• 5631 Citations
  • 46 h-Index
1988 …2020

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Article
2008

Methylseleninic acid inhibits microvascular endothelial G 1 cell cycle progression and decreases tumor microvessel density

Wang, Z., Hu, H., Li, G., Lee, H. J., Jiang, C., Kim, S. H. & Lu, J., Jan 1 2008, In : International Journal of Cancer. 122, 1, p. 15-24 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Mitochondria-cytochrome C-caspase-9 cascade mediates isorhamnetin-induced apoptosis

Lee, H. J., Lee, H. J., Lee, E. O., Ko, S. G., Bae, H. S., Kim, C. H., Ahn, K. S., Lu, J. & Kim, S. H., Nov 8 2008, In : Cancer Letters. 270, 2, p. 342-353 12 p.

Research output: Contribution to journalArticle

79 Scopus citations

Penta-1,2,3,4,6-O-galloyl-β-D-glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo

Hu, H., Lee, H. J., Jiang, C., Zhang, J., Wang, L., Zhao, Y., Xiang, Q., Lee, E. O., Kim, S. H. & Lü, J., Oct 22 2008, In : Molecular cancer therapeutics. 7, 9, p. 2681-2691 11 p.

Research output: Contribution to journalArticle

72 Scopus citations

Quinoline derivative KB3-1 potentiates paclitaxel induced cytotoxicity and cycle arrest via multidrug resistance reversal in MES-SA/DX5 cancer cells

Koo, J. S., Choi, W. C., Rhee, Y. H., Lee, H. J., Lee, E. O., Ahn, K. S., Bae, H. S., Ahn, K. S., Kang, J. M., Choi, S. U., Kim, M. O., Lu, J. & Kim, S. H., Nov 21 2008, In : Life Sciences. 83, 21-22, p. 700-708 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Superior in vivo inhibitory efficacy of methylseleninic acid against human prostate cancer over selenomethionine or selenite

Li, G. X., Lee, H. J., Wang, Z., Hu, H., Liao, J. D., Watts, J. C., Combs, G. F. & LüJ., J., May 1 2008, In : Carcinogenesis. 29, 5, p. 1005-1012 8 p.

Research output: Contribution to journalArticle

108 Scopus citations
2009

Anti-androgen receptor signaling and prostate cancer inhibitory effects of sucrose- and benzophenone-compounds

Wang, Z., Lee, H. J., Wang, L., Jiang, C., Baek, N. I., Kim, S. H. & Lü, J., May 1 2009, In : Pharmaceutical Research. 26, 5, p. 1140-1148 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Cyclooxygenase-2/prostaglandin E2 pathway mediates icariside II induced apoptosis in human PC-3 prostate cancer cells

Lee, K. S., Lee, H. J., Ahn, K. S., Kim, S. H., Nam, D., Kim, D. K., Choi, D. Y., Ahn, K. S., Lu, J. & Kim, S. H., Jul 18 2009, In : Cancer Letters. 280, 1, p. 93-100 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

In vivo anti-cancer activity of Korean Angelica gigas and its major pyranocoumarin decursin

Lee, H. J., Lee, H. J., Lee, E. O., Lee, J. H., Lee, K. S., Kim, K. H., Kim, S. H. & Lü, J., Jan 1 2009, In : American Journal of Chinese Medicine. 37, 1, p. 127-142 16 p.

Research output: Contribution to journalArticle

47 Scopus citations

In vivo molecular mediators of cancer growth suppression and apoptosis by selenium in mammary and prostate models: Lack of involvement of gadd genes

Jiang, W., Jiang, C., Pei, H., Wang, L., Zhang, J., Hu, H. & Lü, J., Mar 1 2009, In : Molecular cancer therapeutics. 8, 3, p. 682-691 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Methyl-selenium compounds inhibit prostate carcinogenesis in the transgenic adenocarcinoma of mouse prostate model with survival benefit

Wang, L., Bonorden, M. J. L., Li, G. X., Lee, H. J., Hu, H., Zhang, Y., Liao, J. D., Cleary, M. P. & Lü, J., May 1 2009, In : Cancer Prevention Research. 2, 5, p. 484-495 12 p.

