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Research Output 2004 2019

2019

Jumonji C demethylases in cellular senescence

Leon, K. E. & Aird, K., Jan 1 2019, In : Genes. 10, 1, 33.

Research output: Contribution to journalReview article

Cell Aging
Histones
Gene Expression
Enzyme Induction
Cell Cycle Checkpoints
3 Citations (Scopus)

NAD + metabolism governs the proinflammatory senescence-associated secretome

Nacarelli, T., Lau, L., Fukumoto, T., Zundell, J., Fatkhutdinov, N., Wu, S., Aird, K., Iwasaki, O., Kossenkov, A. V., Schultz, D., Noma, K. I., Baur, J. A., Schug, Z., Tang, H. Y., Speicher, D. W., David, G. & Zhang, R., Mar 1 2019, In : Nature Cell Biology. 21, 3, p. 397-407 11 p.

Research output: Contribution to journalArticle

NAD
Phenotype
Nicotinamide Phosphoribosyltransferase
High Mobility Group Proteins
Neoplasms

Simultaneous isotope dilution quantification and metabolic tracing of deoxyribonucleotides by liquid chromatography high resolution mass spectrometry

Kuskovsky, R., Buj, R., Xu, P., Hofbauer, S., Doan, M. T., Jiang, H., Bostwick, A., Mesaros, C., Aird, K. & Snyder, N. W., Mar 1 2019, In : Analytical Biochemistry. 568, p. 65-72 8 p.

Research output: Contribution to journalArticle

Deoxyribonucleotides
Liquid chromatography
Liquid Chromatography
Isotopes
Dilution
2018
1 Citation (Scopus)

CLIC1 and CLIC4 complement CA125 as a diagnostic biomarker panel for all subtypes of epithelial ovarian cancer

Singha, B., Harper, S. L., Goldman, A. R., Bitler, B. G., Aird, K., Borowsky, M. E., Cadungog, M. G., Liu, Q., Zhang, R., Jean, S., Drapkin, R. & Speicher, D. W., Dec 1 2018, In : Scientific reports. 8, 1, 14725.

Research output: Contribution to journalArticle

Biomarkers
Neoplasms
Staining and Labeling
Serum
Organ Culture Techniques
3 Citations (Scopus)

Deoxyribonucleotide triphosphate metabolism in cancer and metabolic disease

Buj, R. & Aird, K., Apr 18 2018, In : Frontiers in Endocrinology. 9, APR, 177.

Research output: Contribution to journalShort survey

Deoxyribonucleotides
Metabolic Diseases
Neoplasms
Nucleotides
Metabolic Networks and Pathways

GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment

Worley, B. L., Kim, Y. S., Mardini, J., Zaman, R., Leon, K. E., Vallur, P. G., Nduwumwami, A., Warrick, J., Timmins, P. F., Kesterson, J., Phaeton, R., Lee, N. Y., Walter, V., Endres, L., Mythreye, K., Aird, K. & Hempel, N., Jan 1 2018, (Accepted/In press) In : Redox Biology.

Research output: Contribution to journalArticle

Glutathione Peroxidase
Ovarian Neoplasms
Oxidation-Reduction
Ascites
Adenocarcinoma
2017
33 Citations (Scopus)

ARID1A-mutated ovarian cancers depend on HDAC6 activity

Bitler, B. G., Wu, S., Park, P. H., Hai, Y., Aird, K., Wang, Y., Zhai, Y., Kossenkov, A. V., Vara-Ailor, A., Rauscher, F. J., Zou, W., Speicher, D. W., Huntsman, D. G., Conejo-Garcia, J. R., Cho, K. R., Christianson, D. W. & Zhang, R., Aug 1 2017, In : Nature Cell Biology. 19, 8, p. 962-973 12 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Neoplasms
Apoptosis
Mutation
Chromatin Assembly and Disassembly
5 Citations (Scopus)

Ataxia-telangiectasia mutated modulation of carbon metabolism in cancer

Dahl, E. S. & Aird, K., Nov 29 2017, In : Frontiers in Oncology. 7, NOV, 291.

