Bioorganic and Medicinal Chemistry. 14, 6, p. 1771-1784 14 p.

Research output: Contribution to journalArticle

Stilbenes
Organophosphonates
Cytotoxicity
Hydrogen
Hydrogen bonds
2005
53 Citations (Scopus)

Synthesis of nonracemic 3-deoxyschweinfurthin B

Neighbors, J., Beutler, J. A. & Wiemer, D. F., Feb 4 2005, In : Journal of Organic Chemistry. 70, 3, p. 925-931 7 p.

Research output: Contribution to journalArticle

Cyclization
Epoxy Compounds
Stereochemistry
Enantiomers
Alkenes
23 Citations (Scopus)

Total synthesis of pawhuskin C: A directed ortho metalation approach

Neighbors, J., Salnikova, M. S. & Wiemer, D. F., Feb 21 2005, In : Tetrahedron Letters. 46, 8, p. 1321-1324 4 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Modulators
Alcohols
pawhuskin C
2002
25 Citations (Scopus)

A cascade cyclization approach to schweinfurthin B

Treadwell, E. M., Neighbors, J. & Wiemer, D. F., Oct 17 2002, In : Organic Letters. 4, 21, p. 3639-3642 4 p.

Research output: Contribution to journalArticle

Stereochemistry
Cyclization
stereochemistry
Biological Products
cascades