• 5651 Citations
  • 46 h-Index
1988 …2020

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1,2,3,4,6-penta-o-galloly-beta-D-glucose suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1α and signaling in LNCaP prostate cancer cells

Park, K. Y., Lee, H. J., Jeong, S. J., Lee, H. J., Kim, H. S., Kim, S. H., Lim, S., Kim, H. C., Lü, J. & Kim, S. H., Nov 19 2010, In : Biological and Pharmaceutical Bulletin. 33, 11, p. 1835-1840 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

6-(1-Oxobutyl)-5,8-dimethoxy-1,4-naphthoquinone inhibits Lewis lung cancer by antiangiogenesis and apoptosis

Hyo, J. L., Lee, H. J., Song, G. Y., Li, G., Lee, J. H., Lu, J. & Kim, S. H., Jun 1 2007, In : International Journal of Cancer. 120, 11, p. 2481-2490 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Activation of p53 signaling and inhibition of androgen receptor mediate tanshinone IIA induced G1 arrest in LNCaP prostate cancer cells

Won, S. H., Lee, H. J., Jeong, S. J., Lu, J. & Kim, S. H., May 1 2012, In : Phytotherapy Research. 26, 5, p. 669-674 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

A filter elution assay for the simultaneous detection of DNA double and single strand breaks

Lu, J., Kaeck, M. R., Jiang, C., Garcia, G. & Thompson, H. J., Mar 15 1996, In : Analytical Biochemistry. 235, 2, p. 227-233 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
14 Scopus citations

An oriental herbal cocktail, ka-mi-kae-kyuk-tang, exerts anti-cancer activities by targeting angiogenesis, apoptosis and metastasis

Lee, H. J., Lee, E. O., Rhee, Y. H., Ahn, K. S., Li, G. X., Jiang, C., Lü, J. & Kim, S. H., Dec 1 2006, In : Carcinogenesis. 27, 12, p. 2455-2463 9 p.

Research output: Contribution to journalArticle

63 Scopus citations

A novel class of pyranocoumarin anti-androgen receptor signaling compounds

Guo, J., Jiang, C., Wang, Z., Lee, H. J., Hu, H., Malewicz, B., Lee, H. J., Lee, J. H., Baek, N. I., Jeong, J. H., Kim, D. K., Kang, K. S., Kim, S. H. & Lu, J., Mar 1 2007, In : Molecular cancer therapeutics. 6, 3, p. 907-917 11 p.

Research output: Contribution to journalArticle

46 Scopus citations

A novel sulindac derivative lacking cyclooxygenase-inhibitory activities suppresses carcinogenesis in the transgenic adenocarcinoma of mouse prostate model

Zhang, Y., Zhang, J., Wang, L., Quealy, E., Gary, B. D., Reynolds, R. C., Piazza, G. A. & Lü, J., Jul 1 2010, In : Cancer Prevention Research. 3, 7, p. 885-895 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Anti-androgen receptor signaling and prostate cancer inhibitory effects of sucrose- and benzophenone-compounds

Wang, Z., Lee, H. J., Wang, L., Jiang, C., Baek, N. I., Kim, S. H. & Lü, J., May 1 2009, In : Pharmaceutical Research. 26, 5, p. 1140-1148 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
97 Scopus citations

Anti-cancer and other bioactivities of Korean Angelica gigas Nakai (AGN) and its major pyranocoumarin compounds

Zhang, J., Li, L., Jiang, C., Xing, C., Kim, S. H. & Lu, J., Dec 3 2012, In : Anti-Cancer Agents in Medicinal Chemistry. 12, 10, p. 1239-1254 16 p.

Research output: Contribution to journalArticle

43 Scopus citations

Anti-cancer gallotannin penta-O-galloyl-beta-d-glucose is a nanomolar inhibitor of select mammalian DNA polymerases

Mizushina, Y., Zhang, J., Pugliese, A., Kim, S. H. & Lü, J., Oct 1 2010, In : Biochemical Pharmacology. 80, 8, p. 1125-1132 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
69 Scopus citations

Apoptosis and angiogenesis in cancer prevention by selenium

Lu, J., Aug 7 2001, In : Advances in Experimental Medicine and Biology. 492, p. 131-145 15 p.

