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Research Output 2001 2020

219 Citations (Scopus)

Hepatotoxicity of high oral dose (-)-epigallocatechin-3-gallate in mice

Lambert, J. D., Kennett, M. J., Sang, S., Reuhl, K. R., Ju, J. & Yang, C. S., Jan 1 2010, In : Food and Chemical Toxicology. 48, 1, p. 409-416 8 p.

Research output: Contribution to journalArticle

hepatotoxicity
epigallocatechin
mouth
mice
dosage

Impact of electronic cigarette heating coil resistance on the production of reactive carbonyls, reactive oxygen species and induction of cytotoxicity in human lung cancer cells in vitro

Cirillo, S., Urena, J. F., Lambert, J. D., Vivarelli, F., Canistro, D., Paolini, M., Cardenia, V., Rodriguez-Estrada, M. T., Richie, J. P. & Elias, R. J., Dec 2019, In : Regulatory Toxicology and Pharmacology. 109, 104500.

Research output: Contribution to journalArticle

Cytotoxicity
Tobacco Products
Heating
Reactive Oxygen Species
Lung Neoplasms
4 Citations (Scopus)

Impact of roasting on the flavan-3-ol composition, sensory-related chemistry, and in vitro pancreatic lipase inhibitory activity of cocoa beans

Stanley, T. H., Van Buiten, C. B., Baker, S. A., Elias, R., Anantheswaran, R. C. & Lambert, J. D., Jul 30 2018, In : Food Chemistry. 255, p. 414-420 7 p.

Research output: Contribution to journalArticle

Cocoa
cocoa beans
roasting
Lipase
triacylglycerol lipase
7 Citations (Scopus)
Fragaria
Powders
Blood Vessels
Meals
Cardiovascular Diseases
374 Citations (Scopus)

Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.

Lambert, J. D., Hong, J., Yang, G. Y., Liao, J. & Yang, C. S., Jan 1 2005, In : The American journal of clinical nutrition. 81, 1 Suppl

Research output: Contribution to journalReview article

Polyphenols
Carcinogenesis
Tea
Curcumin
Biological Availability
110 Citations (Scopus)

Inhibition of carcinogenesis by tea constituents

Ju, J., Lu, G., Lambert, J. D. & Yang, C. S., Oct 1 2007, In : Seminars in Cancer Biology. 17, 5, p. 395-402 8 p.

Research output: Contribution to journalReview article

Tea
Carcinogenesis
Neoplasms
Animal Models
Catechin
107 Citations (Scopus)

Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: Structure-activity relationship and molecular-modeling studies

Chen, D., Wang, C. Y., Lambert, J. D., Ai, N., Welsh, W. J. & Yang, C. S., May 15 2005, In : Biochemical Pharmacology. 69, 10, p. 1523-1531 9 p.

Research output: Contribution to journalArticle

Catechol O-Methyltransferase
Molecular modeling
Catechin
Tea
Structure-Activity Relationship
36 Citations (Scopus)

Inhibition of intestinal tumorigenesis in ApcMin/+ mice by green tea polyphenols (Polyphenon E) and individual catechins

Hao, X., Bose, M., Lambert, J. D., Ju, J., Lu, G., Lee, M. J., Park, S., Husain, A., Wang, S., Sun, Y. & Yang, C. S., Jan 1 2007, In : Nutrition and cancer. 59, 1, p. 62-69 8 p.

Research output: Contribution to journalArticle

Catechin
Polyphenols
Tea
Carcinogenesis
Drinking
94 Citations (Scopus)

Inhibition of key digestive enzymes by cocoa extracts and procyanidins

Gu, Y., Hurst, W. J., Stuart, D. A. & Lambert, J. D., May 25 2011, In : Journal of agricultural and food chemistry. 59, 10, p. 5305-5311 7 p.

Research output: Contribution to journalArticle

Cocoa
Proanthocyanidins
procyanidins
digestive enzymes
Lipase
31 Citations (Scopus)

Inhibition of lung cancer growth in mice by dietary mixed tocopherols

Lambert, J. D., Lu, G., Lee, M. J., Hu, J., Ju, J. & Yang, C. S., Aug 1 2009, In : Molecular Nutrition and Food Research. 53, 8, p. 1030-1035 6 p.

