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Research Output 1978 2019

2019

Anti-Inflammatory Effect of Surfactant Lipid in the Vaginal Mucosa: A Pilot Study

Macneill, C., De Guzman, G. S., Lupo, K., Umstead, T., Phelps, D. & Floros, J., Jan 1 2019, In : Journal of Lower Genital Tract Disease. 23, 1, p. 71-74 4 p.

Research output: Contribution to journalArticle

Surface-Active Agents
Mucous Membrane
Anti-Inflammatory Agents
Lipids
Cytokines
1 Citation (Scopus)

Differential effects of human SP-A1 and SP-A2 on the BAL proteome and signaling pathways in response to Klebsiella pneumoniae and ozone exposure

Wang, G., Umstead, T. M., Hu, S., Mikerov, A. N., Phelps, D. S. & Floros, J., Jan 1 2019, In : Frontiers in immunology. 10, MAR, 561.

Research output: Contribution to journalArticle

Open Access
Ozone
Klebsiella pneumoniae
Bronchoalveolar Lavage
Proteome
varespladib methyl

Differential impact of co-expressed SP-A1/SP-A2 protein on AM miRNome; Sex differences

Thorenoor, N., Kawasawa, Y. I., Gandhi, C. K., Zhang, X. & Floros, J., Jan 1 2019, In : Frontiers in immunology. 10, AUG, 1960.

Research output: Contribution to journalArticle

Open Access
Alveolar Macrophages
varespladib methyl
Sex Characteristics
Pulmonary Surfactant-Associated Protein A
Oxidative Stress
1 Citation (Scopus)

Major effect of oxidative stress on the Male, but not female, SP-A1 type II cell miRNome

Noutsios, G. T., Thorenoor, N., Zhang, X., Phelps, D. S., Umstead, T. M., Durrani, F. & Floros, J., Jan 1 2019, In : Frontiers in immunology. 10, JULY, 1514.

Research output: Contribution to journalArticle

Open Access
MicroRNAs
Oxidative Stress
varespladib methyl
Pulmonary Surfactant-Associated Protein A
Messenger RNA

Structural and Functional Determinants of Rodent and Human Surfactant Protein A: A Synthesis of Binding and Computational Data

Nalian, A., Umstead, T. M., Yang, C. H., Silveyra, P., Thomas, N. J., Floros, J., McCormack, F. X. & Chroneos, Z. C., Nov 7 2019, In : Frontiers in immunology. 10, 2613.

Research output: Contribution to journalArticle

Open Access
Pulmonary Surfactant-Associated Protein A
Rodentia
Alveolar Macrophages
varespladib methyl
Surface-Active Agents

Surfactant protein A and D personalized medicine: A healthy day at the SP-A

Floros, J. & D'Ovidio, F., Jun 2019, In : Journal of Thoracic and Cardiovascular Surgery. 157, 6, p. e425

Research output: Contribution to journalLetter

Open Access
Pulmonary Surfactant-Associated Protein D
Pulmonary Surfactant-Associated Protein A
Precision Medicine
2 Citations (Scopus)

Surfactant protein A and D polymorphisms and methylprednisolone pharmacogenetics in donor lungs

Aramini, B., Geraghty, P., Lederer, D. J., Costa, J., DiAngelo, S. L., Floros, J. & D'Ovidio, F., May 2019, In : Journal of Thoracic and Cardiovascular Surgery. 157, 5, p. 2109-2117 9 p.

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Protein D
Pulmonary Surfactant-Associated Protein A
Pharmacogenetics
Methylprednisolone
varespladib methyl
2018
7 Citations (Scopus)

Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex differences

Thorenoor, N., Zhang, X., Umstead, T. M., Scott Halstead, E., Phelps, D. S. & Floros, J., Feb 3 2018, In : Respiratory research. 19, 1, 23.

Research output: Contribution to journalArticle

Klebsiella Infections
Pulmonary Surfactant-Associated Protein A
Klebsiella pneumoniae
varespladib methyl
Surface-Active Agents
1 Citation (Scopus)

Differential expression of PGC1α in intratumor redox subpopulations of breast cancer

Lin, Z., Xu, H. N., Wang, Y., Floros, J. & Li, L. Z., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 177-181 5 p. (Advances in Experimental Medicine and Biology; vol. 1072).

