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Research Output 1988 2019

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Article
2010
21 Citations (Scopus)

Proteomic profiling of potential molecular targets of methyl-selenium compounds in the transgenic adenocarcinoma of mouse prostate model

Zhang, J., Wang, L., Anderson, L. B., Witthuhn, B., Xu, Y. & Lü, J., Aug 1 2010, In : Cancer Prevention Research. 3, 8, p. 994-1006 13 p.

Research output: Contribution to journalArticle

Selenium Compounds
Proteomics
Transgenic Mice
Prostate
Adenocarcinoma
59 Citations (Scopus)

Tanshinone IIa induces mitochondria dependent apoptosis in prostate cancer cells in association with an inhibition of phosphoinositide 3-kinase/AKT pathway

Won, S. H., Lee, H. J., Jeong, S. J., Lee, H. J., Lee, E. O., Jung, D. B., Shin, J. M., Kwon, T. R., Yun, S. M., Lee, M. H., Choi, S. H., Lü, J. & Kim, S. H., Nov 19 2010, In : Biological and Pharmaceutical Bulletin. 33, 11, p. 1828-1834 7 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Prostatic Neoplasms
Mitochondria
Apoptosis
Caspase 3
2009
9 Citations (Scopus)

Anti-androgen receptor signaling and prostate cancer inhibitory effects of sucrose- and benzophenone-compounds

Wang, Z., Lee, H. J., Wang, L., Jiang, C., Baek, N. I., Kim, S. H. & Lu, J., May 1 2009, In : Pharmaceutical Research. 26, 5, p. 1140-1148 9 p.

Research output: Contribution to journalArticle

Androgen Receptors
Sucrose
Prostatic Neoplasms
Prostate-Specific Antigen
Androgens
57 Citations (Scopus)

Cyclooxygenase-2/prostaglandin E2 pathway mediates icariside II induced apoptosis in human PC-3 prostate cancer cells

Lee, K. S., Lee, H. J., Ahn, K. S., Kim, S. H., Nam, D., Kim, D. K., Choi, D. Y., Ahn, K. S., Lu, J. & Kim, S. H., Jul 18 2009, In : Cancer Letters. 280, 1, p. 93-100 8 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Dinoprostone
Prostatic Neoplasms
Apoptosis
Poly(ADP-ribose) Polymerases
47 Citations (Scopus)

In vivo anti-cancer activity of Korean Angelica gigas and its major pyranocoumarin decursin

Lee, H. J., Lee, H. J., Lee, E. O., Lee, J. H., Lee, K. S., Kim, K. H., Kim, S. H. & Lü, J., Jan 1 2009, In : American Journal of Chinese Medicine. 37, 1, p. 127-142 16 p.

Research output: Contribution to journalArticle

Pyranocoumarins
Angelica
Neoplasms
Allografts
Lung Neoplasms
15 Citations (Scopus)

In vivo molecular mediators of cancer growth suppression and apoptosis by selenium in mammary and prostate models: Lack of involvement of gadd genes

Jiang, W., Jiang, C., Pei, H., Wang, L., Zhang, J., Hu, H. & Lü, J., Mar 1 2009, In : Molecular cancer therapeutics. 8, 3, p. 682-691 10 p.

Research output: Contribution to journalArticle

Selenium
Prostate
Breast
Apoptosis
Growth
90 Citations (Scopus)

Methyl-selenium compounds inhibit prostate carcinogenesis in the transgenic adenocarcinoma of mouse prostate model with survival benefit

Wang, L., Bonorden, M. J. L., Li, G. X., Lee, H. J., Hu, H., Zhang, Y., Liao, J. D., Cleary, M. P. & Lü, J., May 1 2009, In : Cancer Prevention Research. 2, 5, p. 484-495 12 p.

Research output: Contribution to journalArticle

Selenium Compounds
Transgenic Mice
Prostate
Carcinogenesis
Adenocarcinoma
42 Citations (Scopus)

Pentagalloylglucose induces autophagy and caspase-independent programmed deaths in human PC-3 and mouse TRAMP-C2 prostate cancer cells

Hu, H., Chai, Y., Wang, L., Zhang, J., Lee, H. J., Kim, S. H. & Lü, J., Oct 1 2009, In : Molecular cancer therapeutics. 8, 10, p. 2833-2843 11 p.