Research output: Contribution to journalShort survey

Ataxia Telangiectasia
Carbon
Neoplasms
Ataxia Telangiectasia Mutated Proteins
Biomass
2 Citations (Scopus)

Ovarian cancer: How can resistance to chemotherapy be tackled?

Karakashev, S. & Aird, K., Dec 1 2017, In : Future Oncology. 13, 30, p. 2737-2739 3 p.

Research output: Contribution to journalReview article

Ovarian Neoplasms
Immunotherapy
Drug Therapy
2016
5 Citations (Scopus)

Epigenetic synthetic lethality in ovarian clear cell carcinoma: EZH2 and ARID1A mutations

Bitler, B. G., Aird, K. & Zhang, R., Jan 2 2016, In : Molecular and Cellular Oncology. 3, 1, e1032476.

Research output: Contribution to journalArticle

Epigenomics
Carcinoma
Mutation
Mutation Rate
Sucrose
27 Citations (Scopus)

HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci

Aird, K., Iwasaki, O., Kossenkov, A. V., Tanizawa, H., Fatkhutdinov, N., Bitler, B. G., Le, L., Alicea, G., Yang, T. L., Johnson, F. B., Noma, K. I. & Zhang, R., Jan 1 2016, In : Journal of Cell Biology. 215, 3, p. 325-334 10 p.

Research output: Contribution to journalReview article

Chromatin
Phenotype
Genes
Heterochromatin
Cell Aging
98 Citations (Scopus)

SFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

Kaur, A., Webster, M. R., Marchbank, K., Behera, R., Ndoye, A., Kugel, C. H., Dang, V. M., Appleton, J., O'Connell, M. P., Cheng, P., Valiga, A. A., Morissette, R., McDonnell, N. B., Ferrucci, L., Kossenkov, A. V., Meeth, K., Tang, H. Y., Yin, X., Wood, W. H., Lehrmann, E. & 26 othersBecker, K. G., Flaherty, K. T., Frederick, D. T., Wargo, J. A., Cooper, Z. A., Tetzlaff, M. T., Hudgens, C., Aird, K., Zhang, R., Xu, X., Liu, Q., Bartlett, E., Karakousis, G., Eroglu, Z., Lo, R. S., Chan, M., Menzies, A. M., Long, G. V., Johnson, D. B., Sosman, J., Schilling, B., Schadendorf, D., Speicher, D. W., Bosenberg, M., Ribas, A. & Weeraratna, A. T., Apr 14 2016, In : Nature. 532, 7598, p. 250-254 5 p.

Research output: Contribution to journalArticle

Melanoma
Neoplasm Metastasis
Fibroblasts
Microphthalmia-Associated Transcription Factor
Therapeutics
5 Citations (Scopus)

Targeting RRM2 and mutant BRAF is a novel combinatorial strategy for melanoma

Fatkhutdinov, N., Sproesser, K., Krepler, C., Liu, Q., Brafford, P. A., Herlyn, M., Aird, K. & Zhang, R., Sep 1 2016, In : Molecular Cancer Research. 14, 9, p. 767-775 9 p.

Research output: Contribution to journalArticle

Melanoma
DNA Damage
Cell Cycle Checkpoints
Oncogenes
Heterografts
2015
41 Citations (Scopus)

ATM Couples Replication Stress and Metabolic Reprogramming during Cellular Senescence

Aird, K., Worth, A. J., Snyder, N. W., Lee, J. V., Sivanand, S., Liu, Q., Blair, I. A., Wellen, K. E. & Zhang, R., May 12 2015, In : Cell Reports. 11, 6, p. 893-901 9 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Cell Aging
Up-Regulation
Nucleotides
Deoxyribonucleotides
6 Citations (Scopus)

ATM in senescence

Aird, K. & Zhang, R., Jan 1 2015, In : Oncotarget. 6, 17, p. 14729-14730 2 p.