Research output: Contribution to journalArticle

Tocopherols
lung neoplasms
tocopherols
Lung Neoplasms
mice
20 Citations (Scopus)

Inhibition of pancreatic lipase by black tea theaflavins: Comparative enzymology and in silico modeling studies

Glisan, S. L., Grove, K. A., Yennawar, N. H. & Lambert, J. D., Feb 1 2017, In : Food Chemistry. 216, p. 296-300 5 p.

Research output: Contribution to journalArticle

theaflavins
enzymology
black tea
Tea
Lipase
5 Citations (Scopus)
Secretory Phospholipase A2
Proanthocyanidins
phospholipase A2
Phospholipases A2
proanthocyanidins
70 Citations (Scopus)

Inhibition of starch digestion by the green tea polyphenol, (-)-epigallocatechin-3-gallate

Forester, S. C., Gu, Y. & Lambert, J. D., Nov 1 2012, In : Molecular Nutrition and Food Research. 56, 11, p. 1647-1654 8 p.

Research output: Contribution to journalArticle

epigallocatechin
Polyphenols
green tea
Tea
Starch
35 Citations (Scopus)

Inhibition of tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate and fish oil

Bose, M., Hao, X., Ju, J., Husain, A., Park, S., Lambert, J. D. & Yang, C. S., Sep 19 2007, In : Journal of agricultural and food chemistry. 55, 19, p. 7695-7700 6 p.

Research output: Contribution to journalArticle

Fish Oils
epigallocatechin
fish oils
carcinogenesis
Carcinogenesis
3 Citations (Scopus)
Open Access
Persea
avocados
seed extracts
Seeds
Antioxidants
125 Citations (Scopus)

Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites

Hong, J., Lambert, J. D., Lee, S. H., Sinko, P. J. & Yang, C. S., Oct 10 2003, In : Biochemical and Biophysical Research Communications. 310, 1, p. 222-227 6 p.

Research output: Contribution to journalArticle

Multidrug Resistance-Associated Proteins
Metabolites
verlukast
Indomethacin
epigallocatechin gallate
123 Citations (Scopus)

Laboratory, epidemiological, and human intervention studies show that tea (Camellia sinensis) may be useful in the prevention of obesity

Grove, K. A. & Lambert, J. D., Mar 1 2010, In : Journal of Nutrition. 140, 3, p. 446-453 8 p.

Research output: Contribution to journalReview article

Camellia sinensis
Tea
Obesity
Polyphenols
Theaceae
11 Citations (Scopus)

Loss of Native Flavanols during Fermentation and Roasting Does Not Necessarily Reduce Digestive Enzyme-Inhibiting Bioactivities of Cocoa

Ryan, C. M., Khoo, W., Ye, L., Lambert, J. D., Okeefe, S. F. & Neilson, A. P., May 11 2016, In : Journal of agricultural and food chemistry. 64, 18, p. 3616-3625 10 p.

Research output: Contribution to journalArticle

Cocoa
Enzyme inhibition
roasting
digestive enzymes
Polyphenols
383 Citations (Scopus)

Mechanisms of cancer prevention by tea constituents

Lambert, J. D. & Yang, C. S., Oct 1 2003, In : Journal of Nutrition. 133, 10

Research output: Contribution to journalArticle

Tea
Polyphenols
Neoplasms
Carcinogenesis
Camellia sinensis
55 Citations (Scopus)

Metabolism of dietary polyphenols and possible interactions with drugs

Lambert, J. D., Sang, S., Lu, A. Y. H. & Yang, C. S., Jun 1 2007, In : Current Drug Metabolism. 8, 5, p. 499-507 9 p.

Research output: Contribution to journalReview article

Polyphenols
Drug Interactions
Metabolism
Pharmaceutical Preparations
Polyphenolic compounds
Tea
Liver
Fats
Nuclear Respiratory Factor 1
Sirtuin 1
33 Citations (Scopus)

Modulation of metabolic syndrome-related inflammation by cocoa

Gu, Y. & Lambert, J. D., Jun 1 2013, In : Molecular Nutrition and Food Research. 57, 6, p. 948-961 14 p.