Research output: Contribution to journalArticle

Prostaglandins G
Autophagy
Caspases
Prostatic Neoplasms
Receptor-Interacting Protein Serine-Threonine Kinases
37 Citations (Scopus)

Penta-O-galloyl-beta-D-glucose induces S- and G1-cell cycle arrests in prostate cancer cells targeting DNA replication and cyclin D1

Hu, H., Zhang, J., Lee, H. J., Kim, S. H. & Lü, J., May 13 2009, In : Carcinogenesis. 30, 5, p. 818-823 6 p.

Research output: Contribution to journalArticle

Prostaglandins G
G1 Phase Cell Cycle Checkpoints
Rubiaceae
Cyclin D1
DNA Replication
2008
49 Citations (Scopus)

Methylseleninic acid enhances taxane drug efficacy against human prostate cancer and down-regulates antiapoptotic proteins Bcl-XL and survivin

Hu, H., Li, G. X., Wang, L., Watts, J., Combs, G. F. & Lü, J., Feb 15 2008, In : Clinical Cancer Research. 14, 4, p. 1150-1158 9 p.

Research output: Contribution to journalArticle

bcl-X Protein
Paclitaxel
Prostatic Neoplasms
Down-Regulation
Pharmaceutical Preparations
37 Citations (Scopus)

Methylseleninic acid inhibits microvascular endothelial G 1 cell cycle progression and decreases tumor microvessel density

Wang, Z., Hu, H., Li, G., Lee, H. J., Jiang, C., Kim, S. H. & Lu, J., Jan 1 2008, In : International Journal of Cancer. 122, 1, p. 15-24 10 p.

Research output: Contribution to journalArticle

Gastrin-Secreting Cells
Microvessels
Cell Cycle
Endothelial Cells
Neoplasms
79 Citations (Scopus)

Mitochondria-cytochrome C-caspase-9 cascade mediates isorhamnetin-induced apoptosis

Lee, H. J., Lee, H. J., Lee, E. O., Ko, S. G., Bae, H. S., Kim, C. H., Ahn, K. S., Lu, J. & Kim, S. H., Nov 8 2008, In : Cancer Letters. 270, 2, p. 342-353 12 p.

Research output: Contribution to journalArticle

Caspase 9
Cytochromes
Mitochondria
Apoptosis
Quercetin
71 Citations (Scopus)

Penta-1,2,3,4,6-O-galloyl-β-D-glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo

Hu, H., Lee, H. J., Jiang, C., Zhang, J., Wang, L., Zhao, Y., Xiang, Q., Lee, E. O., Kim, S. H. & Lü, J., Oct 22 2008, In : Molecular cancer therapeutics. 7, 9, p. 2681-2691 11 p.

Research output: Contribution to journalArticle

Prostaglandins G
STAT3 Transcription Factor
Rubiaceae
Heterografts
Prostate
18 Citations (Scopus)

Quinoline derivative KB3-1 potentiates paclitaxel induced cytotoxicity and cycle arrest via multidrug resistance reversal in MES-SA/DX5 cancer cells

Koo, J. S., Choi, W. C., Rhee, Y. H., Lee, H. J., Lee, E. O., Ahn, K. S., Bae, H. S., Ahn, K. S., Kang, J. M., Choi, S. U., Kim, M. O., Lu, J. & Kim, S. H., Nov 21 2008, In : Life Sciences. 83, 21-22, p. 700-708 9 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
P-Glycoprotein
Cytotoxicity
Paclitaxel
Cells
108 Citations (Scopus)

Superior in vivo inhibitory efficacy of methylseleninic acid against human prostate cancer over selenomethionine or selenite

Li, G. X., Lee, H. J., Wang, Z., Hu, H., Liao, J. D., Watts, J. C., Combs, G. F. & LüJ., J., May 1 2008, In : Carcinogenesis. 29, 5, p. 1005-1012 8 p.