Research output: Contribution to journalArticle

38 Scopus citations

A synthetic decursin analog with increased in vivo stability suppresses androgen receptor signaling in vitro and in vivo

Zhang, Y., Shaik, A. A., Xing, C., Chai, Y., Li, L., Zhang, J., Zhang, W., Kim, S. H., Lü, J. & Jiang, C., Oct 1 2012, In : Investigational New Drugs. 30, 5, p. 1820-1829 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Augmented suppression of androgen receptor signaling by a combination of α-tocopheryl succinate and methylseleninic acid

Zhang, H., Wu, Y., Malewicz, B., Lu, J., Li, S., Marshall, J., Ip, C. & Dong, Y., Dec 15 2006, In : Cancer. 107, 12, p. 2942-2948 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Biological and genetic properties of the p53 null preneoplastic mammary epithelium.

Medina, D., Kittrell, F. S., Shepard, A., Stephens, L. C., Jiang, C., Lu, J., Allred, D. C., McCarthy, M. & Ullrich, R. L., Jun 2002, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 16, 8, p. 881-883 3 p.

Research output: Contribution to journalArticle

85 Scopus citations

Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells

Jiang, C., Wang, Z., Ganther, H. & Lu, J., Apr 1 2001, In : Cancer Research. 61, 7, p. 3062-3070 9 p.

Research output: Contribution to journalArticle

226 Scopus citations

Cellular and metabolic effects of triphenylselenonium chloride in a mammary cell culture model

Lu, J., Jiang, C., Kaeck, M., Ganther, H., Ip, C. & Thompson, H., Mar 1 1995, In : Carcinogenesis. 16, 3, p. 513-517 5 p.

Research output: Contribution to journalArticle

39 Scopus citations

Characterization of the Fluorescence Properties of 4-Dialkylaminochalcones and Investigation of the Cytotoxic Mechanism of Chalcones

Zhou, B., Jiang, P., Lu, J. & Xing, C., Jul 1 2016, In : Archiv der Pharmazie. p. 539-552 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Chemopreventive effect of Korean Angelica root extract on TRAMP carcinogenesis and integrative "omic" profiling of affected neuroendocrine carcinomas

Zhang, J., Wang, L., Zhang, Y., Li, L., Tang, S., Xing, C., Kim, S. H., Jiang, C. & Lü, J., Dec 2015, In : Molecular Carcinogenesis. 54, 12, p. 1567-1583 17 p.

Research output: Contribution to journalArticle

10 Scopus citations

Chemopreventive effects of Korean Angelica versus its major pyranocoumarins on two lineages of transgenic adenocarcinoma of mouse prostate carcinogenesis

Tang, S. N., Zhang, J., Wu, W., Jiang, P., Puppala, M., Zhang, Y., Xing, C., Kim, S. H., Jiang, C. & Lü, J., Sep 1 2015, In : Cancer Prevention Research. 8, 9, p. 835-844 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Comparison of the effects of an organic and an inorganic form of selenium on a mammary carcinoma cell line

Thompson, H. J., Wilson, A., Lu, J., Singh, M., Jiang, C., Upadhyaya, P., El-bayoumy, K. & Ip, C., Feb 1 1994, In : Carcinogenesis. 15, 2, p. 183-186 4 p.

Research output: Contribution to journalArticle

138 Scopus citations

Co-targeting hexokinase 2-mediated Warburg effect and ULK1-dependent autophagy suppresses tumor growth of PTEN- and TP53-deficiency-driven castration-resistant prostate cancer

Wang, L., Wang, J., Xiong, H., Wu, F., Lan, T., Zhang, Y., Guo, X., Wang, H., Saleem, M., Jiang, C., Lu, J. & Deng, Y., May 1 2016, In : EBioMedicine. 7, p. 50-61 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Cyclooxygenase-2/prostaglandin E2 pathway mediates icariside II induced apoptosis in human PC-3 prostate cancer cells

Lee, K. S., Lee, H. J., Ahn, K. S., Kim, S. H., Nam, D., Kim, D. K., Choi, D. Y., Ahn, K. S., Lu, J. & Kim, S. H., Jul 18 2009, In : Cancer Letters. 280, 1, p. 93-100 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

Cytochrome P450 isoforms in the metabolism of decursin and decursinol angelate from Korean angelica

Zhang, J., Li, L., Tang, S., Hale, T. W., Xing, C., Jiang, C. & Lü, J., Sep 1 2015, In : American Journal of Chinese Medicine. 43, 6, p. 1211-1230 20 p.