Research output: Contribution to journalReview article

metabolic syndrome
anti-inflammatory activity
Anti-Inflammatory Agents
inflammation
Polyphenols
127 Citations (Scopus)

Molecular targets for the cancer preventive activity of tea polyphenols

Yang, C. S., Lambert, J. D., Hou, Z., Ju, J., Lu, G. & Hao, X., Jun 1 2006, In : Molecular Carcinogenesis. 45, 6, p. 431-435 5 p.

Research output: Contribution to journalArticle

Polyphenols
Tea
Neoplasms
Animal Models
Cell Culture Techniques
21 Citations (Scopus)

N-Acetylcysteine enhances the lung cancer inhibitory effect of epigallocatechin-3-gallate and forms a new adduct

Lambert, J. D., Sang, S. & Yang, C. S., Mar 15 2008, In : Free Radical Biology and Medicine. 44, 6, p. 1069-1074 6 p.

Research output: Contribution to journalArticle

Acetylcysteine
Lung Neoplasms
Cells
Cell culture
epigallocatechin gallate
2 Citations (Scopus)

Neuroprotective Properties of Dietary Polyphenols in Parkinson's Disease

Darvesh, A. S., Mcclure, M., Sadana, P., Paxos, C., Geldenhuys, W. J., Lambert, J. D., Haqqi, T. M. & Richardson, J. R., Jan 2 2017, Neuroprotective Effects of Phytochemicals in Neurological Disorders. wiley, p. 243-263 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Polyphenols
Parkinson Disease
Dopaminergic Neurons
Tea
Curcuma
23 Citations (Scopus)

Nordihydroguaiaretic acid: A review of its numerous and varied biological activities

Lambert, J. D., Dorr, R. T. & Timmermann, B. N., Apr 1 2004, In : Pharmaceutical Biology. 42, 2, p. 149-158 10 p.

Research output: Contribution to journalReview article

nordihydroguaiaretic acid
Masoprocol
Bioactivity
bioactive properties
Zygophyllaceae
60 Citations (Scopus)

Nordihydroguaiaretic acid: Hepatotoxicity and detoxification in the mouse

Lambert, J. D., Zhao, D., Meyers, R. O., Kuester, R. K., Timmermann, B. N. & Dorr, R. T., Dec 1 2002, In : Toxicon. 40, 12, p. 1701-1708 8 p.

Research output: Contribution to journalArticle

Masoprocol
Detoxification
Larrea
Acids
Metabolism
109 Citations (Scopus)

Peracetylation as a means of enhancing in vitro bioactivity and bioavailability of epigallocatechin-3-gallate

Lambert, J. D., Sang, S., Hong, J., Kwon, S. J., Lee, M. J., Ho, C. T. & Yang, C. S., Dec 1 2006, In : Drug Metabolism and Disposition. 34, 12, p. 2111-2116 6 p.

Research output: Contribution to journalArticle

Biological Availability
In Vitro Techniques
epigallocatechin gallate
Camellia sinensis
HCT116 Cells
1 Citation (Scopus)

Perseorangin: A natural pigment from avocado (Persea americana) seed

Hatzakis, E., Mazzola, E. P., Shegog, R. M., Ziegler, G. R. & Lambert, J. D., Sep 30 2019, In : Food Chemistry. 293, p. 15-22 8 p.

Research output: Contribution to journalArticle

Persea
Persea americana
avocados
Pigments
seed extracts
16 Citations (Scopus)

Pharmacokinetic analysis by high-performance liquid chromatography of intravenous nordihydroguaiaretic acid in the mouse

Lambert, J. D., Meyers, R. O., Timmermann, B. N. & Dorr, R. T., Apr 15 2001, In : Journal of Chromatography B: Biomedical Sciences and Applications. 754, 1, p. 85-90 6 p.