Research output: Contribution to journalArticle

Selenomethionine
Selenious Acid
Selenium
Prostatic Neoplasms
Heterografts
2007
23 Citations (Scopus)

6-(1-Oxobutyl)-5,8-dimethoxy-1,4-naphthoquinone inhibits Lewis lung cancer by antiangiogenesis and apoptosis

Hyo, J. L., Lee, H. J., Song, G. Y., Li, G., Lee, J. H., Lu, J. & Kim, S. H., Jun 1 2007, In : International Journal of Cancer. 120, 11, p. 2481-2490 10 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Apoptosis
Lewis Lung Carcinoma
Vascular Endothelial Growth Factor A
Neoplasms
45 Citations (Scopus)

A novel class of pyranocoumarin anti-androgen receptor signaling compounds

Guo, J., Jiang, C., Wang, Z., Lee, H. J., Hu, H., Malewicz, B., Lee, H. J., Lee, J. H., Baek, N. I., Jeong, J. H., Kim, D. K., Kang, K. S., Kim, S. H. & Lu, J., Mar 1 2007, In : Molecular cancer therapeutics. 6, 3, p. 907-917 11 p.

Research output: Contribution to journalArticle

Pyranocoumarins
Androgen Receptors
Androgens
Ligands
Prostatic Neoplasms
64 Citations (Scopus)

Decursin and decursinol angelate inhibit estrogen-stimulated and estrogen-independent growth and survival of breast cancer cells

Jiang, C., Guo, J., Wang, Z., Xiao, B., Lee, H. J., Lee, E. O., Kim, S. H. & Lu, J., Nov 6 2007, In : Breast Cancer Research. 9, 6, R77.

Research output: Contribution to journalArticle

Estrogens
Breast Neoplasms
Estrogen Receptors
Survival
Growth
95 Citations (Scopus)

Differential involvement of reactive oxygen species in apoptosis induced by two classes of selenium compounds in human prostate cancer cells

Li, G. X., Hu, H., Jiang, C., Schuster, T. & Lü, J., May 1 2007, In : International Journal of Cancer. 120, 9, p. 2034-2043 10 p.

Research output: Contribution to journalArticle

Selenium Compounds
Selenious Acid
Reactive Oxygen Species
Prostatic Neoplasms
Apoptosis
2006
63 Citations (Scopus)

An oriental herbal cocktail, ka-mi-kae-kyuk-tang, exerts anti-cancer activities by targeting angiogenesis, apoptosis and metastasis

Lee, H. J., Lee, E. O., Rhee, Y. H., Ahn, K. S., Li, G. X., Jiang, C., Lü, J. & Kim, S. H., Dec 1 2006, In : Carcinogenesis. 27, 12, p. 2455-2463 9 p.

Research output: Contribution to journalArticle

Apoptosis
Neoplasm Metastasis
Lewis Lung Carcinoma
Blood Vessels
Neoplasms
7 Citations (Scopus)

Augmented suppression of androgen receptor signaling by a combination of α-tocopheryl succinate and methylseleninic acid

Zhang, H., Wu, Y., Malewicz, B., Lu, J., Li, S., Marshall, J., Ip, C. & Dong, Y., Dec 15 2006, In : Cancer. 107, 12, p. 2942-2948 7 p.

Research output: Contribution to journalArticle

Androgen Receptors
Succinic Acid
Prostate-Specific Antigen
Transcriptional Activation
Messenger RNA
83 Citations (Scopus)

Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis through superoxide/p53/Bax-mediated activation of mitochondrial pathway

Hu, H., Jiang, C., Schuster, T., Li, G. X., Daniel, P. T. & Lü, J., Jul 1 2006, In : Molecular cancer therapeutics. 5, 7, p. 1873-1882 10 p.