Research output: Contribution to journalArticle

4 Scopus citations

Decursin and decursinol angelate inhibit estrogen-stimulated and estrogen-independent growth and survival of breast cancer cells

Jiang, C., Guo, J., Wang, Z., Xiao, B., Lee, H. J., Lee, E. O., Kim, S. H. & Lu, J., Nov 6 2007, In : Breast Cancer Research. 9, 6, R77.

Research output: Contribution to journalArticle

65 Scopus citations

Detergents inhibit chloramphenicol acetyl transferase

Lu, J. & Jiang, C., 1992, In : BioTechniques. 12, 5, p. 643-644 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

Differential induction of growth arrest inducible genes by selenium compounds

Kaeck, M., Lu, J., Strange, R., Ip, C., Ganther, H. E. & Thompson, H. J., Apr 4 1997, In : Biochemical Pharmacology. 53, 7, p. 921-926 6 p.

Research output: Contribution to journalArticle

91 Scopus citations

Differential involvement of reactive oxygen species in apoptosis induced by two classes of selenium compounds in human prostate cancer cells

Li, G. X., Hu, H., Jiang, C., Schuster, T. & Lü, J., May 1 2007, In : International Journal of Cancer. 120, 9, p. 2034-2043 10 p.

Research output: Contribution to journalArticle

95 Scopus citations

Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1- (3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice

Narayanapillai, S. C., Balbo, S., Leitzman, P., Grill, A. E., Upadhyaya, P., Shaik, A. A., Zhou, B., Gerard O'Sullivan, M., Peterson, L. A., Lu, J., Hecht, S. S. & Xing, C., Jan 1 2014, In : Carcinogenesis. 35, 10, p. 2365-2372 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Dissociation of the genotoxic and growth inhibitory effects of selenium

Lu, J., Jiang, C., Kaeck, M., Ganther, H., Vadhanavikit, S., Clement, IP. P. & Thompson, H., Jul 17 1995, In : Biochemical Pharmacology. 50, 2, p. 213-219 7 p.

Research output: Contribution to journalArticle

126 Scopus citations
138 Scopus citations

Economically viable efficient synthesis of (±)-methysticin: A component in kava potentially responsible for its cancer chemopreventive activity

Ali Shaik, A., Tan, J., Lü, J. & Xing, C., Jun 29 2012, In : Arkivoc. 2012, 8, p. 137-145 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Effect of an aqueous extract of selenium-enriched garlic on in vitro markers and in vivo efficacy in cancer prevention

Lu, J., Pei, H., Ip, C., Lisk, D. J., Ganther, H. & Thompson, H. J., Sep 1996, In : Carcinogenesis. 17, 9, p. 1903-1907 5 p.

Research output: Contribution to journalArticle

94 Scopus citations

Effect of excess dietary iron on the promotion stage of 1-methyl-1- nitrosourea-induced mammary carcinogenesis: Pathogenetic characteristics and distribution of iron

Singh, M., Lu, J., Briggs, S. P., Mcginley, J. N., Haegele, A. D. & Thompson, H. J., Aug 1 1994, In : Carcinogenesis. 15, 8, p. 1567-1570 4 p.

Research output: Contribution to journalArticle

23 Scopus citations

Effect of excess dietary zinc on pancreatic exocrine function in the chick

Lu, J. & Combs, G. F., Jan 1 1988, In : Journal of Nutrition. 118, 6, p. 681-689 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Effects of methylselenocysteine on PKC activity, cdk2 phosphorylation and gadd gene expression in synchronized mouse mammary epithelial tumor cells

Sinha, R., Kiley, S. C., Lu, J. X., Thompson, H. J., Moraes, R., Jaken, S. & Medina, D., Nov 15 1999, In : Cancer Letters. 146, 2, p. 135-145 11 p.

