• 2255 Citations
  • 22 h-Index
1992 …2021
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Research Output 1992 2019

2019

A small-molecule inhibitor of trans-translation synergistically interacts with cathelicidin antimicrobial peptides to impair survival of staphylococcus aureus

Huang, Y., Alumasa, J. N., Callaghan, L. T., Samuel Baugh, R., Rae, C. D., Keiler, K. C. & McGillivray, S. M., Apr 2019, In : Antimicrobial agents and chemotherapy. 63, 4, e02362-18.

Research output: Contribution to journalArticle

Staphylococcus aureus
Survival
Daptomycin
Anti-Bacterial Agents
Methicillin

Bioresponsive peptide-polysaccharide nanogels — A versatile delivery system to augment the utility of bioactive cargo

Simonson, A. W., Lawanprasert, A., Goralski, T. D. P., Keiler, K. C. & Medina, S. H., Apr 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 17, p. 391-400 10 p.

Research output: Contribution to journalArticle

Hyaluronic acid
Polysaccharides
Peptides
Cells
Proteins
2018
2 Citations (Scopus)

A new mechanism for ribosome rescue can recruit RF1 or RF2 to nonstop ribosomes

Goralski, T. D. P., Kirimanjeswara, G. S. & Keiler, K. C., Nov 1 2018, In : mBio. 9, 6, e02436-18.

Research output: Contribution to journalArticle

Ribosomes
Francisella tularensis
Bacteria
Biological Warfare Agents
High-Throughput Nucleotide Sequencing
2017
18 Citations (Scopus)

Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA

Dillon, N. A., Peterson, N. D., Feaga, H. A., Keiler, K. C. & Baughn, A. D., Dec 1 2017, In : Scientific reports. 7, 1, 6135.

Research output: Contribution to journalArticle

Pyrazinamide
Mycobacterium tuberculosis
Ribosomes
Oligonucleotides
RNA
8 Citations (Scopus)

Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells

Alumasa, J. N., Manzanillo, P. S., Peterson, N. D., Lundrigan, T., Baughn, A. D., Cox, J. S. & Keiler, K. C., Sep 8 2017, In : ACS Infectious Diseases. 3, 9, p. 634-644 11 p.

Research output: Contribution to journalArticle

Ribosomes
Mycobacterium tuberculosis
Anti-Bacterial Agents
Benzamides
Pharmaceutical Preparations
3 Citations (Scopus)

Teaching broader impacts of science with undergraduate research

Keiler, K. C., Jackson, K. L., Jaworski, L., Lopatto, D. & Ades, S. E., Mar 21 2017, In : PLoS biology. 15, 3, e2001318.

Research output: Contribution to journalArticle

college students
Teaching
students
learning
Students
2 Citations (Scopus)
Bacillus anthracis
Spores
Germination
Ciprofloxacin
Tetrazoles
2016
7 Citations (Scopus)

Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria

Feaga, H. A., Quickel, M. D., Hankey-Giblin, P. A. & Keiler, K. C., Mar 2016, In : PLoS genetics. 12, 3, e1005964.

Research output: Contribution to journalArticle

mitochondrion
ribosomes
Ribosomes
Mitochondria
mitochondria
9 Citations (Scopus)

Inhibitors of ribosome rescue arrest growth of francisella tularensis at all stages of intracellular replication

Goralski, T. D. P., Dewan, K. K., Alumasa, J. N., Avanzato, V., Place, D. E., Markley, R. L., Katkere, B., Rabadi, S. M., Bakshi, C. S., Keiler, K. C. & Kirimanjeswara, G. S., Jun 2016, In : Antimicrobial agents and chemotherapy. 60, 6, p. 3276-3282 7 p.

Research output: Contribution to journalArticle

Francisella tularensis
Ribosomes
Growth
Eukaryotic Cells
Bacteria
2015
4 Citations (Scopus)

Clicking on trans-translation drug targets

Alumasa, J. N. & Keiler, K. C., Jan 1 2015, In : Frontiers in Microbiology. 6, MAY, 498.

Research output: Contribution to journalComment/debate

Click Chemistry
Fluorescent Dyes
Pharmaceutical Preparations
7 Citations (Scopus)

Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay

El-Mowafi, S. A., Sineva, E., Alumasa, J. N., Nicoloff, H., Tomsho, J. W., Ades, S. E. & Keiler, K. C., Jan 1 2015, In : Antimicrobial agents and chemotherapy. 59, 1, p. 193-205 13 p.

