• 418 Citations
  • 5 h-Index
20072017
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Fingerprint Dive into the research topics where Kenneth Pak Kin Lee is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Ribonucleases Medicine & Life Sciences
Endoplasmic Reticulum Stress Medicine & Life Sciences
Unfolded Protein Response Medicine & Life Sciences
Endoribonucleases Medicine & Life Sciences
Adenosine Diphosphate Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
RNA Splicing Medicine & Life Sciences
Endoplasmic Reticulum Medicine & Life Sciences

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Research Output 2007 2017

  • 418 Citations
  • 5 h-Index
  • 5 Article
  • 1 Chapter
29 Citations (Scopus)

Molecular structure of human katp in complex with ATP and ADP

Lee, K. P. K., Chen, J. & Mackinnon, R., Dec 29 2017, In : eLife. 6, e32481.

Research output: Contribution to journalArticle

Open Access
Molecular Structure
Adenosine Diphosphate
Molecular structure
Adenosine Triphosphate
KATP Channels
48 Citations (Scopus)

Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors

Sanches, M., Duffy, N. M., Talukdar, M., Thevakumaran, N., Chiovitti, D., Canny, M. D., Lee, K., Kurinov, I., Uehling, D., Al-Awar, R., Poda, G., Prakesch, M., Wilson, B., Tam, V., Schweitzer, C., Toro, A., Lucas, J. L., Vuga, D., Lehmann, L., Durocher, D. & 3 others, Zeng, Q., Patterson, J. B. & Sicheri, F., Aug 28 2014, In : Nature communications. 5, 4202.

Research output: Contribution to journalArticle

Open Access
Endoribonucleases
aldehydes
Aldehydes
inhibitors
Ribonucleases
2 Citations (Scopus)

Principles of IRE1 modulation using chemical tools

Lee, P. K. K. & Sicheri, F., Jan 1 2011, Methods in Enzymology. C ed. Academic Press Inc., p. 271-294 24 p. (Methods in Enzymology; vol. 490, no. C).

Research output: Chapter in Book/Report/Conference proceedingChapter

Endoplasmic Reticulum Stress
Endoplasmic Reticulum
Modulation
Unfolded Protein Response
Carrier Proteins
116 Citations (Scopus)

Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1

Wiseman, R. L., Zhang, Y., Lee, K. P. K., Harding, H. P., Haynes, C. M., Price, J., Sicheri, F. & Ron, D., Apr 23 2010, In : Molecular cell. 38, 2, p. 291-304 14 p.

Research output: Contribution to journalArticle

Open Access
Quercetin
Ribonucleases
Phosphotransferases
Binding Sites
Ligands
200 Citations (Scopus)

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

Lee, K. P. K., Dey, M., Neculai, D., Cao, C., Dever, T. E. & Sicheri, F., Jan 11 2008, In : Cell. 132, 1, p. 89-100 12 p.

Research output: Contribution to journalArticle

Open Access
RNA Splicing
Ribonucleases
Catalysis
RNA
Dimerization