• 6485 Citations
  • 34 h-Index
1979 …2020
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Research Output 1981 2019

2019
Open Access
dopamine beta-monooxygenase
Dopamine beta-Hydroxylase
inflammatory bowel disease
Polymorphism
Inflammatory Bowel Diseases
2 Citations (Scopus)
Voltage-Gated Sodium Channels
Nociception
Abdominal Pain
Pain Perception
Irritable Bowel Syndrome
2018
1 Citation (Scopus)

Exposure to environmental enrichment attenuates addiction-like behavior and alters molecular effects of heroin self-administration in rats

Imperio, C. G., McFalls, A. J., Hadad, N., Blanco-Berdugo, L., Masser, D. R., Colechio, E. M., Coffey, A. A., Bixler, G. V., Stanford, D. R., Vrana, K., Grigson-Kennedy, P. S. & Freeman, W. M., Sep 1 2018, In : Neuropharmacology. 139, p. 26-40 15 p.

Research output: Contribution to journalArticle

Self Administration
Heroin
Environmental Exposure
Methylation
Genetic Promoter Regions
Open Access
Inflammatory Bowel Diseases
Phenotype
Voltage-Gated Sodium Channels
Abdominal Pain
Single Nucleotide Polymorphism
1 Citation (Scopus)

Synthetic cannabinoid activity against colorectal cancer cells

Raup-Konsavage, W. M., Johnson, M., Legare, C. A., Yochum, G., Morgan, D. & Vrana, K., Mar 1 2018, In : Cannabis and Cannabinoid Research. 3, 1, p. 272-281 10 p.

Research output: Contribution to journalArticle

Open Access
Cannabinoids
Colorectal Neoplasms
Cell Survival
Cell Line
Libraries
2017
16 Citations (Scopus)

Review article: the many potential roles of intestinal serotonin (5-hydroxytryptamine, 5-HT) signalling in inflammatory bowel disease

Coates, M., Tekin, I., Vrana, K. & Mawe, G. M., Sep 1 2017, In : Alimentary Pharmacology and Therapeutics. 46, 6, p. 569-580 12 p.

Research output: Contribution to journalReview article

Inflammatory Bowel Diseases
Serotonin
Inflammation
Manuscripts
Serotonin Receptors
2016
8 Citations (Scopus)

Assessment of individual differences in the rat nucleus accumbens transcriptome following taste-heroin extended access

Imperio, C. G., McFalls, A. J., Colechio, E. M., Masser, D. R., Vrana, K., Grigson-Kennedy, P. S. & Freeman, W. M., May 1 2016, In : Brain Research Bulletin. 123, p. 71-80 10 p.

Research output: Contribution to journalArticle

Heroin
Nucleus Accumbens
Transcriptome
Individuality
Cues

Bioinformatic and computational approaches for analysis of genomics data in neurotoxicology research

Gohlke, J. M., Freeman, W. M. & Vrana, K., Apr 19 2016, Neurotoxicology: Third Edition. CRC Press, p. 29-49 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Genomics
Computational Biology
Research
3 Citations (Scopus)

Influence of parental monitoring, sensation seeking, expected social benefits, and refusal efficacy on tobacco and alcohol use in Chinese adolescents

Yu, J., Wu, Q., Yang, C., Vrana, K., Zhou, L., Yang, L., Zhang, H., Yan, D., Li, J., Teng, S., Gong, J., Yan, Y. & Wang, Z., Jan 1 2016, In : Medicine (United States). 95, 11, e2814.

Research output: Contribution to journalArticle

Tobacco Use
Alcohols
China
Students
4 Citations (Scopus)

Novel immunotherapies for hematological malignancies

Vasekar, M., Rizvi, S., Liu, X., Vrana, K. & Zheng, H., Aug 1 2016, In : Current Molecular Pharmacology. 9, 3, p. 264-271 8 p.

Research output: Contribution to journalReview article

Hematologic Neoplasms
Immunotherapy
T-Lymphocytes
Neoplasms
Antigen Presentation
4 Citations (Scopus)

Reward devaluation and heroin escalation is associated with differential expression of CRF signaling genes

McFalls, A. J., Imperio, C. G., Bixler, G., Freeman, W. M., Grigson-Kennedy, P. S. & Vrana, K., May 1 2016, In : Brain Research Bulletin. 123, p. 81-93 13 p.