Research output: Contribution to journalEditorial

Ataxia Telangiectasia Mutated Proteins
Neoplastic Cell Transformation
Proto-Oncogene Proteins c-myc
Gene Knockdown Techniques
Tumor Suppressor Protein p53
16 Citations (Scopus)

EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer

Zhang, J., Wang, C., Chen, X., Takada, M., Fan, C., Zheng, X., Wen, H., Liu, Y., Wang, C., Pestell, R. G., Aird, K., Kaelin, W. G., Liu, X. S. & Zhang, Q., Dec 2 2015, In : EMBO Journal. 34, 23, p. 2953-2970 18 p.

Research output: Contribution to journalArticle

Nuclear Respiratory Factor 1
Breast Neoplasms
Oxidoreductases
Carcinogenesis
Breast
33 Citations (Scopus)

Nucleotide metabolism, oncogene-induced senescence and cancer

Aird, K. & Zhang, R., Jan 28 2015, In : Cancer Letters. 356, 2, p. 204-210 7 p.

Research output: Contribution to journalShort survey

Oncogenes
Nucleotides
Deoxyribonucleotides
Neoplasms
DNA Replication
61 Citations (Scopus)

PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion

Caino, M. C., Ghosh, J. C., Chae, Y. C., Vaira, V., Rivadeneira, D. B., Faversani, A., Rampini, P., Kossenkov, A. V., Aird, K., Zhang, R., Webster, M. R., Weeraratna, A. T., Bosari, S., Languino, L. R. & Altieri, D. C., Jul 14 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 28, p. 8638-8643 6 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Neoplasms
Cell Movement
Therapeutics
Precision Medicine
21 Citations (Scopus)

SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase

Zhu, H., Ren, S., Bitler, B. G., Aird, K., Tu, Z., Skordalakes, E., Zhu, Y., Yan, J., Sun, Y. & Zhang, R., Nov 10 2015, In : Cell Reports. 13, 6, p. 1183-1193 11 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Cell Aging
Tumors
Genes
Sumoylation
220 Citations (Scopus)

Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers

Bitler, B. G., Aird, K., Garipov, A., Li, H., Amatangelo, M., Kossenkov, A. V., Schultz, D. C., Liu, Q., Shih, I. M., Conejo-Garcia, J. R., Speicher, D. W. & Zhang, R., Jan 1 2015, In : Nature Medicine. 21, 3, p. 231-238 8 p.

Research output: Contribution to journalArticle

Methyltransferases
Cells
Gene encoding
Phosphatidylinositol 3-Kinases
Chromatin
2014
19 Citations (Scopus)

Identification of ribonucleotide reductase M2 as a potential target for pro-senescence therapy in epithelial ovarian cancer

Aird, K., Li, H., Xin, F., Konstantinopoulos, P. A. & Zhang, R., Jan 15 2014, In : Cell Cycle. 13, 2, p. 199-207 9 p.

Research output: Contribution to journalArticle

Cell Aging
Therapeutics
ribonucleotide reductase M2
Ovarian epithelial cancer
Epithelium
9 Citations (Scopus)

Metabolic alterations accompanying oncogene-induced senescence

Aird, K. & Zhang, R., Sep 15 2014, In : Molecular and Cellular Oncology. 1, 3, e963481.

Research output: Contribution to journalArticle

Oncogenes
Carcinogenesis
Growth
Cell Aging
Autophagy
2013
8 Citations (Scopus)

Chromatin remodeling, BRCA1, SAHF and cellular senescence

Tu, Z., Aird, K. & Zhang, R., Jun 1 2013, In : Cell Cycle. 12, 11, p. 1653-1654 2 p.

Research output: Contribution to journalEditorial

Chromatin Assembly and Disassembly
Cell Aging
28 Citations (Scopus)

Detection of senescence-associated heterochromatin foci (SAHF)

Aird, K. & Zhang, R., Jan 1 2013, Cell Senescence: Methods and Protocols. Humana Press Inc., p. 185-196 12 p. (Methods in Molecular Biology; vol. 965).

