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Research Output 1992 2018

2018
8 Citations

A research agenda for curing chronic hepatitis B virus infection

Alter, H., Block, T., Brown, N., Brownstein, A., Brosgart, C., Chang, K. M., Chen, P. J., Chisari, F. V., Cohen, C., El-Serag, H., Feld, J., Gish, R., Glenn, J., Greten, T., Guo, H., Guo, J. T., Hoshida, Y., Hu, J., Kowdley, K. V., Li, W. & 15 othersLiang, J., Locarnini, S., Lok, A. S., Mason, W., McMahon, B., Mehta, A., Perrillo, R., Revill, P., Rice, C. M., Rinaudo, J. A., Schinazi, R., Seeger, C., Shetty, K., Tavis, J. & Zoulim, F., Mar 1 2018, In : Hepatology. 67, 3, p. 1127-1131 5 p.

Research output: Contribution to journalArticle

Chronic Hepatitis B
Virus Diseases
Hepatitis B virus
Research
1 Citations

common and distinct capsid and surface protein requirements for secretion of complete and genome-free hepatitis B virions

Ning, X., Luckenbaugh, L., Liu, K., Bruss, V., Sureau, C. & Hu, J., Jul 1 2018, In : Journal of Virology. 92, 14, e00272-18.

Research output: Contribution to journalArticle

protein requirement
hepatitis B
surface proteins
Capsid Proteins
coat proteins
2 Citations

Hepatitis B virus core protein dephosphorylation occurs during pregenomic RNA encapsidation

Zhao, Q., Hu, Z., Cheng, J., Wu, S., Luo, Y., Chang, J., Hu, J. & Guo, J. T., Jul 1 2018, In : Journal of Virology. 92, 13, e02139-17.

Research output: Contribution to journalArticle

Viral Core Proteins
Hepatitis B virus
dephosphorylation
RNA
Capsid
2 Citations

Multiple roles of core protein linker in hepatitis B virus replication

Liu, K., Luckenbaugh, L., Ning, X., Xi, J. & Hu, J., May 1 2018, In : PLoS Pathogens. 14, 5, e1007085.

Research output: Contribution to journalArticle

Virus Replication
Hepatitis B virus
Virion
Capsid
Viral DNA
2017
11 Citations

Capsid phosphorylation state and hepadnavirus virion secretion

Ning, X., Basagoudanavar, S. H., Liu, K., Luckenbaugh, L., Wei, D., Wang, C., Wei, B., Zhao, Y., Yan, T., Delaney, W. & Hu, J., May 1 2017, In : Journal of virology. 91, 9, e00092-17.

Research output: Contribution to journalArticle

Hepadnaviridae
capsid
Capsid
virion
Virion
29 Citations

Complete and incomplete hepatitis B virus particles: Formation, function, and application

Hu, J. & Liu, K., Mar 21 2017, In : Viruses. 9, 3, 56.

Research output: Contribution to journalReview article

Defective Viruses
Hepatitis B virus
Virion
Capsid
Genome
2 Citations

Identification of an intermediate in hepatitis B virus covalently closed circular (CCC) DNA formation and sensitive and selective CCC DNA detection

Luo, J., Cui, X., Gao, L. & Hu, J., Sep 1 2017, In : Journal of virology. 91, 17, e00539-17.

Research output: Contribution to journalArticle

circular DNA
Circular DNA
Hepatitis B virus
spleen exonuclease
DNA
1 Citations

In vitro assays for RNA binding and protein priming of hepatitis B virus polymerase

Clark, D. N., Jones, S. A. & Hu, J., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 157-177 21 p. (Methods in Molecular Biology; vol. 1540).

Research output: Chapter in Book/Report/Conference proceedingChapter

RNA-Binding Proteins
Hepatitis B virus
RNA
Viral DNA
Proteins
1 Citations

Mapping of functional subdomains in the terminal protein domain of hepatitis B virus polymerase

Clark, D. N., Flanagan, J. & Hu, J., Jan 1 2017, In : Journal of virology. 91, 3, e01785-16.