Research output: Contribution to journalArticle

77 Scopus citations

Enhanced apoptotic effects by the combination of curcumin and methylseleninic acid: Potential role of mcl-1 and FAK

Guo, X., Yin, S., Dong, Y., Fan, L., Ye, M., Lu, J. & Hu, H., Nov 1 2013, In : Molecular Carcinogenesis. 52, 11, p. 879-889 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Excess dietary zinc decreases tissue α-tocopherol in chicks

Lu, J. & Combs, G. F., Jan 1 1988, In : Journal of Nutrition. 118, 11, p. 1349-1359 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Galbanic acid decreases androgen receptor abundance and signaling and induces G 1 arrest in prostate cancer cells

Zhang, Y., Kim, K. H., Zhang, W., Guo, Y., Kim, S. H. & Lü, J., Jan 11 2012, In : International Journal of Cancer. 130, 1, p. 200-212 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Galbanic acid isolated from Ferula assafoetida exerts in vivo anti-tumor activity in association with anti-angiogenesis and anti-proliferation

Kim, K. H., Lee, H. J., Jeong, S. J., Lee, H. J., Lee, E. O., Kim, H. S., Zhang, Y., Ryu, S. Y., Lee, M. H., Lu, J. & Kim, S. H., Mar 1 2011, In : Pharmaceutical Research. 28, 3, p. 597-609 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Gene expression changes associated with chemically induced rat mammary carcinogenesis

Lu, J., Pei, H., Kaeck, M. & Thompson, H. J., Oct 1 1997, In : Molecular Carcinogenesis. 20, 2, p. 204-215 12 p.

Research output: Contribution to journalArticle

86 Scopus citations

Gene expression signatures associated with suppression of TRAMP prostate carcinogenesis by a kavalactone-rich Kava fraction

Tang, S. N., Zhang, J., Jiang, P., Datta, P., Leitzman, P., O'Sullivan, M. G., Jiang, C., Xing, C. & Lü, J., Dec 1 2016, In : Molecular Carcinogenesis. 55, 12, p. 2291-2303 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Herbal cocktail Ka-Mi-Kae-Kyuk-Tang stimulates mouse bone marrow stem cell hematopoiesis and Janus-activated kinase 2/signal transducer and activator of transcription 5 pathway

Lee, J. E., Seo, I., Jeong, S. J., Koh, W., Jung, J. H., Kwon, T. R., Lee, H. J., Han, I., Lee, H. J., Lee, E. O., Kim, S. H., Jung, H. J., Lu, J. & Kim, S. H., Nov 18 2011, In : American Journal of Chinese Medicine. 39, 6, p. 1235-1252 18 p.

Research output: Contribution to journalArticle

5 Scopus citations

Herbal compound farnesiferol C exerts antiangiogenic and antitumor activity and targets multiple aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) signaling cascades

Lee, J. H., Choi, S., Lee, Y., Lee, H. J., Kim, K. H., Ahn, K. S., Bae, H., Lee, H. J., Lee, E. O., Ahn, K. S., Ryu, S. Y., Lü, J. & Kim, S. H., Feb 2010, In : Molecular cancer therapeutics. 9, 2, p. 389-399 11 p.

Research output: Contribution to journalArticle

50 Scopus citations

Hexokinase 2-Mediated Warburg Effect Is Required for PTEN- and p53-Deficiency-Driven Prostate Cancer Growth

Wang, L., Xiong, H., Wu, F., Zhang, Y., Wang, J., Zhao, L., Guo, X., Chang, L. J., Zhang, Y., You, M. J., Koochekpour, S., Saleem, M., Huang, H., Lu, J. & Deng, Y., Jan 1 2014, In : Cell Reports. 8, 5, p. 1461-1474 14 p.

Research output: Contribution to journalArticle

105 Scopus citations

Induction of caspase-mediated apoptosis and cell-cycle G1 arrest by selenium metabolite methylselenol

Wang, Z., Jiang, C. & Lu, J., Jul 20 2002, In : Molecular Carcinogenesis. 34, 3, p. 113-120 8 p.

Research output: Contribution to journalArticle

95 Scopus citations
1 Scopus citations

Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis through superoxide/p53/Bax-mediated activation of mitochondrial pathway

Hu, H., Jiang, C., Schuster, T., Li, G. X., Daniel, P. T. & Lü, J., Jul 1 2006, In : Molecular cancer therapeutics. 5, 7, p. 1873-1882 10 p.

Research output: Contribution to journalArticle

83 Scopus citations