Research output: Contribution to journalArticle

Masoprocol
Pharmacokinetics
High performance liquid chromatography
Plasmas
Arachidonate 5-Lipoxygenase
159 Citations (Scopus)

Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice

Lambert, J. D., Hong, J., Kim, D. H., Mishin, V. M. & Yang, C. S., Aug 1 2004, In : Journal of Nutrition. 134, 8, p. 1948-1952 5 p.

Research output: Contribution to journalArticle

piperine
Polyphenols
Tea
Biological Availability
epigallocatechin gallate
159 Citations (Scopus)

Possible controversy over dietary polyphenols: Benefits vs risks

Lambert, J. D., Sang, S. & Yang, C. S., Apr 1 2007, In : Chemical research in toxicology. 20, 4, p. 583-585 3 p.

Research output: Contribution to journalShort survey

Phenols
Polyphenols
Tea
Flavonoids
Gastrointestinal Tract
82 Citations (Scopus)

Possible mechanisms of the cancer-preventive activities of green tea

Yang, C. S., Sang, S., Lambert, J. D., Hou, Z., Ju, J. & Lu, G., Feb 1 2006, In : Molecular Nutrition and Food Research. 50, 2, p. 170-175 6 p.

Research output: Contribution to journalReview article

epigallocatechin
green tea
Tea
tea
neoplasms
9 Citations (Scopus)

Potential role of the mitochondria as a target for the hepatotoxic effects of (-)-epigallocatechin-3-gallate in mice

James, K. D., Kennett, M. J. & Lambert, J. D., Jan 1 2018, In : Food and Chemical Toxicology. 111, p. 302-309 8 p.

Research output: Contribution to journalArticle

Mitochondria
epigallocatechin
mitochondria
green tea
Tea
8 Citations (Scopus)

Prevention of hepatitis C virus infection using a broad cross-neutralizing monoclonal antibody (AR4A) and epigallocatechin gallate

O'Shea, D., Law, J., Egli, A., Douglas, D., Lund, G., Forester, S., Lambert, J., Law, M., Burton, D. R., Tyrrell, D. L. J., Houghton, M., Humar, A. & Kneteman, N., Mar 1 2016, In : Liver Transplantation. 22, 3, p. 324-332 9 p.

Research output: Contribution to journalArticle

Virus Diseases
Neutralizing Antibodies
Hepacivirus
Monoclonal Antibodies
epigallocatechin gallate
100 Citations (Scopus)

Redox properties of tea polyphenols and related biological activities

Sang, S., Hou, Z., Lambert, J. D. & Yang, C. S., Nov 1 2005, In : Antioxidants and Redox Signaling. 7, 11-12, p. 1704-1714 11 p.

Research output: Contribution to journalReview article

Polyphenols
Tea
Bioactivity
Oxidation-Reduction
Cell culture
9 Citations (Scopus)

Research on tea and health

Yang, C. S. & Lambert, J. D., Aug 1 2011, In : Pharmacological Research. 64, 2, p. 85-86 2 p.

Research output: Contribution to journalEditorial

Tea
Health
Research
23 Citations (Scopus)

Reversal of hypermethylation and reactivation of genes by dietary polyphenolic compounds

Yang, C. S., Fang, M., Lambert, J. D., Yan, P. & Huang, T. H. M., Aug 1 2008, In : Nutrition reviews. 66, SUPPL.1, p. S18-S20

Research output: Contribution to journalArticle

DNA Modification Methylases
Genetic Epigenesis
Catechin
Phenols
Enzyme Inhibitors

Role of reactive oxygen species from the green tea catechin, (−)-epigallocatechin-3-gallate in growth modulation of intestinal cells

Kwon, S. J., Lambert, J. D., Yang, C. S. & Hong, J., Aug 3 2015, In : Food Science and Biotechnology. 24, 4, p. 1541-1548 8 p.

Research output: Contribution to journalArticle

Catechin
epigallocatechin
green tea
Tea
catechin
29 Citations (Scopus)

Salivary hydrogen peroxide produced by holding or chewing green tea in the oral cavity

Lambert, J. D., Kwon, S. J., Hong, J. & Yang, C. S., Jul 4 2007, In : Free Radical Research. 41, 7, p. 850-853 4 p.

