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Projects 2015 2019

Nucleotide Metabolism in Senescence and Platinum Resistance of Ovarian Cancer

Aird, K.

National Institutes of Health

4/3/1511/30/19

Project: Research projectResearch Transition Award, Career Transition Award

Platinum
Ovarian Neoplasms
Nucleotides
Neoplastic Stem Cells
Mentors

Research Output 2004 2019

Simultaneous isotope dilution quantification and metabolic tracing of deoxyribonucleotides by liquid chromatography high resolution mass spectrometry

Kuskovsky, R., Buj, R., Xu, P., Hofbauer, S., Doan, M. T., Jiang, H., Bostwick, A., Mesaros, C., Aird, K. & Snyder, N. W., Mar 1 2019, In : Analytical Biochemistry. 568, p. 65-72 8 p.

Research output: Contribution to journalArticle

Deoxyribonucleotides
Liquid chromatography
Liquid Chromatography
Isotopes
Dilution

CLIC1 and CLIC4 complement CA125 as a diagnostic biomarker panel for all subtypes of epithelial ovarian cancer

Singha, B., Harper, S. L., Goldman, A. R., Bitler, B. G., Aird, K., Borowsky, M. E., Cadungog, M. G., Liu, Q., Zhang, R., Jean, S., Drapkin, R. & Speicher, D. W., Dec 1 2018, In : Scientific Reports. 8, 1, 14725.

Research output: Contribution to journalArticle

Biomarkers
Neoplasms
Staining and Labeling
Serum
Organ Culture Techniques
2 Citations

Deoxyribonucleotide triphosphate metabolism in cancer and metabolic disease

Buj, R. & Aird, K., Apr 18 2018, In : Frontiers in Endocrinology. 9, APR, 177.

Research output: Contribution to journalShort survey

Deoxyribonucleotides
Metabolic Diseases
Neoplasms
Nucleotides
Metabolic Networks and Pathways

GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment

Worley, B. L., Kim, Y. S., Mardini, J., Zaman, R., Leon, K. E., Vallur, P. G., Nduwumwami, A., Warrick, J., Timmins, P. F., Kesterson, J., Phaeton, R., Lee, N. Y., Walter, V., Endres, L., Mythreye, K., Aird, K. & Hempel, N., Jan 1 2018, (Accepted/In press) In : Redox Biology.

Research output: Contribution to journalArticle

Glutathione Peroxidase
Ovarian Neoplasms
Oxidation-Reduction
Ascites
Adenocarcinoma
23 Citations

ARID1A-mutated ovarian cancers depend on HDAC6 activity

Bitler, B. G., Wu, S., Park, P. H., Hai, Y., Aird, K., Wang, Y., Zhai, Y., Kossenkov, A. V., Vara-Ailor, A., Rauscher, F. J., Zou, W., Speicher, D. W., Huntsman, D. G., Conejo-Garcia, J. R., Cho, K. R., Christianson, D. W. & Zhang, R., Aug 1 2017, In : Nature Cell Biology. 19, 8, p. 962-973 12 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Neoplasms
Apoptosis
Mutation
Chromatin Assembly and Disassembly