Research output: Contribution to journalArticle

Selenious Acid
Selenium
Superoxides
Prostatic Neoplasms
Apoptosis
94 Citations (Scopus)

Potent antiandrogen and androgen receptor activities of an Angelica gigas-containing herbal formulation: Identification of decursin as a novel and active compound with implications for prevention and treatment of prostate cancer

Jiang, C., Lee, H. J., Li, G. X., Guo, J., Malewicz, B., Zhao, Y., Lee, E. O., Lee, H. J., Lee, J. H., Kim, M. S., Kim, S. H. & Lu, J., Jan 1 2006, In : Cancer Research. 66, 1, p. 453-463 11 p.

Research output: Contribution to journalArticle

Angelica
Androgen Antagonists
Androgen Receptors
Prostatic Neoplasms
Androgens
73 Citations (Scopus)

Potent inhibition of Lewis lung cancer growth by heyneanol A from the roots of Vitis amurensis through apoptotic and anti-angiogenic activities

Lee, E. O., Lee, H. J., Hwang, H. S., Ahn, K. S., Chae, C., Kang, K. S., Lu, J. & Kim, S. H., Oct 1 2006, In : Carcinogenesis. 27, 10, p. 2059-2069 11 p.

Research output: Contribution to journalArticle

Vitis
Lung Neoplasms
Growth
Lewis Lung Carcinoma
Neoplasms
2005
95 Citations (Scopus)

Involvement of c-Jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by sulforaphane in DU145 prostate cancer cells

Cho, S. D., Li, G., Hu, H., Jiang, C., Kang, K. S., Lee, Y. S., Kim, S. H. & Lu, J., Nov 16 2005, In : Nutrition and cancer. 52, 2, p. 213-224 12 p.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
Caspases
Prostatic Neoplasms
Apoptosis
Reactive Oxygen Species
68 Citations (Scopus)

Methylseleninic acid potentiates apoptosis induced by chemotherapeutic drugs in androgen-independent prostate cancer cells

Hu, H., Jiang, C., Ip, C., Rustum, Y. M. & Lü, J., Mar 15 2005, In : Clinical Cancer Research. 11, 6, p. 2379-2388 10 p.

Research output: Contribution to journalArticle

Androgens
Prostatic Neoplasms
Apoptosis
JNK Mitogen-Activated Protein Kinases
Pharmaceutical Preparations
86 Citations (Scopus)

PKB/AKT and ERK regulation of caspase-mediated apoptosis by methylseleninic acid in LNCaP prostate cancer cells

Hu, H., Jiang, C., Li, G. & Lü, J., Aug 1 2005, In : Carcinogenesis. 26, 8, p. 1374-1381 8 p.

Research output: Contribution to journalArticle

Caspases
Prostatic Neoplasms
Apoptosis
Selenious Acid
Caspase Inhibitors
2004
41 Citations (Scopus)

Methyl selenium-induced vascular endothelial apoptosis is executed by caspases and principally mediated by p38 MAPK pathway

Jiang, C., Kim, K. H., Wang, Z. & Lü, J., Jan 1 2004, In : Nutrition and cancer. 49, 2, p. 174-183 10 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Selenium
Caspases
Blood Vessels
Caspase 3
75 Citations (Scopus)

Methyl selenium metabolites decrease prostate-specific antigen expression by inducing protein degradation and suppressing androgen-stimulated transcription

Cho, S. D., Jiang, C., Malewicz, B., Dong, Y., Young, C. Y. F., Kang, K. S., Lee, Y. S., Ip, C. & Lü, J., May 1 2004, In : Molecular cancer therapeutics. 3, 5, p. 605-611 7 p.

Research output: Contribution to journalArticle

Prostate-Specific Antigen
Selenium
Androgens
Proteolysis
Prostatic Neoplasms
85 Citations (Scopus)

Selenite-induced p53 ser-15 phosphorylation and caspase-mediated apoptosis in LNCaP human prostate cancer cells

Jiang, C., Hu, H., Malewicz, B., Wang, Z. & Lü, J., Jul 1 2004, In : Molecular cancer therapeutics. 3, 7, p. 877-884 8 p.

Research output: Contribution to journalArticle

Selenious Acid
Caspases
Prostatic Neoplasms
Phosphorylation
Apoptosis
2002
82 Citations (Scopus)

Biological and genetic properties of the p53 null preneoplastic mammary epithelium.