Research output: Contribution to journalArticle

High-Throughput Screening Assays
Sigma Factor
Cyclic Peptides
Anti-Bacterial Agents
Holoenzymes
68 Citations (Scopus)

Mechanisms of ribosome rescue in bacteria

Keiler, K. C., May 24 2015, In : Nature Reviews Microbiology. 13, 5, p. 285-297 13 p.

Research output: Contribution to journalReview article

Ribosomes
Bacteria
Physiological Phenomena
Messenger RNA
Amino Acid Motifs
2014
13 Citations (Scopus)

Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway

El-Mowafi, S. A., Alumasa, J. N., Ades, S. E. & Keiler, K. C., Sep 2014, In : Antimicrobial agents and chemotherapy. 58, 9, p. 5500-5509 10 p.

Research output: Contribution to journalArticle

RNA
Inteins
Cyclic Peptides
Virulence
Gene Expression
16 Citations (Scopus)

Release of nonstop ribosomes is essential

Feaga, H. A., Viollier, P. H. & Keiler, K. C., Sep 7 2014, In : mBio. 5, 6, e01916-14.

Research output: Contribution to journalArticle

Ribosomes
Caulobacter crescentus
Transfer RNA
Messenger RNA
Genes
29 Citations (Scopus)

Resolving nonstop translation complexes is a matter of life or death

Keiler, K. C. & Feaga, H. A., 2014, In : Journal of bacteriology. 196, 12, p. 2123-2130 8 p.

Research output: Contribution to journalShort survey

Ribosomes
Messenger RNA
Transfer RNA
Bacteria
Terminator Codon
2013
40 Citations (Scopus)

Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity

Ramadoss, N. S., Alumasa, J., Cheng, L., Wang, Y., Li, S., Chambers, B. S., Chang, H., Chatterjee, A. K., Brinker, A., Engels, I. H. & Keiler, K. C., Jun 18 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 25, p. 10282-10287 6 p.

Research output: Contribution to journalArticle

Anti-Bacterial Agents
Protein Biosynthesis
Ribosomes
Proteolysis
Inhibitory Concentration 50
7 Citations (Scopus)

The potential of trans-translation inhibitors as antibiotics

Keiler, K. C. & Alumasa, J. N., Oct 1 2013, In : Future microbiology. 8, 10, p. 1235-1237 3 p.

Research output: Contribution to journalReview article

Bacterial RNA
Pyrazinamide
Protein Biosynthesis
Drug Discovery
Anti-Bacterial Agents
23 Citations (Scopus)

tmRNA Is Essential in Shigella flexneri

Ramadoss, N. S., Zhou, X. & Keiler, K. C., Feb 25 2013, In : PloS one. 8, 2, e57537.

Research output: Contribution to journalArticle

Shigella flexneri
translation (genetics)
Escherichia coli
Bacteria
Messenger RNA

Tsp Protease

Keiler, K. C., Aug 29 2013, Handbook of Proteolytic Enzymes. Elsevier Ltd, Vol. 3. p. 3605-3607 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

C-terminal processing peptidase
2012
24 Citations (Scopus)

Pharmacological inhibition of the ClpXP protease increases bacterial susceptibility to host cathelicidin antimicrobial peptides and cell envelope-active antibiotics

McGillivray, S. M., Tran, D. N., Ramadoss, N. S., Alumasa, J. N., Okumura, C. Y., Sakoulas, G., Vaughn, M. M., Zhang, D. X., Keiler, K. C. & Nizet, V., Apr 1 2012, In : Antimicrobial agents and chemotherapy. 56, 4, p. 1854-1861 8 p.

Research output: Contribution to journalArticle

Bacillus anthracis
Staphylococcus aureus
Peptide Hydrolases
Pharmacology
Daptomycin
1 Citation (Scopus)

RNA visualization in bacteria by fluorescence in situ hybridization

Russell, J. H. & Keiler, K. C., Jul 27 2012, Bacterial Regulatory RNA: Methods and Protocols. Keiler, K. C. (ed.). p. 87-95 9 p. (Methods in Molecular Biology; vol. 905).

Research output: Chapter in Book/Report/Conference proceedingChapter

Fluorescence In Situ Hybridization
RNA
Bacteria
RNA Probes
Oligonucleotide Probes
2011
15 Citations (Scopus)

Bifunctional transfer-messenger RNA

Keiler, K. C. & Ramadoss, N. S., Nov 1 2011, In : Biochimie. 93, 11, p. 1993-1997 5 p.

Research output: Contribution to journalReview article

Transfer RNA
Messenger RNA
Bacteria
RNA
Gene Expression Regulation

Corrigendum to: "RNA localization in bacteria" [Curr. Opin. Microbiol. 14 (2011) 155-159]

Keiler, K. C., Jun 1 2011, In : Current Opinion in Microbiology. 14, 3, 1 p.