Research output: Chapter in Book/Report/Conference proceedingChapter

Oxidation-Reduction
Breast Neoplasms
NAD
Heterografts
Tumors
2 Citations (Scopus)

Genetic association of pulmonary surfactant protein genes, SFTPA1, SFTPA2, SFTPB, SFTPC, and SFTPD with cystic fibrosis

Lin, Z., Thorenoor, N., Wut, R., Di Angelo, S. L., Ye, M., Thomas, N. J., Liao, X., Lin, T. R., Warren, S. & Floros, J., Oct 2 2018, In : Frontiers in immunology. 9, OCT, 2256.

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Proteins
Cystic Fibrosis
Single Nucleotide Polymorphism
Genes
Surface-Active Agents
6 Citations (Scopus)
Klebsiella Infections
Klebsiella pneumoniae
varespladib methyl
Surface-Active Agents
Transgenic Mice
2017
1 Citation (Scopus)

Association of the haem oxygenase-1 gene with inflammatory bowel disease

Lin, Z., Hao, H., Hegarty, J. P., Lin, T. R., Wang, Y., Harris, L. R., Xu, H. N., Wu, R., Thomas, N. J. & Floros, J., Aug 2 2017, In : Swiss Medical Weekly. 147, w14456.

Research output: Contribution to journalArticle

Heme Oxygenase (Decyclizing)
Inflammatory Bowel Diseases
Interleukin-10
Down-Regulation
Genes
9 Citations (Scopus)

Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease

Lin, Z., Wang, Z., Hegarty, J. P., Lin, T. R., Wang, Y., Deiling, S., Wu, R., Thomas, N. J. & Floros, J., Jul 21 2017, In : World journal of gastroenterology. 23, 27, p. 4897-4909 13 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Interleukin-10
Pediatrics
Single Nucleotide Polymorphism
Genes
7 Citations (Scopus)

SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: Pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved

Noutsios, G. T., Thorenoor, N., Zhang, X., Phelps, D. S., Umstead, T. M., Durrani, F. & Floros, J., Dec 4 2017, In : Biology of Sex Differences. 8, 1, 37.

Research output: Contribution to journalArticle

MicroRNAs
varespladib methyl
Oxidants
Sex Characteristics
Oxidative Stress
2016
13 Citations (Scopus)

Human Pulmonary Surfactant Protein SP-A1 Provides Maximal Efficiency of Lung Interfacial Films

Lopez-Rodriguez, E., Pascual, A., Arroyo, R., Floros, J. & Perez-Gil, J., Aug 9 2016, In : Biophysical journal. 111, 3, p. 524-536 13 p.

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Proteins
Pulmonary Surfactants
varespladib methyl
Surface-Active Agents
Pulmonary Surfactant-Associated Protein A
7 Citations (Scopus)
Single-Cell Analysis
Pulmonary Surfactant-Associated Protein A
Alveolar Macrophages
Actin Cytoskeleton
varespladib methyl
2015
1 Citation (Scopus)

14-3-3 isoforms bind directly exon B of the 5ʹ-UTR of human surfactant protein A2 mRNA

Noutsios, G. T., Ghattas, P., Bennett, S. & Floros, J., Jul 15 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 2, p. L147-L157

Research output: Contribution to journalArticle

5' Untranslated Regions
varespladib methyl
Surface-Active Agents
Exons
Protein Isoforms
6 Citations (Scopus)

DNA methylation profile and expression of surfactant protein A2 gene in lung cancer

Grageda, M., Silveyra, P., Thomas, N. J., Diangelo, S. L. & Floros, J., Mar 1 2015, In : Experimental Lung Research. 41, 2, p. 93-102 10 p.

Research output: Contribution to journalArticle

DNA Methylation
varespladib methyl
Surface-Active Agents
Lung Neoplasms
Genes
9 Citations (Scopus)

Oral administration of surfactant protein-a reduces pathology in an experimental model of necrotizing enterocolitis

Quintanilla, H. D., Liu, Y., Fatheree, N. Y., Atkins, C. L., Hashmi, S. S., Floros, J., McCormack, F. X., Rhoads, J. M. A. & Alcorn, J. L., May 1 2015, In : Journal of pediatric gastroenterology and nutrition. 60, 5, p. 613-620 8 p.

