• 5651 Citations
  • 46 h-Index
1988 …2020

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In vitro metabolism of pyranocoumarin isomers decursin and decursinol angelate by liver microsomes from man and rodents

Li, L., Zhang, J., Xing, C., Kim, S. H., Jiang, C. & Lü, J., Sep 13 2013, In : Planta Medica. 79, 16, p. 1536-1544 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

In vivo anti-cancer activity of Korean Angelica gigas and its major pyranocoumarin decursin

Lee, H. J., Lee, H. J., Lee, E. O., Lee, J. H., Lee, K. S., Kim, K. H., Kim, S. H. & Lü, J., Jan 1 2009, In : American Journal of Chinese Medicine. 37, 1, p. 127-142 16 p.

Research output: Contribution to journalArticle

47 Scopus citations

In vivo molecular mediators of cancer growth suppression and apoptosis by selenium in mammary and prostate models: Lack of involvement of gadd genes

Jiang, W., Jiang, C., Pei, H., Wang, L., Zhang, J., Hu, H. & Lü, J., Mar 1 2009, In : Molecular cancer therapeutics. 8, 3, p. 682-691 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Involvement of autophagy induction in penta-1,2,3,4,6-O-galloyl-β-D- glucose-induced senescence-like growth arrest in human cancer cells

Dong, Y., Yin, S., Jiang, C., Luo, X., Guo, X., Zhao, C., Fan, L., Meng, Y., Lu, J., Song, X., Zhang, X., Chen, N. & Hu, H., Feb 2014, In : Autophagy. 10, 2, p. 296-310 15 p.

Research output: Contribution to journalArticle

14 Scopus citations

Involvement of c-Jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by sulforaphane in DU145 prostate cancer cells

Cho, S. D., Li, G., Hu, H., Jiang, C., Kang, K. S., Lee, Y. S., Kim, S. H. & Lu, J., Nov 16 2005, In : Nutrition and cancer. 52, 2, p. 213-224 12 p.

Research output: Contribution to journalArticle

96 Scopus citations

Ka-mi-kae-kyuk-tang oriental herbal cocktail attenuates cyclophosphamide-induced leukopenia side effects in mouse

Seo, I., Kim, S. H., Lee, J. E., Jeong, S. J., Kim, Y. C., Ahn, K. S., Lu, J. & Kim, S. H., Dec 1 2011, In : Immunopharmacology and Immunotoxicology. 33, 4, p. 682-690 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing o6-methylguanine DNA adduct in A/J mice

Leitzman, P., Narayanapillai, S. C., Balbo, S., Zhou, B., Upadhyaya, P., Shaik, A. A., O'Sullivan, M. G., Hecht, S. S., Lu, J. & Xing, C., Jan 1 2014, In : Cancer Prevention Research. 7, 1, p. 86-96 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Lobe-specific lineages of carcinogenesis in the transgenic adenocarcinoma of mouse prostate and their responses to chemopreventive selenium

Wang, L., Zhang, J., Zhang, Y., Nkhata, K., Quealy, E., Liao, J. D., Cleary, M. P. & Lu, J., Sep 15 2011, In : Prostate. 71, 13, p. 1429-1440 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Lobe-specific proteome changes in the dorsal-lateral and ventral prostate of TRAMP mice versus wild-type mice

Zhang, J., Wang, L., Zhang, Y., Li, L., Higgins, L. & Lü, J., Jun 1 2011, In : Proteomics. 11, 12, p. 2542-2549 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice

Johnson, T. E., Hermanson, D., Wang, L., Kassie, F., Upadhyaya, P., O'Sullivan, M. G., Hecht, S. S., Lu, J. & Xing, C., Jul 11 2011, In : American Journal of Chinese Medicine. 39, 4, p. 727-742 16 p.

Research output: Contribution to journalArticle

17 Scopus citations

Mammary cancer promotion and MAPK activation associated with consumption of a corn oil-based high-fat diet

Wang, Z., Pei, H., Kaeck, M. & Lu, J., Jan 1 1999, In : Nutrition and cancer. 34, 2, p. 140-146 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Method for 96-well M13 DNA template preparations for large-scale sequencing

Andersson, B., Lu, J., Edwards, K. E., Muzny, D. M. & Gibbs, R. A., 1996, In : BioTechniques. 20, 6, p. 1022-1027 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Methylseleninic acid enhances taxane drug efficacy against human prostate cancer and down-regulates antiapoptotic proteins Bcl-XL and survivin

Hu, H., Li, G. X., Wang, L., Watts, J., Combs, G. F. & Lü, J., Feb 15 2008, In : Clinical Cancer Research. 14, 4, p. 1150-1158 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

Methylseleninic acid inhibits microvascular endothelial G 1 cell cycle progression and decreases tumor microvessel density

Wang, Z., Hu, H., Li, G., Lee, H. J., Jiang, C., Kim, S. H. & Lu, J., Jan 1 2008, In : International Journal of Cancer. 122, 1, p. 15-24 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Methylseleninic acid potentiates apoptosis induced by chemotherapeutic drugs in androgen-independent prostate cancer cells

Hu, H., Jiang, C., Ip, C., Rustum, Y. M. & Lü, J., Mar 15 2005, In : Clinical Cancer Research. 11, 6, p. 2379-2388 10 p.

