• 556 Citations
  • 13 h-Index
20012019
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Personal profile

Research interests

Dr. Kebin Hu's laboratory is interested in understanding the cellular and molecular mechanisms of tissue fibrogenesis and inflammation, identifying novel signal mediators, and developing therapeutic strategies for the treatment of fibrotic or inflammatory diseases.

The hallmark of chronic kidney disease (CKD) is renal interstitial fibrosis and inflammation, which is characterized by proliferation and activation of interstitial cells, florid infiltrations, extensive deposition of extracellular matrix (ECM) components and the eventual destruction of normal kidney structure. Members of plasminogen activator system including tissue-type plasminogen activator (tPA) are the key regulators in the homeostasis of ECM. In addition to its protease activities, Dr. Hu's lab demonstrated that tPA is actually a cytokine promoting renal fibrosis and inflammation through its receptors-mediated activation of different cascades of intracellular signal transduction.

With the support of grants from NIH, American Heart Association, as well as other foundations, Dr. Hu's laboratory is currently utilizing integral in vivo and in vitro approaches to define novel signal pathways in the regulation of fibroblast or macrophage differentiation and transdifferentiation and their roles in tissue fibrosis and inflammation, and to explore novel therapeutic remedies to retard or even reverse the progression of CKD.

Education/Academic qualification

PhD, Nanjing University Medical School

… → 2001

MD, Nanjing University Medical School

… → 1997

External positions

Member, Special Emphasis Panel, George M. O'Brien Kidney Research Core Centers Program, NIDDK

2017 → …

Ad Hoc Member, Pathobiology of Kidney Disease Study Section, Center for Scientific Review, NIH

2017 → …

Member, Early Career Reviewer Program, Center for Scientific Review, NIH

20142015

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Projects 2014 2019

90-kDa Ribosomal Protein S6 Kinases
Chronic Renal Insufficiency
Low Density Lipoprotein Receptor-Related Protein-1
Kidney
Fibrosis

Research Output 2001 2018

  • 556 Citations
  • 13 h-Index
  • 22 Article
  • 2 Review article
  • 1 Chapter
2 Citations (Scopus)

The hedgehog and Wnt/β-catenin system machinery mediate myofibroblast differentiation of LR-MSCs in pulmonary

Chen, X., Shi, C., Cao, H., Chen, L., Hou, J., Xiang, Z., Hu, K. & Han, X., Jun 1 2018, In : Cell Death and Disease. 9, 6, 692.

Research output: Contribution to journalArticle

Catenins
Myofibroblasts
Pulmonary Fibrosis
Lung
Idiopathic Pulmonary Fibrosis
11 Citations (Scopus)

Macrophage-derived apoptotic bodies promote the proliferation of the recipient cells via shuttling microRNA-221/222

Zhu, Z., Zhang, D., Lee, H., Menon, A. A., Wu, J., Hu, K. & Jin, Y., Jan 1 2017, In : Journal of Leukocyte Biology. 101, 6, p. 1349-1359 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Macrophages
Cell Proliferation
Epithelial Cells
Alveolar Macrophages
7 Citations (Scopus)

The role of miR-497-5p in myofibroblast differentiation of LR-MSCs and pulmonary fibrogenesis

Chen, X., Shi, C., Wang, C., Liu, W., Chu, Y., Xiang, Z., Hu, K., Dong, P. & Han, X., Jan 18 2017, In : Scientific reports. 7, 40958.

Research output: Contribution to journalArticle

Myofibroblasts
Mesenchymal Stromal Cells
Lung
Idiopathic Pulmonary Fibrosis
Pulmonary Fibrosis
3 Citations (Scopus)

Tissue-type plasminogen activator modulates macrophage M2 to M1 phenotypic change through annexin A2-mediated NF-κB pathway

Lin, L. & Hu, K., Jan 1 2017, In : Oncotarget. 8, 50, p. 88094-88103 10 p.

Research output: Contribution to journalArticle

Annexin A2
Tissue Plasminogen Activator
Macrophages
Plasminogen Activators
Kidney
15 Citations (Scopus)

Inhibition of Wnt/β-catenin signaling suppresses bleomycin-induced pulmonary fibrosis by attenuating the expression of TGF-β1 and FGF-2

Chen, X., Shi, C., Meng, X., Zhang, K., Li, X., Wang, C., Xiang, Z., Hu, K. & Han, X., Aug 1 2016, In : Experimental and Molecular Pathology. 101, 1, p. 22-30 9 p.

Research output: Contribution to journalArticle

Catenins
Pulmonary Fibrosis
Bleomycin
Transforming Growth Factors
Fibroblast Growth Factor 2