Jeremy Hengst, PhD

    • 414 Citations
    • 13 h-Index
    20022017

    Research output per year

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    Research Output

    • 414 Citations
    • 13 h-Index
    • 19 Article
    • 2 Chapter
    • 1 Short survey
    • 1 Review article
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    Article
    2017

    SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models

    Hengst, J., Dick, T. E., Sharma, A., Doi, K., Hegde, S., Tan, S. F., Geffert, L., Fox, T. E., Sharma, A. K., Desai, D., Amin, S., Kester, M., Loughran, T. P., Paulson, R., Claxton, D., Wang, H-G. & Yun, J., 2017, In : Cancer Translational Medicine. 3, 4, p. 109-121

    Research output: Contribution to journalArticle

    2015

    Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia

    LeBlanc, F. R., Liu, X., Hengst, J., Fox, T., Calvert, V., Petricoin, E. F., Yun, J., Feith, D. J. & Loughran, T. P., Dec 2 2015, In : Cancer Biology and Therapy. 16, 12, p. 1830-1840 11 p.

    Research output: Contribution to journalArticle

    13 Scopus citations

    The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines

    Dick, T. E., Hengst, J. A., Fox, T. E., Colledge, A. L., Kale, V. P., Sung, S. S., Sharma, A., Amin, S., Loughran, T. P., Kester, M., Wang, H. G. & Yun, J. K., Mar 1 2015, In : Journal of Pharmacology and Experimental Therapeutics. 352, 3, p. 494-508 15 p.

    Research output: Contribution to journalArticle

    20 Scopus citations
    2014

    A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion

    Kale, V. P., Hengst, J. A., Desai, D. H., Dick, T. E., Choe, K. N., Colledge, A. L., Takahashi, Y., Sung, S. S., Amin, S. G. & Yun, J. K., Nov 28 2014, In : Cancer Letters. 354, 2, p. 299-310 12 p.

    Research output: Contribution to journalArticle

    11 Scopus citations

    Functional characterization of the S41Y (C2755A) polymorphism of tryptophan hydroxylase 2.

    Salli, N., Salli, U., Tekin, I., Hengst, J., Zhao, M. K., Gilman, T. L., Andrews, A. M. & Vrana, K., Jan 1 2014, In : Journal of neurochemistry. 130, 6, p. 748-758 11 p.

    Research output: Contribution to journalArticle

    3 Scopus citations
    2013

    PhotoImmunoNanoTherapy reveals an anticancer role for sphingosine kinase 2 and dihydrosphingosine-1-phosphate

    Barth, B. M., Shanmugavelandy, S. S., Kaiser, J. M., McGovern, C., Altinoǧlu, E. I., Haakenson, J. K., Hengst, J. A., Gilius, E. L., Knupp, S. A., Fox, T. E., Smith, J. P., Ritty, T. M., Adair, J. H. & Kester, M., Mar 26 2013, In : ACS nano. 7, 3, p. 2132-2144 13 p.

    Research output: Contribution to journalArticle

    20 Scopus citations
    2012

    Targeting sphingosine kinase-1 to inhibit melanoma

    Madhunapantula, S. V., Hengst, J., Gowda, R., Fox, T. E., Yun, J. K. & Robertson, G. P., Mar 1 2012, In : Pigment Cell and Melanoma Research. 25, 2, p. 259-274 16 p.

    Research output: Contribution to journalArticle

    37 Scopus citations
    2011

    Effect of HFE variants on sphingolipid expression by SH-SY5Y human neuroblastoma cells

    Ali-Rahmani, F., Hengst, J. A., Connor, J. R. & Schengrund, C. L., Sep 1 2011, In : Neurochemical Research. 36, 9, p. 1687-1696 10 p.

    Research output: Contribution to journalArticle

    8 Scopus citations
    2010

    Development of a sphingosine kinase 1 specific small-molecule inhibitor

    Hengst, J., Wang, X., Sk, U. H., Sharma, A., Amin, S. & Yun, J., Dec 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 24, p. 7498-7502 5 p.

    Research output: Contribution to journalArticle

    35 Scopus citations

    Enhancement of sphingosine kinase 1 catalytic activity by deletion of 21 amino acids from the COOH-terminus

    Hengst, J., Guilford, J. M., Conroy, E. J., Wang, X. & Yun, J., Feb 1 2010, In : Archives of Biochemistry and Biophysics. 494, 1, p. 23-31 9 p.

    Research output: Contribution to journalArticle

    11 Scopus citations

    Selenium-containing analogs of SAHA induce cytotoxicity in lung cancer cells

    Karelia, N., Desai, D., Hengst, J. A., Amin, S., Rudrabhatla, S. V. & Yun, J., Nov 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 22, p. 6816-6819 4 p.

    Research output: Contribution to journalArticle

    26 Scopus citations

    Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs

    Sharma, A. K., Sk, U. H., Gimbor, M. A., Hengst, J. A., Wang, X., Yun, J. & Amin, S., Sep 1 2010, In : European Journal of Medicinal Chemistry. 45, 9, p. 4149-4156 8 p.

    Research output: Contribution to journalArticle

    15 Scopus citations
    2009

    Sphingosine kinase 1 localized to the plasma membrane lipid raft microdomain overcomes serum deprivation induced growth inhibition

    Hengst, J. A., Guilford, J. M., Fox, T. E., Wang, X., Conroy, E. J. & Yun, J. K., Jan 1 2009, In : Archives of Biochemistry and Biophysics. 492, 1-2, p. 62-73 12 p.

    Research output: Contribution to journalArticle

    33 Scopus citations
    2008

    Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions

    Bayerl, M., Bruggeman, R. D., Conroy, E. J., Hengst, J., King, T., Jimenez, M., Claxton, D. & Yun, J., May 1 2008, In : Leukemia and Lymphoma. 49, 5, p. 948-954 7 p.

    Research output: Contribution to journalArticle

    60 Scopus citations
    2007

    Sphingosine 1-phosphate has dual functions in the regulation of endothelial cell permeability and Ca2+ metabolism

    Itagaki, K., Yun, J., Hengst, J., Yatani, A., Hauser, C. J., Spolarics, Z. & Deitch, E. A., Oct 1 2007, In : Journal of Pharmacology and Experimental Therapeutics. 323, 1, p. 186-191 6 p.

    Research output: Contribution to journalArticle

    20 Scopus citations
    24 Scopus citations
    2004
    15 Scopus citations
    2002

    Chaperone interactions of the metalloproteinase meprin A in the secretory or proteasomal-degradative pathway

    Tsukuba, T., Kadowaki, T., Hengst, J. A. & Bond, J. S., Jan 15 2002, In : Archives of Biochemistry and Biophysics. 397, 2, p. 191-198 8 p.

    Research output: Contribution to journalArticle

    13 Scopus citations

    Probing the active sites and mechanisms of rat metalloproteases meprin A and B

    Bertenshaw, G. P., Villa, J. P., Hengst, J. A. & Bond, J. S., Jul 1 2002, In : Biological Chemistry. 383, 7-8, p. 1175-1183 9 p.

    Research output: Contribution to journalArticle

    29 Scopus citations