Research output: Contribution to journalArticle

68 Scopus citations

Methylseleninic acid potentiates multiple types of cancer cells to ABT-737-induced apoptosis by targeting Mcl-1 and Bad

Yin, S., Dong, Y., Li, J., Fan, L., Wang, L., Lu, J., Vang, O. & Hu, H., Apr 1 2012, In : Apoptosis. 17, 4, p. 388-399 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Methylseleninic acid superactivates p53-senescence cancer progression barrier in prostate lesions of pten-knockout mouse

Wang, L., Guo, X., Wang, J., Jiang, C., Bosland, M. C., Lü, J. & Deng, Y., Jan 2016, In : Cancer Prevention Research. 9, 1, p. 35-42 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Methylseleninic acid suppresses pancreatic cancer growth involving multiple pathways

Wang, L., Hu, H., Wang, Z., Xiong, H., Cheng, Y., Liao, J. D., Deng, Y. & Lü, J., Feb 1 2014, In : Nutrition and cancer. 66, 2, p. 295-307 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Methyl-selenium compounds inhibit prostate carcinogenesis in the transgenic adenocarcinoma of mouse prostate model with survival benefit

Wang, L., Bonorden, M. J. L., Li, G. X., Lee, H. J., Hu, H., Zhang, Y., Liao, J. D., Cleary, M. P. & Lü, J., May 1 2009, In : Cancer Prevention Research. 2, 5, p. 484-495 12 p.

Research output: Contribution to journalArticle

90 Scopus citations

Methyl selenium-induced vascular endothelial apoptosis is executed by caspases and principally mediated by p38 MAPK pathway

Jiang, C., Kim, K. H., Wang, Z. & Lü, J., Jan 1 2004, In : Nutrition and cancer. 49, 2, p. 174-183 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

Methyl selenium metabolites decrease prostate-specific antigen expression by inducing protein degradation and suppressing androgen-stimulated transcription

Cho, S. D., Jiang, C., Malewicz, B., Dong, Y., Young, C. Y. F., Kang, K. S., Lee, Y. S., Ip, C. & Lü, J., May 1 2004, In : Molecular cancer therapeutics. 3, 5, p. 605-611 7 p.

Research output: Contribution to journalArticle

76 Scopus citations

Mitochondria-cytochrome C-caspase-9 cascade mediates isorhamnetin-induced apoptosis

Lee, H. J., Lee, H. J., Lee, E. O., Ko, S. G., Bae, H. S., Kim, C. H., Ahn, K. S., Lu, J. & Kim, S. H., Nov 8 2008, In : Cancer Letters. 270, 2, p. 342-353 12 p.

Research output: Contribution to journalArticle

79 Scopus citations

Monomethyl selenium-specific inhibition of MMP-2 and VEGF expression: Implications for angiogenic switch regulation

Jiang, C., Ganther, H. & Lu, J., Dec 1 2000, In : Molecular Carcinogenesis. 29, 4, p. 236-250 15 p.

Research output: Contribution to journalArticle

107 Scopus citations

Mouse prostate proteome changes induced by oral pentagalloylglucose treatment suggest targets for cancer chemoprevention

Zhang, J., Nkhata, K., Shaik, A. A., Wang, L., Li, L., Zhang, Y., Higgins, L. A., Kim, K. H., Liao, J. D., Xing, C., Kim, S. H. & Lü, J., Sep 1 2011, In : Current Cancer Drug Targets. 11, 7, p. 787-798 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Mouse prostate proteomes are differentially altered by supranutritional intake of four selenium compounds

Zhang, J., Wang, L., Li, G., Anderson, L. B., Xu, Y., Witthuhn, B. & Lu, J., Jul 1 2011, In : Nutrition and cancer. 63, 5, p. 778-789 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Optimizing live-animal bioluminescence imaging prediction of tumor burden in human prostate cancer xenograft models in SCID-NSG mice

Kim, S., Zhang, Y., Tang, S., Qin, C., Karelia, D., Sharma, A., Jiang, C. & Lu, J., Jun 15 2019, In : Prostate. 79, 9, p. 949-960 12 p.

