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Dr. Kebin Hu is the director of nephrology research in the Department of Medicine at Penn State College of Medicine.
Dr. Hu's laboratory is interested in understanding the cellular and molecular mechanisms of tissue fibrogenesis and inflammation, identifying novel signal mediators and developing therapeutic strategies for the treatment of fibrotic or inflammatory diseases.
The hallmark of chronic kidney disease (CKD) is renal interstitial fibrosis and inflammation, which is characterized by proliferation and activation of interstitial cells, florid infiltrations, extensive deposition of extracellular matrix (ECM) components and the eventual destruction of normal kidney structure. Members of plasminogen activator system including tissue-type plasminogen activator (tPA) are the key regulators in the homeostasis of ECM. In addition to its protease activities, Dr. Hu's lab has demonstrated that tPA is actually a cytokine promoting renal fibrosis and inflammation through its receptors-mediated activation of different cascades of intracellular signal transduction.
With the support of grants from federal, state and foundation sources, Dr. Hu's laboratory is currently utilizing integral in vivo and in vitro approaches to:
Dr. Kebin Hu is a faculty member in the Biomedical Sciences graduate program at Penn State College of Medicine. He is actively involved in small-group education and mentoring of junior faculty, postdoctoral fellows, graduate students and visiting scholars.
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
PhD, Nanjing University Medical School
… → 2001
MD, Nanjing University Medical School
… → 1997
Reviewer, NIH Researching COVID to Enhance Recovery (RECOVER) Initiative, National Institutes of Health
2022 → …
Reviewer, NIH Research Initiative on Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), National Heart and Lung and Blood Institute
2021 → …
Member, Special Emphasis Panel, George M. O'Brien Kidney Research Core Centers Program, NIDDK
2017 → …
Ad Hoc Member, Pathobiology of Kidney Disease Study Section, Center for Scientific Review, NIH
2017 → …
Member, Early Career Reviewer Program, Center for Scientific Review, NIH
2014 → 2015
Research output: Contribution to journal › Review article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Editorial › peer-review