Jeremy Hengst, PhD

    • 406 Citations
    • 13 h-Index
    20022017
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    Research Output 2002 2017

    • 406 Citations
    • 13 h-Index
    • 19 Article
    • 2 Chapter
    • 1 Short survey
    • 1 Review article
    2017

    SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models

    Hengst, J., Dick, T. E., Sharma, A., Doi, K., Hegde, S., Tan, S. F., Geffert, L., Fox, T. E., Sharma, A. K., Desai, D., Amin, S., Kester, M., Loughran, T. P., Paulson, R., Claxton, D., Wang, H-G. & Yun, J., 2017, In : Cancer Translational Medicine. 3, 4, p. 109-121

    Research output: Contribution to journalArticle

    2015
    11 Citations (Scopus)

    Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia

    LeBlanc, F. R., Liu, X., Hengst, J., Fox, T., Calvert, V., Petricoin, E. F., Yun, J., Feith, D. J. & Loughran, T. P., Dec 2 2015, In : Cancer Biology and Therapy. 16, 12, p. 1830-1840 11 p.

    Research output: Contribution to journalArticle

    Large Granular Lymphocytic Leukemia
    Cell Death
    Sphingolipids
    G2 Phase Cell Cycle Checkpoints
    Apoptosis
    19 Citations (Scopus)

    The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines

    Dick, T. E., Hengst, J. A., Fox, T. E., Colledge, A. L., Kale, V. P., Sung, S. S., Sharma, A., Amin, S., Loughran, T. P., Kester, M., Wang, H. G. & Yun, J. K., Mar 1 2015, In : Journal of Pharmacology and Experimental Therapeutics. 352, 3, p. 494-508 15 p.

    Research output: Contribution to journalArticle

    Myeloid Cells
    Acute Myeloid Leukemia
    Cell Line
    CDC2 Protein Kinase
    Cyclin-Dependent Kinases
    14 Citations (Scopus)

    The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration

    Kale, V. P., Hengst, J., Desai, D., Amin, S. & Yun, J., Jun 1 2015, In : Cancer Letters. 361, 2, p. 185-196 12 p.

    Research output: Contribution to journalShort survey

    Cell Movement
    Phosphotransferases
    Neoplasms
    Signal Transduction
    Therapeutics
    2014
    11 Citations (Scopus)

    A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion

    Kale, V. P., Hengst, J., Desai, D., Dick, T. E., Choe, K. N., Colledge, A. L., Takahashi, Y., Sung, S., Amin, S. & Yun, J., Nov 28 2014, In : Cancer Letters. 354, 2, p. 299-310 12 p.

    Research output: Contribution to journalArticle

    Myotonic Dystrophy
    Cell Movement
    Phosphotransferases
    Neoplasms
    rho-Associated Kinases
    3 Citations (Scopus)

    Functional characterization of the S41Y (C2755A) polymorphism of tryptophan hydroxylase 2.

    Salli, N., Salli, U., Tekin, I., Hengst, J., Zhao, M. K., Gilman, T. L., Andrews, A. M. & Vrana, K., Jan 1 2014, In : Journal of neurochemistry. 130, 6, p. 748-758 11 p.

    Research output: Contribution to journalArticle

    Tryptophan Hydroxylase
    Polymorphism
    Serotonin
    Bipolar Disorder
    Enzymes
    2013
    20 Citations (Scopus)

    PhotoImmunoNanoTherapy reveals an anticancer role for sphingosine kinase 2 and dihydrosphingosine-1-phosphate

    Barth, B. M., Shanmugavelandy, S. S., Kaiser, J. M., McGovern, C., Altinoǧlu, E. I., Haakenson, J. K., Hengst, J. A., Gilius, E. L., Knupp, S. A., Fox, T. E., Smith, J. P., Ritty, T. M., Adair, J. H. & Kester, M., Mar 26 2013, In : ACS nano. 7, 3, p. 2132-2144 13 p.

    Research output: Contribution to journalArticle

    Sphingosines
    Immunosuppressive Agents
    Indocyanine Green
    Tumors
    phosphates
    2012
    6 Citations (Scopus)

    Sphingosine kinase: A key to solving the 'French Paradox'?

    Hengst, J. A. & Yun, J. K., Jul 1 2012, In : British Journal of Pharmacology. 166, 5, p. 1603-1604 2 p.

    Research output: Contribution to journalReview article

    Sphingolipids
    Polyphenols
    Wine
    Metabolic Networks and Pathways
    Neoplasms
    36 Citations (Scopus)

    Targeting sphingosine kinase-1 to inhibit melanoma

    Madhunapantula, S. V., Hengst, J., Gowda, R., Fox, T. E., Yun, J. K. & Robertson, G. P., Mar 1 2012, In : Pigment Cell and Melanoma Research. 25, 2, p. 259-274 16 p.

    Research output: Contribution to journalArticle

    Melanoma
    Small Interfering RNA
    Pharmacology
    Ceramides
    Caspase 7
    2011
    8 Citations (Scopus)

    Effect of HFE variants on sphingolipid expression by SH-SY5Y human neuroblastoma cells

    Ali-Rahmani, F., Hengst, J. A., Connor, J. R. & Schengrund, C. L., Sep 1 2011, In : Neurochemical Research. 36, 9, p. 1687-1696 10 p.