Research output: Contribution to journalArticle

Heroin
Reward
Saccharin
Self Administration
Genes
Tyrosine 3-Monooxygenase
Gait
Freezing
Parkinson Disease
Catecholamines
1 Citation (Scopus)

Validation of the Obsessive Compulsive Drug Use Scale (OCDUS) Among Male Heroin Addicts in China

Yang, C., Wei, W., Vrana, K., Xiao, Y., Peng, Y., Chen, D., Yu, J., Wang, D., Ding, F. & Wang, Z., Oct 1 2016, In : International Journal of Mental Health and Addiction. 14, 5, p. 803-819 17 p.

Research output: Contribution to journalArticle

Heroin
China
Pharmaceutical Preparations
Heroin Dependence
Marriage
2015
10 Citations (Scopus)

Associating schizophrenia, long non-coding RNAs and neurostructural dynamics

Merelo, V., Durand, D., Lescallette, A. R., Vrana, K., Hong, L. E., Faghihi, M. A. & Bellon, A., Sep 30 2015, In : Frontiers in Molecular Neuroscience. 8, SEPTEMBER, 57.

Research output: Contribution to journalReview article

Long Noncoding RNA
Schizophrenia
Neuronal Plasticity
Brain
Dendrites
2 Citations (Scopus)
Health Expenditures
Biomedical Research
2014
1 Citation (Scopus)

Caveat Emptor: Single nucleotide polymorphism reporting in pharmacogenomics

Tekin, I. & Vrana, K., Jan 1 2014, In : Pharmacology. 92, 5-6, p. 319-323 5 p.

Research output: Contribution to journalReview article

Pharmacogenetics
Single Nucleotide Polymorphism
Databases
Information Centers
Biotechnology
44 Citations (Scopus)

Complex molecular regulation of tyrosine hydroxylase

Tekin, I., Roskoski, R., Salli, N. & Vrana, K., Nov 22 2014, In : Journal of Neural Transmission. 121, 12, p. 1451-1481 31 p.

Research output: Contribution to journalReview article

Tyrosine 3-Monooxygenase
Catecholamines
Enzymes
Phosphoprotein Phosphatases
Epigenomics
3 Citations (Scopus)

Functional characterization of the S41Y (C2755A) polymorphism of tryptophan hydroxylase 2.

Salli, N., Salli, U., Tekin, I., Hengst, J., Zhao, M. K., Gilman, T. L., Andrews, A. M. & Vrana, K., Jan 1 2014, In : Journal of Neurochemistry. 130, 6, p. 748-758 11 p.

Research output: Contribution to journalArticle

Tryptophan Hydroxylase
Polymorphism
Serotonin
Bipolar Disorder
Enzymes
6 Citations (Scopus)

Single nucleotide polymorphisms in osteogenic genes in atrophic delayed fracture-healing: A preliminary investigation

Sathyendra, V., Donahue, H. J., Vrana, K., Berg, A., Fryzel, D., Gandhi, J. & Reid, J., Aug 6 2014, In : Journal of Bone and Joint Surgery - American Volume. 96, 15, p. 1242-1248 7 p.

Research output: Contribution to journalArticle

Fracture Healing
Single Nucleotide Polymorphism
Genes
Bone Morphogenetic Protein 6
Alleles
2013
12 Citations (Scopus)
pharmacology
Problem-Based Learning
Medical Schools
Curriculum
learning environment

"Making it Real" Time

Vrana, K., Jun 1 2013, In : BioTechniques. 54, 6, p. 312-313 2 p.

Research output: Contribution to journalArticle

Polymerase chain reaction
Amplification
Polymerase Chain Reaction
Monitoring
Coloring Agents
2012
21 Citations (Scopus)

A Longitudinal Analysis of Circulating Stress-Related Proteins and Chronic Ethanol Self-Administration in Cynomolgus Macaques

Helms, C. M., Messaoudi, I., Jeng, S., Freeman, W. M., Vrana, K. & Grant, K. A., Jun 1 2012, In : Alcoholism: Clinical and Experimental Research. 36, 6, p. 995-1003 9 p.

Research output: Contribution to journalArticle

Self Administration
Macaca
Heat-Shock Proteins
Ethanol
Adrenocorticotropic Hormone
11 Citations (Scopus)

A retrospective chart review to identify perinatal factors associated with food allergies

Karpa, K. D., Paul, I. M., Leckie, J. A., Shung, S., Carkaci-Salli, N., Vrana, K. E., Mauger, D., Fausnight, T. & Poger, J., Oct 24 2012, In : Nutrition Journal. 11, 1, 87.

