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Personal profile

Research interests

Dr. Junxuan "Johnny" Lu's research interests and expertise include angiogenesis, apoptosis, autophagy, cell cycle regulation, senescence, prostate and mammary carcinogenesis models, androgen and estrogen receptor signaling; Proteomics-iTRAQ; transcriptomics; metabolomics; PK/PD; biomarkers; immunity and cancer; and clinical translation research.

The major areas of ongoing studies in the Lu lab include: 

  • Herbal compounds as novel cancer chemopreventive and therapeutic agents. The Lu lab faculty and associates discovered pyranocoumarins from Korean angelica as a novel class of anti-androgens. They are studying Korean angelica extract and compounds for anti-cancer efficacy and mechanisms using xenograft and transgenic models. They are planning clinical trials in prostate cancer patients with oncologists and urologists at Penn State Cancer Institute. 
  • Next-gen selenium compounds for cancer chemoprevention. The Lu lab has used cell culture models (cancer, vascular endothelial cells) to identify the lead Se compounds with cancer chemopreventive potential and their cellular and molecular mechanisms. They assess in vivo efficacy in animal models including xenografts, transgenic and conditional knockout mice models. The Lu lab collaborates with chemist colleagues in the department to study novel selenium hybrid drugs. 
  • Precision therapy of cancer. The Lu lab has contributed to the findings that hexokinase 2 (HK2) plays a crucial role in subsets of aggressive prostate cancer and the proof of principle that co-targeting HK2-mediated Warburg effect with 2-deoxyglucose and its ULK1-mediated anti-apoptotic autophagy with chloroquine remarkably regresses these cancers in mouse models. The lab is collaborating with oncologists to repurpose these drugs to cancer patients.

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Prostatic Neoplasms Medicine & Life Sciences
Selenium Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Prostate Medicine & Life Sciences
Angelica Medicine & Life Sciences
Androgen Receptors Medicine & Life Sciences
Carcinogenesis Medicine & Life Sciences

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Projects 1997 2020

Castration
Deoxyglucose
Prostatic Neoplasms
Hexokinase
Toxicology
Selenium
Prostate
Carcinogenesis
Methionine
Prostatic Neoplasms

Prevention of PTEN deletion driven prostate cancer by selenium

Lu, J., Lu, J., Deng, Y. & Deng, Y.

National Institutes of Health

12/15/1011/30/13

Project: Research project

Selenium
Prostatic Neoplasms
Selenomethionine
Prostate
Vitamin E
Herbal Medicine
Chemoprevention
Prostate
Prostatic Neoplasms
Neoplasm Metastasis
Rubiaceae
Chemoprevention
Prostatic Neoplasms
Glucose
Apoptosis

Research Output 1988 2018

2 Citations (Scopus)
Androgen Receptors
Reactive Oxygen Species
Prostatic Neoplasms
Apoptosis
Prostate-Specific Antigen

Role of P53-Senescence Induction in Suppression of LNCaP Prostate Cancer Growth by Cardiotonic Compound Bufalin

Zhang, Y., Dong, Y., Melkus, M. W., Yin, S., Tang, S. N., Jiang, P., Pramanik, K., Wu, W., Kim, S., Ye, M., Hu, H., Lu, J. & Jiang, C., Nov 1 2018, In : Molecular cancer therapeutics. 17, 11, p. 2341-2352 12 p.

Research output: Contribution to journalArticle

Cardiotonic Agents
Prostatic Neoplasms
Growth
Androgen Receptors
Caspases
1 Citation (Scopus)

Prostate Cancer Xenograft Inhibitory Activity and Pharmacokinetics of Decursinol, a Metabolite of Angelica gigas Pyranocoumarins, in Mouse Models

Wu, W., Tang, S. N., Zhang, Y., Puppala, M., Cooper, T. K., Xing, C., Jiang, C. & Lu, J., Jan 1 2017, In : American Journal of Chinese Medicine. 45, 8, p. 1773-1792 20 p.

Research output: Contribution to journalArticle

Pyranocoumarins
Angelica
Heterografts
Prostatic Neoplasms
Pharmacokinetics
23 Citations (Scopus)

Cancer chemoprevention research with selenium in the post-SELECT era: Promises and challenges

Lu, J., Zhang, J., Jiang, C., Deng, Y., Özten, N. & Bosland, M. C., Jan 2 2016, In : Nutrition and cancer. 68, 1, p. 1-17 17 p.

Research output: Contribution to journalReview article

Selenomethionine
Chemoprevention
Selenium
Yeasts
Research

Cancer prevention with selenium costly lessons and difficult but bright future prospects

Lu, J., Jiang, C. & Zhang, J., Apr 19 2016, Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention. CRC Press, p. 477-494 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Selenium
selenium
neoplasms
Neoplasms