Joseph M. Bollinger, Jr.

    • United States

    • 9032 Citations
    • 53 h-Index
    1989 …2020
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    Research Output 1989 2020

    2010
    17 Citations (Scopus)

    Biochemistry: Getting the metal right

    Bollinger, Jr., J. M., May 6 2010, In : Nature. 465, 7294, p. 40-41 2 p.

    Research output: Contribution to journalShort survey

    Methylococcus capsulatus
    methanogenic bacterium
    Carbon Cycle
    Oxygenases
    biochemistry
    40 Citations (Scopus)

    Cryoreduction of the NO-Adduct of Taurine: α-Ketoglutarate Dioxygenase (TauD) Yields an Elusive {FeNO}8 Species

    Ye, S., Price, J. C., Barr, E. W., Green, M. T., Bollinger, J. M., Krebs, C. & Neese, F., Apr 7 2010, In : Journal of the American Chemical Society. 132, 13, p. 4739-4751 13 p.

    Research output: Contribution to journalArticle

    Dioxygenases
    Taurine
    Reaction intermediates
    Enzymes
    Ground state
    49 Citations (Scopus)

    Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

    Flashman, E., Hoffart, L. M., Hamed, R. B., Bollinger, J. M., Krebs, C. & Schofield, C. J., Oct 2010, In : FEBS Journal. 277, 19, p. 4089-4099 11 p.

    Research output: Contribution to journalArticle

    Hypoxia-Inducible Factor-Proline Dioxygenases
    Prolyl Hydroxylases
    Oxygenases
    Oxygen
    Oxygen sensors
    41 Citations (Scopus)
    Nitrobenzoates
    Streptomyces
    Electrons
    Oxygenases
    para-Aminobenzoates
    3 Citations (Scopus)

    Remote enzyme microsurgery

    Bollinger, J. M. & Matthews, M. L., Mar 12 2010, In : Science. 327, 5971, p. 1337-1338 2 p.

    Research output: Contribution to journalShort survey

    Microsurgery
    Coenzymes
    Amino Acids
    Enzymes
    Proteins
    84 Citations (Scopus)

    Substrate activation by iron superoxo intermediates

    van der Donk, W. A., Krebs, C. & Bollinger, Jr., J. M., Dec 1 2010, In : Current Opinion in Structural Biology. 20, 6, p. 673-683 11 p.

    Research output: Contribution to journalReview article

    Iron
    Oxygenases
    Superoxides
    Hydrogen
    Oxidoreductases
    20 Citations (Scopus)

    The nonribosomal peptide synthetase enzyme DdaD tethers N β-fumaramoyl-l -2,3-diaminopropionate for Fe(II)/α- ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis

    Hollenhorst, M. A., Bumpus, S. B., Matthews, M. L., Bollinger, Jr., J. M., Kelleher, N. L. & Walsh, C. T., Nov 10 2010, In : Journal of the American Chemical Society. 132, 44, p. 15773-15781 9 p.

    Research output: Contribution to journalArticle

    Peptide Synthases
    Epoxidation
    Biosynthesis
    Antibiotics
    Peptides
    19 Citations (Scopus)
    Ribonucleotide Reductases
    Hydroxyurea
    Chlamydia trachomatis
    Electrons
    Proteins
    2009
    50 Citations (Scopus)

    A long-lived, substrate-hydroxylating peroxodiiron(III/III) intermediate in the amine oxygenase, AurF, from Streptomyces thioluteus

    Korboukh, V. K., Li, N., Barr, E. W., Bollinger, J. M. & Krebs, C., Oct 13 2009, In : Journal of the American Chemical Society. 131, 38, p. 13608-13609 2 p.

    Research output: Contribution to journalArticle

    para-Aminobenzoates
    Oxygenases
    Streptomyces
    Nitrobenzoates
    Amines
    10 Citations (Scopus)

    Freeze-quench 57Fe-Mössbauer spectroscopy: Trapping reactive intermediates

    Krebs, C. & Bollinger, J. M., Nov 1 2009, In : Photosynthesis research. 102, 2, p. 295-304 10 p.

    Research output: Contribution to journalReview article

    trapping
    spectroscopy
    Spectrum Analysis
    Iron
    Spectroscopy
    20 Citations (Scopus)

    Frontiers in enzymatic C-H-bond activation

    Bollinger, J. M. & Broderick, J. B., Feb 1 2009, In : Current Opinion in Chemical Biology. 13, 1, p. 51-57 7 p.