Research output: Contribution to journalArticle

Oral administration of penta-O-galloyl-β-d-glucose suppresses triple-negative breast cancer xenograft growth and metastasis in strong association with JAK1-STAT3 inhibition

Lee, H. J., Seo, N. J., Jeong, S. J., Park, Y., Jung, D. B., Koh, W., Lee, H. J., Lee, E. O., Ahn, K. S., Ahn, K. S., Lü, J. & Kim, S. H., Jun 14 2011, In : Carcinogenesis. 32, 6, p. 804-811 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

Pathogenetic characterization of 1-methyl-1-nitrosourea-induced mammary carcinomas in the rat

Lu, J., Jiang, C., Mitrenga, T., Cutter, G. & Thompson, H. J., Jan 1 1998, In : Carcinogenesis. 19, 1, p. 223-227 5 p.

Research output: Contribution to journalArticle

25 Scopus citations

Penicillamine: Pharmacokinetics and differential effects on zinc and copper status in chicks

Lu, J. & Combs, G. F., Jan 1 1992, In : Journal of Nutrition. 122, 2, p. 355-362 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Penta-1,2,3,4,6-O-galloyl-beta-D-glucose induces senescence-like terminal S-phase arrest in human hepatoma and breast cancer cells

Yin, S., Dong, Y., Li, J., Lu, J. & Hu, H., Aug 1 2011, In : Molecular Carcinogenesis. 50, 8, p. 592-600 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Penta-1,2,3,4,6-O-galloyl-β-D-glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo

Hu, H., Lee, H. J., Jiang, C., Zhang, J., Wang, L., Zhao, Y., Xiang, Q., Lee, E. O., Kim, S. H. & Lü, J., Oct 22 2008, In : Molecular cancer therapeutics. 7, 9, p. 2681-2691 11 p.

Research output: Contribution to journalArticle

72 Scopus citations

Pentagalloylglucose induces autophagy and caspase-independent programmed deaths in human PC-3 and mouse TRAMP-C2 prostate cancer cells

Hu, H., Chai, Y., Wang, L., Zhang, J., Lee, H. J., Kim, S. H. & Lü, J., Oct 1 2009, In : Molecular cancer therapeutics. 8, 10, p. 2833-2843 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Penta-O-galloyl-beta-D-glucose induces S- and G1-cell cycle arrests in prostate cancer cells targeting DNA replication and cyclin D1

Hu, H., Zhang, J., Lee, H. J., Kim, S. H. & Lü, J., May 13 2009, In : Carcinogenesis. 30, 5, p. 818-823 6 p.

Research output: Contribution to journalArticle

38 Scopus citations
37 Scopus citations

Persistent P21CIP1 induction mediates G1 cell cycle arrest by methylseleninic acid in DU145 prostate cancer cells

Wang, Z., Lee, H. J., Chai, Y., Hu, H., Wang, L., Zhang, Y., Jiang, C. & Lü, J., Jun 3 2010, In : Current Cancer Drug Targets. 10, 3, p. 307-318 12 p.

Research output: Contribution to journalArticle

19 Scopus citations
5 Scopus citations

PKB/AKT and ERK regulation of caspase-mediated apoptosis by methylseleninic acid in LNCaP prostate cancer cells

Hu, H., Jiang, C., Li, G. & Lü, J., Aug 1 2005, In : Carcinogenesis. 26, 8, p. 1374-1381 8 p.

Research output: Contribution to journalArticle

86 Scopus citations

Potent antiandrogen and androgen receptor activities of an Angelica gigas-containing herbal formulation: Identification of decursin as a novel and active compound with implications for prevention and treatment of prostate cancer

Jiang, C., Lee, H. J., Li, G. X., Guo, J., Malewicz, B., Zhao, Y., Lee, E. O., Lee, H. J., Lee, J. H., Kim, M. S., Kim, S. H. & Lu, J., Jan 1 2006, In : Cancer Research. 66, 1, p. 453-463 11 p.

Research output: Contribution to journalArticle

94 Scopus citations

Potent inhibition of Lewis lung cancer growth by heyneanol A from the roots of Vitis amurensis through apoptotic and anti-angiogenic activities

Lee, E. O., Lee, H. J., Hwang, H. S., Ahn, K. S., Chae, C., Kang, K. S., Lu, J. & Kim, S. H., Oct 1 2006, In : Carcinogenesis. 27, 10, p. 2059-2069 11 p.