Research output: Contribution to journalArticle

90 Scopus citations

Pentagalloylglucose induces autophagy and caspase-independent programmed deaths in human PC-3 and mouse TRAMP-C2 prostate cancer cells

Hu, H., Chai, Y., Wang, L., Zhang, J., Lee, H. J., Kim, S. H. & Lü, J., Oct 1 2009, In : Molecular cancer therapeutics. 8, 10, p. 2833-2843 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Penta-O-galloyl-beta-D-glucose induces S- and G1-cell cycle arrests in prostate cancer cells targeting DNA replication and cyclin D1

Hu, H., Zhang, J., Lee, H. J., Kim, S. H. & Lü, J., May 13 2009, In : Carcinogenesis. 30, 5, p. 818-823 6 p.

Research output: Contribution to journalArticle

37 Scopus citations
2010

1,2,3,4,6-penta-o-galloly-beta-D-glucose suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1α and signaling in LNCaP prostate cancer cells

Park, K. Y., Lee, H. J., Jeong, S. J., Lee, H. J., Kim, H. S., Kim, S. H., Lim, S., Kim, H. C., Lü, J. & Kim, S. H., Nov 19 2010, In : Biological and Pharmaceutical Bulletin. 33, 11, p. 1835-1840 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

A novel sulindac derivative lacking cyclooxygenase-inhibitory activities suppresses carcinogenesis in the transgenic adenocarcinoma of mouse prostate model

Zhang, Y., Zhang, J., Wang, L., Quealy, E., Gary, B. D., Reynolds, R. C., Piazza, G. A. & Lü, J., Jul 1 2010, In : Cancer Prevention Research. 3, 7, p. 885-895 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Anti-cancer gallotannin penta-O-galloyl-beta-d-glucose is a nanomolar inhibitor of select mammalian DNA polymerases

Mizushina, Y., Zhang, J., Pugliese, A., Kim, S. H. & Lü, J., Oct 1 2010, In : Biochemical Pharmacology. 80, 8, p. 1125-1132 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Herbal compound farnesiferol C exerts antiangiogenic and antitumor activity and targets multiple aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) signaling cascades

Lee, J. H., Choi, S., Lee, Y., Lee, H. J., Kim, K. H., Ahn, K. S., Bae, H., Lee, H. J., Lee, E. O., Ahn, K. S., Ryu, S. Y., Lü, J. & Kim, S. H., Feb 2010, In : Molecular cancer therapeutics. 9, 2, p. 389-399 11 p.

Research output: Contribution to journalArticle

50 Scopus citations
37 Scopus citations

Persistent P21CIP1 induction mediates G1 cell cycle arrest by methylseleninic acid in DU145 prostate cancer cells

Wang, Z., Lee, H. J., Chai, Y., Hu, H., Wang, L., Zhang, Y., Jiang, C. & Lü, J., Jun 3 2010, In : Current Cancer Drug Targets. 10, 3, p. 307-318 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Proteomic profiling of potential molecular targets of methyl-selenium compounds in the transgenic adenocarcinoma of mouse prostate model

Zhang, J., Wang, L., Anderson, L. B., Witthuhn, B., Xu, Y. & Lü, J., Aug 1 2010, In : Cancer Prevention Research. 3, 8, p. 994-1006 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

Tanshinone IIa induces mitochondria dependent apoptosis in prostate cancer cells in association with an inhibition of phosphoinositide 3-kinase/AKT pathway

Won, S. H., Lee, H. J., Jeong, S. J., Lee, H. J., Lee, E. O., Jung, D. B., Shin, J. M., Kwon, T. R., Yun, S. M., Lee, M. H., Choi, S. H., Lü, J. & Kim, S. H., Nov 19 2010, In : Biological and Pharmaceutical Bulletin. 33, 11, p. 1828-1834 7 p.

