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Research Output 1988 2019

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21 Citations (Scopus)

1,2,3,4,6-penta-o-galloly-beta-D-glucose suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1α and signaling in LNCaP prostate cancer cells

Park, K. Y., Lee, H. J., Jeong, S. J., Lee, H. J., Kim, H. S., Kim, S. H., Lim, S., Kim, H. C., Lu, J. & Kim, S. H., Nov 19 2010, In : Biological and Pharmaceutical Bulletin. 33, 11, p. 1835-1840 6 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Rubiaceae
Prostatic Neoplasms
Glucose
1-Phosphatidylinositol 4-Kinase
23 Citations (Scopus)

6-(1-Oxobutyl)-5,8-dimethoxy-1,4-naphthoquinone inhibits Lewis lung cancer by antiangiogenesis and apoptosis

Hyo, J. L., Lee, H. J., Song, G. Y., Li, G., Lee, J. H., Lu, J. & Kim, S. H., Jun 1 2007, In : International Journal of Cancer. 120, 11, p. 2481-2490 10 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Apoptosis
Lewis Lung Carcinoma
Vascular Endothelial Growth Factor A
Neoplasms
26 Citations (Scopus)

Activation of p53 signaling and inhibition of androgen receptor mediate tanshinone IIA induced G1 arrest in LNCaP prostate cancer cells

Won, S. H., Lee, H. J., Jeong, S. J., Lu, J. & Kim, S. H., May 1 2012, In : Phytotherapy Research. 26, 5, p. 669-674 6 p.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
Cyclin D1
Cell Cycle Checkpoints
Small Interfering RNA
9 Citations (Scopus)

A filter elution assay for the simultaneous detection of DNA double and single strand breaks

Lu, J., Kaeck, M. R., Jiang, C., Garcia, G. & Thompson, H. J., Mar 15 1996, In : Analytical Biochemistry. 235, 2, p. 227-233 7 p.

Research output: Contribution to journalArticle

Single-Stranded DNA Breaks
Double-Stranded DNA Breaks
Assays
DNA
Gravitation
14 Citations (Scopus)
Chalcone
Cell Cycle Checkpoints
Prostatic Neoplasms
Apoptosis
Growth
63 Citations (Scopus)

An oriental herbal cocktail, ka-mi-kae-kyuk-tang, exerts anti-cancer activities by targeting angiogenesis, apoptosis and metastasis

Lee, H. J., Lee, E. O., Rhee, Y. H., Ahn, K. S., Li, G. X., Jiang, C., Lü, J. & Kim, S. H., Dec 1 2006, In : Carcinogenesis. 27, 12, p. 2455-2463 9 p.

Research output: Contribution to journalArticle

Apoptosis
Neoplasm Metastasis
Lewis Lung Carcinoma
Blood Vessels
Neoplasms
45 Citations (Scopus)

A novel class of pyranocoumarin anti-androgen receptor signaling compounds

Guo, J., Jiang, C., Wang, Z., Lee, H. J., Hu, H., Malewicz, B., Lee, H. J., Lee, J. H., Baek, N. I., Jeong, J. H., Kim, D. K., Kang, K. S., Kim, S. H. & Lu, J., Mar 1 2007, In : Molecular cancer therapeutics. 6, 3, p. 907-917 11 p.

Research output: Contribution to journalArticle

Pyranocoumarins
Androgen Receptors
Androgens
Ligands
Prostatic Neoplasms
8 Citations (Scopus)

A novel sulindac derivative lacking cyclooxygenase-inhibitory activities suppresses carcinogenesis in the transgenic adenocarcinoma of mouse prostate model

Zhang, Y., Zhang, J., Wang, L., Quealy, E., Gary, B. D., Reynolds, R. C., Piazza, G. A. & Lü, J., Jul 1 2010, In : Cancer Prevention Research. 3, 7, p. 885-895 11 p.

