• 627 Citations
  • 15 h-Index
20012019
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Personal profile

Research interests

Dr. Kebin Hu's laboratory is interested in understanding the cellular and molecular mechanisms of tissue fibrogenesis and inflammation, identifying novel signal mediators, and developing therapeutic strategies for the treatment of fibrotic or inflammatory diseases.

The hallmark of chronic kidney disease (CKD) is renal interstitial fibrosis and inflammation, which is characterized by proliferation and activation of interstitial cells, florid infiltrations, extensive deposition of extracellular matrix (ECM) components and the eventual destruction of normal kidney structure. Members of plasminogen activator system including tissue-type plasminogen activator (tPA) are the key regulators in the homeostasis of ECM. In addition to its protease activities, Dr. Hu's lab demonstrated that tPA is actually a cytokine promoting renal fibrosis and inflammation through its receptors-mediated activation of different cascades of intracellular signal transduction.

With the support of grants from NIH, American Heart Association, as well as other foundations, Dr. Hu's laboratory is currently utilizing integral in vivo and in vitro approaches to define novel signal pathways in the regulation of fibroblast or macrophage differentiation and transdifferentiation and their roles in tissue fibrosis and inflammation, and to explore novel therapeutic remedies to retard or even reverse the progression of CKD.

Education/Academic qualification

PhD, Nanjing University Medical School

… → 2001

MD, Nanjing University Medical School

… → 1997

External positions

Member, Special Emphasis Panel, George M. O'Brien Kidney Research Core Centers Program, NIDDK

Jan 1 2017 → …

Ad Hoc Member, Pathobiology of Kidney Disease Study Section, Center for Scientific Review, NIH

Jan 1 2017 → …

Member, Special Emphasis Panel, George M. O'Brien Kidney Research Core Centers Program, NIDDK

2017 → …

Ad Hoc Member, Pathobiology of Kidney Disease Study Section, Center for Scientific Review, NIH

2017 → …

Member, Early Career Reviewer Program, Center for Scientific Review, NIH

Jan 1 2014Jan 1 2015

Member, Early Career Reviewer Program, Center for Scientific Review, NIH

20142015

Fingerprint Dive into the research topics where Kebin Hu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Tissue Plasminogen Activator Medicine & Life Sciences
Plasminogen Activators Medicine & Life Sciences
Myofibroblasts Medicine & Life Sciences
Lung Medicine & Life Sciences
Macrophages Medicine & Life Sciences
Kidney Medicine & Life Sciences
Low Density Lipoprotein Receptor-Related Protein-1 Medicine & Life Sciences
Fibroblasts Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2014 2019

90-kDa Ribosomal Protein S6 Kinases
Chronic Renal Insufficiency
Low Density Lipoprotein Receptor-Related Protein-1
Kidney
Fibrosis

Research Output 2001 2019

  • 627 Citations
  • 15 h-Index
  • 23 Article
  • 3 Review article
  • 1 Chapter
  • 1 Editorial
1 Citation (Scopus)

Role of p90RSK in kidney and other diseases

Lin, L., White, S. A. & Hu, K., Feb 2 2019, In : International journal of molecular sciences. 20, 4, 972.

Research output: Contribution to journalReview article

Open Access
kidney diseases
Ribosomal Protein S6 Kinases
Kidney Diseases
activation
effectors

The Ser/Thr kinase p90RSK promotes kidney fibrosis by modulating fibroblast-epithelial crosstalk

Lin, L., Shi, C., Sun, Z., Le, N. T., Abe, J. I. & Hu, K., Jan 1 2019, In : Journal of Biological Chemistry. 294, 25, p. 9901-9910 10 p.

Research output: Contribution to journalArticle

Fibroblasts
Crosstalk
Fibrosis
Phosphotransferases
Catenins
1 Citation (Scopus)

Macrophage functions and regulation: Roles in diseases and implications in therapeutics

Hu, K., Jin, Y., Chroneos, Z., Han, X., Liu, H. & Lin, L., Jan 1 2018, In : Journal of immunology research. 2018, 7590350.

Research output: Contribution to journalEditorial

Th2 Cells
Th1 Cells
Autoimmune Diseases
Cell Differentiation
Central Nervous System
5 Citations (Scopus)

The hedgehog and Wnt/β-catenin system machinery mediate myofibroblast differentiation of LR-MSCs in pulmonary

Chen, X., Shi, C., Cao, H., Chen, L., Hou, J., Xiang, Z., Hu, K. & Han, X., Jun 1 2018, In : Cell Death and Disease. 9, 6, 692.

Research output: Contribution to journalArticle

Catenins
Myofibroblasts
Pulmonary Fibrosis
Lung
Idiopathic Pulmonary Fibrosis
17 Citations (Scopus)

Macrophage-derived apoptotic bodies promote the proliferation of the recipient cells via shuttling microRNA-221/222

Zhu, Z., Zhang, D., Lee, H., Menon, A. A., Wu, J., Hu, K. & Jin, Y., Jan 1 2017, In : Journal of Leukocyte Biology. 101, 6, p. 1349-1359 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Macrophages
Cell Proliferation
Epithelial Cells
Alveolar Macrophages