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Kenneth Charles Keiler

    • 2247 Citations
    • 22 h-Index
    1992 …2021
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    • 5 Similar Profiles
    Ribosomes Medicine & Life Sciences
    Caulobacter crescentus Medicine & Life Sciences
    Bacteria Medicine & Life Sciences
    RNA Medicine & Life Sciences
    Messenger RNA Medicine & Life Sciences
    Transfer RNA Medicine & Life Sciences
    Proteins Medicine & Life Sciences
    Bacterial RNA Medicine & Life Sciences

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    Projects 2004 2021

    Physiology of ribosome rescue in bacteria

    Keiler, K. C.

    National Institutes of Health

    8/1/17 → 4/30/21

    Project: Research project

    Ribosomes
    Bacteria
    Bacterial Physiological Phenomena
    Francisella tularensis
    Anti-Bacterial Agents

    Validation and development of trans-translation as a drug target for MRSA

    Keiler, K. C.

    National Institutes of Health

    3/1/14 → 2/28/17

    Project: Research project

    Methicillin-Resistant Staphylococcus aureus
    Staphylococcus aureus
    Pharmaceutical Preparations
    High-Throughput Screening Assays
    Anti-Bacterial Agents

    The role of tmRNA in development of C. crescentus

    Keiler, K. C.

    National Institutes of Health

    5/1/04 → 5/31/16

    Project: Research project

    Caulobacter crescentus
    Untranslated RNA
    translation (genetics)
    DNA Replication
    Gene Expression Regulation

    Research Output 1992 2019

    A small-molecule inhibitor of trans-translation synergistically interacts with cathelicidin antimicrobial peptides to impair survival of staphylococcus aureus

    Huang, Y., Alumasa, J., Callaghan, L. T., Samuel Baugh, R., Rae, C. D., Keiler, K. C. & McGillivray, S. M., Apr 1 2019, In : Antimicrobial agents and chemotherapy. 63, 4, e02362-18.

    Research output: Contribution to journal › Article

    Staphylococcus aureus
    Survival
    Daptomycin
    Anti-Bacterial Agents
    Methicillin

    Bioresponsive peptide-polysaccharide nanogels — A versatile delivery system to augment the utility of bioactive cargo

    Simonson, A. W., Lawanprasert, A., Goralski, T. D. P., Keiler, K. C. & Medina, S. H., Apr 1 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 17, p. 391-400 10 p.

    Research output: Contribution to journal › Article

    Hyaluronic acid
    Polysaccharides
    Peptides
    Cells
    Proteins
    1 Citation (Scopus)

    A new mechanism for ribosome rescue can recruit RF1 or RF2 to nonstop ribosomes

    Goralski, T. D. P., Kirimanjeswara, G. S. & Keiler, K. C., Nov 1 2018, In : mBio. 9, 6, e02436-18.

    Research output: Contribution to journal › Article

    Ribosomes
    Francisella tularensis
    Bacteria
    Biological Warfare Agents
    High-Throughput Nucleotide Sequencing
    18 Citations (Scopus)

    Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA

    Dillon, N. A., Peterson, N. D., Feaga, H. A., Keiler, K. C. & Baughn, A. D., Dec 1 2017, In : Scientific reports. 7, 1, 6135.

    Research output: Contribution to journal › Article

    Pyrazinamide
    Mycobacterium tuberculosis
    Ribosomes
    Oligonucleotides
    RNA
    8 Citations (Scopus)

    Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells

    Alumasa, J., Manzanillo, P. S., Peterson, N. D., Lundrigan, T., Baughn, A. D., Cox, J. S. & Keiler, K. C., Sep 8 2017, In : ACS Infectious Diseases. 3, 9, p. 634-644 11 p.

    Research output: Contribution to journal › Article

    Ribosomes
    Mycobacterium tuberculosis
    Anti-Bacterial Agents
    Benzamides
    Pharmaceutical Preparations