Research output: Contribution to journalArticle

Sulindac
Androgen Receptors
Prostaglandin-Endoperoxide Synthases
Transgenic Mice
Prostate
9 Citations (Scopus)

Anti-androgen receptor signaling and prostate cancer inhibitory effects of sucrose- and benzophenone-compounds

Wang, Z., Lee, H. J., Wang, L., Jiang, C., Baek, N. I., Kim, S. H. & Lu, J., May 1 2009, In : Pharmaceutical Research. 26, 5, p. 1140-1148 9 p.

Research output: Contribution to journalArticle

Androgen Receptors
Sucrose
Prostatic Neoplasms
Prostate-Specific Antigen
Androgens
96 Citations (Scopus)
Silymarin
Endothelial cells
Flavonoids
Endothelial Cells
Antioxidants
42 Citations (Scopus)

Anti-cancer and other bioactivities of Korean Angelica gigas Nakai (AGN) and its major pyranocoumarin compounds

Zhang, J., Li, L., Jiang, C., Xing, C., Kim, S. H. & Lu, J., Dec 3 2012, In : Anti-Cancer Agents in Medicinal Chemistry. 12, 10, p. 1239-1254 16 p.

Research output: Contribution to journalArticle

Pyranocoumarins
Angelica
Neoplasms
Korea
Urinary Bladder Neoplasms
20 Citations (Scopus)

Anti-cancer gallotannin penta-O-galloyl-beta-d-glucose is a nanomolar inhibitor of select mammalian DNA polymerases

Mizushina, Y., Zhang, J., Pugliese, A., Kim, S. H. & Lü, J., Oct 1 2010, In : Biochemical Pharmacology. 80, 8, p. 1125-1132 8 p.

Research output: Contribution to journalArticle

Prostaglandins G
Hydrolyzable Tannins
DNA-Directed DNA Polymerase
Glucose
Neoplasms
69 Citations (Scopus)
Phosphatidylinositol 3-Kinase
JNK Mitogen-Activated Protein Kinases
Extracellular Signal-Regulated MAP Kinases
p38 Mitogen-Activated Protein Kinases
Endothelial Cells
38 Citations (Scopus)

Apoptosis and angiogenesis in cancer prevention by selenium

Lu, J., Aug 7 2001, In : Advances in Experimental Medicine and Biology. 492, p. 131-145 15 p.

Research output: Contribution to journalArticle

Selenium
Antineoplastic Agents
Rats
Animals
Antioxidants
10 Citations (Scopus)

A synthetic decursin analog with increased in vivo stability suppresses androgen receptor signaling in vitro and in vivo

Zhang, Y., Shaik, A. A., Xing, C., Chai, Y., Li, L., Zhang, J., Zhang, W., Kim, S. H., Lü, J. & Jiang, C., Oct 1 2012, In : Investigational New Drugs. 30, 5, p. 1820-1829 10 p.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
In Vitro Techniques
decursin
Prostate-Specific Antigen
7 Citations (Scopus)

Augmented suppression of androgen receptor signaling by a combination of α-tocopheryl succinate and methylseleninic acid

Zhang, H., Wu, Y., Malewicz, B., Lu, J., Li, S., Marshall, J., Ip, C. & Dong, Y., Dec 15 2006, In : Cancer. 107, 12, p. 2942-2948 7 p.

Research output: Contribution to journalArticle

Androgen Receptors
Succinic Acid
Prostate-Specific Antigen
Transcriptional Activation
Messenger RNA
82 Citations (Scopus)

Biological and genetic properties of the p53 null preneoplastic mammary epithelium.

Medina, D., Kittrell, F. S., Shepard, A., Stephens, L. C., Jiang, C., Lu, J., Allred, D. C., McCarthy, M. & Ullrich, R. L., Jan 1 2002, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 16, 8, p. 881-883 3 p.

Research output: Contribution to journalArticle

Breast
Epithelium
Telomerase
Progesterone Receptors
Estrogen Receptors
222 Citations (Scopus)

Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells

Jiang, C., Wang, Z., Ganther, H. & Lu, J., Apr 1 2001, In : Cancer Research. 61, 7, p. 3062-3070 9 p.

