• 6864 Citations
  • 45 h-Index
1978 …2020

Research output per year

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Research Output

2020

Donor surfactant protein A2 polymorphism and lung transplant survival

D'Ovidio, F., Floros, J., Aramini, B., Lederer, D., DiAngelo, S. L., Arcasoy, S., Sonett, J. R., Robbins, H., Shah, L., Costa, J. & Urso, A., Mar 1 2020, In : European Respiratory Journal. 55, 3, 1900618.

Research output: Contribution to journalArticle

Open Access
Open Access
2019

Anti-Inflammatory Effect of Surfactant Lipid in the Vaginal Mucosa: A Pilot Study

Macneill, C., De Guzman, G. S., Lupo, K., Umstead, T., Phelps, D. & Floros, J., Jan 1 2019, In : Journal of Lower Genital Tract Disease. 23, 1, p. 71-74 4 p.

Research output: Contribution to journalArticle

Differential effects of human SP-A1 and SP-A2 on the BAL proteome and signaling pathways in response to Klebsiella pneumoniae and ozone exposure

Wang, G., Umstead, T. M., Hu, S., Mikerov, A. N., Phelps, D. S. & Floros, J., Jan 1 2019, In : Frontiers in immunology. 10, MAR, 561.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
Open Access

Major effect of oxidative stress on the Male, but not female, SP-A1 type II cell miRNome

Noutsios, G. T., Thorenoor, N., Zhang, X., Phelps, D. S., Umstead, T. M., Durrani, F. & Floros, J., Jan 1 2019, In : Frontiers in immunology. 10, JULY, 1514.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Structural and Functional Determinants of Rodent and Human Surfactant Protein A: A Synthesis of Binding and Computational Data

Nalian, A., Umstead, T. M., Yang, C. H., Silveyra, P., Thomas, N. J., Floros, J., McCormack, F. X. & Chroneos, Z. C., Nov 7 2019, In : Frontiers in immunology. 10, 2613.

Research output: Contribution to journalArticle

Open Access

Surfactant protein A and D personalized medicine: A healthy day at the SP-A

Floros, J. & D'Ovidio, F., Jun 2019, In : Journal of Thoracic and Cardiovascular Surgery. 157, 6, p. e425

Research output: Contribution to journalLetter

Open Access

Surfactant protein A and D polymorphisms and methylprednisolone pharmacogenetics in donor lungs

Aramini, B., Geraghty, P., Lederer, D. J., Costa, J., DiAngelo, S. L., Floros, J. & D'Ovidio, F., May 2019, In : Journal of Thoracic and Cardiovascular Surgery. 157, 5, p. 2109-2117 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
2018
9 Scopus citations

Differential expression of PGC1α in intratumor redox subpopulations of breast cancer

Lin, Z., Xu, H. N., Wang, Y., Floros, J. & Li, L. Z., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 177-181 5 p. (Advances in Experimental Medicine and Biology; vol. 1072).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Genetic association of pulmonary surfactant protein genes, SFTPA1, SFTPA2, SFTPB, SFTPC, and SFTPD with cystic fibrosis

Lin, Z., Thorenoor, N., Wut, R., Di Angelo, S. L., Ye, M., Thomas, N. J., Liao, X., Lin, T. R., Warren, S. & Floros, J., Oct 2 2018, In : Frontiers in immunology. 9, OCT, 2256.

Research output: Contribution to journalArticle

3 Scopus citations
9 Scopus citations
2017

Association of the haem oxygenase-1 gene with inflammatory bowel disease

Lin, Z., Hao, H., Hegarty, J. P., Lin, T. R., Wang, Y., Harris, L. R., Xu, H. N., Wu, R., Thomas, N. J. & Floros, J., Aug 2 2017, In : Swiss Medical Weekly. 147, w14456.

Research output: Contribution to journalArticle

1 Scopus citations

Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease

Lin, Z., Wang, Z., Hegarty, J. P., Lin, T. R., Wang, Y., Deiling, S., Wu, R., Thomas, N. J. & Floros, J., Jul 21 2017, In : World journal of gastroenterology. 23, 27, p. 4897-4909 13 p.

Research output: Contribution to journalArticle

11 Scopus citations
10 Scopus citations
2016

Human Pulmonary Surfactant Protein SP-A1 Provides Maximal Efficiency of Lung Interfacial Films

Lopez-Rodriguez, E., Pascual, A., Arroyo, R., Floros, J. & Perez-Gil, J., Aug 9 2016, In : Biophysical journal. 111, 3, p. 524-536 13 p.