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Protein A
Necrotizing Enterocolitis
Surface-Active Agents
Oral Administration
Theoretical Models
1 Citation (Scopus)

Regulation of translation by upstream translation initiation codons of surfactant protein A1 splice variants

Tsotakos, N., Silveyra, P., Lin, Z., Thomas, N., Vaid, M. & Floros, J., Jan 1 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 308, 1, p. L58-L75

Research output: Contribution to journalArticle

Initiator Codon
Surface-Active Agents
Exons
Protein Isoforms
5' Untranslated Regions
9 Citations (Scopus)

SP-R210 (Myo18A) isoforms as intrinsic modulators of macrophage priming and activation

Yang, L., Carrillo, M., Wu, Y. M., DiAngelo, S. L., Silveyra, P., Umstead, T. M., Halstead, E. S., Davies, M. L., Hu, S., Floros, J., McCormack, F. X., Christensen, N. D. & Chroneos, Z. C., May 12 2015, In : PloS one. 10, 5, e0126576.

Research output: Contribution to journalArticle

Macrophage Activation
Macrophages
Modulators
Protein Isoforms
macrophages
2014
6 Citations (Scopus)
Pulmonary Surfactant-Associated Protein A
MicroRNAs
Cell Culture Techniques
Gene Expression
Genes
31 Citations (Scopus)

Childhood asthma: Causes, risks, and protective factors; a role of innate immunity

Noutsios, G. T. & Floros, J., Jan 1 2014, In : Swiss Medical Weekly. 144, w14036.

Research output: Contribution to journalReview article

Innate Immunity
Asthma
Pulmonary Surfactant-Associated Protein D
Pulmonary Surfactant-Associated Protein A
Alveolar Macrophages
8 Citations (Scopus)

Effect of hypoxia on lung gene expression and proteomic profile: Insights into the pulmonary surfactant response

Olmeda, B., Umstead, T. M., Silveyra, P., Pascual, A., López-Barneo, J., Phelps, D., Floros, J. & Pérez-Gil, J., Apr 14 2014, In : Journal of Proteomics. 101, p. 179-191 13 p.

Research output: Contribution to journalArticle

Pulmonary Surfactants
Transcriptome
Gene expression
Proteomics
Bronchoalveolar Lavage
8 Citations (Scopus)

Effect of ozone exposure and infection on bronchoalveolar lavage: Sex differences in response patterns

Mikerov, A. N., Phelps, D. S., Gan, X., Umstead, T. M., Haque, R., Wang, G. & Floros, J., Oct 5 2014, In : Toxicology Letters. 230, 2, p. 333-344 12 p.

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Protein A
Oxidative stress
Ozone
Bronchoalveolar Lavage
Sex Characteristics

Erratum: Pilot study exploring lung allograft surfactant protein A (SP-A) expression in association with lung transplant outcome (American Journal of Transplantation (2013) 13 (2722-2729) DOI: 10.1111/ajt.12407)

D'Ovidio, F., Kaneda, H., Chaparro, C., Mura, M., Lederer, D., Di Angelo, S., Takahashi, H., Gutierrez, C., Hutcheon, M., Singer, L. G., Waddell, T. K., Floros, J., Liu, M. & Keshavjee, S., Feb 1 2014, In : American Journal of Transplantation. 14, 2, 1 p.

Research output: Contribution to journalComment/debate

Pulmonary Surfactant-Associated Proteins
Pulmonary Surfactant-Associated Protein A
Allografts
Transplantation
Transplants

In remembrance of Dr. Mary Ellen Avery

Floros, J., Mar 1 2014, In : Frontiers in Pediatrics. 2, MAR, 21.

Research output: Contribution to journalArticle

Open Access
Neonatology
4 Citations (Scopus)

Knockdown of Drosha in human alveolar type II cells alters expression of SP-A in culture: A pilot study

Silveyra, P., Chroneos, Z. C., Diangelo, S. L., Thomas, N. J., Noutsios, G. T., Tsotakos, N., Howrylak, J. A., Umstead, T. M. & Floros, J., Sep 2014, In : Experimental Lung Research. 40, 7, p. 354-366 13 p.

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Protein A
Alveolar Epithelial Cells
MicroRNAs
3' Untranslated Regions
Cultured Cells
9 Citations (Scopus)

Sex differences in the acute in vivo effects of different human SP-A variants on the mouse alveolar macrophage proteome

Phelps, D. S., Umstead, T. M. & Floros, J., Aug 28 2014, In : Journal of Proteomics. 108, p. 427-444 18 p.

