• 5669 Citations
  • 46 h-Index
1988 …2020

Research output per year

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Research Output

2020

The Impact of One-week Dietary Supplementation with Kava on Biomarkers of Tobacco Use and Nitrosamine-based Carcinogenesis Risk among Active Smokers

Wang, Y., Narayanapillai, S. C., Tessier, K. M., Strayer, L. G., Upadhyaya, P., Hu, Q., Kingston, R., Salloum, R. G., Lu, J., Hecht, S. S., Hatsukami, D. K., Fujioka, N. & Xing, C., May 1 2020, In : Cancer prevention research (Philadelphia, Pa.). 13, 5, p. 483-492 10 p.

Research output: Contribution to journalArticle

2019

Optimizing live-animal bioluminescence imaging prediction of tumor burden in human prostate cancer xenograft models in SCID-NSG mice

Kim, S., Zhang, Y., Tang, S., Qin, C., Karelia, D., Sharma, A., Jiang, C. & Lu, J., Jun 15 2019, In : Prostate. 79, 9, p. 949-960 12 p.

Research output: Contribution to journalArticle

2018
5 Scopus citations

Role of p53-senescence induction in suppression of LNCaP prostate cancer growth by cardiotonic compound bufalin

Zhang, Y., Dong, Y., Melkus, M. W., Yin, S., Tang, S. N., Jiang, P., Pramanik, K., Wu, W., Kim, S., Ye, M., Hu, H., Lu, J. & Jiang, C., Nov 2018, In : Molecular cancer therapeutics. 17, 11, p. 2341-2352 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Prostate Cancer Xenograft Inhibitory Activity and Pharmacokinetics of Decursinol, a Metabolite of Angelica gigas Pyranocoumarins, in Mouse Models

Wu, W., Tang, S. N., Zhang, Y., Puppala, M., Cooper, T. K., Xing, C., Jiang, C. & Lü, J., Jan 1 2017, In : American Journal of Chinese Medicine. 45, 8, p. 1773-1792 20 p.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Cancer chemoprevention research with selenium in the post-SELECT era: Promises and challenges

Lü, J., Zhang, J., Jiang, C., Deng, Y., Özten, N. & Bosland, M. C., Jan 2 2016, In : Nutrition and cancer. 68, 1, p. 1-17 17 p.

Research output: Contribution to journalReview article

29 Scopus citations

Cancer prevention with selenium costly lessons and difficult but bright future prospects

Lu, J., Jiang, C. & Zhang, J., Apr 19 2016, Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention. CRC Press, p. 477-494 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Characterization of the Fluorescence Properties of 4-Dialkylaminochalcones and Investigation of the Cytotoxic Mechanism of Chalcones

Zhou, B., Jiang, P., Lu, J. & Xing, C., Jul 1 2016, In : Archiv der Pharmazie. p. 539-552 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Co-targeting hexokinase 2-mediated Warburg effect and ULK1-dependent autophagy suppresses tumor growth of PTEN- and TP53-deficiency-driven castration-resistant prostate cancer

Wang, L., Wang, J., Xiong, H., Wu, F., Lan, T., Zhang, Y., Guo, X., Wang, H., Saleem, M., Jiang, C., Lu, J. & Deng, Y., May 1 2016, In : EBioMedicine. 7, p. 50-61 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Gene expression signatures associated with suppression of TRAMP prostate carcinogenesis by a kavalactone-rich Kava fraction

Tang, S. N., Zhang, J., Jiang, P., Datta, P., Leitzman, P., O'Sullivan, M. G., Jiang, C., Xing, C. & Lü, J., Dec 1 2016, In : Molecular Carcinogenesis. 55, 12, p. 2291-2303 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Methylseleninic acid superactivates p53-senescence cancer progression barrier in prostate lesions of pten-knockout mouse

Wang, L., Guo, X., Wang, J., Jiang, C., Bosland, M. C., Lü, J. & Deng, Y., Jan 2016, In : Cancer Prevention Research. 9, 1, p. 35-42 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Pyranocoumarin Tissue Distribution, Plasma Metabolome and Prostate Transcriptome Impacts of Sub-Chronic Exposure to Korean Angelica Supplement in Mice

Zhang, J., Li, L., Tang, S., Zhang, Y., Markiewski, M., Xing, C., Jiang, C. & Lü, J., Apr 1 2016, In : American Journal of Chinese Medicine. 44, 2, p. 321-353 33 p.

Research output: Contribution to journalArticle

3 Scopus citations

Unambiguous Identification of β-Tubulin as the Direct Cellular Target Responsible for the Cytotoxicity of Chalcone by Photoaffinity Labeling

Zhou, B., Yu, X., Zhuang, C., Villalta, P., Lin, Y., Lu, J. & Xing, C., Jan 1 2016, In : ChemMedChem. 11, 13, p. 1436-1445 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015

Cancer Chemoprevention with Korean Angelica: Active Compounds, Pharmacokinetics, and Human Translational Considerations

Lü, J., Zhang, J., Li, L., Jiang, C. & Xing, C., Dec 1 2015, In : Current Pharmacology Reports. 1, 6, p. 373-381 9 p.