Research output: Contribution to journalArticle

15 Scopus citations
8 Scopus citations
2015

14-3-3 isoforms bind directly exon B of the 5ʹ-UTR of human surfactant protein A2 mRNA

Noutsios, G. T., Ghattas, P., Bennett, S. & Floros, J., Jul 15 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 2, p. L147-L157

Research output: Contribution to journalArticle

2 Scopus citations

DNA methylation profile and expression of surfactant protein A2 gene in lung cancer

Grageda, M., Silveyra, P., Thomas, N. J., Diangelo, S. L. & Floros, J., Mar 1 2015, In : Experimental Lung Research. 41, 2, p. 93-102 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Oral administration of surfactant protein-a reduces pathology in an experimental model of necrotizing enterocolitis

Quintanilla, H. D., Liu, Y., Fatheree, N. Y., Atkins, C. L., Hashmi, S. S., Floros, J., McCormack, F. X., Rhoads, J. M. A. & Alcorn, J. L., May 1 2015, In : Journal of pediatric gastroenterology and nutrition. 60, 5, p. 613-620 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Regulation of translation by upstream translation initiation codons of surfactant protein A1 splice variants

Tsotakos, N., Silveyra, P., Lin, Z., Thomas, N., Vaid, M. & Floros, J., Jan 1 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 308, 1, p. L58-L75

Research output: Contribution to journalArticle

1 Scopus citations

SP-R210 (Myo18A) isoforms as intrinsic modulators of macrophage priming and activation

Yang, L., Carrillo, M., Wu, Y. M., DiAngelo, S. L., Silveyra, P., Umstead, T. M., Halstead, E. S., Davies, M. L., Hu, S., Floros, J., McCormack, F. X., Christensen, N. D. & Chroneos, Z. C., May 12 2015, In : PloS one. 10, 5, e0126576.

Research output: Contribution to journalArticle

9 Scopus citations
2014
6 Scopus citations

Childhood asthma: Causes, risks, and protective factors; a role of innate immunity

Noutsios, G. T. & Floros, J., Jan 1 2014, In : Swiss Medical Weekly. 144, w14036.

Research output: Contribution to journalReview article

33 Scopus citations

Effect of hypoxia on lung gene expression and proteomic profile: Insights into the pulmonary surfactant response

Olmeda, B., Umstead, T. M., Silveyra, P., Pascual, A., López-Barneo, J., Phelps, D. S., Floros, J. & Pérez-Gil, J., Apr 14 2014, In : Journal of Proteomics. 101, p. 179-191 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Effect of ozone exposure and infection on bronchoalveolar lavage: Sex differences in response patterns

Mikerov, A. N., Phelps, D. S., Gan, X., Umstead, T. M., Haque, R., Wang, G. & Floros, J., Oct 5 2014, In : Toxicology Letters. 230, 2, p. 333-344 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Erratum: Pilot study exploring lung allograft surfactant protein A (SP-A) expression in association with lung transplant outcome (American Journal of Transplantation (2013) 13 (2722-2729) DOI: 10.1111/ajt.12407)

D'Ovidio, F., Kaneda, H., Chaparro, C., Mura, M., Lederer, D., Di Angelo, S., Takahashi, H., Gutierrez, C., Hutcheon, M., Singer, L. G., Waddell, T. K., Floros, J., Liu, M. & Keshavjee, S., Feb 1 2014, In : American Journal of Transplantation. 14, 2, 1 p.

Research output: Contribution to journalComment/debate

In remembrance of Dr. Mary Ellen Avery

Floros, J., Mar 1 2014, In : Frontiers in Pediatrics. 2, MAR, 21.

Research output: Contribution to journalArticle

Open Access

Knockdown of Drosha in human alveolar type II cells alters expression of SP-A in culture: A pilot study

Silveyra, P., Chroneos, Z. C., Diangelo, S. L., Thomas, N. J., Noutsios, G. T., Tsotakos, N., Howrylak, J. A., Umstead, T. M. & Floros, J., Sep 2014, In : Experimental Lung Research. 40, 7, p. 354-366 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Sex differences in the acute in vivo effects of different human SP-A variants on the mouse alveolar macrophage proteome

Phelps, D. S., Umstead, T. M. & Floros, J., Aug 28 2014, In : Journal of Proteomics. 108, p. 427-444 18 p.

Research output: Contribution to journalArticle

10 Scopus citations
2013

Donor surfactant protein D (SP-D) polymorphisms are associated with lung transplant outcome

Aramini, B., Kim, C., Diangelo, S., Petersen, E., Lederer, D. J., Shah, L., Robbins, H., Floros, J., Arcasoy, S. M., Sonett, J. R. & D'Ovidio, F., Aug 1 2013, In : American Journal of Transplantation. 13, 8, p. 2130-2136 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Essential Regulation of Lung Surfactant Homeostasis by the Orphan G Protein-Coupled Receptor GPR116

Yang, M. Y., Hilton, M. B., Seaman, S., Haines, D. C., Nagashima, K., Burks, C. M., Tessarollo, L., Ivanova, P. T., Brown, H. A., Umstead, T. M., Floros, J., Chroneos, Z. C. & St.Croix, B., May 30 2013, In : Cell Reports. 3, 5, p. 1457-1464 8 p.