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Protein A
Alveolar Macrophages
Proteome
varespladib methyl
Sex Characteristics
2013
15 Citations (Scopus)

Donor surfactant protein D (SP-D) polymorphisms are associated with lung transplant outcome

Aramini, B., Kim, C., Diangelo, S., Petersen, E., Lederer, D. J., Shah, L., Robbins, H., Floros, J., Arcasoy, S. M., Sonett, J. R. & D'Ovidio, F., Aug 1 2013, In : American Journal of Transplantation. 13, 8, p. 2130-2136 7 p.

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Protein D
Transplants
Lung
Allografts
Innate Immunity
34 Citations (Scopus)

Essential Regulation of Lung Surfactant Homeostasis by the Orphan G Protein-Coupled Receptor GPR116

Yang, M. Y., Hilton, M. B., Seaman, S., Haines, D. C., Nagashima, K., Burks, C. M., Tessarollo, L., Ivanova, P. T., Brown, H. A., Umstead, T. M., Floros, J., Chroneos, Z. C. & St.Croix, B., May 30 2013, In : Cell Reports. 3, 5, p. 1457-1464 8 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Surface-Active Agents
Homeostasis
Lung
Lipids
6 Citations (Scopus)
varespladib methyl
Surface-Active Agents
Exons
Messenger RNA
Proteins
10 Citations (Scopus)

Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2

Silveyra, P. & Floros, J., Dec 1 2013, In : Gene. 531, 2, p. 126-132 7 p.

Research output: Contribution to journalReview article

Pulmonary Surfactant-Associated Protein A
Medical Genetics
varespladib methyl
Surface-Active Agents
Proteins
2 Citations (Scopus)

Highlights of early pulmonary surfactant: Research from bench to clinic

Noutsios, G. T. & Floros, J., Dec 1 2013, In : Pneumon. 26, 4, p. 350-354 5 p.

Research output: Contribution to journalReview article

Pulmonary Surfactants
Lung
Research
History
19 Citations (Scopus)

Pilot study exploring lung allograft surfactant protein A (SP-A) expression in association with lung transplant outcome

D'Ovidio, F., Kaneda, H., Chaparro, C., Mura, M., Lederer, D., Di Angelo, S., Takahashi, H., Gutierrez, C., Hutcheon, M., Singer, L. G., Waddell, T. K., Floros, J., Liu, M. & Keshavjee, S., Oct 2013, In : American Journal of Transplantation. 13, 10, p. 2722-2729 8 p.

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Proteins
Pulmonary Surfactant-Associated Protein A
Allografts
Transplants
Lung
2012
20 Citations (Scopus)

Air pollution and epigenetics: Effects on SP-A and innate host defence in the lung

Silveyra, P. & Floros, J., May 1 2012, In : Swiss Medical Weekly. 142, MAY, w13579.

Research output: Contribution to journalReview article

Air Pollution
Epigenomics
Ozone
Lung
Particulate Matter
21 Citations (Scopus)

Cyclic changes in the level of the innate immune molecule, surfactant protein-a, and cytokines in vaginal fluid

Macneill, C., de Guzman, G., Sousa, G. E., Umstead, T. M., Phelps, D., Floros, J., Ahn, K. & Weisz, J., Sep 1 2012, In : American Journal of Reproductive Immunology. 68, 3, p. 244-250 7 p.

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Protein A
Surface-Active Agents
Gonadal Hormones
Cytokines
Proteins
37 Citations (Scopus)

Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury

Silveyra, P. & Floros, J., Jan 1 2012, In : Frontiers in Bioscience. 17, 2, p. 407-429 23 p.

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Protein D
Acute Lung Injury
Lung Injury
Surface-Active Agents
Pulmonary diseases
18 Citations (Scopus)

Gonadal hormones and oxidative stress interaction differentially affects survival of male and female mice after lung Klebsiella Pneumoniae infection

Durrani, F., Phelps, D., Weisz, J., Silveyra, P., Hu, S., Mikerov, A. N. & Floros, J., May 1 2012, In : Experimental Lung Research. 38, 4, p. 165-172 8 p.