Research output: Contribution to journalArticle

Hepatitis B virus
Proteins
proteins
RNA
Mutagenesis
2016
18 Citations

Cell-free hepatitis B virus capsid assembly dependent on the core protein C-terminal domain and regulated by phosphorylation

Ludgate, L., Liu, K., Luckenbaugh, L., Streck, N., Eng, S., Voitenleitner, C., Delaney, W. E. & Hu, J., Jun 1 2016, In : Journal of virology. 90, 12, p. 5830-5844 15 p.

Research output: Contribution to journalArticle

Virus Assembly
capsid
Hepatitis B virus
Capsid
Protein C
7 Citations

Minicircle HBV cccDNA with a Gaussia luciferase reporter for investigating HBV cccDNA biology and developing cccDNA-targeting drugs

Li, F., Cheng, L., Murphy, C. M., Reszka-Blanco, N. J., Wu, Y., Chi, L., Hu, J. & Su, L., Nov 7 2016, In : Scientific Reports. 6, 36483.

Research output: Contribution to journalArticle

Circular DNA
Drug Delivery Systems
Luciferases
Hepatitis B virus
Chronic Hepatitis B
20 Citations

Viral DNA-dependent induction of innate immune response to hepatitis B virus in immortalized mouse hepatocytes

Cui, X., Clark, D. N., Liu, K., Xu, X. D., Guo, J. T. & Hu, J., Jan 1 2016, In : Journal of virology. 90, 1, p. 486-496 11 p.

Research output: Contribution to journalArticle

circular DNA
Circular DNA
Hepatitis B virus
Viral DNA
Innate Immunity
2015
14 Citations

Alteration of mature nucleocapsid and enhancement of covalently closed circular DNA formation by hepatitis B virus core mutants defective in complete-virion formation

Cui, X., Luckenbaugh, L., Bruss, V. & Hu, J., Jan 1 2015, In : Journal of virology. 89, 19, p. 10064-10072 9 p.

Research output: Contribution to journalArticle

circular DNA
Circular DNA
Nucleocapsid
nucleocapsid
Hepatitis B virus
26 Citations

Does tyrosyl DNA phosphodiesterase-2 play a role in hepatitis B virus genome repair?

Cui, X., McAllister, R., Boregowda, R., Sohn, J. A., Ledesma, F. C., Caldecott, K. W., Seeger, C. & Hu, J., Jun 16 2015, In : PloS one. 10, 6, e0128401.

Research output: Contribution to journalArticle

circular DNA
Circular DNA
Hepatitis B virus
Viruses
Repair
Virology
Antiviral Agents
Hepatitis B virus P protein
26 Citations

Genome-free hepatitis B virion levels in patient sera as a potential marker to monitor response to antiviral therapy

Luckenbaugh, L., Kitrinos, K. M., Delaney, W. E. & Hu, J., Jan 1 2015, In : Journal of Viral Hepatitis. 22, 6, p. 561-570 10 p.

Research output: Contribution to journalArticle

Hepatitis B
Virion
Antiviral Agents
Hepatitis B virus
Hepatitis B Surface Antigens
26 Citations

Hepadnavirus genome replication and persistence

Hu, J. & Seeger, C., Jan 1 2015, In : Cold Spring Harbor Perspectives in Medicine. 5, 7

Research output: Contribution to journalArticle

Hepadnaviridae
Circular DNA
Genes
Genome
Transcription
19 Citations

Hepatitis B virus covalently closed circular DNA formation in immortalized mouse hepatocytes associated with nucleocapsid destabilization

Cui, X., Guo, J. T. & Hu, J., Jan 1 2015, In : Journal of virology. 89, 17, p. 9021-9028 8 p.

Research output: Contribution to journalArticle

circular DNA
Circular DNA
Nucleocapsid
nucleocapsid
Hepatitis B virus
23 Citations

Hepatitis B virus reverse transcriptase - Target of current antiviral therapy and future drug development

Clark, D. N. & Hu, J., Nov 1 2015, In : Antiviral Research. 123, p. 132-137 6 p.