    Research output: Contribution to journalEditorial

    Chemical activation
    Enzymes
    28 Citations (Scopus)

    Kinetic analysis of cysteine desulfurase CD0387 from Synechocystis sp. PCC 6803: Formation of the persulfide intermediate

    Behshad, E. & Bollinger, Jr., J. M., Dec 22 2009, In : Biochemistry. 48, 50, p. 12014-12023 10 p.

    Research output: Contribution to journalArticle

    Synechocystis
    Kinetics
    Isotopes
    Enzymes
    Sulfhydryl Compounds
    35 Citations (Scopus)

    Kinetic mechanism of ornithine hydroxylase (PvdA) from Pseudomonas aeruginosa: Substrate triggering of O2 addition but not flavin reduction

    Meneely, K. M., Barr, E. W., Bollinger, J. M. & Lamb, A. L., May 26 2009, In : Biochemistry. 48, 20, p. 4371-4376 6 p.

    Research output: Contribution to journalArticle

    Ornithine
    Mixed Function Oxygenases
    Kinetics
    Substrates
    NADP
    52 Citations (Scopus)

    Myo-Inositol oxygenase: A radical new pathway for O2 and C-H activation at a nonheme diiron cluster

    Bollinger, Jr., J. M., Diao, Y., Matthews, M. L., Xing, G. & Krebs, C., Mar 24 2009, In : Dalton Transactions. 6, p. 905-914 10 p.

    Research output: Contribution to journalArticle

    Inositol Oxygenase
    Inositol
    Chemical activation
    Cell signaling
    Glucuronic Acid
    125 Citations (Scopus)

    Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2

    Matthews, M. L., Neumann, C. S., Miles, L. A., Grove, T. L., Booker, S. J., Krebs, C., Walsh, C. T. & Bollinger, J. M., Oct 20 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 42, p. 17723-17728 6 p.

    Research output: Contribution to journalArticle

    Halogenation
    Hydroxylation
    Halogens
    Mixed Function Oxygenases
    Ligands
    144 Citations (Scopus)

    Substrate-triggered formation and remarkable stability of the C-H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2

    Matthews, M. L., Krest, C. M., Barr, E. W., Vaillancourt, F. H., Walsh, C. T., Green, M. T., Krebs, C. & Bollinger, J. M., May 26 2009, In : Biochemistry. 48, 20, p. 4331-4343 13 p.

    Research output: Contribution to journalArticle

    Carrier Proteins
    Amino Acids
    Peptide Synthases
    Substrates
    Extended X ray absorption fine structure spectroscopy
    2008
    32 Citations (Scopus)

    Biochemistry: Electron relay in proteins

    Bollinger, J. M., Jun 27 2008, In : Science. 320, 5884, p. 1730-1731 2 p.

    Research output: Contribution to journalShort survey

    Biochemistry
    Electrons
    Proteins
    40 Citations (Scopus)

    Branched activation- and catalysis-specific pathways for electron relay to the manganese/iron cofactor in ribonucleotide reductase from Chlamydia trachomatis

    Jiang, W., Saleh, L., Barr, E. W., Xie, J., Gardner, M. M., Krebs, C. & Bollinger, Jr., J. M., Aug 19 2008, In : Biochemistry. 47, 33, p. 8477-8484 8 p.

    Research output: Contribution to journalArticle

    Ribonucleotide Reductases
    Chlamydia trachomatis
    Manganese
    Catalysis
    Iron
    1 Citation (Scopus)

    Characterization of the kinetics of Fe (II) binding by the R2 protein subunit of E. coli ribonucleotide reductase

    Chaudhuri, D. & Bollinger, Jr., J. M., Jul 1 2008, In : Hyperfine Interactions. 185, 1-3, p. 57-62 6 p.

    Research output: Contribution to journalArticle

    Ribonucleotide Reductases
    Protein Subunits
    Escherichia coli
    proteins
    Kinetics
    40 Citations (Scopus)

    Formation and function of the manganese(iv)/iron(iii) cofactor in chlamydia trachomatis ribonucleotide reductase

    Jiang, W., Yun, D., Saleh, L., Martin Bollinger, J. & Krebs, C., Dec 30 2008, In : Biochemistry. 47, 52, p. 13736-13744 9 p.

    Research output: Contribution to journalReview article

    Ribonucleotide Reductases
    Chlamydia trachomatis
    Manganese
    Iron
    Electrons
    37 Citations (Scopus)

    Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues

    Graci, J. D., Too, K., Smidansky, E. D., Edathil, J. P., Barr, E. W., Harki, D. A., Galarraga, J. E., Bollinger, J. M., Peterson, B. R., Loakes, D., Brown, D. M. & Cameron, C. E., Mar 1 2008, In : Antimicrobial agents and chemotherapy. 52, 3, p. 971-979 9 p.

