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2020

Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells

Kim, Y. S., Gupta Vallur, P., Jones, V. M., Worley, B. L., Shimko, S., Shin, D. H., Crawford, L. T. C., Chen, C. W., Aird, K. M., Abraham, T., Shepherd, T. G., Warrick, J. I., Lee, N. Y., Phaeton, R., Mythreye, K. & Hempel, N., Feb 20 2020, In : Oncogene. 39, 8, p. 1619-1633 15 p.

Research output: Contribution to journalArticle

2019

GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment

Worley, B. L., Kim, Y. S., Mardini, J., Zaman, R., Leon, K. E., Vallur, P. G., Nduwumwami, A., Warrick, J. I., Timmins, P. F., Kesterson, J. P., Phaëton, R., Lee, N. Y., Walter, V., Endres, L., Mythreye, K., Aird, K. M. & Hempel, N., Jul 2019, In : Redox Biology. 25, 101051.

Research output: Contribution to journalArticle

5 Scopus citations

NAD + metabolism governs the proinflammatory senescence-associated secretome

Nacarelli, T., Lau, L., Fukumoto, T., Zundell, J., Fatkhutdinov, N., Wu, S., Aird, K. M., Iwasaki, O., Kossenkov, A. V., Schultz, D., Noma, K. I., Baur, J. A., Schug, Z., Tang, H. Y., Speicher, D. W., David, G. & Zhang, R., Mar 1 2019, In : Nature Cell Biology. 21, 3, p. 397-407 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

p16: cycling off the beaten path

Buj, R. & Aird, K. M., Nov 2 2019, In : Molecular and Cellular Oncology. 6, 6, e1677140.

Research output: Contribution to journalArticle

Open Access

Simultaneous isotope dilution quantification and metabolic tracing of deoxyribonucleotides by liquid chromatography high resolution mass spectrometry

Kuskovsky, R., Buj, R., Xu, P., Hofbauer, S., Doan, M. T., Jiang, H., Bostwick, A., Mesaros, C., Aird, K. M. & Snyder, N. W., Mar 1 2019, In : Analytical Biochemistry. 568, p. 65-72 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

Buj, R., Chen, C. W., Dahl, E. S., Leon, K. E., Kuskovsky, R., Maglakelidze, N., Navaratnarajah, M., Zhang, G., Doan, M. T., Jiang, H., Zaleski, M., Kutzler, L., Lacko, H., Lu, Y., Mills, G. B., Gowda, R., Robertson, G. P., Warrick, J. I., Herlyn, M., Imamura, Y. & 4 others, Kimball, S. R., DeGraff, D. J., Snyder, N. W. & Aird, K. M., Aug 20 2019, In : Cell Reports. 28, 8, p. 1971-1980.e8

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Targeting IDH1 as a prosenescent therapy in high-grade serous ovarian cancer

Dahl, E. S., Buj, R., Leon, K. E., Newell, J. M., Imamura, Y., Bitler, B. G., Snyder, N. W. & Aird, K. M., Aug 1 2019, In : Molecular Cancer Research. 17, 8, p. 1710-1720 11 p.

Research output: Contribution to journalArticle

2018

CLIC1 and CLIC4 complement CA125 as a diagnostic biomarker panel for all subtypes of epithelial ovarian cancer

Singha, B., Harper, S. L., Goldman, A. R., Bitler, B. G., Aird, K. M., Borowsky, M. E., Cadungog, M. G., Liu, Q., Zhang, R., Jean, S., Drapkin, R. & Speicher, D. W., Dec 1 2018, In : Scientific reports. 8, 1, 14725.

Research output: Contribution to journalArticle

5 Scopus citations
2017

ARID1A-mutated ovarian cancers depend on HDAC6 activity

Bitler, B. G., Wu, S., Park, P. H., Hai, Y., Aird, K. M., Wang, Y., Zhai, Y., Kossenkov, A. V., Vara-Ailor, A., Rauscher, F. J., Zou, W., Speicher, D. W., Huntsman, D. G., Conejo-Garcia, J. R., Cho, K. R., Christianson, D. W. & Zhang, R., Aug 1 2017, In : Nature Cell Biology. 19, 8, p. 962-973 12 p.

Research output: Contribution to journalArticle

56 Scopus citations
2016

Epigenetic synthetic lethality in ovarian clear cell carcinoma: EZH2 and ARID1A mutations

Bitler, B. G., Aird, K. M. & Zhang, R., Jan 2 2016, In : Molecular and Cellular Oncology. 3, 1, e1032476.