Research output: Chapter in Book/Report/Conference proceedingChapter

Heterochromatin
Cell Cycle
Information Dissemination
Cell Aging
Cytostatic Agents
110 Citations (Scopus)

Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence

Aird, K., Zhang, G., Li, H., Tu, Z., Bitler, B. G., Garipov, A., Wu, H., Wei, Z., Wagner, S. N., Herlyn, M. & Zhang, R., Apr 25 2013, In : Cell Reports. 3, 4, p. 1252-1265 14 p.

Research output: Contribution to journalArticle

Deoxyribonucleotides
Oncogenes
Metabolism
Cell growth
Nucleotides
2012
6 Citations (Scopus)

Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function

Morse, M. A., Hobeika, A., Serra, D., Aird, K., McKinney, M., Aldrich, A., Clay, T., Mourich, D., Lyerly, H. K., Iversen, P. L. & Devi, G. R., Jan 1 2012, In : Cancer gene therapy. 19, 1, p. 30-37 8 p.

Research output: Contribution to journalArticle

Cell-Penetrating Peptides
Morpholinos
Regulatory T-Lymphocytes
Arginine
Immunotherapy
33 Citations (Scopus)

ErbB1/2 tyrosine kinase inhibitor mediates oxidative stress-induced apoptosis in inflammatory breast cancer cells

Aird, K., Allensworth, J. L., Batinic-Haberle, I., Lyerly, H. K., Dewhirst, M. W. & Devi, G. R., Feb 1 2012, In : Breast Cancer Research and Treatment. 132, 1, p. 109-119 11 p.

Research output: Contribution to journalArticle

TYK2 Kinase
Inflammatory Breast Neoplasms
Oxidative Stress
Apoptosis
Reactive Oxygen Species
2 Citations (Scopus)

RAS, cellular senescence and transformation: The BRCA1 DNA repair pathway at the crossroads

Tu, Z., Aird, K. & Zhang, R., Jan 1 2012, In : Small GTPases. 3, 3, p. 1-5 5 p.

Research output: Contribution to journalArticle

Cell Aging
Oncogenes
DNA Repair
Tumors
Repair
47 Citations (Scopus)

XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cells

Allensworth, J. L., Aird, K., Aldrich, A. J., Batinic-Haberle, I. & Devi, G. R., Jul 1 2012, In : Molecular Cancer Therapeutics. 11, 7, p. 1518-1527 10 p.

Research output: Contribution to journalArticle

X-Linked Inhibitor of Apoptosis Protein
Inflammatory Breast Neoplasms
Reactive Oxygen Species
Apoptosis
Caspases
2011
35 Citations (Scopus)

Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate

Ye, X., Fels, D., Tovmasyan, A., Aird, K., Dedeugd, C., Allensworth, J. L., Kos, I., Park, W., Spasojevic, I., Devi, G. R., Dewhirst, M. W., Leong, K. W. & Batinic-Haberle, I., Nov 1 2011, In : Free Radical Research. 45, 11-12, p. 1289-1306 18 p.

Research output: Contribution to journalArticle

Reducing Agents
Peroxides
Isomers
Tumors
Neoplasms
46 Citations (Scopus)

Oncogenic Ras Regulates BRIP1 Expression to Induce Dissociation of BRCA1 from Chromatin, Inhibit DNA Repair, and Promote Senescence

Tu, Z., Aird, K., Bitler, B. G., Nicodemus, J. P., Beeharry, N., Xia, B., Yen, T. J. & Zhang, R., Dec 13 2011, In : Developmental Cell. 21, 6, p. 1077-1091 15 p.

