Projects per year
Personal profile
Research interests
In summary, Dr. Keith Cheng's research interests currently include phage genetics, E. coli genetics, recombination, cancer genetics, model system genetics, human genetics, human population genetics, genomics, phenomics, anatomic pathology, computational phenomics, automated phenotyping, microCT, synchrotron microCT, high-throughput imaging, machine learning, skin pigmentation, race, natural selection, social selection, music and medicine, piano, violin, classical music, chamber music, public media and web-based resources.
The Cheng lab is interested in making fundamental contributions to the understanding of genetic and molecular mechanisms involved in human biology and disease. The lab is interested in genetic aspects of human disease, use of model systems such as the zebrafish, contribution to web-based scientific resources and new, potentially high-throughput forms of 3D imaging.
Some of the Cheng lab's specific work is aimed at increasing understanding of the basis of phenotypic variability, particularly as it may impact cancer; basic mechanisms underlying the relationship between human skin pigmentation and skin cancer; contributing to web-based infrastructures for science, education and public service; and working toward a 3D derivative of histology that also allows the identification and characterization of all cell types but utilizes the computer to define slice angle, thickness, point of view and definition of tissues of interest. Obvious implications include automation of phenotyping, including diagnostics.
Teaching and educational interests
As a student of the history of science, Dr. Cheng has been fascinated with the discovery of the cell, the cellular basis of disease, and of 2D and 3D imaging. He loves to teach students about the scientific progress of asking what we think might be important questions, how those questions have been posed and answered elegantly, leading to discovery, including Nobel prizes. From his own career, he has been fascinated by the role of serendipity in science, including the role of chance encounters with other scientists during one's career.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Co-Chair, Validation of Animal Models of Human Biology and Disease, NIH, Office of Research Infrastructure and Programs
2020 → 2022
Fingerprint
- 1 Similar Profiles
Network
Projects
- 3 Finished
-
Generation and Study of Zebrafish Genomic Instability Mutants
4/1/97 → 8/31/00
Project: Research project
-
Genetic Diversity in Insular Southeast Asia
Deka, R., Saha, N. & Cheng, K.
8/15/96 → 7/31/98
Project: Research project
-
Generation and Initial Study of Zebrafish Genomic Instability Mutants
3/1/94 → 8/31/97
Project: Research project
-
A wide-field micro-computed tomography detector: micron resolution at half-centimetre scale
Yakovlev, M. A., Vanselow, D. J., Ngu, M. S., Zaino, C. R., Katz, S. R., Ding, Y., Parkinson, D., Wang, S. Y., Ang, K. C., La Riviere, P. & Cheng, K. C., Mar 1 2022, In: Journal of Synchrotron Radiation. 29, p. 505-514 10 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Promoting validation and cross-phylogenetic integration in model organism research
Cheng, K. C., Burdine, R. D., Dickinson, M. E., Ekker, S. C., Lin, A. Y., Lloyd, K. C. K., Lutz, C. M., MacRae, C. A., Morrison, J. H., O'Connor, D. H., Postlethwait, J. H., Rogers, C. D., Sanchez, S., Simpson, J. H., Talbot, W. S., Wallace, D. C., Weimer, J. M. & Bellen, H. J., Sep 2022, In: DMM Disease Models and Mechanisms. 15, 9, dmm049600.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Quantitative relationship between cerebrovascular network and neuronal cell types in mice
Wu, Y. T., Bennett, H. C., Chon, U., Vanselow, D. J., Zhang, Q., Muñoz-Castañeda, R., Cheng, K. C., Osten, P., Drew, P. J. & Kim, Y., Jun 21 2022, In: Cell Reports. 39, 12, 110978.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Whole-Brain Wiring Diagram of Oxytocin System in Adult Mice
Son, S., Manjila, S. B., Newmaster, K. T., Wu, Y. T., Vanselow, D. J., Ciarletta, M., Anthony, T. E., Cheng, K. C. & Kim, Y., Jun 22 2022, In: Journal of Neuroscience. 42, 25, p. 5021-5033 13 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
A Multi-attribute Controllable Generative Model for Histopathology Image Synthesis
Ye, J., Xue, Y., Liu, P., Zaino, R., Cheng, K. C. & Huang, X., 2021, Medical Image Computing and Computer Assisted Intervention – MICCAI 2021 - 24th International Conference, Proceedings. de Bruijne, M., Cattin, P. C., Cotin, S., Padoy, N., Speidel, S., Zheng, Y. & Essert, C. (eds.). Springer Science and Business Media Deutschland GmbH, p. 613-623 11 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 12908 LNCS).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
1 Scopus citations
Prizes
-
-
Career Citation Milestone Award - D (500) Club
Bixler, Edward (Recipient) & Cheng, Keith (Recipient), 2016
Prize
-
Career Citation Milestone Award - M (1000) Club
Carrel, Laura (Recipient), Cheng, Keith (Recipient) & Chin, Thomas (Recipient), 2020
Prize
-
Activities
- 3 Oral presentation
-
Motivations and Potential for a 3D Image Informatics for Histopathology (Panel Discussion)
Keith Cheng (Speaker)
Nov 4 2017Activity: Talk types › Oral presentation
-
From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics
Keith Cheng (Speaker), Y Ding (Speaker), SR Katz (Speaker), AY Lin (Speaker), D van Rossum (Speaker) & D Vanselow (Speaker)
Sep 27 2017Activity: Talk types › Oral presentation
-
Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish
Keith Cheng (Speaker), Y Ding (Speaker), AY Lin (Speaker), M Yakovlev (Speaker), D Vanselow (Speaker), X Xin (Speaker), S Katz (Speaker), D Vanselow (Speaker) & PJ La Riviere (Speaker)
Jul 5 2017Activity: Talk types › Oral presentation