Research output: Contribution to journalArticle

7 Scopus citations

SFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

Kaur, A., Webster, M. R., Marchbank, K., Behera, R., Ndoye, A., Kugel, C. H., Dang, V. M., Appleton, J., O'Connell, M. P., Cheng, P., Valiga, A. A., Morissette, R., McDonnell, N. B., Ferrucci, L., Kossenkov, A. V., Meeth, K., Tang, H. Y., Yin, X., Wood, W. H., Lehrmann, E. & 26 others, Becker, K. G., Flaherty, K. T., Frederick, D. T., Wargo, J. A., Cooper, Z. A., Tetzlaff, M. T., Hudgens, C., Aird, K. M., Zhang, R., Xu, X., Liu, Q., Bartlett, E., Karakousis, G., Eroglu, Z., Lo, R. S., Chan, M., Menzies, A. M., Long, G. V., Johnson, D. B., Sosman, J., Schilling, B., Schadendorf, D., Speicher, D. W., Bosenberg, M., Ribas, A. & Weeraratna, A. T., Apr 14 2016, In : Nature. 532, 7598, p. 250-254 5 p.

Research output: Contribution to journalArticle

120 Scopus citations

Targeting RRM2 and mutant BRAF is a novel combinatorial strategy for melanoma

Fatkhutdinov, N., Sproesser, K., Krepler, C., Liu, Q., Brafford, P. A., Herlyn, M., Aird, K. M. & Zhang, R., Sep 1 2016, In : Molecular Cancer Research. 14, 9, p. 767-775 9 p.

Research output: Contribution to journalArticle

6 Scopus citations
2015

ATM Couples Replication Stress and Metabolic Reprogramming during Cellular Senescence

Aird, K. M., Worth, A. J., Snyder, N. W., Lee, J. V., Sivanand, S., Liu, Q., Blair, I. A., Wellen, K. E. & Zhang, R., May 12 2015, In : Cell Reports. 11, 6, p. 893-901 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer

Zhang, J., Wang, C., Chen, X., Takada, M., Fan, C., Zheng, X., Wen, H., Liu, Y., Wang, C., Pestell, R. G., Aird, K. M., Kaelin, W. G., Liu, X. S. & Zhang, Q., Dec 2 2015, In : EMBO Journal. 34, 23, p. 2953-2970 18 p.

Research output: Contribution to journalArticle

21 Scopus citations

PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion

Caino, M. C., Ghosh, J. C., Chae, Y. C., Vaira, V., Rivadeneira, D. B., Faversani, A., Rampini, P., Kossenkov, A. V., Aird, K. M., Zhang, R., Webster, M. R., Weeraratna, A. T., Bosari, S., Languino, L. R. & Altieri, D. C., Jul 14 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 28, p. 8638-8643 6 p.

Research output: Contribution to journalArticle

82 Scopus citations

SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase

Zhu, H., Ren, S., Bitler, B. G., Aird, K. M., Tu, Z., Skordalakes, E., Zhu, Y., Yan, J., Sun, Y. & Zhang, R., Nov 10 2015, In : Cell Reports. 13, 6, p. 1183-1193 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers

Bitler, B. G., Aird, K., Garipov, A., Li, H., Amatangelo, M., Kossenkov, A. V., Schultz, D. C., Liu, Q., Shih, I. M., Conejo-Garcia, J. R., Speicher, D. W. & Zhang, R., Jan 1 2015, In : Nature Medicine. 21, 3, p. 231-238 8 p.

Research output: Contribution to journalArticle

277 Scopus citations
2014

Identification of ribonucleotide reductase M2 as a potential target for pro-senescence therapy in epithelial ovarian cancer

Aird, K. M., Li, H., Xin, F., Konstantinopoulos, P. A. & Zhang, R., Jan 15 2014, In : Cell Cycle. 13, 2, p. 199-207 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Metabolic alterations accompanying oncogene-induced senescence

Aird, K. M. & Zhang, R., Sep 15 2014, In : Molecular and Cellular Oncology. 1, 3, e963481.

Research output: Contribution to journalArticle

14 Scopus citations
2013

Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence

Aird, K. M., Zhang, G., Li, H., Tu, Z., Bitler, B. G., Garipov, A., Wu, H., Wei, Z., Wagner, S. N., Herlyn, M. & Zhang, R., Apr 25 2013, In : Cell Reports. 3, 4, p. 1252-1265 14 p.