Research output: Contribution to journalReview article

RNA-Directed DNA Polymerase
Hepatitis B virus
Antiviral Agents
Drug Therapy
Viral DNA
18 Citations

Regulation of multiple stages of hepadnavirus replication by the carboxyl-terminal domain of viral core protein in trans

Liu, K., Ludgate, L., Yuan, Z. & Hu, J., Jan 1 2015, In : Journal of virology. 89, 5, p. 2918-2930 13 p.

Research output: Contribution to journalArticle

Hepadnaviridae
Duck Hepatitis B Viruses
Viral Core Proteins
Duck hepatitis B virus
circular DNA
6 Citations

Unveiling the roles of HBV polymerase for new antiviral strategies

Clark, D. N. & Hu, J., Jan 1 2015, In : Future Virology. 10, 3, p. 283-295 13 p.

Research output: Contribution to journalReview article

Antiviral Agents
RNA-Directed DNA Polymerase
RNA-Binding Proteins
DNA
RNA Stability
2014
15 Citations

Comparative analysis of hepatitis B virus polymerase sequences required for viral RNA binding, RNA packaging, and protein priming

Jones, S. A., Clark, D. N., Cao, F., Tavis, J. E. & Hu, J., Feb 1 2014, In : Journal of virology. 88, 3, p. 1564-1572 9 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Hepatitis B virus
Viral RNA
Product Packaging
RNA
11 Citations

Sequences in the terminal protein and reverse transcriptase domains of the hepatitis B virus polymerase contribute to RNA binding and encapsidation

Cao, F., Jones, S., Li, W., Cheng, X., Hu, Y., Hu, J. & Tavis, J. E., Jan 1 2014, In : Journal of Viral Hepatitis. 21, 12, p. 882-893 12 p.

Research output: Contribution to journalArticle

RNA-Directed DNA Polymerase
Hepatitis B virus
RNA
Ducks
Proteins
2013
RNA-Directed DNA Polymerase
Anti-Infective Agents
Nucleosides
Hepatitis B virus
Drug Therapy

In Vitro Epsilon RNA-Dependent Protein Priming Activity of Human Hepatitis B Virus Polymerase

Jones, S. A., Boregowda, R., Spratt, T. E. & Hu, J., Oct 29 2013, In : Journal of Virology. 87, 22, 1 p.

Research output: Contribution to journalComment/debate

Hepatitis B virus
RNA
proteins
2 Citations

Maturation-associated destabilization of hepatitis b virus nucleocapsid

Cui, X., Ludgate, L., Ning, X. & Hu, J., Oct 25 2013, In : Journal of virology. 87, 21, p. 11493-11503 11 p.

Research output: Contribution to journalArticle

circular DNA
Circular DNA
Nucleocapsid
nucleocapsid
Hepatitis Viruses
31 Citations

Maturation-associated destabilization of hepatitis B virus nucleocapsid.

Cui, X., Ludgate, L., Ning, X. & Hu, J., Nov 1 2013, In : Journal of virology. 87, 21, p. 11494-11503 10 p.

Research output: Contribution to journalArticle

circular DNA
Circular DNA
Nucleocapsid
nucleocapsid
Hepatitis B virus
16 Citations

Noncompetitive inhibition of hepatitis B virus reverse transcriptase protein priming and DNA synthesis by the nucleoside analog clevudine

Jones, S. A., Murakami, E., Delaney, W., Furman, P. & Hu, J., Sep 1 2013, In : Antimicrobial agents and chemotherapy. 57, 9, p. 4181-4189 9 p.

Research output: Contribution to journalArticle

RNA-Directed DNA Polymerase
Nucleosides
Hepatitis B virus
Tenofovir
DNA
15 Citations

Protein-primed terminal transferase activity of hepatitis B virus polymerase

Jones, S. A. & Hu, J., Mar 1 2013, In : Journal of Virology. 87, 5, p. 2563-2576 14 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Transferases
transferases
DNA
synthesis
2 Citations

Protein-Primed Terminal Transferase Activity of Hepatitis B Virus Polymerase

Jones, S. A. & Hu, J., Oct 29 2013, In : Journal of Virology. 87, 22, 1 p.

