Jeffrey Sundstrom, MD, PhD

    • 589 Citations
    • 10 h-Index
    20062019
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    Personal profile

    Research interests

    Dr. Jeffrey Sundstrom’s laboratory is focused on understanding mechanisms of vision loss in retinal disease. The most prevalent retinal diseases, macular degeneration and diabetic retinopathy, develop over an extensive time period and are genetically complex. These disease characteristics prevent pre-clinical models from faithfully recapitulating the human disease state. Historically, access to ocular tissue has been limited by both practical and ethical considerations. Recently, Dr. Sundstrom has developed a protocol for the acquisition and proteomic analysis of vitreous fluid. Studies in his lab have verified that proteomic analysis of vitreous fluid allows for the identification of pathways altered in retinal disease. Given the success of this work, Dr. Sundstrom established a vitreous biorepository with over 1,200 samples from patients with macular degeneration, diabetic retinopathy, retinal detachment and ocular cancer.


    Recent studies in the Sundstrom laboratory have shown that vitreous fluid contains several billion exosomes per milliliter. These extracellular vesicles play a fundamental role in cell-cell communication and are known to mediate several physiological and pathological processes. This finding further validates the use of vitreous fluid to identify mechanisms of retinal disease and suggests that the vitreous may play a more active role in retinal disease than had been previously appreciated. The Sundstrom laboratory is currently elucidating the role of exosomes in retinal angiogenesis as well as in the development of macular degeneration.

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    Research Output 2006 2019

    • 589 Citations
    • 10 h-Index
    • 14 Article
    • 2 Review article

    Dust mite induces leukocyte exosomes with proinflammatory effects toward airway epithelial cells

    Lambert, K. A., Hsu, M. H., Laryea, Z. C., Zhao, Y., Roff, A. N., Sundstrom, J. & Ishmael, F., Jul 1 2019, In : Journal of Allergy and Clinical Immunology. 144, 1, p. 315-317 3 p.

    Research output: Contribution to journalArticle

    Exosomes
    Mites
    Dust
    Leukocytes
    Epithelial Cells

    Exosomes impact survival to radiation exposure in cell line models of nervous system cancer

    Mrowczynski, O. D., Madhankumar, A., Sundstrom, J., Zhao, Y., Imamura, Y., Slagle-Webb, B., Mau, C., Payne, R. A., Rizk, E., Zacharia, B. & Connor, J., Nov 1 2018, In : Oncotarget. 9, 90, p. 36083-36101 19 p.

    Research output: Contribution to journalArticle

    Exosomes
    Nervous System
    Cell Line
    Survival
    Neoplasms
    6 Citations (Scopus)

    Liquid biopsy of vitreous reveals an abundant vesicle population consistent with the size and morphology of exosomes

    Zhao, Y., Weber, S. R., Lease, J., Russo, M., Siedlecki, C., Xu, L., Chen, H., Wang, W., Ford, M., Simó, R. & Sundstrom, J., May 1 2018, In : Translational Vision Science and Technology. 7, 3, 6.

    Research output: Contribution to journalArticle

    Exosomes
    Biopsy
    Ontology
    Genes
    Retinal Diseases
    8 Citations (Scopus)

    Proteomic analysis of early diabetic retinopathy reveals mediators of neurodegenerative brain diseases

    Sundstrom, J. M., Hernández, C., Weber, S. R., Zhao, Y., Dunklebarger, M., Tiberti, N., Laremore, T., Simó-Servat, O., Garcia-Ramirez, M., Barber, A. J., Gardner, T. W. & Simó, R., May 2018, In : Investigative Ophthalmology and Visual Science. 59, 6, p. 2264-2274 11 p.

    Research output: Contribution to journalArticle

    Brain Diseases
    Diabetic Retinopathy
    Neurodegenerative Diseases
    Proteomics
    Retina
    7 Citations (Scopus)

    A proposal for early and personalized treatment of diabetic retinopathy based on clinical pathophysiology and molecular phenotyping

    Gardner, T. W. & Sundstrom, J., Oct 1 2017, In : Vision Research. 139, p. 153-160 8 p.

    Research output: Contribution to journalArticle

    Diabetic Retinopathy
    Therapeutics
    Proteomics
    Blood Vessels
    Inflammation