Projects per year
Personal profile
Research interests
Dr. Kebin Hu's laboratory is interested in understanding the cellular and molecular mechanisms of tissue fibrogenesis and inflammation, identifying novel signal mediators, and developing therapeutic strategies for the treatment of fibrotic or inflammatory diseases.
The hallmark of chronic kidney disease (CKD) is renal interstitial fibrosis and inflammation, which is characterized by proliferation and activation of interstitial cells, florid infiltrations, extensive deposition of extracellular matrix (ECM) components and the eventual destruction of normal kidney structure. Members of plasminogen activator system including tissue-type plasminogen activator (tPA) are the key regulators in the homeostasis of ECM. In addition to its protease activities, Dr. Hu's lab demonstrated that tPA is actually a cytokine promoting renal fibrosis and inflammation through its receptors-mediated activation of different cascades of intracellular signal transduction.
With the support of grants from NIH, American Heart Association, as well as other foundations, Dr. Hu's laboratory is currently utilizing integral in vivo and in vitro approaches to define novel signal pathways in the regulation of fibroblast or macrophage differentiation and transdifferentiation and their roles in tissue fibrosis and inflammation, and to explore novel therapeutic remedies to retard or even reverse the progression of CKD.
Education/Academic qualification
PhD, Nanjing University Medical School
… → 2001
MD, Nanjing University Medical School
… → 1997
External positions
Member, Special Emphasis Panel, George M. O'Brien Kidney Research Core Centers Program, NIDDK
2017 → …Ad Hoc Member, Pathobiology of Kidney Disease Study Section, Center for Scientific Review, NIH
2017 → …Member, Early Career Reviewer Program, Center for Scientific Review, NIH
2014 → 2015Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
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Projects 2014 2019
- 1 Active
p90 Ribosomal S6 Kinase and Chronic Kidney Disease
8/10/14 → 5/31/19
Project: Research project › Research Project
Research Output 2001 2018
The hedgehog and Wnt/β-catenin system machinery mediate myofibroblast differentiation of LR-MSCs in pulmonary
Chen, X., Shi, C., Cao, H., Chen, L., Hou, J., Xiang, Z., Hu, K. & Han, X., Jun 1 2018, In : Cell Death and Disease. 9, 6, 692.Research output: Contribution to journal › Article
Macrophage-derived apoptotic bodies promote the proliferation of the recipient cells via shuttling microRNA-221/222
Zhu, Z., Zhang, D., Lee, H., Menon, A. A., Wu, J., Hu, K. & Jin, Y., Jan 1 2017, In : Journal of Leukocyte Biology. 101, 6, p. 1349-1359 11 p.Research output: Contribution to journal › Article
The role of miR-497-5p in myofibroblast differentiation of LR-MSCs and pulmonary fibrogenesis
Chen, X., Shi, C., Wang, C., Liu, W., Chu, Y., Xiang, Z., Hu, K., Dong, P. & Han, X., Jan 18 2017, In : Scientific reports. 7, 40958.Research output: Contribution to journal › Article
Tissue-type plasminogen activator modulates macrophage M2 to M1 phenotypic change through annexin A2-mediated NF-κB pathway
Lin, L. & Hu, K., Jan 1 2017, In : Oncotarget. 8, 50, p. 88094-88103 10 p.Research output: Contribution to journal › Article
Inhibition of Wnt/β-catenin signaling suppresses bleomycin-induced pulmonary fibrosis by attenuating the expression of TGF-β1 and FGF-2
Chen, X., Shi, C., Meng, X., Zhang, K., Li, X., Wang, C., Xiang, Z., Hu, K. & Han, X., Aug 1 2016, In : Experimental and Molecular Pathology. 101, 1, p. 22-30 9 p.Research output: Contribution to journal › Article
Prizes
Endowed Career Development Professor in Nephrology, Department of Medicine
Kebin Hu (Recipient), 2016
Prize