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Personal profile

Research interests

In summary, Dr. Keith Cheng's research interests currently include phage genetics, E. coli genetics, recombination, cancer genetics, model system genetics, human genetics, human population genetics, genomics, phenomics, anatomic pathology, computational phenomics, automated phenotyping, microCT, synchrotron microCT, high-throughput imaging, machine learning, skin pigmentation, race, natural selection, social selection, music and medicine, piano, violin, classical music, chamber music, public media and web-based resources.

The Cheng lab is interested in making fundamental contributions to the understanding of genetic and molecular mechanisms involved in human biology and disease. The lab is interested in genetic aspects of human disease, use of model systems such as the zebrafish, contribution to web-based scientific resources and new, potentially high-throughput forms of 3D imaging.

Some of the Cheng lab's specific work is aimed at increasing understanding of the basis of phenotypic variability, particularly as it may impact cancer; basic mechanisms underlying the relationship between human skin pigmentation and skin cancer; contributing to web-based infrastructures for science, education and public service; and working toward a 3D derivative of histology that also allows the identification and characterization of all cell types but utilizes the computer to define slice angle, thickness, point of view  and definition of tissues of interest. Obvious implications include automation of phenotyping, including diagnostics.

Fingerprint Dive into the research topics where Keith Cheng is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 5 Similar Profiles
Zebrafish Medicine & Life Sciences
Skin Pigmentation Medicine & Life Sciences
Mutation Medicine & Life Sciences
Genomic Instability Medicine & Life Sciences
Pigmentation Medicine & Life Sciences
Histology Medicine & Life Sciences
Phenotype Medicine & Life Sciences
Tissue Chemical Compounds

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Projects 1994 2019

X-Ray Microtomography
Synchrotrons
Zebrafish
Daphnia
Research Personnel
Zebrafish
Genomics
Precision Medicine
Drug Discovery
Research
Genomic Instability
Zebrafish
Neoplasms
Genes
Vertebrates
Pigmentation
Melanosomes
Calcium
Melanins
Skin Pigmentation

Research Output 1984 2019

Abstracts of Presentations at the Association of Clinical Scientists 139th Meeting Hershey, PA, May 15-18, 2019

Donaldson, K., Buchanich, J. M., Grigson-Kennedy, P. S., Deneke, E., Vrana, K., Sacks, D. B., Kuehn, G. J., Cardamone, D., Pesce, A., Smiley, S., Nickley, J., Krock, K., Thomas, R., Wilkerson, M. L., Farag, H. A., Challa, S. R., Tice, A. M., Wolk, D. M., Prichard, J., Grant, M. L. & 102 others, Regmi, S., Kerbacher, B., Quinton, L. E., Tice, A. M., Olson, J., Haynes, A., Yu, E., McCully, K. S., Assi, J., Wong, M., Zarrin-Khameh, N., Nifong, T. P., Hawker, C. D., Carlton, G. T., Rivera, J. M., Foulis, P. R., Zuraw, A., Morlote, D., Peker, D., Reddy, V., Harada, S., Crutchfield, C., Zander, D., Barbhuiya, M. A., Pederson, E. C., Straub, M. L., Scott, S. C., Neibauer, T. L., Salter, W. F., Creer, M. H., Zhu, Y., Bornhorst, J. A., Theobald, J. P., Algeciras-Schimnich, A., Cao, L., Knox, J., Hardy, R., Texas, H. J., McGuire, M. F., Hunter, R. L., Brown, R. E., Hicks, J., Cai, Z., Brown, R. E., Ali, Y., Cheng, K., Katz, S. R., Ding, Y., Vanselow, D. J., Yakovlev, M. A., Lin, A. Y., Clark, D. P., Vargas, P., Xin, X., Copper, J. E., Canfield, V., Ang, K., Wang, Y., Xiao, X., De Carlo, F., Van Rossum, D. B., La Rivière, P. J., Newell, J., Hossler, C., Roche, M., Warrick, J., Phaeton, R., Kesterson, J., Myers, C., Barrios, R., Mintz, P., Robyak, K., Hamilton, C., McGhee, P., Pederson, C., Straub, M., Scott, S., Neibauer, T., Salter, W., Robyak, K., Singh, N., Morlote, D., Vnencak-Jones, C., Yemelyanova, A., Harada, S., Shah, M., Moghadamtousi, S. Z., Lan, C., Duose, D., Hu, P., Esquenazi, Y., Luthra, R., Ballester, L. Y., Koenig, A. N., Liu, C. G., Zhang, J., Kalia, A., Al-Habib, A., Van Arsdall, M., Dhingra, S., Patel, K. & Tatevian, N., May 1 2019, In : Annals of clinical and laboratory science. 49, 3, p. 403-416 14 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Comparative analysis of fixation and embedding techniques for optimized histological preparation of zebrafish

Copper, J. E., Budgeon, L. R., Foutz, C. A., Van Rossum, D. B., Vanselow, D. J., Hubley, M. J., Clark, D. P., Mandrell, D. T. & Cheng, K., Jun 1 2018, In : Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology. 208, p. 38-46 9 p.

Research output: Contribution to journalArticle

Histological Techniques
Zebrafish
Tissue
Histology
Hydration
7 Citations (Scopus)

Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice

Peters, D. G., Pollack, A. N., Cheng, K., Sun, D., Saido, T., Haaf, M. P., Yang, Q., Connor, J. & Meadowcroft, M., Mar 1 2018, In : Metallomics. 10, 3, p. 426-443 18 p.

Research output: Contribution to journalArticle

Dietary Iron
Alzheimer Disease
Iron
Brain
Amyloid
1 Citation (Scopus)

Rigid Embedding of Fixed and Stained, Whole, Millimeter-Scale Specimens for Section-free 3D Histology by Micro-Computed Tomography

Lin, A. Y., Ding, Y., Vanselow, D. J., Katz, S. R., Yakovlev, M. A., Clark, D. P., Mandrell, D., Copper, J. E., Van Rossum, D. B. & Cheng, K., Oct 17 2018, In : Journal of visualized experiments : JoVE. 140

Research output: Contribution to journalArticle

Histology
Tomography
Tissue
X rays
Immobilization

Synchrotron microCT imaging of soft tissue in juvenile zebrafish reveals retinotectal projections

Xin, X., Clark, D., Ang, K., Van Rossum, D. B., Copper, J., Xiao, X., La Riviere, P. J. & Cheng, K., Jan 1 2017, Optical Biopsy XV: Toward Real-Time Spectroscopic Imaging and Diagnosis. Alfano, R. R. & Demos, S. G. (eds.). SPIE, 100601I. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10060).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

X-Ray Microtomography
Synchrotrons
Zebrafish
synchrotrons
projection

Activities 2017 2017

  • 3 Oral presentation

From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics

Keith Cheng (Speaker), Y Ding (Speaker), SR Katz (Speaker), AY Lin (Speaker), D van Rossum (Speaker), D Vanselow (Speaker)
Sep 27 2017

Activity: Talk typesOral presentation

Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish

Keith Cheng (Speaker), Y Ding (Speaker), AY Lin (Speaker), M Yakovlev (Speaker), D Vanselow (Speaker), X Xin (Speaker), S Katz (Speaker), D Vanselow (Speaker), PJ La Riviere (Speaker)
Jul 5 2017

Activity: Talk typesOral presentation