Research output: Contribution to journalComment/debate

Hepatitis B virus
transferases
proteins
2012
27 Citations

Cyclin-dependent kinase 2 phosphorylates S/T-P sites in the hepadnavirus core protein C-terminal domain and is incorporated into viral capsids

Ludgate, L., Ning, X., Nguyen, D. H., Adams, C., Mentzer, L. & Hu, J., Nov 1 2012, In : Journal of virology. 86, 22, p. 12237-12250 14 p.

Research output: Contribution to journalArticle

Hepadnaviridae
Cyclin-Dependent Kinase 2
capsid
Hepatitis B virus
cyclin-dependent kinase
37 Citations

In vitro epsilon RNA-dependent protein priming activity of human hepatitis B virus polymerase

Jones, S. A., Boregowd, R., Spratt, T. E. & Hu, J., May 1 2012, In : Journal of Virology. 86, 9, p. 5134-5150 17 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Human Activities
RNA
Product Packaging
reverse transcription
6 Citations

TP-RT domain interactions of duck hepatitis B virus reverse transcriptase in cis and in trans during protein-primed initiation of DNA synthesis in vitro

Boregowda, R. K., Adams, C. & Hu, J., Jul 1 2012, In : Journal of virology. 86, 12, p. 6522-6536 15 p.

Research output: Contribution to journalArticle

Duck hepatitis B virus
Duck Hepatitis B Viruses
RNA-directed DNA polymerase
RNA-Directed DNA Polymerase
synthesis
2011
16 Citations

A theoretical model for the dynamic structure of hepatitis B nucleocapsid

Meng, D., Hjelm, R. P., Hu, J. & Wu, J., Nov 16 2011, In : Biophysical journal. 101, 10, p. 2476-2484 9 p.

Research output: Contribution to journalArticle

Nucleocapsid
Hepatitis B
Theoretical Models
Reverse Transcription
Hepatitis B virus
12 Citations

Cryptic protein priming sites in two different domains of duck hepatitis B virus reverse transcriptase for initiating DNA synthesis in vitro

Boregowda, R. K., Lin, L., Zhu, Q., Tian, F. & Hu, J., Aug 1 2011, In : Journal of virology. 85, 15, p. 7754-7765 12 p.

Research output: Contribution to journalArticle

Duck hepatitis B virus
Duck Hepatitis B Viruses
RNA-directed DNA polymerase
RNA-Directed DNA Polymerase
synthesis
12 Citations

Phosphorylation State-Dependent interactions of hepadnavirus core protein with host factors

Ludgate, L., Adams, C. & Hu, J., Dec 22 2011, In : PLoS One. 6, 12, e29566.

Research output: Contribution to journalArticle

Hepadnaviridae
Integration Host Factors
Phosphorylation
phosphorylation
Duck hepatitis B virus
69 Citations

Secretion of genome-free hepatitis b virus - single strand blocking model for virion morphogenesis of para-retrovirus

Ning, X., Nguyen, D., Mentzer, L., Adams, C., Lee, H., Ashley, R., Hafenstein, S. & Hu, J., Sep 1 2011, In : PLoS Pathogens. 7, 9, e1002255.

Research output: Contribution to journalArticle

Hepatitis Viruses
Retroviridae
Morphogenesis
Virion
Genome
2009
16 Citations

An interdomain RNA binding site on the hepadnaviral polymerase that is essential for reverse transcription

Badtke, M. P., Khan, I., Cao, F., Hu, J. & Tavis, J. E., Jul 20 2009, In : Virology. 390, 1, p. 130-138 9 p.

Research output: Contribution to journalArticle

Viral RNA
Reverse Transcription
Binding Sites
RNA
DNA
19 Citations

RNA-protein interactions in hepadnavirus reverse transcription

Hu, J. & Lin, L., Jan 1 2009, In : Frontiers in Bioscience. 14, 5, p. 1606-1618 13 p.