Research output: Contribution to journalArticle

59 Scopus citations
2011

Galbanic acid isolated from Ferula assafoetida exerts in vivo anti-tumor activity in association with anti-angiogenesis and anti-proliferation

Kim, K. H., Lee, H. J., Jeong, S. J., Lee, H. J., Lee, E. O., Kim, H. S., Zhang, Y., Ryu, S. Y., Lee, M. H., Lu, J. & Kim, S. H., Mar 1 2011, In : Pharmaceutical Research. 28, 3, p. 597-609 13 p.

Research output: Contribution to journalArticle

32 Scopus citations

Herbal cocktail Ka-Mi-Kae-Kyuk-Tang stimulates mouse bone marrow stem cell hematopoiesis and Janus-activated kinase 2/signal transducer and activator of transcription 5 pathway

Lee, J. E., Seo, I., Jeong, S. J., Koh, W., Jung, J. H., Kwon, T. R., Lee, H. J., Han, I., Lee, H. J., Lee, E. O., Kim, S. H., Jung, H. J., Lu, J. & Kim, S. H., Nov 18 2011, In : American Journal of Chinese Medicine. 39, 6, p. 1235-1252 18 p.

Research output: Contribution to journalArticle

5 Scopus citations

Ka-mi-kae-kyuk-tang oriental herbal cocktail attenuates cyclophosphamide-induced leukopenia side effects in mouse

Seo, I., Kim, S. H., Lee, J. E., Jeong, S. J., Kim, Y. C., Ahn, K. S., Lu, J. & Kim, S. H., Dec 1 2011, In : Immunopharmacology and Immunotoxicology. 33, 4, p. 682-690 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Lobe-specific lineages of carcinogenesis in the transgenic adenocarcinoma of mouse prostate and their responses to chemopreventive selenium

Wang, L., Zhang, J., Zhang, Y., Nkhata, K., Quealy, E., Liao, J. D., Cleary, M. P. & Lu, J., Sep 15 2011, In : Prostate. 71, 13, p. 1429-1440 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Lobe-specific proteome changes in the dorsal-lateral and ventral prostate of TRAMP mice versus wild-type mice

Zhang, J., Wang, L., Zhang, Y., Li, L., Higgins, L. & Lü, J., Jun 1 2011, In : Proteomics. 11, 12, p. 2542-2549 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice

Johnson, T. E., Hermanson, D., Wang, L., Kassie, F., Upadhyaya, P., O'Sullivan, M. G., Hecht, S. S., Lu, J. & Xing, C., Jul 11 2011, In : American Journal of Chinese Medicine. 39, 4, p. 727-742 16 p.

Research output: Contribution to journalArticle

16 Scopus citations

Mouse prostate proteome changes induced by oral pentagalloylglucose treatment suggest targets for cancer chemoprevention

Zhang, J., Nkhata, K., Shaik, A. A., Wang, L., Li, L., Zhang, Y., Higgins, L. A., Kim, K. H., Liao, J. D., Xing, C., Kim, S. H. & Lü, J., Sep 1 2011, In : Current Cancer Drug Targets. 11, 7, p. 787-798 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Mouse prostate proteomes are differentially altered by supranutritional intake of four selenium compounds

Zhang, J., Wang, L., Li, G., Anderson, L. B., Xu, Y., Witthuhn, B. & Lu, J., Jul 1 2011, In : Nutrition and cancer. 63, 5, p. 778-789 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Oral administration of penta-O-galloyl-β-d-glucose suppresses triple-negative breast cancer xenograft growth and metastasis in strong association with JAK1-STAT3 inhibition

Lee, H. J., Seo, N. J., Jeong, S. J., Park, Y., Jung, D. B., Koh, W., Lee, H. J., Lee, E. O., Ahn, K. S., Ahn, K. S., Lü, J. & Kim, S. H., Jun 14 2011, In : Carcinogenesis. 32, 6, p. 804-811 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