Research output: Contribution to journalReview article

Food Hypersensitivity
Probiotics
Immunologic Factors
Mothers
Anti-Bacterial Agents
6 Citations (Scopus)

Boosting serotonin in the brain: Is it time to revamp the treatment of depression?

Torrente, M. P., Gelenberg, A. J. & Vrana, K., May 1 2012, In : Journal of Psychopharmacology. 26, 5, p. 629-635 7 p.

Research output: Contribution to journalReview article

Serotonin
Depression
Brain
Tryptophan Hydroxylase
Antidepressive Agents
40 Citations (Scopus)

Differential gene expression in tamoxifen-resistant breast cancer cells revealed by a new analytical model of RNA-seq data

Huber-Keener, K. J., Liu, X., Wang, Z., Wang, Y., Freeman, W., Wu, S., Planas-Silva, M. D., Ren, X., Cheng, Y., Zhang, Y., Vrana, K., Liu, C. G., Yang, J-M. & Wu, R., Jul 23 2012, In : PloS one. 7, 7, e41333.

Research output: Contribution to journalArticle

tamoxifen
Tamoxifen
Gene expression
breast neoplasms
Analytical models

Gender-specific regulation of tyrosine hydroxylase in thymocyte differentiation antigen-1 knockout mice

Salli, N., Battula, S., Wang, X., Connor, J. & Vrana, K., Aug 1 2012, In : Journal of Neuroscience Research. 90, 8, p. 1583-1588 6 p.

Research output: Contribution to journalArticle

Differentiation Antigens
Tyrosine 3-Monooxygenase
Thymocytes
Knockout Mice
Phosphoserine
20 Citations (Scopus)

Protein biomarkers of alcohol abuse

Torrente, M. P., Freeman, W. M. & Vrana, K., Aug 1 2012, In : Expert Review of Proteomics. 9, 4, p. 425-436 12 p.

Research output: Contribution to journalReview article

Biomarkers
Alcoholism
Alcohols
Alcohol Drinking
Proteomics
2011
8 Citations (Scopus)

Plasma proteomic alterations in non-human primates and humans after chronic alcohol self-administration

Freeman, W. M., Vanguilder, H. D., Guidone, E., Krystal, J. H., Grant, K. A. & Vrana, K., Aug 1 2011, In : International Journal of Neuropsychopharmacology. 14, 7, p. 899-911 13 p.

Research output: Contribution to journalArticle

Self Administration
Proteomics
Primates
Two-Dimensional Difference Gel Electrophoresis
Biomarkers
20 Citations (Scopus)

Proteomic investigation of epigenetics in neuropychiatric disorders: A missing link between genetics and behavior?

Plazas-Mayorca, M. D. & Vrana, K., Jan 7 2011, In : Journal of Proteome Research. 10, 1, p. 58-65 8 p.

Research output: Contribution to journalReview article

Epigenomics
Proteomics
Chromatin
Genes
Throughput
18 Citations (Scopus)

TPH2 in the ventral tegmental area of the male rat brain

Salli, N., Salli, U., Kuntz-Melcavage, K. L., Pennock, M. M., Ozgen, H., Tekin, I., Freeman, W. M. & Vrana, K., Apr 5 2011, In : Brain Research Bulletin. 84, 6, p. 376-380 5 p.

Research output: Contribution to journalArticle

Tryptophan Hydroxylase
Ventral Tegmental Area
Brain
Proteins
Messenger RNA
2010
96 Citations (Scopus)

Circulating cytokines as biomarkers of alcohol abuse and alcoholism

Achur, R. N., Freeman, W. M. & Vrana, K., Mar 1 2010, In : Journal of Neuroimmune Pharmacology. 5, 1, p. 83-91 9 p.

Research output: Contribution to journalReview article

Alcoholism
Biomarkers
Cytokines
Alcohols
Interleukin-1alpha
20 Citations (Scopus)

Classification of alcohol abuse by plasma protein biomarkers

Freeman, W. M., Salzberg, A. C., Gonzales, S. W., Grant, K. A. & Vrana, K., Aug 1 2010, In : Biological Psychiatry. 68, 3, p. 219-222 4 p.

