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Kenneth Charles Keiler

    • 2255 Citations
    • 22 h-Index
    1992 …2021
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    • 5 Similar Profiles
    Ribosomes Medicine & Life Sciences
    Caulobacter crescentus Medicine & Life Sciences
    Bacteria Medicine & Life Sciences
    RNA Medicine & Life Sciences
    Messenger RNA Medicine & Life Sciences
    Transfer RNA Medicine & Life Sciences
    Proteins Medicine & Life Sciences
    Bacterial RNA Medicine & Life Sciences

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    Projects 2004 2021

    Physiology of ribosome rescue in bacteria

    Keiler, K. C.

    National Institutes of Health

    8/1/17 → 4/30/21

    Project: Research project

    Ribosomes
    Bacteria
    Bacterial Physiological Phenomena
    Francisella tularensis
    Anti-Bacterial Agents

    Validation and development of trans-translation as a drug target for MRSA

    Keiler, K. C.

    National Institutes of Health

    3/1/14 → 2/28/17

    Project: Research project

    Methicillin-Resistant Staphylococcus aureus
    Staphylococcus aureus
    Pharmaceutical Preparations
    High-Throughput Screening Assays
    Anti-Bacterial Agents

    The role of tmRNA in development of C. crescentus

    Keiler, K. C.

    National Institutes of Health

    5/1/04 → 5/31/16

    Project: Research project

    Caulobacter crescentus
    Untranslated RNA
    translation (genetics)
    DNA Replication
    Gene Expression Regulation

    Research Output 1992 2019

    A small-molecule inhibitor of trans-translation synergistically interacts with cathelicidin antimicrobial peptides to impair survival of staphylococcus aureus

    Huang, Y., Alumasa, J. N., Callaghan, L. T., Samuel Baugh, R., Rae, C. D., Keiler, K. C. & McGillivray, S. M., Apr 2019, In : Antimicrobial agents and chemotherapy. 63, 4, e02362-18.

    Research output: Contribution to journal › Article

    Staphylococcus aureus
    Survival
    Daptomycin
    Anti-Bacterial Agents
    Methicillin

    Bioresponsive peptide-polysaccharide nanogels — A versatile delivery system to augment the utility of bioactive cargo

    Simonson, A. W., Lawanprasert, A., Goralski, T. D. P., Keiler, K. C. & Medina, S. H., Apr 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 17, p. 391-400 10 p.

    Research output: Contribution to journal › Article

    Hyaluronic acid
    Polysaccharides
    Peptides
    Cells
    Proteins
    2 Citations (Scopus)

    A new mechanism for ribosome rescue can recruit RF1 or RF2 to nonstop ribosomes

    Goralski, T. D. P., Kirimanjeswara, G. S. & Keiler, K. C., Nov 1 2018, In : mBio. 9, 6, e02436-18.

    Research output: Contribution to journal › Article

    Ribosomes
    Francisella tularensis
    Bacteria
    Biological Warfare Agents
    High-Throughput Nucleotide Sequencing
    18 Citations (Scopus)

    Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA

    Dillon, N. A., Peterson, N. D., Feaga, H. A., Keiler, K. C. & Baughn, A. D., Dec 1 2017, In : Scientific reports. 7, 1, 6135.

    Research output: Contribution to journal › Article

    Pyrazinamide
    Mycobacterium tuberculosis
    Ribosomes
    Oligonucleotides
    RNA
    8 Citations (Scopus)

    Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells

    Alumasa, J. N., Manzanillo, P. S., Peterson, N. D., Lundrigan, T., Baughn, A. D., Cox, J. S. & Keiler, K. C., Sep 8 2017, In : ACS Infectious Diseases. 3, 9, p. 634-644 11 p.

    Research output: Contribution to journal › Article

    Ribosomes
    Mycobacterium tuberculosis
    Anti-Bacterial Agents
    Benzamides
    Pharmaceutical Preparations