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Research interests

The overall goals of Dr. Karam El-Bayoumy’s research are to understand the mechanisms at the cellular and molecular levels that can account for cancer induction and develop biomarkers for early detection. For more than 30 years, his laboratory has been funded from NCI, NIEHS, NIDCR, DOD and The Komen Foundation, and he has more than 240 peer-reviewed publications.

Dr. El-Bayoumy’s research is focused on the prevention of tobacco and environmentally-related cancers by various synthetic and naturally-occurring chemopreventive agents, combined with dietary manipulation initially in preclinical model systems, then translates the findings into clinical cancer prevention initiatives. He discovered novel chemopreventive selenium compounds against the development of several cancers in preclinical animal models and showed for the first time that selenized yeast reduced oxidative stress in healthy men.

His team demonstrated, using a novel animal model developed in his lab, that black raspberry (BRB) inhibited DNA damage, mutagenesis and oral squamous cell carcinoma (OSCC) induced by the tobacco smoke constituent dibenzo[a,l]pyrene (DB[a,l]P) in the mouse oral cavity; he also reported that BRB enhanced DNA repair of bulky lesions induced by chemical DB[a,l]P and physical (UV) carcinogens. His team also showed that hypomethylated Fgf3 (a gene frequently amplified in OSCC and is involved in epithelial mesenchymal transition) is a potential biomarker for early detection of OSCC; this gene was altered by BRB in a manner consistent with its chemopreventive action.

Dr. El-Bayoumy focuses on developing highly effective chemopreventive agents against tobacco smoke inducing lung cancer and developing biomarkers for early detection in noninvasive fluids indicative of cigarette smoking using various proteomic approaches.

During the last decade, he has been focusing on understanding the mechanistic role of Omega-3 fatty acids in breast cancer prevention in preclinical and clinical studies as well as developing novel liposomal formulation as an effective strategy to deliver select chemopreventive agents.

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Projects 1981 2013

1-nitropyrene
Breast Neoplasms
DNA Adducts
Breast
Carcinogens

EXPERIMENTAL TOBACCO CARCINOGENESIS

El-Bayoumy, K., Prokopczyk, B., Hecht, S., Silverman, J., Lavoie, E., Haley, N., Rivenson, A. S., Brunnemann, K. & Hoffman, D.

National Institutes of Health

6/15/811/31/97

Project: Research project

Tobacco
Amines
Smoking
Smoke
Smokeless Tobacco

Research Output 1979 2018

Metabolites
DNA Damage
Ovary
DNA
Epoxy Compounds
2 Citations (Scopus)
obesity
Docosahexaenoic Acids
breast
constrictions
Obesity
3 Citations (Scopus)

Effects of Black Raspberry on Dibenzo[a,l]Pyrene Diol Epoxide Induced DNAAdducts, Mutagenesis, and Tumorigenesis in the Mouse Oral Cavity

Chen, K-M., Guttenplan, J. B., Sun, Y-W., Cooper, T., Shalaby, N. A. E., Kosinska, W., Benitez, G., Aliaga, C., Zhu, J., Liao, J. J., Gowda, K., Amin, S., Stoner, G. & El-Bayoumy, K., Mar 1 2018, In : Cancer Prevention Research. 11, 3, p. 157-164 8 p.

Research output: Contribution to journalArticle

Mutagenesis
Powders
Mouth
Carcinogenesis
DNA Damage
10 Citations (Scopus)

Carcinogenesis of the oral cavity: Environmental causes and potential prevention by black raspberry

El-Bayoumy, K., Chen, K-M., Zhang, S. M., Sun, Y-W., Amin, S., Stoner, G. & Guttenplan, J. B., Jan 1 2017, In : Chemical Research in Toxicology. 30, 1, p. 126-144 19 p.

Research output: Contribution to journalReview article

Mouth Neoplasms
Mouth
Environmental Carcinogens
Carcinogenesis
Animal Models
3 Citations (Scopus)

Effects of Black Raspberry Extract and Berry Compounds on Repair of DNA Damage and Mutagenesis Induced by Chemical and Physical Agents in Human Oral Leukoplakia and Rat Oral Fibroblasts

Guttenplan, J. B., Chen, K-M., Sun, Y-W., Lajara, B., Shalaby, N. A. E., Kosinska, W., Benitez, G., Gowda, K., Amin, S., Stoner, G. & El-Bayoumy, K., Dec 18 2017, In : Chemical Research in Toxicology. 30, 12, p. 2159-2164 6 p.

Research output: Contribution to journalArticle

Oral Leukoplakia
Mutagenesis
DNA Adducts
Fibroblasts
DNA Damage