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Personal profile

Research interests

Dr. Krishne Gowda's research efforts combine synthetic organic chemistry, biochemical and molecular biological tools in an interdisciplinary approach to designing and synthesis of small molecules that specifically target diseased cells or infectious agents.

The long-term goal of the research is the development of selective strategies for the treatment of cancer and infectious diseases. Topics of current interest include:

  • Development of selective modulators of Aryl hydrocarbon receptor (SAhRM) activity. Recently, the lab developed a molecule SGA360 and analogs as selective modulators of aryl hydrocarbon receptor, which was shown to inhibit a set of inflammatory cytokines. Future studies are needed to test whether SGA360 and analogs would be useful in treating chronic inflammatory diseases.
  • Development of novel therapeutic agents for cancer. Currently, the lab has developed novel isatin derivatives that were demonstrated as aldehyde dehydrogenase (ALDH) inhibitors and suitable candidates for further study for the anticancer activity. The lab developed maritoclax and pyoluteorin derivatives as Mcl-1 inhibitors and is also involved in the synthesis of various carcinogens like polycyclic aromatic hydrocarbons and their metabolites like diols and diol epoxides and tobacco-specific N-nitrosamines, wherein they prepare specific carcinogens and their metabolites for bioassays and the exploration of DNA adducts formation. The lab uses mechanisms of chemical carcinogenesis as a tool for developing chemopreventive strategies to reduce the morbidity and mortality from cancer.

Education/Academic qualification

Postdoctoral Fellowship, Department of Pharmacology

May 1 2006Aug 31 2009

Postdoctoral Fellowship, Department of Biochemistry and Molecular Biology

Jan 1 2002Apr 30 2006

Organic/Medicinal Chemistry, PhD, University of Mysore

… → 2000

Organic Chemistry, MS, University of Mysore

… → 1987

Chemistry, Physics, Mathematics, BS, University of Mysore

… → 1985

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  • 13 Similar Profiles
Aryl Hydrocarbon Receptors Medicine & Life Sciences
Glycosylphosphatidylinositols Medicine & Life Sciences
Plasmodium falciparum Medicine & Life Sciences
Tobacco Chemical Compounds
DNA Damage Medicine & Life Sciences
Metabolites Chemical Compounds
Neoplasms Medicine & Life Sciences
Cells Chemical Compounds

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Research Output 1999 2019

  • 1738 Citations
  • 25 h-Index
  • 56 Article
N'-nitrosonornicotine
Oral Leukoplakia
Tobacco
Tongue
Carcinogens
2 Citations (Scopus)

Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline

Hubbard, T. D., Liu, Q., Murray, I. A., Dong, F., Miller, C., Smith, P. B., Gowda, K., Lin, J. M., Amin, S., Patterson, A. D. & Perdew, G. H., Apr 5 2019, In : Journal of Proteome Research. 18, 4, p. 1715-1724 10 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Microbiota
Metabolism
Hydroxyquinolines
Chemical activation

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

Muku, G. E., Kusnadi, A., Kuzu, G., Tanos, R., Murray, I. A., Gowda, K., Amin, S. & Perdew, G. H., Jan 1 2019, (Accepted/In press) In : Laboratory Investigation.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 2
Aryl Hydrocarbon Receptors
Cholesterol
Ligands
Genes
Metabolites
DNA Damage
Ovary
DNA
Epoxy Compounds
1 Citation (Scopus)

D1 dopamine receptors intrinsic activity and functional selectivity affect working memory in prefrontal cortex

Yang, Y., Lee, S. M., Imamura, F., Gowda, K., Amin, S. & Mailman, R., Jan 1 2018, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Arrestin
Prefrontal Cortex
Short-Term Memory
Dopamine
Adenylyl Cyclases