Research output: Contribution to journalReview article

8 Scopus citations

Chemopreventive effect of Korean Angelica root extract on TRAMP carcinogenesis and integrative "omic" profiling of affected neuroendocrine carcinomas

Zhang, J., Wang, L., Zhang, Y., Li, L., Tang, S., Xing, C., Kim, S. H., Jiang, C. & Lü, J., Dec 2015, In : Molecular Carcinogenesis. 54, 12, p. 1567-1583 17 p.

Research output: Contribution to journalArticle

10 Scopus citations

Chemopreventive effects of Korean Angelica versus its major pyranocoumarins on two lineages of transgenic adenocarcinoma of mouse prostate carcinogenesis

Tang, S. N., Zhang, J., Wu, W., Jiang, P., Puppala, M., Zhang, Y., Xing, C., Kim, S. H., Jiang, C. & Lü, J., Sep 1 2015, In : Cancer Prevention Research. 8, 9, p. 835-844 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Cytochrome P450 isoforms in the metabolism of decursin and decursinol angelate from Korean angelica

Zhang, J., Li, L., Tang, S., Hale, T. W., Xing, C., Jiang, C. & Lü, J., Sep 1 2015, In : American Journal of Chinese Medicine. 43, 6, p. 1211-1230 20 p.

Research output: Contribution to journalArticle

4 Scopus citations

Single oral dose pharmacokinetics of decursin and decursinol angelate in healthy adult men and women

Zhang, J., Li, L., Hale, T. W., Chee, W., Xing, C., Jiang, C. & Lü, J., Feb 19 2015, In : PloS one. 10, 2, e0114992.

Research output: Contribution to journalArticle

15 Scopus citations

Targeting hexokinase 2 in castration-resistant prostate cancer

Deng, Y. & Lu, J., Jul 3 2015, In : Molecular and Cellular Oncology. 2, 3, e974465.

Research output: Contribution to journalComment/debate

9 Scopus citations
2014

Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1- (3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice

Narayanapillai, S. C., Balbo, S., Leitzman, P., Grill, A. E., Upadhyaya, P., Shaik, A. A., Zhou, B., Gerard O'Sullivan, M., Peterson, L. A., Lu, J., Hecht, S. S. & Xing, C., Jan 1 2014, In : Carcinogenesis. 35, 10, p. 2365-2372 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Hexokinase 2-Mediated Warburg Effect Is Required for PTEN- and p53-Deficiency-Driven Prostate Cancer Growth

Wang, L., Xiong, H., Wu, F., Zhang, Y., Wang, J., Zhao, L., Guo, X., Chang, L. J., Zhang, Y., You, M. J., Koochekpour, S., Saleem, M., Huang, H., Lu, J. & Deng, Y., Jan 1 2014, In : Cell Reports. 8, 5, p. 1461-1474 14 p.

Research output: Contribution to journalArticle

108 Scopus citations

Involvement of autophagy induction in penta-1,2,3,4,6-O-galloyl-β-D- glucose-induced senescence-like growth arrest in human cancer cells

Dong, Y., Yin, S., Jiang, C., Luo, X., Guo, X., Zhao, C., Fan, L., Meng, Y., Lu, J., Song, X., Zhang, X., Chen, N. & Hu, H., Feb 2014, In : Autophagy. 10, 2, p. 296-310 15 p.

Research output: Contribution to journalArticle

14 Scopus citations

Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing o6-methylguanine DNA adduct in A/J mice

Leitzman, P., Narayanapillai, S. C., Balbo, S., Zhou, B., Upadhyaya, P., Shaik, A. A., O'Sullivan, M. G., Hecht, S. S., Lu, J. & Xing, C., Jan 1 2014, In : Cancer Prevention Research. 7, 1, p. 86-96 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Methylseleninic acid suppresses pancreatic cancer growth involving multiple pathways

Wang, L., Hu, H., Wang, Z., Xiong, H., Cheng, Y., Liao, J. D., Deng, Y. & Lü, J., Feb 1 2014, In : Nutrition and cancer. 66, 2, p. 295-307 13 p.