Research output: Contribution to journalArticle

35 Scopus citations
6 Scopus citations

Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2

Silveyra, P. & Floros, J., Dec 1 2013, In : Gene. 531, 2, p. 126-132 7 p.

Research output: Contribution to journalReview article

11 Scopus citations

Highlights of early pulmonary surfactant: Research from bench to clinic

Noutsios, G. T. & Floros, J., Dec 1 2013, In : Pneumon. 26, 4, p. 350-354 5 p.

Research output: Contribution to journalReview article

2 Scopus citations

Pilot study exploring lung allograft surfactant protein A (SP-A) expression in association with lung transplant outcome

D'Ovidio, F., Kaneda, H., Chaparro, C., Mura, M., Lederer, D., Di Angelo, S., Takahashi, H., Gutierrez, C., Hutcheon, M., Singer, L. G., Waddell, T. K., Floros, J., Liu, M. & Keshavjee, S., Oct 2013, In : American Journal of Transplantation. 13, 10, p. 2722-2729 8 p.

Research output: Contribution to journalArticle

21 Scopus citations
2012

Air pollution and epigenetics: Effects on SP-A and innate host defence in the lung

Silveyra, P. & Floros, J., May 1 2012, In : Swiss Medical Weekly. 142, MAY, w13579.

Research output: Contribution to journalReview article

20 Scopus citations

Cyclic changes in the level of the innate immune molecule, surfactant protein-a, and cytokines in vaginal fluid

Macneill, C., de Guzman, G., Sousa, G. E., Umstead, T. M., Phelps, D., Floros, J., Ahn, K. & Weisz, J., Sep 1 2012, In : American Journal of Reproductive Immunology. 68, 3, p. 244-250 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury

Silveyra, P. & Floros, J., Jan 1 2012, In : Frontiers in Bioscience. 17, 2, p. 407-429 23 p.

Research output: Contribution to journalArticle

40 Scopus citations

Gonadal hormones and oxidative stress interaction differentially affects survival of male and female mice after lung Klebsiella Pneumoniae infection

Durrani, F., Phelps, D., Weisz, J., Silveyra, P., Hu, S., Mikerov, A. N. & Floros, J., May 1 2012, In : Experimental Lung Research. 38, 4, p. 165-172 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

IL-18R1 and IL-18RAP SNPs may be associated with bronchopulmonary dysplasia in African-American infants

Floros, J., Londono, D., Gordon, D., Silveyra, P., Diangelo, S. L., Viscardi, R. M., Worthen, G. S., Shenberger, J., Wang, G., Lin, Z. & Thomas, N. J., Jan 1 2012, In : Pediatric Research. 71, 1, p. 107-114 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Impact of sex and ozone exposure on the course of pneumonia in wild type and SP-A (-/-) mice

Mikerov, A. N., Hu, S., Durrani, F., Gan, X., Wang, G., Umstead, T. M., Phelps, D. & Floros, J., Apr 1 2012, In : Microbial Pathogenesis. 52, 4, p. 239-249 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Sex differences in the response of the alveolar macrophage proteome to treatment with exogenous surfactant protein-A

Phelps, D., Umstead, T. M. & Floros, J., Jul 23 2012, In : Proteome Science. 10, 1, 44.

Research output: Contribution to journalArticle

13 Scopus citations
2011

Genetic Variants and Monoallelic Expression of Surfactant Protein-D in Inflammatory Bowel Disease

Lin, Z., John, G., Hegarty, J. P., Berg, A., Yu, W., Wang, Y., Kelly, A. A., Peterson, B. Z., Poritz, L. S., Floros, J. & Koltun, W. A., Sep 1 2011, In : Annals of Human Genetics. 75, 5, p. 559-568 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
15 Scopus citations
20 Scopus citations

Surfactant protein A is defective in abrogating inflammation in asthma

Wang, Y., Voelker, D. R., Lugogo, N. L., Wang, G., Floros, J., Ingram, J. L., Chu, H. W., Church, T. D., Kandasamy, P., Fertel, D., Wright, J. R. & Kraft, M., Oct 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 4, p. L598-L606

Research output: Contribution to journalArticle

31 Scopus citations

Surfactant protein genetics in community-acquired pneumonia: Balancing the host inflammatory state

Floros, J. & Thomas, N. J., Apr 21 2011, In : Critical Care. 15, 2, 156.

Research output: Contribution to journalComment/debate

4 Scopus citations

The toll of ozone

Umstead, T. M., Phelps, D. & Floros, J., Jan 1 2011, In : Pneumon. 24, 1, p. 17-23 7 p.

Research output: Contribution to journalEditorial

2 Scopus citations