Research output: Contribution to journalArticle

73 Scopus citations

Preparation of penta-O-galloyl-β-d-glucose from tannic acid and plasma pharmacokinetic analyses by liquid-liquid extraction and reverse-phase HPLC

Li, L., Shaik, A. A., Zhang, J., Nhkata, K., Wang, L., Zhang, Y., Xing, C., Kim, S. H. & Lü, J., Feb 20 2011, In : Journal of Pharmaceutical and Biomedical Analysis. 54, 3, p. 545-550 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

Prostate Cancer Xenograft Inhibitory Activity and Pharmacokinetics of Decursinol, a Metabolite of Angelica gigas Pyranocoumarins, in Mouse Models

Wu, W., Tang, S. N., Zhang, Y., Puppala, M., Cooper, T. K., Xing, C., Jiang, C. & Lü, J., Jan 1 2017, In : American Journal of Chinese Medicine. 45, 8, p. 1773-1792 20 p.

Research output: Contribution to journalArticle

2 Scopus citations

Proteomic profiling of potential molecular targets of methyl-selenium compounds in the transgenic adenocarcinoma of mouse prostate model

Zhang, J., Wang, L., Anderson, L. B., Witthuhn, B., Xu, Y. & Lü, J., Aug 1 2010, In : Cancer Prevention Research. 3, 8, p. 994-1006 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Pyranocoumarin Tissue Distribution, Plasma Metabolome and Prostate Transcriptome Impacts of Sub-Chronic Exposure to Korean Angelica Supplement in Mice

Zhang, J., Li, L., Tang, S., Zhang, Y., Markiewski, M., Xing, C., Jiang, C. & Lü, J., Apr 1 2016, In : American Journal of Chinese Medicine. 44, 2, p. 321-353 33 p.

Research output: Contribution to journalArticle

3 Scopus citations

Quantitative determination of decursin, decursinol angelate, and decursinol in mouse plasma and tumor tissue using liquid-liquid extraction and HPLC

Li, L., Zhang, J., Shaik, A. A., Zhang, Y., Wang, L., Xing, C., Kim, S. H. & Lü, J., Jan 1 2012, In : Planta Medica. 78, 3, p. 252-259 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Quantitative Determination of Decursin, Decursinol Angelate, and Decursinol in Mouse Plasma and Tumor Tissue Using Liquid-Liquid Extraction and HPLC

Li, L., Zhang, J., Shaik, A. A., Zhang, Y., Wang, L., Xing, C., Kim, S. H. & Lü, J., Nov 24 2011, (Accepted/In press) In : Planta Medica.

Research output: Contribution to journalArticle

Quinoline derivative KB3-1 potentiates paclitaxel induced cytotoxicity and cycle arrest via multidrug resistance reversal in MES-SA/DX5 cancer cells

Koo, J. S., Choi, W. C., Rhee, Y. H., Lee, H. J., Lee, E. O., Ahn, K. S., Bae, H. S., Ahn, K. S., Kang, J. M., Choi, S. U., Kim, M. O., Lu, J. & Kim, S. H., Nov 21 2008, In : Life Sciences. 83, 21-22, p. 700-708 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Ras May Mediate Mammary Cancer Promotion By High Fat

Lu, J., Jiang, C., Fontaine, S. & Thompson, H. J., Jan 1 1995, In : Nutrition and cancer. 23, 3, p. 283-290 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Reactive oxygen species-mediated activation of JNK and down-regulation of DAXX are critically involved in penta-O-galloyl-beta-d-glucose-induced apoptosis in chronic myeloid leukemia K562 cells

Kwon, T. R., Jeong, S. J., Lee, H. J., Lee, H. J., Sohn, E. J., Jung, J. H., Kim, J. H., Jung, D. B., Lu, J. & Kim, S. H., Aug 3 2012, In : Biochemical and Biophysical Research Communications. 424, 3, p. 530-537 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Role of p53-senescence induction in suppression of LNCaP prostate cancer growth by cardiotonic compound bufalin

Zhang, Y., Dong, Y., Melkus, M. W., Yin, S., Tang, S. N., Jiang, P., Pramanik, K., Wu, W., Kim, S., Ye, M., Hu, H., Lu, J. & Jiang, C., Nov 2018, In : Molecular cancer therapeutics. 17, 11, p. 2341-2352 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Selenite-induced p53 ser-15 phosphorylation and caspase-mediated apoptosis in LNCaP human prostate cancer cells

Jiang, C., Hu, H., Malewicz, B., Wang, Z. & Lü, J., Jul 1 2004, In : Molecular cancer therapeutics. 3, 7, p. 877-884 8 p.

Research output: Contribution to journalArticle

86 Scopus citations