Penta-1,2,3,4,6-O-galloyl-beta-D-glucose induces senescence-like terminal S-phase arrest in human hepatoma and breast cancer cells

Yin, S., Dong, Y., Li, J., Lu, J. & Hu, H., Aug 1 2011, In : Molecular Carcinogenesis. 50, 8, p. 592-600 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Preparation of penta-O-galloyl-β-d-glucose from tannic acid and plasma pharmacokinetic analyses by liquid-liquid extraction and reverse-phase HPLC

Li, L., Shaik, A. A., Zhang, J., Nhkata, K., Wang, L., Zhang, Y., Xing, C., Kim, S. H. & Lü, J., Feb 20 2011, In : Journal of Pharmaceutical and Biomedical Analysis. 54, 3, p. 545-550 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

Quantitative Determination of Decursin, Decursinol Angelate, and Decursinol in Mouse Plasma and Tumor Tissue Using Liquid-Liquid Extraction and HPLC

Li, L., Zhang, J., Shaik, A. A., Zhang, Y., Wang, L., Xing, C., Kim, S. H. & Lü, J., Nov 24 2011, (Accepted/In press) In : Planta Medica.

Research output: Contribution to journalArticle

2012

Activation of p53 signaling and inhibition of androgen receptor mediate tanshinone IIA induced G1 arrest in LNCaP prostate cancer cells

Won, S. H., Lee, H. J., Jeong, S. J., Lu, J. & Kim, S. H., May 1 2012, In : Phytotherapy Research. 26, 5, p. 669-674 6 p.

Research output: Contribution to journalArticle

27 Scopus citations
14 Scopus citations

Anti-cancer and other bioactivities of Korean Angelica gigas Nakai (AGN) and its major pyranocoumarin compounds

Zhang, J., Li, L., Jiang, C., Xing, C., Kim, S. H. & Lu, J., Dec 3 2012, In : Anti-Cancer Agents in Medicinal Chemistry. 12, 10, p. 1239-1254 16 p.

Research output: Contribution to journalArticle

43 Scopus citations

A synthetic decursin analog with increased in vivo stability suppresses androgen receptor signaling in vitro and in vivo

Zhang, Y., Shaik, A. A., Xing, C., Chai, Y., Li, L., Zhang, J., Zhang, W., Kim, S. H., Lü, J. & Jiang, C., Oct 1 2012, In : Investigational New Drugs. 30, 5, p. 1820-1829 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Economically viable efficient synthesis of (±)-methysticin: A component in kava potentially responsible for its cancer chemopreventive activity

Ali Shaik, A., Tan, J., Lü, J. & Xing, C., Jun 29 2012, In : Arkivoc. 2012, 8, p. 137-145 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Galbanic acid decreases androgen receptor abundance and signaling and induces G 1 arrest in prostate cancer cells

Zhang, Y., Kim, K. H., Zhang, W., Guo, Y., Kim, S. H. & Lü, J., Jan 11 2012, In : International Journal of Cancer. 130, 1, p. 200-212 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Methylseleninic acid potentiates multiple types of cancer cells to ABT-737-induced apoptosis by targeting Mcl-1 and Bad

Yin, S., Dong, Y., Li, J., Fan, L., Wang, L., Lu, J., Vang, O. & Hu, H., Apr 1 2012, In : Apoptosis. 17, 4, p. 388-399 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Quantitative determination of decursin, decursinol angelate, and decursinol in mouse plasma and tumor tissue using liquid-liquid extraction and HPLC

Li, L., Zhang, J., Shaik, A. A., Zhang, Y., Wang, L., Xing, C., Kim, S. H. & Lü, J., Jan 1 2012, In : Planta Medica. 78, 3, p. 252-259 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Reactive oxygen species-mediated activation of JNK and down-regulation of DAXX are critically involved in penta-O-galloyl-beta-d-glucose-induced apoptosis in chronic myeloid leukemia K562 cells