Research output: Contribution to journalArticle

Hepadnaviridae
Transcription
Reverse Transcription
RNA
RNA-Directed DNA Polymerase
1 Citations

trans-Complementation of HBV rtM204I mutant replication by HBV wild-type polymerase

Heipertz, R. A., Starkey, J. L., Miller, T. G., Hu, J. & Isom, H. C., May 25 2009, In : Virology. 388, 1, p. 57-67 11 p.

Research output: Contribution to journalArticle

Hepatitis B virus
RNA
Genome
Baculoviridae
Hep G2 Cells
2008
17 Citations
Hepadnaviridae
reverse transcription
RNA-directed DNA polymerase
RNA-Directed DNA Polymerase
metal ions
64 Citations

Hepatitis B virus-cell interactions and pathogenesis

Nguyen, D. H., Ludgate, L. & Hu, J., Aug 1 2008, In : Journal of Cellular Physiology. 216, 2, p. 289-294 6 p.

Research output: Contribution to journalShort survey

Viruses
Hepatitis B virus
Cell Communication
Nucleocapsid
Transcription
31 Citations

Inhibition of hepadnavirus reverse transcriptase-ε RNA interaction by porphyrin compounds

Lin, L. & Hu, J., Mar 1 2008, In : Journal of virology. 82, 5, p. 2305-2312 8 p.

Research output: Contribution to journalArticle

Hepadnaviridae
porphyrins
RNA-directed DNA polymerase
RNA-Directed DNA Polymerase
Porphyrins
43 Citations

Reverse transcriptase- and RNA packaging signal-dependent incorporation of APOBEC3G into hepatitis B virus nucleocapsids

Nguyen, D. H. & Hu, J., Jul 1 2008, In : Journal of virology. 82, 14, p. 6852-6861 10 p.

Research output: Contribution to journalArticle

Nucleocapsid
nucleocapsid
Hepatitis B virus
RNA-directed DNA polymerase
RNA-Directed DNA Polymerase
2007
94 Citations

Deamination-independent inhibition of hepatitis B virus reverse transcription by APOBEC3G

Nguyen, D. H., Gummuluru, S. & Hu, J., May 1 2007, In : Journal of virology. 81, 9, p. 4465-4472 8 p.

Research output: Contribution to journalArticle

deamination
Deamination
reverse transcription
Hepatitis B virus
Reverse Transcription
103 Citations

Formation of hepatitis B virus covalently closed circular DNA: Removal of genome-linked protein

Gao, W. & Hu, J., Jun 1 2007, In : Journal of virology. 81, 12, p. 6164-6174 11 p.

Research output: Contribution to journalArticle

circular DNA
Circular DNA
Hepatitis B virus
Genome
genome
17 Citations

HIV-HBV and HIV-HCV coinfection and liver cancer development.

Hu, J. & Ludgate, L., 2007, In : Cancer Treatment and Research. 133, p. 241-252 12 p.

Research output: Contribution to journalReview article

Liver Neoplasms
Coinfection
HIV
Chronic Hepatitis
Viruses
50 Citations

Regulation of hepadnavirus reverse transcription by dynamic nucleocapsid phosphorylation

Basagoudanavar, S. H., Perlman, D. H. & Hu, J., Feb 2007, In : Journal of Virology. 81, 4, p. 1641-1649 9 p.

Research output: Contribution to journalArticle

Hepadnaviridae
Nucleocapsid
nucleocapsid
reverse transcription
Reverse Transcription
2006
57 Citations

Hepatitis B virus reverse transcriptase and ε RNA sequences required for specific interaction in vitro

Hu, J. & Boyer, M., Mar 2006, In : Journal of Virology. 80, 5, p. 2141-2150 10 p.

Research output: Contribution to journalArticle

Hepatitis B virus
RNA-directed DNA polymerase
RNA-Directed DNA Polymerase
nucleotide sequences
Product Packaging
2005
77 Citations

Reverse transcription-associated dephosphorylation of hepadnavirus nucleocapsids

Perlman, D. H., Berg, E. A., O'Connor, P. B., Costello, C. E. & Hu, J., Jun 21 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 25, p. 9020-9025 6 p.

Research output: Contribution to journalArticle

Hepadnaviridae
Nucleocapsid
Reverse Transcription
RNA
Virion