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Personal profile

Research interests

Dr. Jose Stoute is a physician scientist who is board-certified in internal medicine and infectious diseases. He began his career in malaria research during his infectious diseases fellowship at Walter Reed Army Medical Center and Walter Reed Army Institute of Research. Following the completion of his fellowship, Dr. Stoute was assigned to the Walter Reed Army Institute of Research, where he carried out studies on vaccine development in mouse models and clinical trials to test experimental vaccines in humans. From 1997 to 2003, he was assigned to the U.S. Army Medical Research Unit, Kenya, where he carried out clinical trials to test the efficacy of vaccines and drugs against malaria. During that time, he also began to study the pathogenesis of severe Plasmodium falciparum malaria in children with an emphasis on the role of complement regulators. His laboratory made significant discoveries on the role of complement receptor 1 (CR1) and other complement regulators on the pathogenesis and biology of the parasite and is now considered one of the leading laboratories in the field.

The role of complement in the biology and pathogenesis of malaria has continued to be a central focus of Dr. Stoute’s research. His long-term goal is to develop a highly effective vaccine against malaria that enhances the ability of the complement system to kill the parasite. His expertise spans clinical trials as well as basic molecular biology and immunology. 

Clinical interests

As an infectious disease physician, Dr. Jose Stoute is interested in general infectious disease topics, with special interest in malaria, babesia and other parasites.

Education/Academic qualification

Board Certified in Internal Medicine and Infectious Diseases, Global Health Innovation Technology Program

2018 → …

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Malaria Medicine & Life Sciences
Plasmodium falciparum Medicine & Life Sciences
Complement C1 Medicine & Life Sciences
Complement Receptors Medicine & Life Sciences
Erythrocytes Medicine & Life Sciences
Anemia Medicine & Life Sciences
Kenya Medicine & Life Sciences
Malaria Vaccines Medicine & Life Sciences

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Projects 2002 2009

Malaria
Biomedical Research
Kenya
Pediatrics
Education
Antigen-Antibody Complex
Anemia
Malaria
Cytokines
Complement System Proteins

Research Output 1982 2018

Complement Activation
Malaria
Immunity
Infection
Cerebral Malaria

Mechanisms of complement activation in malaria

Taylor, R. P., Stoute, J. & Lindorfer, M. A., Jan 1 2018, Complement Activation in Malaria Immunity and Pathogenesis. Springer International Publishing, p. 31-49 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Complement Activation
Malaria
Alternative Complement Pathway
Erythrocytes
Complement Hemolytic Activity Assay

Mechanisms of Complement Activation in Malaria

Taylor, RP., Stoute, J. & Lindorfer, MA., 2018, Complement Activation in Malaria Immunity and Pathogenesis. 1 ed. Springer International Publishing, p. 31-49

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Plasmodium falciparum strains spontaneously switch invasion phenotype in suspension culture

Awandare, G. A., Nyarko, P. B., Aniweh, Y., Ayivor-Djanie, R. & Stoute, J. A., Dec 1 2018, In : Scientific reports. 8, 1, 5782.

Research output: Contribution to journalArticle

N-Acetylneuraminic Acid
Plasmodium falciparum
Suspensions
Phenotype
Reticulocytes