• 681 Citations
  • 15 h-Index
20012019

Research output per year

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Personal profile

Research interests

Dr. Kebin Hu's laboratory is interested in understanding the cellular and molecular mechanisms of tissue fibrogenesis and inflammation, identifying novel signal mediators, and developing therapeutic strategies for the treatment of fibrotic or inflammatory diseases.

The hallmark of chronic kidney disease (CKD) is renal interstitial fibrosis and inflammation, which is characterized by proliferation and activation of interstitial cells, florid infiltrations, extensive deposition of extracellular matrix (ECM) components and the eventual destruction of normal kidney structure. Members of plasminogen activator system including tissue-type plasminogen activator (tPA) are the key regulators in the homeostasis of ECM. In addition to its protease activities, Dr. Hu's lab demonstrated that tPA is actually a cytokine promoting renal fibrosis and inflammation through its receptors-mediated activation of different cascades of intracellular signal transduction.

With the support of grants from NIH, American Heart Association, as well as other foundations, Dr. Hu's laboratory is currently utilizing integral in vivo and in vitro approaches to define novel signal pathways in the regulation of fibroblast or macrophage differentiation and transdifferentiation and their roles in tissue fibrosis and inflammation, and to explore novel therapeutic remedies to retard or even reverse the progression of CKD.

Education/Academic qualification

PhD, Nanjing University Medical School

… → 2001

MD, Nanjing University Medical School

… → 1997

External positions

Member, Special Emphasis Panel, George M. O'Brien Kidney Research Core Centers Program, NIDDK

Jan 1 2017 → …

Ad Hoc Member, Pathobiology of Kidney Disease Study Section, Center for Scientific Review, NIH

Jan 1 2017 → …

Member, Special Emphasis Panel, George M. O'Brien Kidney Research Core Centers Program, NIDDK

2017 → …

Ad Hoc Member, Pathobiology of Kidney Disease Study Section, Center for Scientific Review, NIH

2017 → …

Member, Early Career Reviewer Program, Center for Scientific Review, NIH

Jan 1 2014Jan 1 2015

Member, Early Career Reviewer Program, Center for Scientific Review, NIH

20142015

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Projects

p90 Ribosomal S6 Kinase and Chronic Kidney Disease

Hu, K.

8/10/145/31/15

Project: Research project

Research Output

  • 681 Citations
  • 15 h-Index
  • 23 Article
  • 3 Review article
  • 1 Chapter
  • 1 Editorial

Role of p90RSK in kidney and other diseases

Lin, L., White, S. A. & Hu, K., Feb 2 2019, In : International journal of molecular sciences. 20, 4, 972.

Research output: Contribution to journalReview article

Open Access
  • 4 Scopus citations

    The Ser/Thr kinase p90RSK promotes kidney fibrosis by modulating fibroblast-epithelial crosstalk

    Lin, L., Shi, C., Sun, Z., Le, N. T., Abe, J. I. & Hu, K., Jun 21 2019, In : Journal of Biological Chemistry. 294, 25, p. 9901-9910 10 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Macrophage functions and regulation: Roles in diseases and implications in therapeutics

    Hu, K., Jin, Y., Chroneos, Z., Han, X., Liu, H. & Lin, L., Jan 1 2018, In : Journal of immunology research. 2018, 7590350.

    Research output: Contribution to journalEditorial

    1 Scopus citations

    The hedgehog and Wnt/β-catenin system machinery mediate myofibroblast differentiation of LR-MSCs in pulmonary

    Chen, X., Shi, C., Cao, H., Chen, L., Hou, J., Xiang, Z., Hu, K. & Han, X., Jun 1 2018, In : Cell Death and Disease. 9, 6, 692.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Macrophage-derived apoptotic bodies promote the proliferation of the recipient cells via shuttling microRNA-221/222

    Zhu, Z., Zhang, D., Lee, H., Menon, A. A., Wu, J., Hu, K. & Jin, Y., Jan 1 2017, In : Journal of Leukocyte Biology. 101, 6, p. 1349-1359 11 p.

    Research output: Contribution to journalArticle

  • 23 Scopus citations