Research output: Contribution to journalArticle

Klebsiella Infections
Gonadal Hormones
Oxidative stress
Klebsiella pneumoniae
Dihydrotestosterone
12 Citations (Scopus)

IL-18R1 and IL-18RAP SNPs may be associated with bronchopulmonary dysplasia in African-American infants

Floros, J., Londono, D., Gordon, D., Silveyra, P., Diangelo, S. L., Viscardi, R. M., Worthen, G. S., Shenberger, J., Wang, G., Lin, Z. & Thomas, N. J., Jan 1 2012, In : Pediatric Research. 71, 1, p. 107-114 8 p.

Research output: Contribution to journalArticle

Bronchopulmonary Dysplasia
African Americans
Single Nucleotide Polymorphism
Infant, Newborn, Diseases
Genetic Association Studies
14 Citations (Scopus)

Impact of sex and ozone exposure on the course of pneumonia in wild type and SP-A (-/-) mice

Mikerov, A. N., Hu, S., Durrani, F., Gan, X., Wang, G., Umstead, T. M., Phelps, D. & Floros, J., Apr 1 2012, In : Microbial Pathogenesis. 52, 4, p. 239-249 11 p.

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Protein A
Ozone
Pneumonia
Lung
Spleen
12 Citations (Scopus)

Sex differences in the response of the alveolar macrophage proteome to treatment with exogenous surfactant protein-A

Phelps, D., Umstead, T. M. & Floros, J., Jul 23 2012, In : Proteome Science. 10, 1, 44.

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Protein A
Alveolar Macrophages
Proteome
Sex Characteristics
Knockout Mice
2011
9 Citations (Scopus)

Genetic Variants and Monoallelic Expression of Surfactant Protein-D in Inflammatory Bowel Disease

Lin, Z., John, G., Hegarty, J. P., Berg, A., Yu, W., Wang, Y., Kelly, A. A., Peterson, B., Poritz, L., Floros, J. & Koltun, W., Sep 1 2011, In : Annals of Human Genetics. 75, 5, p. 559-568 10 p.

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Protein D
Ulcerative Colitis
Inflammatory Bowel Diseases
Crohn Disease
Single Nucleotide Polymorphism
15 Citations (Scopus)
Ozone
Klebsiella pneumoniae
Sex Characteristics
Lung
Air
19 Citations (Scopus)
Alveolar Macrophages
Proteome
Knockout Mice
Actins
Proteins
31 Citations (Scopus)

Surfactant protein A is defective in abrogating inflammation in asthma

Wang, Y., Voelker, D. R., Lugogo, N. L., Wang, G., Floros, J., Ingram, J. L., Chu, H. W., Church, T. D., Kandasamy, P., Fertel, D., Wright, J. R. & Kraft, M., Oct 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 4, p. L598-L606

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Protein A
Asthma
Inflammation
Mycoplasma pneumoniae
Bronchoalveolar Lavage
4 Citations (Scopus)

Surfactant protein genetics in community-acquired pneumonia: Balancing the host inflammatory state

Floros, J. & Thomas, N. J., Apr 21 2011, In : Critical Care. 15, 2, 156.

Research output: Contribution to journalComment/debate

Pulmonary Surfactant-Associated Protein A
Surface-Active Agents
Pneumonia
Lung
Irritants
2 Citations (Scopus)

The toll of ozone

Umstead, T. M., Phelps, D. & Floros, J., Jan 1 2011, In : Pneumon. 24, 1, p. 17-23 7 p.

Research output: Contribution to journalEditorial

Ozone
11 Citations (Scopus)

The untranslated exon B of human surfactant protein A2 mRNAs is an enhancer for transcription and translation

Silveyra, P., Raval, M., Simmons, B., Diangelo, S., Wang, G. & Floros, J., Nov 1 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 5

Research output: Contribution to journalArticle

varespladib methyl
Surface-Active Agents
Exons
5' Untranslated Regions
Messenger RNA
2010
13 Citations (Scopus)

Differences in the BAL proteome after Klebsiella pneumoniae infection in wild type and SP-A-/- mice

Ali, M., Umstead, T. M., Haque, R., Mikerov, A. N., Freeman, W. M., Floros, J. & Phelps, D., Jun 17 2010, In : Proteome Science. 8, 34.

Research output: Contribution to journalArticle

Klebsiella Infections
Pulmonary Surfactant-Associated Protein A
Klebsiella pneumoniae
Bronchoalveolar Lavage
Proteome