Research output: Contribution to journalArticle

Mastication
Tea
Hydrogen Peroxide
Mouth
Catechin
12 Citations (Scopus)
Dietary Carbohydrates
Hep G2 Cells
Lipids
Carbohydrates
Liver
5 Citations (Scopus)

Soy protein concentrate mitigates markers of colonic inflammation and loss of gut barrier function in vitro and in vivo

Bitzer, Z. T., Wopperer, A. L., Chrisfield, B. J., Tao, L., Cooper, T. K., Vanamala, J., Elias, R. J., Hayes, J. E. & Lambert, J. D., Feb 1 2017, In : Journal of Nutritional Biochemistry. 40, p. 201-208 8 p.

Research output: Contribution to journalArticle

Soybean Proteins
Dextran Sulfate
Inflammation
Caspase 1
Splenomegaly
18 Citations (Scopus)
Lung Neoplasms
Cell Line
Inhibitory Concentration 50
Catechol O-Methyltransferase
Growth
16 Citations (Scopus)

Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid

Meyers, R. O., Lambert, J. D., Hajicek, N., Pourpak, A., Kalaitzis, J. A. & Dorr, R. T., Aug 15 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 16, p. 4752-4755 4 p.

Research output: Contribution to journalArticle

Masoprocol
Carbonates
Cytotoxicity
Heterografts
Sulfates
76 Citations (Scopus)

Synthesis and biological activity of the tea catechin metabolites, M4 and M6 and their methoxy-derivatives

Lambert, J. D., Rice, J. E., Hong, J., Hou, Z. & Yang, C. S., Feb 15 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 4, p. 873-876 4 p.

Research output: Contribution to journalArticle

Catechin
Polyphenols
Tea
Metabolites
Bioactivity
75 Citations (Scopus)

Synthesis and structure identification of thiol conjugates of (-)-epigallocatechin gallate and their urinary levels in mice

Sang, S., Lambert, J. D., Hong, J., Tian, S., Lee, M. J., Stark, R. E., Ho, C. T. & Yang, C. S., Nov 1 2005, In : Chemical research in toxicology. 18, 11, p. 1762-1769 8 p.

Research output: Contribution to journalArticle

Sulfhydryl Compounds
Glutathione
Urine
Tea
epigallocatechin gallate
197 Citations (Scopus)

Tea and cancer prevention: Molecular mechanisms and human relevance

Yang, C. S., Lambert, J. D., Ju, J., Lu, G. & Sang, S., Nov 1 2007, In : Toxicology and Applied Pharmacology. 224, 3, p. 265-273 9 p.

Research output: Contribution to journalReview article

Tea
Neoplasms
Animals
Polyphenols
Animal Models

Tea and Its Constituents

Lambert, J. D., Yang, C. S., Gelderblom, W. C. A., Gamieldien, K. & Joubert, E., Jul 16 2009, Chemoprevention of Cancer and DNA Damage by Dietary Factors. Wiley - VCH Verlag GmbH & CO. KGaA, p. 595-633 39 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tea
Biotransformation
Mutagenesis
Biological Availability
Reactive Oxygen Species
46 Citations (Scopus)

Tea consumption is inversely associated with weight status and other markers for metabolic syndrome in US adults

Vernarelli, J. A. & Lambert, J. D., Apr 1 2013, In : European Journal of Nutrition. 52, 3, p. 1039-1048 10 p.

Research output: Contribution to journalArticle

Tea
Weights and Measures
Waist Circumference
Energy Intake
Camellia sinensis
52 Citations (Scopus)

tetra-O-Methylnordihydroguaiaretic acid inhibits melanoma in vivo

Lambert, J. D., Meyers, R. O., Timmermann, B. N. & Dorr, R. T., Aug 28 2001, In : Cancer Letters. 171, 1, p. 47-56 10 p.

Research output: Contribution to journalArticle

Masoprocol
Melanoma
Lignans
G2 Phase
Growth