Research output: Contribution to journalComment/debate

RNA
Bacteria
corrigendum
1 Citation (Scopus)

Localization of the bacterial RNA infrastructure

Keiler, K. C., Oct 12 2011, RNA Infrastructure and Networks. Collins, L. (ed.). p. 231-238 8 p. (Advances in Experimental Medicine and Biology; vol. 722).

Research output: Chapter in Book/Report/Conference proceedingChapter

Bacterial RNA
Intracellular Space
RNA
RNA Stability
Protein Biosynthesis
29 Citations (Scopus)

RNA localization in bacteria

Keiler, K. C., Apr 1 2011, In : Current Opinion in Microbiology. 14, 2, p. 155-159 5 p.

Research output: Contribution to journalReview article

RNA
Bacteria
Bacterial Physiological Phenomena
RNA-Binding Proteins
Gene Expression Regulation
2010
62 Citations (Scopus)

Beyond ribosome rescue: tmRNA and co-translational processes

Hayes, C. S. & Keiler, K. C., Jan 21 2010, In : FEBS Letters. 584, 2, p. 413-419 7 p.

Research output: Contribution to journalReview article

Ribosomes
Protein folding
Peptides
Protein Folding
Transfer RNA
20 Citations (Scopus)

Protein localization and dynamics within a bacterial organelle

Hughes, H. V., Huitema, E., Pritchard, S., Keiler, K. C., Brun, Y. V. & Viollier, P. H., Mar 23 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 12, p. 5599-5604 6 p.

Research output: Contribution to journalArticle

Organelles
Caulobacter crescentus
Proteins
Anatomy
Cell Cycle
2009
20 Citations (Scopus)

Correct timing of dnaA transcription and initiation of DNA replication requires trans translation

Cheng, L. & Keiler, K. C., Jul 1 2009, In : Journal of bacteriology. 191, 13, p. 4268-4275 8 p.

Research output: Contribution to journalArticle

DNA Replication
DNA Replication Timing
Caulobacter crescentus
Phenotype
Gene Expression
52 Citations (Scopus)

Subcellular localization of a bacterial regulatory RNA

Russell, J. H. & Keiler, K. C., Sep 22 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 38, p. 16405-16409 5 p.

Research output: Contribution to journalArticle

Bacterial RNA
RNA
Eukaryota
Bacteria
Ribosomes
2008
153 Citations (Scopus)

Biology of trans-translation

Keiler, K. C., Oct 20 2008, In : Annual Review of Microbiology. 62, p. 133-151 19 p.

Research output: Contribution to journalReview article

Quality Control
Messenger RNA
Ribosomal Frameshifting
Bacteria
Ribonucleoproteins
8 Citations (Scopus)

Screen for localized proteins in Caulobacter crescentus

Russell, J. H. & Keiler, K. C., Mar 12 2008, In : PloS one. 3, 3, e1756.

Research output: Contribution to journalArticle

Caulobacter crescentus
Cells
Proteins
proteins
cell cycle
2007
46 Citations (Scopus)

Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease

Cheng, L., Naumann, T. A., Horswill, A. R., Hong, S. J., Venters, B. J., Tomsho, J. W., Benkovic, S. & Keiler, K. C., Aug 1 2007, In : Protein Science. 16, 8, p. 1535-1542 8 p.

Research output: Contribution to journalArticle

Cyclic Peptides
Peptide Hydrolases
Escherichia coli
Caulobacter crescentus
Proteolysis
9 Citations (Scopus)

Peptide signals encode protein localization

Russell, J. H. & Keiler, K. C., Nov 1 2007, In : Journal of bacteriology. 189, 21, p. 7581-7585 5 p.

Research output: Contribution to journalArticle

Protein Sorting Signals
Proteins
Peptide Library
Peptides
Bacterial Proteins
38 Citations (Scopus)

Physiology of tmRNA: what gets tagged and why?

Keiler, K. C., Apr 1 2007, In : Current Opinion in Microbiology. 10, 2, p. 169-175 7 p.

Research output: Contribution to journalReview article

Transfer RNA
Ribosomes
Messenger RNA
Quality Control
Peptides
22 Citations (Scopus)

Proteolytic adaptor for transfer-messenger RNA-tagged proteins from α-proteobacteria

Lessner, F. H., Venters, B. J. & Keiler, K. C., Jan 1 2007, In : Journal of bacteriology. 189, 1, p. 272-275 4 p.