Kwon, T. R., Jeong, S. J., Lee, H. J., Lee, H. J., Sohn, E. J., Jung, J. H., Kim, J. H., Jung, D. B., Lu, J. & Kim, S. H., Aug 3 2012, In : Biochemical and Biophysical Research Communications. 424, 3, p. 530-537 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Tanshinones from Chinese medicinal herb Danshen (Salvia miltiorrhiza Bunge) suppress prostate cancer growth and androgen receptor signaling

Zhang, Y., Won, S. H., Jiang, C., Lee, H. J., Jeong, S. J., Lee, E. O., Zhang, J., Ye, M., Kim, S. H. & Lu, J., Jun 1 2012, In : Pharmaceutical Research. 29, 6, p. 1595-1608 14 p.

Research output: Contribution to journalArticle

33 Scopus citations
2013

Enhanced apoptotic effects by the combination of curcumin and methylseleninic acid: Potential role of mcl-1 and FAK

Guo, X., Yin, S., Dong, Y., Fan, L., Ye, M., Lu, J. & Hu, H., Nov 1 2013, In : Molecular Carcinogenesis. 52, 11, p. 879-889 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

In vitro metabolism of pyranocoumarin isomers decursin and decursinol angelate by liver microsomes from man and rodents

Li, L., Zhang, J., Xing, C., Kim, S. H., Jiang, C. & Lü, J., Sep 13 2013, In : Planta Medica. 79, 16, p. 1536-1544 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Single oral dose pharmacokinetics of decursin, decursinol angelate, and decursinol in rats

Li, L., Zhang, J., Xing, C., Kim, S. H. & Lü, J., Feb 1 2013, In : Planta Medica. 79, 3-4, p. 275-280 6 p.

Research output: Contribution to journalArticle

14 Scopus citations
2014

Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1- (3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice

Narayanapillai, S. C., Balbo, S., Leitzman, P., Grill, A. E., Upadhyaya, P., Shaik, A. A., Zhou, B., Gerard O'Sullivan, M., Peterson, L. A., Lu, J., Hecht, S. S. & Xing, C., Jan 1 2014, In : Carcinogenesis. 35, 10, p. 2365-2372 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Hexokinase 2-Mediated Warburg Effect Is Required for PTEN- and p53-Deficiency-Driven Prostate Cancer Growth

Wang, L., Xiong, H., Wu, F., Zhang, Y., Wang, J., Zhao, L., Guo, X., Chang, L. J., Zhang, Y., You, M. J., Koochekpour, S., Saleem, M., Huang, H., Lu, J. & Deng, Y., Jan 1 2014, In : Cell Reports. 8, 5, p. 1461-1474 14 p.

Research output: Contribution to journalArticle

104 Scopus citations

Involvement of autophagy induction in penta-1,2,3,4,6-O-galloyl-β-D- glucose-induced senescence-like growth arrest in human cancer cells

Dong, Y., Yin, S., Jiang, C., Luo, X., Guo, X., Zhao, C., Fan, L., Meng, Y., Lu, J., Song, X., Zhang, X., Chen, N. & Hu, H., Feb 2014, In : Autophagy. 10, 2, p. 296-310 15 p.

Research output: Contribution to journalArticle

14 Scopus citations

Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing o6-methylguanine DNA adduct in A/J mice

Leitzman, P., Narayanapillai, S. C., Balbo, S., Zhou, B., Upadhyaya, P., Shaik, A. A., O'Sullivan, M. G., Hecht, S. S., Lu, J. & Xing, C., Jan 1 2014, In : Cancer Prevention Research. 7, 1, p. 86-96 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Methylseleninic acid suppresses pancreatic cancer growth involving multiple pathways

Wang, L., Hu, H., Wang, Z., Xiong, H., Cheng, Y., Liao, J. D., Deng, Y. & Lü, J., Feb 1 2014, In : Nutrition and cancer. 66, 2, p. 295-307 13 p.

Research output: Contribution to journalArticle

8 Scopus citations