Research output: Contribution to journalArticle

9 Scopus citations
2013

Enhanced apoptotic effects by the combination of curcumin and methylseleninic acid: Potential role of mcl-1 and FAK

Guo, X., Yin, S., Dong, Y., Fan, L., Ye, M., Lu, J. & Hu, H., Nov 1 2013, In : Molecular Carcinogenesis. 52, 11, p. 879-889 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

In vitro metabolism of pyranocoumarin isomers decursin and decursinol angelate by liver microsomes from man and rodents

Li, L., Zhang, J., Xing, C., Kim, S. H., Jiang, C. & Lü, J., Sep 13 2013, In : Planta Medica. 79, 16, p. 1536-1544 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Single oral dose pharmacokinetics of decursin, decursinol angelate, and decursinol in rats

Li, L., Zhang, J., Xing, C., Kim, S. H. & Lü, J., Feb 1 2013, In : Planta Medica. 79, 3-4, p. 275-280 6 p.

Research output: Contribution to journalArticle

14 Scopus citations
2012

Activation of p53 signaling and inhibition of androgen receptor mediate tanshinone IIA induced G1 arrest in LNCaP prostate cancer cells

Won, S. H., Lee, H. J., Jeong, S. J., Lü, J. & Kim, S. H., May 1 2012, In : Phytotherapy Research. 26, 5, p. 669-674 6 p.

Research output: Contribution to journalArticle

27 Scopus citations
14 Scopus citations

Anti-cancer and other bioactivities of Korean Angelica gigas Nakai (AGN) and its major pyranocoumarin compounds

Zhang, J., Li, L., Jiang, C., Xing, C., Kim, S. H. & Lu, J., Dec 3 2012, In : Anti-Cancer Agents in Medicinal Chemistry. 12, 10, p. 1239-1254 16 p.

Research output: Contribution to journalArticle

43 Scopus citations

A synthetic decursin analog with increased in vivo stability suppresses androgen receptor signaling in vitro and in vivo

Zhang, Y., Shaik, A. A., Xing, C., Chai, Y., Li, L., Zhang, J., Zhang, W., Kim, S. H., Lü, J. & Jiang, C., Oct 1 2012, In : Investigational New Drugs. 30, 5, p. 1820-1829 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Economically viable efficient synthesis of (±)-methysticin: A component in kava potentially responsible for its cancer chemopreventive activity

Ali Shaik, A., Tan, J., Lü, J. & Xing, C., Jun 29 2012, In : Arkivoc. 2012, 8, p. 137-145 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Galbanic acid decreases androgen receptor abundance and signaling and induces G 1 arrest in prostate cancer cells

Zhang, Y., Kim, K. H., Zhang, W., Guo, Y., Kim, S. H. & Lü, J., Jan 11 2012, In : International Journal of Cancer. 130, 1, p. 200-212 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Methylseleninic acid potentiates multiple types of cancer cells to ABT-737-induced apoptosis by targeting Mcl-1 and Bad

Yin, S., Dong, Y., Li, J., Fan, L., Wang, L., Lu, J., Vang, O. & Hu, H., Apr 1 2012, In : Apoptosis. 17, 4, p. 388-399 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Quantitative determination of decursin, decursinol angelate, and decursinol in mouse plasma and tumor tissue using liquid-liquid extraction and HPLC

Li, L., Zhang, J., Shaik, A. A., Zhang, Y., Wang, L., Xing, C., Kim, S. H. & Lü, J., Jan 1 2012, In : Planta Medica. 78, 3, p. 252-259 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Reactive oxygen species-mediated activation of JNK and down-regulation of DAXX are critically involved in penta-O-galloyl-beta-d-glucose-induced apoptosis in chronic myeloid leukemia K562 cells

Kwon, T. R., Jeong, S. J., Lee, H. J., Lee, H. J., Sohn, E. J., Jung, J. H., Kim, J. H., Jung, D. B., Lu, J. & Kim, S. H., Aug 3 2012, In : Biochemical and Biophysical Research Communications. 424, 3, p. 530-537 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Tanshinones: Sources, pharmacokinetics and anti-cancer activities

Zhang, Y., Jiang, P., Ye, M., Kim, S. H., Jiang, C. & Lü, J., Oct 1 2012, In : International journal of molecular sciences. 13, 10, p. 13621-13666 46 p.

Research output: Contribution to journalReview article

108 Scopus citations

Tanshinones from Chinese medicinal herb Danshen (Salvia miltiorrhiza Bunge) suppress prostate cancer growth and androgen receptor signaling

Zhang, Y., Won, S. H., Jiang, C., Lee, H. J., Jeong, S. J., Lee, E. O., Zhang, J., Ye, M., Kim, S. H. & Lü, J., Jun 1 2012, In : Pharmaceutical Research. 29, 6, p. 1595-1608 14 p.

Research output: Contribution to journalArticle

33 Scopus citations
2011

Antiangiogenic phytochemicals and medicinal herbs

Jeong, S. J., Koh, W., Lee, E. O., Lee, H. J., Lee, H. J., Bae, H., Lü, J. & Kim, S. H., Jan 1 2011, In : Phytotherapy Research. 25, 1, p. 1-10 10 p.