Research output: Contribution to journalArticle

Anoikis
Selenium
Caspases
Prostatic Neoplasms
Apoptosis
39 Citations (Scopus)

Cellular and metabolic effects of triphenylselenonium chloride in a mammary cell culture model

Lu, J., Jiang, C., Kaeck, M., Ganther, H., Ip, C. & Thompson, H., Mar 1 1995, In : Carcinogenesis. 16, 3, p. 513-517 5 p.

Research output: Contribution to journalArticle

Selenious Acid
Selenium Compounds
Breast
Cell Culture Techniques
Selenium
6 Citations (Scopus)

Characterization of the Fluorescence Properties of 4-Dialkylaminochalcones and Investigation of the Cytotoxic Mechanism of Chalcones

Zhou, B., Jiang, P., Lu, J. & Xing, C., Jul 1 2016, In : Archiv der Pharmazie. p. 539-552 14 p.

Research output: Contribution to journalArticle

Chalcones
Fluorescence
Tubulin
Detergents
Chalcone
9 Citations (Scopus)

Chemopreventive effect of Korean Angelica root extract on TRAMP carcinogenesis and integrative "omic" profiling of affected neuroendocrine carcinomas

Zhang, J., Wang, L., Zhang, Y., Li, L., Tang, S., Xing, C., Kim, S. H., Jiang, C. & Lü, J., Dec 2015, In : Molecular Carcinogenesis. 54, 12, p. 1567-1583 17 p.

Research output: Contribution to journalArticle

Angelica
Neuroendocrine Carcinoma
Transgenic Mice
Prostate
Carcinogenesis
11 Citations (Scopus)

Chemopreventive effects of Korean Angelica versus its major pyranocoumarins on two lineages of transgenic adenocarcinoma of mouse prostate carcinogenesis

Tang, S. N., Zhang, J., Wu, W., Jiang, P., Puppala, M., Zhang, Y., Xing, C., Kim, S. H., Jiang, C. & Lü, J., Sep 1 2015, In : Cancer Prevention Research. 8, 9, p. 835-844 10 p.

Research output: Contribution to journalArticle

Pyranocoumarins
Angelica
Transgenic Mice
Prostate
Carcinogenesis
137 Citations (Scopus)

Comparison of the effects of an organic and an inorganic form of selenium on a mammary carcinoma cell line

Thompson, H. J., Wilson, A., Lu, J., Singh, M., Jiang, C., Upadhyaya, P., El-bayoumy, K. & Ip, C., Feb 1 1994, In : Carcinogenesis. 15, 2, p. 183-186 4 p.

Research output: Contribution to journalArticle

Selenious Acid
Selenium
Apoptosis
Breast Neoplasms
Cell Line
19 Citations (Scopus)

Co-targeting hexokinase 2-mediated Warburg effect and ULK1-dependent autophagy suppresses tumor growth of PTEN- and TP53-deficiency-driven castration-resistant prostate cancer

Wang, L., Wang, J., Xiong, H., Wu, F., Lan, T., Zhang, Y., Guo, X., Wang, H., Saleem, M., Jiang, C., Lu, J. & Deng, Y., May 1 2016, In : EBioMedicine. 7, p. 50-61 12 p.

Research output: Contribution to journalArticle

Hexokinase
Castration
Autophagy
Deoxyglucose
Tumors
57 Citations (Scopus)

Cyclooxygenase-2/prostaglandin E2 pathway mediates icariside II induced apoptosis in human PC-3 prostate cancer cells

Lee, K. S., Lee, H. J., Ahn, K. S., Kim, S. H., Nam, D., Kim, D. K., Choi, D. Y., Ahn, K. S., Lu, J. & Kim, S. H., Jul 18 2009, In : Cancer Letters. 280, 1, p. 93-100 8 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Dinoprostone
Prostatic Neoplasms
Apoptosis
Poly(ADP-ribose) Polymerases
4 Citations (Scopus)

Cytochrome P450 isoforms in the metabolism of decursin and decursinol angelate from Korean angelica

Zhang, J., Li, L., Tang, S., Hale, T. W., Xing, C., Jiang, C. & Lü, J., Sep 1 2015, In : American Journal of Chinese Medicine. 43, 6, p. 1211-1230 20 p.

