If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research interests

Dr. John Richie's research focuses on the elucidation of factors that regulate cancer risk in individuals and in populations.

Using an interdisciplinary research approach, the aim is to identify the roles and mechanisms of key factors, alone and in combination, that impact cancer risk, with the ultimate goal of utilizing this information in the design and development of targeted prevention strategies.

The major areas of focus include aging, nutrition, tobacco and race/ethnicity as regulators or determinants of cancer risk. Particular emphasis is given to factors related to the generation of and protection against oxidative damage. In an ongoing molecular epidemiology study of tobacco-related cancers in black and white Americans, metabolic and genetic factors that may be responsible, in part, for observed racial differences in tobacco-related cancer rates are being investigated.

In other studies, Dr. Richie's team is examining the role of glutathione, the major endogenous antioxidant in nearly all cells and tissues, in protecting against oxidative damage during aging and its relationship with cancer development at numerous sites.

Fingerprint Dive into the research topics where John Richie is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 14 Similar Profiles
Glutathione Medicine & Life Sciences
Tobacco Products Medicine & Life Sciences
Smoking Medicine & Life Sciences
Smoke Medicine & Life Sciences
Tobacco Medicine & Life Sciences
Biomarkers Medicine & Life Sciences
Nicotine Medicine & Life Sciences
Blood Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 1991 2019

nicotine
science
mood
chemistry
anxiety

INTERDISCIPLINARY STUDIES IN CANCER EPIDEMIOLOGY

Richie, J., Zang, E., Djordjevic, M., Koo, L., Stellman, S. & Lazarus, P.

National Institutes of Health

9/8/958/31/08

Project: Research project

Tobacco
Epidemiology
Carcinogens
Neoplasms
Biomarkers

BPH GROWTH REGULATION MODEL

Richie, J. & Richie, J.

National Institutes of Health

9/30/929/29/98

Project: Research project

Hyperplasia
Intercellular Signaling Peptides and Proteins
Fibroblast Growth Factor 2
Growth
Transgenic Mice
Mouth Neoplasms
Biochemistry
Mouth
Mouth Mucosa
Neoplasms

Research Output 1981 2019

Are Ergothioneine Levels in Blood Associated with Chronic Peripheral Neuropathy in Colorectal Cancer Patients Who Underwent Chemotherapy?

Winkels, R., Van Brakel, L., Van Baar, H., Beelman, R. B., Van Duijnhoven, F. J. B., Geijsen, A., Van Halteren, H. K., Hansson, B. M. E., Richie, J., Sun, D., Wesselink, E., Van Zutphen, M., Kampman, E. & Kok, D. E., Jan 1 2019, In : Nutrition and cancer.

Research output: Contribution to journalArticle

Open Access
Ergothioneine
Peripheral Nervous System Diseases
Colorectal Neoplasms
Drug Therapy
Sample Size

Dietary methionine influences therapy in mouse cancer models and alters human metabolism

Gao, X., Sanderson, S. M., Dai, Z., Reid, M. A., Cooper, D. E., Lu, M., Richie, J., Ciccarella, A., Calcagnotto, A., Mikhael, P. G., Mentch, S. J., Liu, J., Ables, G., Kirsch, D. G., Hsu, D. S., Nichenametla, S. N. & Locasale, J. W., Aug 15 2019, In : Nature. 572, 7769, p. 397-401 5 p.

Research output: Contribution to journalLetter

Methionine
Neoplasms
Radiation
Therapeutics
Metabolic Networks and Pathways

Effect of cigarette rod length on smokers switching to SPECTRUM cigarettes

Hrabovsky, S., Midya, V., Lester, C., Veldheer, S., Yingst, J. M., Allen, S. I., Krebs, N. M., Liao, J. J., Reinhart, L., Modesto, J., Evins, A. E., Richie, J., Muscat, J., Horn, K. & Foulds, J., Mar 1 2019, In : American Journal of Health Behavior. 43, 2, p. 380-392 13 p.

Research output: Contribution to journalArticle

Tobacco Products
smoking
Group
nicotine
habits

Emissions of Free Radicals, Carbonyls, and Nicotine from the NIDA Standardized Research Electronic Cigarette and Comparison to Similar Commercial Devices

Bitzer, Z. T., Goel, R., Reilly, S. M., Bhangu, G., Trushin, N., Foulds, J., Muscat, J. & Richie, J., Jan 22 2019, In : Chemical Research in Toxicology. 32, 1, p. 130-138 9 p.

Research output: Contribution to journalReview article

National Institute on Drug Abuse (U.S.)
Aerosols
Nicotine
Tobacco Products
Free Radicals
2 Citations (Scopus)

Micronutrients and Bioactive Compounds in Mushrooms: A Recipe for Healthy Aging?

Beelman, R. B., Kalaras, M. D. & Richie, J., Jan 1 2019, In : Nutrition Today. 54, 1, p. 16-22 7 p.

Research output: Contribution to journalArticle

Ergothioneine
Micronutrients
Agaricales
Fungi
Soil