    Research output: Contribution to journalArticle

    Purine Nucleosides
    Picornaviridae
    Poliovirus
    Mutation Rate
    Mutagenesis
    28 Citations (Scopus)

    Rapid and quantitative activation of Chlamydia trachomatis ribonucleotide reductase by hydrogen peroxide

    Jiang, W., Xie, J., Nørgaard, H., Bollinger, Jr., J. M. & Krebs, C., Apr 15 2008, In : Biochemistry. 47, 15, p. 4477-4483 7 p.

    Research output: Contribution to journalArticle

    Ribonucleotide Reductases
    Chlamydia trachomatis
    Hydrogen Peroxide
    Biochemistry
    Chemical activation
    48 Citations (Scopus)
    Extended X ray absorption fine structure spectroscopy
    Ribonucleotide Reductases
    Chlamydia trachomatis
    Structural analysis
    Density functional theory
    48 Citations (Scopus)
    Ribonucleotide Reductases
    Chlamydia trachomatis
    Manganese
    Protons
    Iron
    2007
    52 Citations (Scopus)

    (μ-1,2-peroxo)diiron(III/IIl) complex as a precursor to the diiron(III/IV) intermediate X in the assembly of the iron-radical cofactor of ribonucleotide reductase from mouse

    Yun, D., García-Serres, R., Chicalese, B. M., An, Y. H., Huynh, B. H. & Bollinger, Jr., J. M., Feb 20 2007, In : Biochemistry. 46, 7, p. 1925-1932 8 p.

    Research output: Contribution to journalArticle

    acyl-(acyl-carrier-protein)desaturase
    methane monooxygenase
    Acyl Carrier Protein
    Ribonucleotide Reductases
    Oxygenases
    4 Citations (Scopus)

    Addition of oxygen to the diiron(II/II) cluster is the slowest step in formation of the tyrosyl radical in the W103Y variant of ribonucleotide reductase protein R2 from mouse

    Yun, D., Saleh, L., Garcia-Serres, R., Chicalese, B. M., An, Y. H., Boi, H. H. & Bollinger, Jr., J. M., Nov 13 2007, In : Biochemistry. 46, 45, p. 13067-13073 7 p.

    Research output: Contribution to journalArticle

    Ribonucleotide Reductases
    Electron injection
    Substitution reactions
    Electrons
    Oxygen
    140 Citations (Scopus)

    A manganese(IV)/iron(III) cofactor in Chlamydia trachomatis ribonucleotide reductase

    Jiang, W., Yun, D., Saleh, L., Barr, E. W., Xing, G., Hoffart, L. M., Maslak, M. A., Krebs, C. & Bollinger, J. M., May 25 2007, In : Science. 316, 5828, p. 1188-1191 4 p.

    Research output: Contribution to journalArticle

    Ribonucleotide Reductases
    Chlamydia trachomatis
    Manganese
    Iron
    Cysteine
    58 Citations (Scopus)

    A manganese(IV)/iron(IV) intermediate in assembly of the manganese(IV)/iron(III) cofactor of Chlamydia trachomatis ribonucleotide reductase

    Jiang, W., Hoffart, L. M., Krebs, C. & Bollinger, Jr., J. M., Jul 31 2007, In : Biochemistry. 46, 30, p. 8709-8716 8 p.

    Research output: Contribution to journalArticle

    Ribonucleotide Reductases
    Chlamydia trachomatis
    Reducing Agents
    Pathogens
    Manganese
    28 Citations (Scopus)

    AurF from Streptomyces thioluteus and a possible new family of manganese/iron oxygenases

    Krebs, C., Matthews, M. L., Jiang, W. & Bollinger, Jr., J. M., Sep 18 2007, In : Biochemistry. 46, 37, p. 10413-10418 6 p.

    Research output: Contribution to journalArticle

    Oxygenases
    Streptomyces
    Manganese
    Iron
    Chlamydia trachomatis
    61 Citations (Scopus)

    CD and MCD of CytC3 and taurine dioxygenase: Role of the facial triad in α-KG-dependent oxygenases

    Neidig, M. L., Brown, C. D., Light, K. M., Fujimori, D. G., Nolan, E. M., Price, J. C., Barr, E. W., Bollinger, J. M., Krebs, C., Walsh, C. T. & Solomon, E. I., Nov 21 2007, In : Journal of the American Chemical Society. 129, 46, p. 14224-14231 8 p.