Research output: Contribution to journalArticle

Alcoholism
Drinking
Blood Proteins
Biomarkers
Alcohols
14 Citations (Scopus)

Dual-platform proteomics study of plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass

Umstead, T. M., Lu, C. J. K., Freeman, W. M., Myers, J., Clark, J., Thomas, N., Chinchilli, V., Vrana, K., Undar, A. & Phelps, D., Jun 1 2010, In : Pediatric Research. 67, 6, p. 641-649 9 p.

Research output: Contribution to journalArticle

Cardiopulmonary Bypass
Proteomics
Two-Dimensional Difference Gel Electrophoresis
Biomarkers
Pediatrics
24 Citations (Scopus)

Future prospects for biomarkers of alcohol consumption and alcohol-induced disorders

Freeman, W. M. & Vrana, K., Jan 1 2010, In : Alcoholism: Clinical and Experimental Research. 34, 6, p. 946-954 9 p.

Research output: Contribution to journalComment/debate

Alcohol-Induced Disorders
Biomarkers
Alcohol Drinking
Alcohols
Research
33 Citations (Scopus)

Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration

Freeman, W. M., Lull, M. E., Patel, K. M., Brucklacher, R. M., Morgan, D., Roberts, D. C. S. & Vrana, K., Feb 26 2010, In : BMC Neuroscience. 11, 29.

Research output: Contribution to journalArticle

Self Administration
Nucleus Accumbens
Prefrontal Cortex
Cocaine
Gene Expression
38 Citations (Scopus)

Robust activation of the human but not mouse telomerase gene during the induction of pluripotency

Mathew, R., Jia, W., Sharma, A., Zhao, Y., Clarke, L. E., Cheng, X., Wang, H., Salli, U., Vrana, K., Robertson, G., Zhu, J. & Wang, S., Aug 1 2010, In : FASEB Journal. 24, 8, p. 2702-2715 14 p.

Research output: Contribution to journalArticle

Telomerase
Genes
Stem cells
Chemical activation
Glycogen Synthase Kinase 3
36 Citations (Scopus)

SelSA, selenium analogs of SAHA as potent histone deacetylase inhibitors

Desai, D., Salli, U., Vrana, K. & Amin, S., Mar 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 6, p. 2044-2047 4 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Selenium
Selenium Compounds
Neoplasms
trichostatin A
13 Citations (Scopus)

The use of neuroproteomics in drug abuse research

Lull, M. E., Freeman, W. M., VanGuilder, H. D. & Vrana, K., Feb 1 2010, In : Drug and Alcohol Dependence. 107, 1, p. 11-22 12 p.

Research output: Contribution to journalReview article

Substance-Related Disorders
Proteomics
Research
Pharmaceutical Preparations
Two-Dimensional Difference Gel Electrophoresis
2009
9 Citations (Scopus)

2-D DIGE identification of differentially expressed heterogeneous nuclear ribonucleoproteins and transcription factors during neural differentiation of human embryonic stem cells

Barthéléry, M., Jaishankar, A., Salli, U., Freeman, W. M. & Vrana, K., May 14 2009, In : Proteomics - Clinical Applications. 3, 4, p. 505-514 10 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoproteins
Neural Stem Cells
Stem cells
Transcription Factors
Nestin
1 Citation (Scopus)

Emerging molecular approaches in stem cell biology

Jaishankar, A. & Vrana, K., Apr 1 2009, In : BioTechniques. 46, 5 SPEC. ISSUE, p. 367-371 5 p.

Research output: Contribution to journalReview article

Cytology
Stem cells
Cell Biology
Stem Cells
Systems Biology
28 Citations (Scopus)

Gene expression changes following extinction testing in a heroin behavioral incubation model

Kuntz-Melcavage, K. L., Brucklacher, R. M., Grigson-Kennedy, P. S., Freeman, W. M. & Vrana, K., Aug 7 2009, In : BMC Neuroscience. 10, 95.

Research output: Contribution to journalArticle

Heroin
Gene Expression
Drug-Seeking Behavior
Self Administration
Pharmaceutical Preparations
16 Citations (Scopus)

Human embryonic and mesenchymal stem cells express different nuclear proteomes

Jaishankar, A., Barthelery, M., Freeman, W. M., Salli, U., Ritty, T. M. & Vrana, K., Jun 1 2009, In : Stem Cells and Development. 18, 5, p. 793-801 9 p.