Medina, D., Kittrell, F. S., Shepard, A., Stephens, L. C., Jiang, C., Lu, J., Allred, D. C., McCarthy, M. & Ullrich, R. L., Jan 1 2002, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 16, 8, p. 881-883 3 p.

Research output: Contribution to journalArticle

Breast
Epithelium
Telomerase
Progesterone Receptors
Estrogen Receptors
137 Citations (Scopus)
Selenious Acid
Cell Cycle Proteins
Protein Kinases
Prostatic Neoplasms
Selenium
95 Citations (Scopus)

Induction of caspase-mediated apoptosis and cell-cycle G1 arrest by selenium metabolite methylselenol

Wang, Z., Jiang, C. & Lu, J., Jul 20 2002, In : Molecular Carcinogenesis. 34, 3, p. 113-120 8 p.

Research output: Contribution to journalArticle

G1 Phase Cell Cycle Checkpoints
Selenium
Caspases
Apoptosis
Methionine
106 Citations (Scopus)

Selenium compounds inhibit IκB kinase (IKK) and nuclear factor-κB (NF-κB) in prostate cancer cells

Gasparian, A. V., Yao, Y. J., Lu, J., Yemelyanov, A. Y., Lyakh, L. A., Slaga, T. J. & Budunova, I. V., Oct 1 2002, In : Molecular cancer therapeutics. 1, 12, p. 1079-1087 9 p.

Research output: Contribution to journalArticle

Selenium Compounds
Prostatic Neoplasms
Phosphotransferases
Prostate
Sodium Selenite
2001
69 Citations (Scopus)
Phosphatidylinositol 3-Kinase
JNK Mitogen-Activated Protein Kinases
Extracellular Signal-Regulated MAP Kinases
p38 Mitogen-Activated Protein Kinases
Endothelial Cells
38 Citations (Scopus)

Apoptosis and angiogenesis in cancer prevention by selenium

Lu, J., Aug 7 2001, In : Advances in Experimental Medicine and Biology. 492, p. 131-145 15 p.

Research output: Contribution to journalArticle

Selenium
Antineoplastic Agents
Rats
Animals
Antioxidants
222 Citations (Scopus)

Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells

Jiang, C., Wang, Z., Ganther, H. & Lu, J., Apr 1 2001, In : Cancer Research. 61, 7, p. 3062-3070 9 p.

Research output: Contribution to journalArticle

Anoikis
Selenium
Caspases
Prostatic Neoplasms
Apoptosis
2000
96 Citations (Scopus)
Silymarin
Endothelial cells
Flavonoids
Endothelial Cells
Antioxidants
107 Citations (Scopus)

Monomethyl selenium-specific inhibition of MMP-2 and VEGF expression: Implications for angiogenic switch regulation

Jiang, C., Ganther, H. & Lu, J., Dec 1 2000, In : Molecular Carcinogenesis. 29, 4, p. 236-250 15 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 2
Selenium
Vascular Endothelial Growth Factor A
Selenious Acid
Mitogen-Activated Protein Kinase 1
1999
77 Citations (Scopus)

Effects of methylselenocysteine on PKC activity, cdk2 phosphorylation and gadd gene expression in synchronized mouse mammary epithelial tumor cells

Sinha, R., Kiley, S. C., Lu, J., Thompson, H. J., Moraes, R., Jaken, S. & Medina, D., Nov 15 1999, In : Cancer Letters. 146, 2, p. 135-145 11 p.

Research output: Contribution to journalArticle

Protein Kinase C
Epithelial Cells
Phosphorylation
Breast Neoplasms
Gene Expression
9 Citations (Scopus)

Mammary cancer promotion and MAPK activation associated with consumption of a corn oil-based high-fat diet

Wang, Z., Pei, H., Kaeck, M. & Lu, J., Jan 1 1999, In : Nutrition and cancer. 34, 2, p. 140-146 7 p.