Research output: Contribution to journalArticle

Angelica
Cytochrome P-450 Enzyme System
Protein Isoforms
Genotype
decursin
64 Citations (Scopus)

Decursin and decursinol angelate inhibit estrogen-stimulated and estrogen-independent growth and survival of breast cancer cells

Jiang, C., Guo, J., Wang, Z., Xiao, B., Lee, H. J., Lee, E. O., Kim, S. H. & Lu, J., Nov 6 2007, In : Breast Cancer Research. 9, 6, R77.

Research output: Contribution to journalArticle

Estrogens
Breast Neoplasms
Estrogen Receptors
Survival
Growth
3 Citations (Scopus)

Detergents inhibit chloramphenicol acetyl transferase

Lu, J. & Jiang, C., 1992, In : BioTechniques. 12, 5, p. 643-644 2 p.

Research output: Contribution to journalArticle

Chloramphenicol O-Acetyltransferase
Chloramphenicol
Transferases
HeLa Cells
Detergents
91 Citations (Scopus)

Differential induction of growth arrest inducible genes by selenium compounds

Kaeck, M., Lu, J., Strange, R., Ip, C., Ganther, H. E. & Thompson, H. J., Apr 4 1997, In : Biochemical Pharmacology. 53, 7, p. 921-926 6 p.

Research output: Contribution to journalArticle

Selenium Compounds
Genes
Selenium
Growth
Cell Death
95 Citations (Scopus)

Differential involvement of reactive oxygen species in apoptosis induced by two classes of selenium compounds in human prostate cancer cells

Li, G. X., Hu, H., Jiang, C., Schuster, T. & Lü, J., May 1 2007, In : International Journal of Cancer. 120, 9, p. 2034-2043 10 p.

Research output: Contribution to journalArticle

Selenium Compounds
Selenious Acid
Reactive Oxygen Species
Prostatic Neoplasms
Apoptosis
15 Citations (Scopus)

Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1- (3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice

Narayanapillai, S. C., Balbo, S., Leitzman, P., Grill, A. E., Upadhyaya, P., Shaik, A. A., Zhou, B., Gerard O'Sullivan, M., Peterson, L. A., Lu, J., Hecht, S. S. & Xing, C., Jan 1 2014, In : Carcinogenesis. 35, 10, p. 2365-2372 8 p.

Research output: Contribution to journalArticle

Kava
Carcinogens
DNA Damage
Tobacco
Carcinogenesis
126 Citations (Scopus)

Dissociation of the genotoxic and growth inhibitory effects of selenium

Lu, J., Jiang, C., Kaeck, M., Ganther, H., Vadhanavikit, S., Clement, IP. P. & Thompson, H., Jul 17 1995, In : Biochemical Pharmacology. 50, 2, p. 213-219 7 p.

Research output: Contribution to journalArticle

Selenium
Single-Stranded DNA Breaks
Growth
Cell proliferation
Cell death
137 Citations (Scopus)
Selenious Acid
Cell Cycle Proteins
Protein Kinases
Prostatic Neoplasms
Selenium
4 Citations (Scopus)

Economically viable efficient synthesis of (±)-methysticin: A component in kava potentially responsible for its cancer chemopreventive activity

Ali Shaik, A., Tan, J., Lü, J. & Xing, C., Jun 29 2012, In : Arkivoc. 2012, 8, p. 137-145 9 p.