    Research output: Contribution to journalArticle

    Dioxygenases
    Oxygenases
    Taurine
    Catalytic Domain
    Hydroxylation
    130 Citations (Scopus)

    Direct spectroscopic evidence for a high-spin Fe(IV) intermediate in tyrosine hydroxylase

    Eser, B. E., Barr, E. W., Frantom, P. A., Saleh, L., Bollinger, Jr., J. M., Krebs, C. & Fitzpatrick, P. F., Sep 19 2007, In : Journal of the American Chemical Society. 129, 37, p. 11334-11335 2 p.

    Research output: Contribution to journalArticle

    Hydroxylation
    Tyrosine 3-Monooxygenase
    Aromatic Amino Acids
    Dihydroxyphenylalanine
    Mixed Function Oxygenases
    107 Citations (Scopus)

    Enzymatic C-H activation by metal-superoxo intermediates

    Bollinger, Jr., J. M. & Krebs, C., Apr 1 2007, In : Current Opinion in Chemical Biology. 11, 2, p. 151-158 8 p.

    Research output: Contribution to journalReview article

    Metalloids
    Metals
    Chemical activation
    Arsenals
    Oxidation
    569 Citations (Scopus)

    Non-heme Fe(IV)-oxo intermediates

    Krebs, C., Fujimori, D. G., Walsh, C. T. & Bollinger, Jr., J. M., Jul 1 2007, In : Accounts of Chemical Research. 40, 7, p. 484-492 9 p.

    Research output: Contribution to journalArticle

    Hydroxylation
    Halogenation
    Substrates
    Iron
    Oxygenases
    129 Citations (Scopus)
    Dioxygenases
    Taurine
    Escherichia coli
    Ligands
    Density functional theory
    55 Citations (Scopus)
    Ribonucleotide Reductases
    Dimers
    Electronic structure
    Paramagnetic resonance
    Catalytic Domain
    91 Citations (Scopus)

    Spectroscopic evidence for a high-spin Br-Fe(IV)-OxO intermediate in the α-ketoglutarate-dependent halogenase CytC3 from Streptomyces

    Fujimori, D. G., Barr, E. W., Matthews, M. L., Koch, G. M., Yonce, J. R., Walsh, C. T., Bollinger, J. M., Krebs, C. & Riggs-Gelasco, P. J., Nov 7 2007, In : Journal of the American Chemical Society. 129, 44, p. 13408-13409 2 p.

    Research output: Contribution to journalArticle

    X-Ray Absorption Spectroscopy
    Dioxygenases
    Reaction intermediates
    X ray absorption spectroscopy
    Streptomyces
    41 Citations (Scopus)
    Ribonucleotide Reductases
    Chlamydia trachomatis
    Ground state
    Proteins
    Nucleotides
    220 Citations (Scopus)

    Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3

    Galonić, D. P., Barr, E. W., Walsh, C. T., Bollinger, Jr., J. M. & Krebs, C., Jan 1 2007, In : Nature Chemical Biology. 3, 2, p. 113-116 4 p.

    Research output: Contribution to journalArticle

    Halogenation
    Iron
    Halogens
    Streptomyces
    Enzymes
    2006
    39 Citations (Scopus)

    A coupled dinuclear iron cluster that is perturbed by substrate binding in myo-inositol oxygenase

    Xing, G., Hoffart, L. M., Diao, Y., Prabhu, K. S., Arner, R. J., Reddy, C. C., Krebs, C. & Bollinger, Jr., J. M., May 2 2006, In : Biochemistry. 45, 17, p. 5393-5401 9 p.

    Research output: Contribution to journalArticle

    Inositol Oxygenase
    Inositol
    acyl-(acyl-carrier-protein)desaturase
    Iron
    methane monooxygenase
    12 Citations (Scopus)
    Ribonucleotide Reductases
    Escherichia coli Proteins
    Escherichia coli
    Cations
    Nucleotides
    10 Citations (Scopus)

    Demonstration by 2H ENDOR spectroscopy that myo-inositol binds via an alkoxide bridge to the mixed-valent diiron center of myo-inositol oxygenase

    Kim, S. H., Xing, G., Bollinger, J. M., Krebs, C. & Hoffman, B. M., Aug 16 2006, In : Journal of the American Chemical Society. 128, 32, p. 10374-10375 2 p.