Research output: Contribution to journalArticle

DNA Repair
Chromatin
Repair
DNA Damage
DNA
36 Citations (Scopus)

Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration

Thomas, Z. I., Gibson, W., Sexton, J. Z., Aird, K., Ingram, S. M., Aldrich, A., Lyerly, H. K., Devi, G. R. & Williams, K. P., May 10 2011, In : British Journal of Cancer. 104, 10, p. 1575-1586 12 p.

Research output: Contribution to journalArticle

Inflammatory Breast Neoplasms
Apoptosis
Cell Movement
Cell Line
Cell Migration Assays
2010
43 Citations (Scopus)

X-linked inhibitor of apoptosis protein inhibits apoptosis in inflammatory breast cancer cells with acquired resistance to an ErbB1/2 tyrosine kinase inhibitor

Aird, K., Ghanayem, R. B., Peplinski, S., Lyerly, H. K. & Devi, G. R., May 1 2010, In : Molecular Cancer Therapeutics. 9, 5, p. 1432-1442 11 p.

Research output: Contribution to journalArticle

TYK2 Kinase
X-Linked Inhibitor of Apoptosis Protein
Inflammatory Breast Neoplasms
Apoptosis
Breast Neoplasms
2009
12 Citations (Scopus)

Cellular uptake of neutral phosphorodiamidate morpholino oligomers

Iversen, P. L., Aird, K., Wu, R., Morse, M. M. & Devi, G. R., Dec 16 2009, In : Current Pharmaceutical Biotechnology. 10, 6, p. 579-588 10 p.

Research output: Contribution to journalArticle

Morpholinos
Cell Culture Techniques
Transformed Cell Line
Gene Targeting
RNA Precursors
2008
56 Citations (Scopus)

Trastuzumab signaling in ErbB2-overexpressing inflammatory breast cancer correlates with X-linked inhibitor of apoptosis protein expression

Aird, K., Ding, X., Baras, A., Wei, J., Morse, M. A., Clay, T., Lyerly, H. K. & Devi, G. R., Jan 1 2008, In : Molecular Cancer Therapeutics. 7, 1, p. 38-47 10 p.

Research output: Contribution to journalArticle

X-Linked Inhibitor of Apoptosis Protein
Inflammatory Breast Neoplasms
Inhibitor of Apoptosis Proteins
Caspase 9
Epidermal Growth Factor Receptor
2005
11 Citations (Scopus)

Effects of dexamethasone and transient malnutrition on rabbits infected with aerosolized Mycobacterium tuberculosis CDC1551

Kesavan, A. K., Mendez, S. E., Hatem, C. L., Lopez-Molina, J., Aird, K., Pitt, M. L. M., Dannenberg, A. M. & Manabe, Y. C., Oct 1 2005, In : Infection and Immunity. 73, 10, p. 7056-7060 5 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Cellular Immunity
Malnutrition
Dexamethasone
Rabbits
2004

Erratum: Susceptibility to tuberculosis: Clues from studies with inbred and outbred New Zealand white rabbits (Infection and Immunity (2004) 72, 3 (1700-1705))

Dorman, S. E., Hatem, C. L., Tyagi, S., Aird, K., Lopez-Molina, J., Pitt, M. L. M., Zook, B. C., Dannenberg, A. M., Bishai, W. R. & Manabe, Y. C., Jun 1 2004, In : Infection and Immunity. 72, 6, 1 p.

Research output: Contribution to journalComment/debate

Immunity
Tuberculosis
Rabbits
Infection
41 Citations (Scopus)

Susceptibility to Tuberculosis: Clues from Studies with Inbred and Outbred New Zealand White Rabbits

Dorman, S. E., Hatem, C. L., Tyagi, S., Aird, K., Lopez-Molina, J., Pitt, M. L. M., Zook, B. C., Dannenberg, A. M., Bishai, W. R. & Manabe, Y. C., Mar 1 2004, In : Infection and Immunity. 72, 3, p. 1700-1705 6 p.

Research output: Contribution to journalArticle

Tuberculosis
Rabbits
Delayed Hypersensitivity
Granuloma
Mycobacterium tuberculosis