Research output: Contribution to journalArticle

Purification
methysticin
piperonal
94 Citations (Scopus)

Effect of an aqueous extract of selenium-enriched garlic on in vitro markers and in vivo efficacy in cancer prevention

Lu, J., Pei, H., Ip, C., Lisk, D. J., Ganther, H. & Thompson, H. J., Sep 1996, In : Carcinogenesis. 17, 9, p. 1903-1907 5 p.

Research output: Contribution to journalArticle

Garlic
Selenium
Neoplasms
Selenious Acid
Single-Stranded DNA Breaks
23 Citations (Scopus)

Effect of excess dietary iron on the promotion stage of 1-methyl-1- nitrosourea-induced mammary carcinogenesis: Pathogenetic characteristics and distribution of iron

Singh, M., Lu, J., Briggs, S. P., Mcginley, J. N., Haegele, A. D. & Thompson, H. J., Aug 1 1994, In : Carcinogenesis. 15, 8, p. 1567-1570 4 p.

Research output: Contribution to journalArticle

Dietary Iron
Carcinogenesis
Breast
Iron
ras Genes
36 Citations (Scopus)

Effect of excess dietary zinc on pancreatic exocrine function in the chick

Lu, J. & Combs, G. F., Jan 1 1988, In : Journal of Nutrition. 118, 6, p. 681-689 9 p.

Research output: Contribution to journalArticle

Zinc
Diet
Pancreas
Selenium
Tocopherols
77 Citations (Scopus)

Effects of methylselenocysteine on PKC activity, cdk2 phosphorylation and gadd gene expression in synchronized mouse mammary epithelial tumor cells

Sinha, R., Kiley, S. C., Lu, J., Thompson, H. J., Moraes, R., Jaken, S. & Medina, D., Nov 15 1999, In : Cancer Letters. 146, 2, p. 135-145 11 p.

Research output: Contribution to journalArticle

Protein Kinase C
Epithelial Cells
Phosphorylation
Breast Neoplasms
Gene Expression
8 Citations (Scopus)

Enhanced apoptotic effects by the combination of curcumin and methylseleninic acid: Potential role of mcl-1 and FAK

Guo, X., Yin, S., Dong, Y., Fan, L., Ye, M., Lu, J. & Hu, H., Nov 1 2013, In : Molecular Carcinogenesis. 52, 11, p. 879-889 11 p.

Research output: Contribution to journalArticle

Curcumin
Apoptosis
Apoptosis Inducing Factor
Prostatic Neoplasms
Breast Neoplasms
7 Citations (Scopus)

Excess dietary zinc decreases tissue α-tocopherol in chicks

Lu, J. & Combs, G. F., Jan 1 1988, In : Journal of Nutrition. 118, 11, p. 1349-1359 11 p.

Research output: Contribution to journalArticle

Tocopherols
Zinc
Diet
Pancreas
Exocrine Pancreatic Insufficiency
18 Citations (Scopus)

Galbanic acid decreases androgen receptor abundance and signaling and induces G 1 arrest in prostate cancer cells

Zhang, Y., Kim, K. H., Zhang, W., Guo, Y., Kim, S. H. & Lu, J., Jan 11 2012, In : International Journal of Cancer. 130, 1, p. 200-212 13 p.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
galbanic acid
Ferula
Growth
32 Citations (Scopus)

Galbanic acid isolated from Ferula assafoetida exerts in vivo anti-tumor activity in association with anti-angiogenesis and anti-proliferation

Kim, K. H., Lee, H. J., Jeong, S. J., Lee, H. J., Lee, E. O., Kim, H. S., Zhang, Y., Ryu, S. Y., Lee, M. H., Lu, J. & Kim, S. H., Mar 1 2011, In : Pharmaceutical Research. 28, 3, p. 597-609 13 p.

Research output: Contribution to journalArticle

Ferula
Tumors
Association reactions
Lung Neoplasms
Vascular Endothelial Growth Factor A
86 Citations (Scopus)

Gene expression changes associated with chemically induced rat mammary carcinogenesis

Lu, J., Pei, H., Kaeck, M. & Thompson, H. J., Oct 1 1997, In : Molecular Carcinogenesis. 20, 2, p. 204-215 12 p.