Research output: Contribution to journalArticle

Caulobacter crescentus
Proteobacteria
Transfer RNA
Messenger RNA
Proteolysis
22 Citations (Scopus)

Proteomic identification of tmRNA substrates

Hong, S. J., Lessner, F. H., Mahen, E. M. & Keiler, K. C., Oct 23 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 43, p. 17128-17133 6 p.

Research output: Contribution to journalArticle

Proteomics
DNA Replication
Caulobacter crescentus
Recombinational DNA Repair
Nucleotide Motifs
2005
58 Citations (Scopus)

Cell cycle-regulated degradation of tmRNA is controlled by RNase R and SmpB

Hong, S. J., Tran, Q. A. & Keiler, K. C., Jul 1 2005, In : Molecular Microbiology. 57, 2, p. 565-575 11 p.

Research output: Contribution to journalArticle

Cell Cycle
RNA
RNA Stability
Caulobacter crescentus
Bacteria
2003
43 Citations (Scopus)

tmRNA in Caulobacter crescentus is cell cycle regulated by temporally controlled transcription and RNA degradation

Keiler, K. C. & Shapiro, L., Mar 1 2003, In : Journal of bacteriology. 185, 6, p. 1825-1830 6 p.

Research output: Contribution to journalArticle

Caulobacter crescentus
RNA Stability
Cell Cycle
RNA
S Phase
74 Citations (Scopus)

tmRNA is required for correct timing of DNA replication in Caulobacter crescentus

Keiler, K. C. & Shapiro, L., Jan 2003, In : Journal of bacteriology. 185, 2, p. 573-580 8 p.

Research output: Contribution to journalArticle

DNA Replication Timing
Caulobacter crescentus
Ribosomes
Gene Deletion
DNA Replication
2002
1 Citation (Scopus)

13 Tsp and related tail-specific proteases

Keiler, K. C. & Sauer, R. T., Jan 1 2002, Enzymes. C ed. Academic Press, p. 373-386 14 p. (Enzymes; vol. 22, no. C).

Research output: Chapter in Book/Report/Conference proceedingChapter

C-terminal processing peptidase
2001
14 Citations (Scopus)

Conserved promoter motif is required for cell cycle timing of dnaX transcription in Caulobacter

Keiler, K. C. & Shapiro, L., Aug 15 2001, In : Journal of bacteriology. 183, 16, p. 4860-4865 6 p.

Research output: Contribution to journalArticle

Caulobacter
Cell Cycle
Caulobacter crescentus
Gene Expression
cdc Genes
2000
138 Citations (Scopus)
Caulobacter
Bacterial Genomes
Transfer RNA
Proteolysis
Proteobacteria
1996
813 Citations (Scopus)

Role of a peptide tagging system in degradation of proteins synthesized from damaged messenger RNA

Keiler, K. C., Waller, P. R. H. & Sauer, R. T., Feb 16 1996, In : Science. 271, 5251, p. 990-993 4 p.

Research output: Contribution to journalArticle

Proteolysis
Periplasm
Messenger RNA
Peptides
Terminator Codon
86 Citations (Scopus)

Sequence determinants of C-terminal substrate recognition by the Tsp protease

Keiler, K. C. & Sauer, R. T., Feb 2 1996, In : Journal of Biological Chemistry. 271, 5, p. 2589-2593 5 p.

Research output: Contribution to journalArticle

Cytochromes
Substrates
Escherichia coli
Bearings (structural)
Periplasm
1995
46 Citations (Scopus)

C‐terminal specific protein degradation: Activity and substrate specificity of the Tsp protease

Keiler, K. C., Silber, K. R., Sauer, R. T., Downard, K. M., Papayannopoulos, I. A. & Biemann, K., Jan 1 1995, In : Protein Science. 4, 8, p. 1507-1515 9 p.

Research output: Contribution to journalArticle

Substrate Specificity
Proteolysis
Degradation
Peptides
Substrates
59 Citations (Scopus)

Identification of active site residues of the Tsp protease

Keiler, K. C. & Sauer, R. T., Jan 1 1995, In : Journal of Biological Chemistry. 270, 48, p. 28864-28868 5 p.

Research output: Contribution to journalArticle

Catalytic Domain
Peptide Hydrolases
Alanine
Cysteine
Asparagine
1992
145 Citations (Scopus)

Tsp: A tail-specific protease that selectively degrades proteins with nonpolar C termini

Silber, K. R., Keiler, K. C. & Sauer, R. T., Jan 1 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 1, p. 295-299 5 p.

Research output: Contribution to journalArticle

Proteins
Substrate Specificity
Genes
Peptide Hydrolases
Escherichia coli