Projects per year
Personal profile
Research interests
In summary, Dr. Keith Cheng's research interests currently include phage genetics, E. coli genetics, recombination, cancer genetics, model system genetics, human genetics, human population genetics, genomics, phenomics, anatomic pathology, computational phenomics, automated phenotyping, microCT, synchrotron microCT, high-throughput imaging, machine learning, skin pigmentation, race, natural selection, social selection, music and medicine, piano, violin, classical music, chamber music, public media and web-based resources.
The Cheng lab is interested in making fundamental contributions to the understanding of genetic and molecular mechanisms involved in human biology and disease. The lab is interested in genetic aspects of human disease, use of model systems such as the zebrafish, contribution to web-based scientific resources and new, potentially high-throughput forms of 3D imaging.
Some of the Cheng lab's specific work is aimed at increasing understanding of the basis of phenotypic variability, particularly as it may impact cancer; basic mechanisms underlying the relationship between human skin pigmentation and skin cancer; contributing to web-based infrastructures for science, education and public service; and working toward a 3D derivative of histology that also allows the identification and characterization of all cell types but utilizes the computer to define slice angle, thickness, point of view and definition of tissues of interest. Obvious implications include automation of phenotyping, including diagnostics.
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Projects
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Groundwork for a Synchrotron MicroCT Imaging Resource for Biology (SMIRB)
Cheng, K. & CHENG, K. C.
8/1/15 → 7/31/21
Project: Research project
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Web-based Atlas of Zebrafish Microanatomy as a Community Resource
Cheng, K., CHENG, K. C., CHENG, K. C. & CHENG, K. C.
9/1/12 → 8/31/16
Project: Research project
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Genetic analysis of genomic instability and cancer in zebrafish
Cheng, K., CHENG, K. C., CHENG, K. C. & CHENG, K. C.
7/1/08 → 5/31/14
Project: Research project
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Function of calcium exchangers in vetebrate pigmentation
Cheng, K. & CHENG, K. C.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/15/06 → 7/31/12
Project: Research project
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Virtual microscopy of zebrafish as a community resource
Cheng, K., CHENG, K. C. & CHENG, K. C.
National Center for Research Resources
7/1/04 → 8/31/12
Project: Research project
Research Output
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Selective synthetic augmentation with HistoGAN for improved histopathology image classification
Xue, Y., Ye, J., Zhou, Q., Long, L. R., Antani, S., Xue, Z., Cornwell, C., Zaino, R., Cheng, K. & Huang, X., Jan 2021, In: Medical Image Analysis. 67, 101816.Research output: Contribution to journal › Article › peer-review
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Synthetic sample selection via reinforcement learning
Ye, J., Xue, Y., Long, L. R., Antani, S., Xue, Z., Cheng, K. & Huang, X., 2020, Medical Image Computing and Computer Assisted Intervention – MICCAI 2020 - 23rd International Conference, Proceedings. Martel, A. L., Abolmaesumi, P., Stoyanov, D., Mateus, D., Zuluaga, M. A., Zhou, S. K., Racoceanu, D. & Joskowicz, L. (eds.). Springer Science and Business Media Deutschland GmbH, p. 53-63 11 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 12261 LNCS).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
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Abstracts of Presentations at the Association of Clinical Scientists 139th Meeting Hershey, PA, May 15-18, 2019
Donaldson, K., Buchanich, J. M., Grigson, P. S., Deneke, E., Vrana, K. E., Sacks, D. B., Kuehn, G. J., Cardamone, D., Pesce, A., Smiley, S., Nickley, J., Krock, K., Thomas, R., Wilkerson, M. L., Farag, H. A., Challa, S. R., Tice, A. M., Wolk, D. M., Prichard, J., Grant, M. L. & 102 others, , May 1 2019, In: Annals of clinical and laboratory science. 49, 3, p. 403-416 14 p.Research output: Contribution to journal › Article › peer-review
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Computational 3d histological phenotyping of whole zebrafish by x-ray histotomography
Ding, Y., Vanselow, D. J., Yakovlev, M. A., Katz, S. R., Lin, A. Y., Clark, D. P., Vargas, P., Xin, X., Copper, J. E., Canfield, V. A., Ang, K. C., Wang, Y., Xiao, X., Carlo, F. D., Rossum, D. B. V., Riviere, P. L. & Cheng, K. C., May 2019, In: eLife. 8, e44898.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Enhanced and unified anatomical labeling for a common mouse brain atlas
Chon, U., Vanselow, D. J., Cheng, K. C. & Kim, Y., Dec 1 2019, In: Nature communications. 10, 1, 5067.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations
Activities
- 3 Oral presentation
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Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish
Keith Cheng (Speaker), Y Ding (Speaker), AY Lin (Speaker), M Yakovlev (Speaker), D Vanselow (Speaker), X Xin (Speaker), S Katz (Speaker), D Vanselow (Speaker) & PJ La Riviere (Speaker)
Jul 5 2017Activity: Talk types › Oral presentation
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From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics
Keith Cheng (Speaker), Y Ding (Speaker), SR Katz (Speaker), AY Lin (Speaker), D van Rossum (Speaker) & D Vanselow (Speaker)
Sep 27 2017Activity: Talk types › Oral presentation
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Motivations and Potential for a 3D Image Informatics for Histopathology (Panel Discussion)
Keith Cheng (Speaker)
Nov 4 2017Activity: Talk types › Oral presentation