    Research output: Contribution to journalArticle

    Sphingolipids
    Transcription
    Neuroblastoma
    Cells
    Genes
    2010
    34 Citations (Scopus)

    Development of a sphingosine kinase 1 specific small-molecule inhibitor

    Hengst, J., Wang, X., Sk, U. H., Sharma, A., Amin, S. & Yun, J., Dec 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 24, p. 7498-7502 5 p.

    Research output: Contribution to journalArticle

    Sphingolipids
    Molecules
    Enzyme Inhibitors
    Metabolic Networks and Pathways
    Enzymes
    11 Citations (Scopus)

    Enhancement of sphingosine kinase 1 catalytic activity by deletion of 21 amino acids from the COOH-terminus

    Hengst, J., Guilford, J. M., Conroy, E. J., Wang, X. & Yun, J., Feb 1 2010, In : Archives of Biochemistry and Biophysics. 494, 1, p. 23-31 9 p.

    Research output: Contribution to journalArticle

    Catalyst activity
    Amino Acids
    Phosphorylation
    HEK293 Cells
    Cell growth
    26 Citations (Scopus)

    Selenium-containing analogs of SAHA induce cytotoxicity in lung cancer cells

    Karelia, N., Desai, D., Hengst, J., Amin, S., Rudrabhatla, S. V. & Yun, J., Nov 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 22, p. 6816-6819 4 p.

    Research output: Contribution to journalArticle

    Histone Deacetylase Inhibitors
    Cytotoxicity
    Selenium
    Lung Neoplasms
    Cells
    15 Citations (Scopus)

    Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs

    Sharma, A. K., Sk, U. H., Gimbor, M. A., Hengst, J. A., Wang, X., Yun, J. & Amin, S., Sep 1 2010, In : European Journal of Medicinal Chemistry. 45, 9, p. 4149-4156 8 p.

    Research output: Contribution to journalArticle

    Bioactivity
    Pharmacokinetics
    Prodrugs
    Half-Life
    Neoplasms
    2009
    33 Citations (Scopus)

    Sphingosine kinase 1 localized to the plasma membrane lipid raft microdomain overcomes serum deprivation induced growth inhibition

    Hengst, J., Guilford, J. M., Fox, T. E., Wang, X., Conroy, E. J. & Yun, J., Jan 1 2009, In : Archives of Biochemistry and Biophysics. 492, 1-2, p. 62-73 12 p.

    Research output: Contribution to journalArticle

    Cell membranes
    Membrane Lipids
    Cell Membrane
    Growth
    Serum
    2008
    59 Citations (Scopus)

    Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions

    Bayerl, M., Bruggeman, R. D., Conroy, E. J., Hengst, J., King, T., Jimenez, M., Claxton, D. & Yun, J., May 1 2008, In : Leukemia and Lymphoma. 49, 5, p. 948-954 7 p.

    Research output: Contribution to journalArticle

    Non-Hodgkin's Lymphoma
    Pharmacology
    Messenger RNA
    Proteins
    Pseudolymphoma
    2007

    Control and regulation of gene expression

    Hengst, J. & Yun, J., Jan 1 2007, xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., p. 1-5 5 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Gene Expression Regulation

    Gene therapy

    Hengst, J. & Yun, J., Jan 1 2007, xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., p. 1-5 5 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Genetic Therapy
    19 Citations (Scopus)

    Sphingosine 1-phosphate has dual functions in the regulation of endothelial cell permeability and Ca2+ metabolism

    Itagaki, K., Yun, J., Hengst, J., Yatani, A., Hauser, C. J., Spolarics, Z. & Deitch, E. A., Oct 1 2007, In : Journal of Pharmacology and Experimental Therapeutics. 323, 1, p. 186-191 6 p.

    Research output: Contribution to journalArticle

    Permeability
    Endothelial Cells
    Thrombin
    Histamine
    Endoplasmic Reticulum
    24 Citations (Scopus)
    Phosphatidylinositol 3-Kinases
    Smooth Muscle Myocytes
    Muscle
    Coronary Vessels
    Cells
    2004
    15 Citations (Scopus)
    Tiopronin
    Oligomerization
    Secretory Pathway
    Endoplasmic Reticulum
    Disulfides
    2002
    13 Citations (Scopus)

    Chaperone interactions of the metalloproteinase meprin A in the secretory or proteasomal-degradative pathway

    Tsukuba, T., Kadowaki, T., Hengst, J. A. & Bond, J. S., Jan 15 2002, In : Archives of Biochemistry and Biophysics. 397, 2, p. 191-198 8 p.

    Research output: Contribution to journalArticle

    meprin A
    Tiopronin
    Metalloproteases
    Calnexin
    Calreticulin
    29 Citations (Scopus)

    Probing the active sites and mechanisms of rat metalloproteases meprin A and B

    Bertenshaw, G. P., Villa, J. P., Hengst, J. A. & Bond, J. S., Jul 1 2002, In : Biological Chemistry. 383, 7-8, p. 1175-1183 9 p.

    Research output: Contribution to journalArticle

    meprin A
    Tiopronin
    Metalloproteases
    Rats
    Catalytic Domain