Research output: Contribution to journalArticle

126 Scopus citations
2012

Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function

Morse, M. A., Hobeika, A., Serra, D., Aird, K., McKinney, M., Aldrich, A., Clay, T., Mourich, D., Lyerly, H. K., Iversen, P. L. & Devi, G. R., Jan 1 2012, In : Cancer gene therapy. 19, 1, p. 30-37 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

ErbB1/2 tyrosine kinase inhibitor mediates oxidative stress-induced apoptosis in inflammatory breast cancer cells

Aird, K. M., Allensworth, J. L., Batinic-Haberle, I., Lyerly, H. K., Dewhirst, M. W. & Devi, G. R., Feb 1 2012, In : Breast Cancer Research and Treatment. 132, 1, p. 109-119 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

RAS, cellular senescence and transformation: The BRCA1 DNA repair pathway at the crossroads

Tu, Z., Aird, K. M. & Zhang, R., Jan 1 2012, In : Small GTPases. 3, 3, p. 1-5 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cells

Allensworth, J. L., Aird, K. M., Aldrich, A. J., Batinic-Haberle, I. & Devi, G. R., Jul 1 2012, In : Molecular cancer therapeutics. 11, 7, p. 1518-1527 10 p.

Research output: Contribution to journalArticle

53 Scopus citations
2011

Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate

Ye, X., Fels, D., Tovmasyan, A., Aird, K. M., Dedeugd, C., Allensworth, J. L., Kos, I., Park, W., Spasojevic, I., Devi, G. R., Dewhirst, M. W., Leong, K. W. & Batinic-Haberle, I., Nov 1 2011, In : Free Radical Research. 45, 11-12, p. 1289-1306 18 p.

Research output: Contribution to journalArticle

38 Scopus citations

Oncogenic Ras Regulates BRIP1 Expression to Induce Dissociation of BRCA1 from Chromatin, Inhibit DNA Repair, and Promote Senescence

Tu, Z., Aird, K., Bitler, B. G., Nicodemus, J. P., Beeharry, N., Xia, B., Yen, T. J. & Zhang, R., Dec 13 2011, In : Developmental Cell. 21, 6, p. 1077-1091 15 p.

Research output: Contribution to journalArticle

51 Scopus citations

Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration

Thomas, Z. I., Gibson, W., Sexton, J. Z., Aird, K. M., Ingram, S. M., Aldrich, A., Lyerly, H. K., Devi, G. R. & Williams, K. P., May 10 2011, In : British Journal of Cancer. 104, 10, p. 1575-1586 12 p.

Research output: Contribution to journalArticle

37 Scopus citations
2010

X-linked inhibitor of apoptosis protein inhibits apoptosis in inflammatory breast cancer cells with acquired resistance to an ErbB1/2 tyrosine kinase inhibitor

Aird, K. M., Ghanayem, R. B., Peplinski, S., Lyerly, H. K. & Devi, G. R., May 1 2010, In : Molecular cancer therapeutics. 9, 5, p. 1432-1442 11 p.

Research output: Contribution to journalArticle

45 Scopus citations
2009

Cellular uptake of neutral phosphorodiamidate morpholino oligomers

Iversen, P. L., Aird, K., Wu, R., Morse, M. M. & Devi, G. R., Dec 16 2009, In : Current Pharmaceutical Biotechnology. 10, 6, p. 579-588 10 p.

Research output: Contribution to journalArticle

12 Scopus citations
2008

Trastuzumab signaling in ErbB2-overexpressing inflammatory breast cancer correlates with X-linked inhibitor of apoptosis protein expression

Aird, K. M., Ding, X., Baras, A., Wei, J., Morse, M. A., Clay, T., Lyerly, H. K. & Devi, G. R., Jan 1 2008, In : Molecular cancer therapeutics. 7, 1, p. 38-47 10 p.

Research output: Contribution to journalArticle

57 Scopus citations
2005

Effects of dexamethasone and transient malnutrition on rabbits infected with aerosolized Mycobacterium tuberculosis CDC1551

Kesavan, A. K., Mendez, S. E., Hatem, C. L., Lopez-Molina, J., Aird, K., Pitt, M. L. M., Dannenberg, A. M. & Manabe, Y. C., Oct 1 2005, In : Infection and Immunity. 73, 10, p. 7056-7060 5 p.

Research output: Contribution to journalArticle

12 Scopus citations
2004

Susceptibility to Tuberculosis: Clues from Studies with Inbred and Outbred New Zealand White Rabbits

Dorman, S. E., Hatem, C. L., Tyagi, S., Aird, K., Lopez-Molina, J., Pitt, M. L. M., Zook, B. C., Dannenberg, A. M., Bishai, W. R. & Manabe, Y. C., Mar 1 2004, In : Infection and Immunity. 72, 3, p. 1700-1705 6 p.

Research output: Contribution to journalArticle

43 Scopus citations