    Research output: Contribution to journalArticle

    Inositol Oxygenase
    Electron Spin Resonance Spectroscopy
    Inositol
    Spectrum Analysis
    Demonstrations
    228 Citations (Scopus)

    Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylase

    Hoffart, L. M., Barr, E. W., Guyer, R. B., Bollinger, J. M. & Krebs, C., Oct 3 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 40, p. 14738-14743 6 p.

    Research output: Contribution to journalArticle

    Prolyl Hydroxylases
    Dioxygenases
    Taurine
    Hydroxylation
    Enzymes
    86 Citations (Scopus)

    Evidence for C-H cleavage by an iron-superoxide complex in the glycol cleavage reaction catalyzed by myo-inositol oxygenase

    Xing, G., Diao, Y., Hoffart, L. M., Barr, E. W., Prabhu, K. S., Arner, R. J., Reddy, C. C., Krebs, C. & Bollinger, J. M., Apr 18 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 16, p. 6130-6135 6 p.

    Research output: Contribution to journalArticle

    Inositol Oxygenase
    Glycols
    Inositol
    Superoxides
    Iron
    78 Citations (Scopus)

    Flavin redox chemistry precedes substrate chlorination during the reaction of the flavin-dependent halogenase RebH

    Yeh, E., Cole, L. J., Barr, E. W., Bollinger, J. M., Ballou, D. P. & Walsh, C. T., Jun 27 2006, In : Biochemistry. 45, 25, p. 7904-7912 9 p.

    Research output: Contribution to journalArticle

    Flavin-Adenine Dinucleotide
    Chlorination
    Halogenation
    Oxidation-Reduction
    Tryptophan
    38 Citations (Scopus)

    Oxygen activation by a mixed-valent, diiron(II/III) cluster in the glycol cleavage reaction catalyzed by myo-inositol oxygenase

    Xing, G., Barr, E. W., Diao, Y., Hoffart, L. M., Prabhu, K. S., Arner, R. J., Reddy, C. C., Krebs, C. & Bollinger, J. M., May 2 2006, In : Biochemistry. 45, 17, p. 5402-5412 11 p.

    Research output: Contribution to journalArticle

    Inositol Oxygenase
    Glycols
    Inositol
    Chemical activation
    Oxygen
    101 Citations (Scopus)

    Stalking intermediates in oxygen activation by iron enzymes: Motivation and method

    Bollinger, J. M. & Krebs, C., Apr 1 2006, In : Journal of Inorganic Biochemistry. 100, 4, p. 586-605 20 p.

    Research output: Contribution to journalReview article

    Stalking
    Enzyme Activation
    Motivation
    Iron
    Chemical activation
    2005
    118 Citations (Scopus)

    Kinetic dissection of the catalytic mechanism of taurine:α- ketoglutarate dioxygenase (TauD) from Escherichia coli

    Price, J. C., Barr, E. W., Hoffart, L. M., Krebs, C. & Bollinger, J. M., Jun 7 2005, In : Biochemistry. 44, 22, p. 8138-8147 10 p.

    Research output: Contribution to journalArticle

    Dioxygenases
    Dissection
    Taurine
    Escherichia coli
    Kinetics
    129 Citations (Scopus)

    Mechanism of taurine: α-ketoglutarate dioxygenase (TauD) from Escherichia coli

    Bollinger, Jr., J. M., Price, J. C., Hoffart, L. M., Barr, E. W. & Krebs, C., Nov 4 2005, In : European Journal of Inorganic Chemistry. 21, p. 4245-4254 10 p.

    Research output: Contribution to journalShort survey

    Dioxygenases
    Taurine
    Escherichia coli
    Hydroxylation
    Substrates
    100 Citations (Scopus)

    Rapid freeze-quench 57Fe Mössbauer spectroscopy: Monitoring changes of an iron-containing active site during a biochemical reaction

    Krebs, C., Price, J. C., Baldwin, J., Saleh, L., Green, M. T. & Bollinger, J. M., Feb 21 2005, In : Inorganic chemistry. 44, 4, p. 742-757 16 p.

    Research output: Contribution to journalReview article

    Iron
    Spectroscopy
    iron
    Monitoring
    spectroscopy
    7 Citations (Scopus)

    Structure of Escherichia coli ribonucleotide reductase R2 in space group P6122

    Sommerhalter, M., Saleh, L., Bollinger, J. M. & Rosenzweig, A. C., Dec 1 2005, In : Acta Crystallographica Section D: Biological Crystallography. 61, 12, p. 1649-1654 6 p.

    Research output: Contribution to journalArticle

    Ribonucleotide Reductases
    Escherichia
    Crystallization
    Escherichia coli
    Metals