Research output: Contribution to journalArticle

Corn Oil
High Fat Diet
Mitogen-Activated Protein Kinases
Fats
Breast Neoplasms
176 Citations (Scopus)

Selenium-induced inhibition of angiogenesis in mammary cancer at chemopreventive levels of intake

Jiang, C., Jiang, W., Ip, C., Ganther, H. & Lu, J., Dec 20 1999, In : Molecular Carcinogenesis. 26, 4, p. 213-225 13 p.

Research output: Contribution to journalArticle

Selenium
Breast Neoplasms
Microvessels
Human Umbilical Vein Endothelial Cells
Neoplasms
1998
25 Citations (Scopus)

Pathogenetic characterization of 1-methyl-1-nitrosourea-induced mammary carcinomas in the rat

Lu, J., Jiang, C., Mitrenga, T., Cutter, G. & Thompson, H. J., Jan 1 1998, In : Carcinogenesis. 19, 1, p. 223-227 5 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Carcinoma
Codon
Human Mammary Glands
Genotype
1997
91 Citations (Scopus)

Differential induction of growth arrest inducible genes by selenium compounds

Kaeck, M., Lu, J., Strange, R., Ip, C., Ganther, H. E. & Thompson, H. J., Apr 4 1997, In : Biochemical Pharmacology. 53, 7, p. 921-926 6 p.

Research output: Contribution to journalArticle

Selenium Compounds
Genes
Selenium
Growth
Cell Death
86 Citations (Scopus)

Gene expression changes associated with chemically induced rat mammary carcinogenesis

Lu, J., Pei, H., Kaeck, M. & Thompson, H. J., Oct 1 1997, In : Molecular Carcinogenesis. 20, 2, p. 204-215 12 p.

Research output: Contribution to journalArticle

Carcinogenesis
Breast
Gene Expression
Breast Neoplasms
Genes
196 Citations (Scopus)

Sulfone metabolite of sulindac inhibits mammary carcinogenesis

Thompson, H. J., Jiang, C., Lu, J., Mehta, R. G., Piazza, G. A., Paranka, N. S., Pamukcu, R. & Ahnen, D. J., Jan 28 1997, In : Cancer Research. 57, 2, p. 267-271 5 p.

Research output: Contribution to journalArticle

sulfoxide
Sulfones
Carcinogenesis
Breast
Sulindac
1996
9 Citations (Scopus)

A filter elution assay for the simultaneous detection of DNA double and single strand breaks

Lu, J., Kaeck, M. R., Jiang, C., Garcia, G. & Thompson, H. J., Mar 15 1996, In : Analytical Biochemistry. 235, 2, p. 227-233 7 p.

Research output: Contribution to journalArticle

Single-Stranded DNA Breaks
Double-Stranded DNA Breaks
Assays
DNA
Gravitation
94 Citations (Scopus)

Effect of an aqueous extract of selenium-enriched garlic on in vitro markers and in vivo efficacy in cancer prevention

Lu, J., Pei, H., Ip, C., Lisk, D. J., Ganther, H. & Thompson, H. J., Sep 1996, In : Carcinogenesis. 17, 9, p. 1903-1907 5 p.

Research output: Contribution to journalArticle

Garlic
Selenium
Neoplasms
Selenious Acid
Single-Stranded DNA Breaks
15 Citations (Scopus)

Method for 96-well M13 DNA template preparations for large-scale sequencing

Andersson, B., Lu, J., Edwards, K. E., Muzny, D. M. & Gibbs, R. A., 1996, In : BioTechniques. 20, 6, p. 1022-1027 6 p.

Research output: Contribution to journalArticle

Bacteriophages
DNA
Bacteriophage M13
DNA Sequence Analysis
Data Accuracy
1995
39 Citations (Scopus)

Cellular and metabolic effects of triphenylselenonium chloride in a mammary cell culture model

Lu, J., Jiang, C., Kaeck, M., Ganther, H., Ip, C. & Thompson, H., Mar 1 1995, In : Carcinogenesis. 16, 3, p. 513-517 5 p.

Research output: Contribution to journalArticle

Selenious Acid
Selenium Compounds
Breast
Cell Culture Techniques
Selenium