Kent Vrana, PhD

    • 6231 Citations
    • 33 h-Index
    1979 …2020
    If you made any changes in Pure, your changes will be visible here soon.

    Personal profile

    Research interests

    Dr. Kent Vrana possesses over thirty years of research experience in molecular neuropharmacology. Notably, he has been actively involved in the neuroenzymology and molecular neurobiology since a graduate student in 1979. Over the years, his laboratory was the first to create a full-length cDNA clone for tyrosine hydroxylase and to characterize the role of catecholamine-derived quinones in neuronal toxicity. He is currently using next-generation sequencing technologies to explore the roles of naturally-occurring sequence variants in the progression and severity of Parkinson’s disease and inflammatory bowel disease. In addition, he has a long history of studying the proteomics and transcriptomics of substance abuse (alcohol, cocaine, and heroin). Dr. Vrana’s laboratory was part of a team that established a new mechanism for generating embryonic stem cells. He has published widely on stem cell biology and has also patented a method for using nanoliposomal delivery of the bioactive lipid ceramide to maintain human induced pluripotent and embryonic stem cells in their undifferentiated state. More recently, he has been investigating the role of synthetic cannabinoids in colon cancer, glioblastoma and neuroblastoma. From a technical standpoint, Dr. Vrana's laboratory has been instrumental in developing and disseminating tools for analyzing gene and protein expression, as well as characterizing normal and pathological processes.

    Education/Academic qualification

    Biochemistry, PhD, Louisiana State University Health Sciences Center

    … → 1983

    Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

    • 6 Similar Profiles
    Tryptophan Hydroxylase Medicine & Life Sciences
    Tyrosine 3-Monooxygenase Medicine & Life Sciences
    Gene Expression Medicine & Life Sciences
    Self Administration Medicine & Life Sciences
    Gene expression Chemical Compounds
    Cocaine Medicine & Life Sciences
    Messenger RNA Medicine & Life Sciences
    Enzymes Medicine & Life Sciences

    Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Projects 1979 2020

    MULTI-DISCIPLINARY TRAINING IN THE BIOLOGY OF ALCOHOLISM

    Vrana, K., Samson, H., Grant, K., McCool, B. & Friedman, D.

    National Institutes of Health

    7/1/946/30/19

    Project: Research projectInstitutional National Research Service Award

    Alcoholism
    Alcohols
    Neurosciences
    Biochemistry
    Students

    CENTER FOR NEUROBIOLOGICAL INVESTIGATION OF DRUG ABUSE

    Vrana, K., Wood, F., Ferris, M., Jones, S. R., Booze, R., Howlett, A., Dworkin, S., Porrino, L., Davies, H. M., Deadwyler, S. A., Roberts, D. C. S., Morgan, D., Morton, K., Hemby, S. E., Beveridge, T. J. R., Childers, S., Nader, M., Bennett, B., Porrino, L. J., Deadwyler, S. A., Roberts, D. C. S., Davies, H. & Smith, J.

    National Institutes of Health

    9/30/912/29/20

    Project: Research projectSpecialized Center

    Epigenomics
    Substance-Related Disorders
    Street Drugs
    Pharmaceutical Preparations
    Cocaine

    TRANSCRIPTION FACTORS IN THE 5S RNA GENE SYSTEM

    Vrana, K.

    National Institutes of Health

    7/1/85 → …

    Project: Research projectPostdoctoral Individual National Research Service Award

    A diagnostic plasma protein panel for alcohol abuse

    Vrana, K.

    National Institutes of Health

    6/15/143/31/18

    Project: Research projectResearch Project

    Alcoholism
    Blood Proteins
    Biomarkers
    Drinking Behavior
    Finland
    Self Administration
    Primates
    Alcoholism
    Biomarkers
    Alcohols

    Research Output 1981 2018

    Exposure to environmental enrichment attenuates addiction-like behavior and alters molecular effects of heroin self-administration in rats

    Imperio, C. G., McFalls, A. J., Hadad, N., Blanco-Berdugo, L., Masser, D. R., Colechio, E. M., Coffey, A. A., Bixler, G. V., Stanford, D. R., Vrana, K. E., Grigson, P. S. & Freeman, W. M., Sep 1 2018, In : Neuropharmacology. 139, p. 26-40 15 p.

    Research output: Contribution to journalArticle

    Self Administration
    Heroin
    Environmental Exposure
    Methylation
    Genetic Promoter Regions
    Voltage-Gated Sodium Channels
    Nociception
    Abdominal Pain
    Pain Perception
    Irritable Bowel Syndrome
    7 Citations

    Review article: the many potential roles of intestinal serotonin (5-hydroxytryptamine, 5-HT) signalling in inflammatory bowel disease

    Coates, M., Tekin, I., Vrana, K. & Mawe, G. M., Sep 1 2017, In : Alimentary Pharmacology and Therapeutics. 46, 6, p. 569-580 12 p.

    Research output: Contribution to journalReview article

    Inflammatory Bowel Diseases
    Serotonin
    Inflammation
    Manuscripts
    Serotonin Receptors
    5 Citations

    Assessment of individual differences in the rat nucleus accumbens transcriptome following taste-heroin extended access

    Imperio, C. G., McFalls, A. J., Colechio, E. M., Masser, D. R., Vrana, K., Grigson-Kennedy, P. S. & Freeman, W. M., May 1 2016, In : Brain Research Bulletin. 123, p. 71-80 10 p.

    Research output: Contribution to journalArticle

    Heroin
    Nucleus Accumbens
    Transcriptome
    Individuality
    Cues

    Bioinformatic and computational approaches for analysis of genomics data in neurotoxicology research

    Gohlke, J. M., Freeman, W. M. & Vrana, K. E., Apr 19 2016, Neurotoxicology: Third Edition. CRC Press, p. 29-49 21 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Genomics
    Computational Biology
    Research

    Prizes

    Fellow (Elected)

    Kent Vrana (Recipient), 2016

    Prize: Honorary award