Research output: Contribution to journalArticle

Carcinogenesis
Breast
Gene Expression
Breast Neoplasms
Genes
2 Citations (Scopus)

Gene expression signatures associated with suppression of TRAMP prostate carcinogenesis by a kavalactone-rich Kava fraction

Tang, S. N., Zhang, J., Jiang, P., Datta, P., Leitzman, P., O'Sullivan, M. G., Jiang, C., Xing, C. & Lü, J., Dec 1 2016, In : Molecular Carcinogenesis. 55, 12, p. 2291-2303 13 p.

Research output: Contribution to journalArticle

Kava
Transcriptome
Transgenic Mice
Prostate
Carcinogenesis
5 Citations (Scopus)

Herbal cocktail Ka-Mi-Kae-Kyuk-Tang stimulates mouse bone marrow stem cell hematopoiesis and Janus-activated kinase 2/signal transducer and activator of transcription 5 pathway

Lee, J. E., Seo, I., Jeong, S. J., Koh, W., Jung, J. H., Kwon, T. R., Lee, H. J., Han, I., Lee, H. J., Lee, E. O., Kim, S. H., Jung, H. J., Lu, J. & Kim, S. H., Nov 18 2011, In : American Journal of Chinese Medicine. 39, 6, p. 1235-1252 18 p.

Research output: Contribution to journalArticle

STAT5 Transcription Factor
Janus Kinase 2
Hematopoiesis
Hematopoietic Stem Cells
Bone Marrow Cells
49 Citations (Scopus)

Herbal compound farnesiferol C exerts antiangiogenic and antitumor activity and targets multiple aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) signaling cascades

Lee, J. H., Choi, S., Lee, Y., Lee, H. J., Kim, K. H., Ahn, K. S., Bae, H., Lee, H. J., Lee, E. O., Ahn, K. S., Ryu, S. Y., Lü, J. & Kim, S. H., Feb 2010, In : Molecular cancer therapeutics. 9, 2, p. 389-399 11 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Focal Adhesion Protein-Tyrosine Kinases
Phosphotransferases
Ferula
farnesiferol C
101 Citations (Scopus)

Hexokinase 2-Mediated Warburg Effect Is Required for PTEN- and p53-Deficiency-Driven Prostate Cancer Growth

Wang, L., Xiong, H., Wu, F., Zhang, Y., Wang, J., Zhao, L., Guo, X., Chang, L. J., Zhang, Y., You, M. J., Koochekpour, S., Saleem, M., Huang, H., Lu, J. & Deng, Y., Jan 1 2014, In : Cell Reports. 8, 5, p. 1461-1474 14 p.

Research output: Contribution to journalArticle

Hexokinase
Prostatic Neoplasms
Growth
Tumors
Messenger RNA
95 Citations (Scopus)

Induction of caspase-mediated apoptosis and cell-cycle G1 arrest by selenium metabolite methylselenol

Wang, Z., Jiang, C. & Lu, J., Jul 20 2002, In : Molecular Carcinogenesis. 34, 3, p. 113-120 8 p.

Research output: Contribution to journalArticle

G1 Phase Cell Cycle Checkpoints
Selenium
Caspases
Apoptosis
Methionine
1 Citation (Scopus)
Chloramphenicol O-Acetyltransferase
Detergents
Octoxynol
Chloramphenicol
Kinetics
83 Citations (Scopus)

Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis through superoxide/p53/Bax-mediated activation of mitochondrial pathway

Hu, H., Jiang, C., Schuster, T., Li, G. X., Daniel, P. T. & Lü, J., Jul 1 2006, In : Molecular cancer therapeutics. 5, 7, p. 1873-1882 10 p.

Research output: Contribution to journalArticle

Selenious Acid
Selenium
Superoxides
Prostatic Neoplasms
Apoptosis