Research output: Contribution to journalArticle

Proteome
Mesenchymal Stromal Cells
Catenins
Proteomics
Two-Dimensional Difference Gel Electrophoresis
8 Citations (Scopus)

Pediatric cardiopulmonary bypass circuits: A review of studies conducted at the Penn State pediatric cardiac research laboratories

Miller, A., Lu, C. K., Wang, S., Umstead, T. M., Freeman, W. M., Vrana, K., Yang, S., Myers, J., Phelps, D., Zahn, J. D. & Undar, A., Mar 2009, In : Journal of Extra-Corporeal Technology. 41, 1

Research output: Contribution to journalArticle

Cardiopulmonary Bypass
Pediatrics
Research
Pediatric Hospitals
Congenital Heart Defects
4 Citations (Scopus)

Penn state hershey - Center for pediatric cardiovascular research: Guest editorial

Undar, A., Pauliks, L., Clark, J., Zahn, J., Rosenberg, G., Kunselman, A., Sun, Q., Pekkan, K., Saliba, K., Carney, E., Thomas, N., Freeman, W., Vrana, K., El-Banayosy, A., Ural, S., Wilson, R., Umstead, T. M., Floros, J., Phelps, D., Weiss, W. & 15 others, Snyder, A., Yang, S., Kimatian, S., Cyran, S., Chinchilli, V., Guan, Y., Rider, A., Haines, N., Rogerson, A., Alkan-Bozkaya, T., Akcevin, A., Sun, K., Wang, S., Cun, L. & Myers, J., Nov 1 2009, In : Artificial organs. 33, 11, p. 883-887 5 p.

Research output: Contribution to journalReview article

Pediatrics
Research
Perfusion
Students
National Heart, Lung, and Blood Institute (U.S.)
17 Citations (Scopus)

Persistent proteonnic alterations in the medial prefrontal cortex with abstinence from cocaine self-administration

Lull, M. E., Erwin, M. S., Morgan, D., Roberts, D. C. S., Vrana, K. & Freeman, W. M., May 14 2009, In : Proteomics - Clinical Applications. 3, 4, p. 462-472 11 p.

Research output: Contribution to journalArticle

Self Administration
Prefrontal Cortex
Cocaine
Proteins
Dynamin I
14 Citations (Scopus)

Propagation of undifferentiated human embryonic stem cells with nano-liposomal ceramide

Salli, U., Fox, T. E., Salli, N., Sharma, A., Robertson, G., Kester, M. & Vrana, K., Jan 1 2009, In : Stem Cells and Development. 18, 1, p. 55-66 12 p.

Research output: Contribution to journalArticle

Ceramides
Feeder Cells
Nestin
Human Embryonic Stem Cells
Pluripotent Stem Cells
5 Citations (Scopus)

Reptin52 expression during in vitro neural differentiation of human embryonic stem cells

Barthéléry, M., Jaishankar, A., Salli, U. & Vrana, K., Mar 6 2009, In : Neuroscience Letters. 452, 1, p. 47-51 5 p.

Research output: Contribution to journalArticle

Catenins
Neural Stem Cells
Histone Code
Nestin
Wnt Signaling Pathway
31 Citations (Scopus)

T lineage differentiation from induced pluripotent stem cells

Lei, F., Haque, R., Weiler, L., Vrana, K. & Song, J., Oct 9 2009, In : Cellular Immunology. 260, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
T-Lymphocytes
Adoptive Transfer
Interleukin-2
Cell Differentiation
2008
22 Citations (Scopus)

Cannabinoid receptor-mediated translocation of NO-sensitive guanylyl cyclase and production of cyclic GMP in neuronal cells

Jones, J. D., Carney, S. T., Vrana, K., Norford, D. C. & Howlett, A. C., Jan 1 2008, In : Neuropharmacology. 54, 1, p. 23-30 8 p.

Research output: Contribution to journalArticle

rimonabant
Cannabinoid Receptors
Guanylate Cyclase
Cyclic GMP
Cannabinoid Receptor CB1
21 Citations (Scopus)

Correlating human and animal studies of cocaine abuse and gene expression

Lull, M. E., Freeman, W. M., Vrana, K. & Mash, D. C., Jan 1 2008, Addiction Reviews 2008. Blackwell Publishing Inc., p. 58-75 18 p. (Annals of the New York Academy of Sciences; vol. 1141).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cocaine-Related Disorders
Cocaine
Gene expression
Animals
Gene Expression