Research output: Contribution to journalReview article

42 Scopus citations

Galbanic acid isolated from Ferula assafoetida exerts in vivo anti-tumor activity in association with anti-angiogenesis and anti-proliferation

Kim, K. H., Lee, H. J., Jeong, S. J., Lee, H. J., Lee, E. O., Kim, H. S., Zhang, Y., Ryu, S. Y., Lee, M. H., Lü, J. & Kim, S. H., Mar 1 2011, In : Pharmaceutical Research. 28, 3, p. 597-609 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Herbal cocktail Ka-Mi-Kae-Kyuk-Tang stimulates mouse bone marrow stem cell hematopoiesis and Janus-activated kinase 2/signal transducer and activator of transcription 5 pathway

Lee, J. E., Seo, I., Jeong, S. J., Koh, W., Jung, J. H., Kwon, T. R., Lee, H. J., Han, I., Lee, H. J., Lee, E. O., Kim, S. H., Jung, H. J., Lu, J. & Kim, S. H., Nov 18 2011, In : American Journal of Chinese Medicine. 39, 6, p. 1235-1252 18 p.

Research output: Contribution to journalArticle

5 Scopus citations

Ka-mi-kae-kyuk-tang oriental herbal cocktail attenuates cyclophosphamide-induced leukopenia side effects in mouse

Seo, I., Kim, S. H., Lee, J. E., Jeong, S. J., Kim, Y. C., Ahn, K. S., Lu, J. & Kim, S. H., Dec 1 2011, In : Immunopharmacology and Immunotoxicology. 33, 4, p. 682-690 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Lobe-specific lineages of carcinogenesis in the transgenic adenocarcinoma of mouse prostate and their responses to chemopreventive selenium

Wang, L., Zhang, J., Zhang, Y., Nkhata, K., Quealy, E., Liao, J. D., Cleary, M. P. & Lü, J., Sep 15 2011, In : Prostate. 71, 13, p. 1429-1440 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Lobe-specific proteome changes in the dorsal-lateral and ventral prostate of TRAMP mice versus wild-type mice

Zhang, J., Wang, L., Zhang, Y., Li, L., Higgins, L. & Lü, J., Jun 1 2011, In : Proteomics. 11, 12, p. 2542-2549 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice

Johnson, T. E., Hermanson, D., Wang, L., Kassie, F., Upadhyaya, P., O'Sullivan, M. G., Hecht, S. S., Lu, J. & Xing, C., Jul 11 2011, In : American Journal of Chinese Medicine. 39, 4, p. 727-742 16 p.

Research output: Contribution to journalArticle

17 Scopus citations

Mouse prostate proteome changes induced by oral pentagalloylglucose treatment suggest targets for cancer chemoprevention

Zhang, J., Nkhata, K., Shaik, A. A., Wang, L., Li, L., Zhang, Y., Higgins, L. A., Kim, K. H., Liao, J. D., Xing, C., Kim, S. H. & Lü, J., Sep 1 2011, In : Current Cancer Drug Targets. 11, 7, p. 787-798 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Mouse prostate proteomes are differentially altered by supranutritional intake of four selenium compounds

Zhang, J., Wang, L., Li, G., Anderson, L. B., Xu, Y., Witthuhn, B. & Lu, J., Jul 1 2011, In : Nutrition and cancer. 63, 5, p. 778-789 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Oral administration of penta-O-galloyl-β-d-glucose suppresses triple-negative breast cancer xenograft growth and metastasis in strong association with JAK1-STAT3 inhibition

Lee, H. J., Seo, N. J., Jeong, S. J., Park, Y., Jung, D. B., Koh, W., Lee, H. J., Lee, E. O., Ahn, K. S., Ahn, K. S., Lü, J. & Kim, S. H., Jun 14 2011, In : Carcinogenesis. 32, 6, p. 804-811 8 p.

Research output: Contribution to journalArticle

49 Scopus citations

Penta-1,2,3,4,6-O-galloyl-beta-D-glucose induces senescence-like terminal S-phase arrest in human hepatoma and breast cancer cells

Yin, S., Dong, Y., Li, J., Lü, J. & Hu, H., Aug 1 2011, In : Molecular Carcinogenesis. 50, 8, p. 592-600 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Preparation of penta-O-galloyl-β-d-glucose from tannic acid and plasma pharmacokinetic analyses by liquid-liquid extraction and reverse-phase HPLC

Li, L., Shaik, A. A., Zhang, J., Nhkata, K., Wang, L., Zhang, Y., Xing, C., Kim, S. H. & Lü, J., Feb 20 2011, In : Journal of Pharmaceutical and Biomedical Analysis. 54, 3, p. 545-550 6 p.

Research output: Contribution to journalArticle

35 Scopus citations