• 1828 Citations
  • 25 h-Index
19992020

Research output per year

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Research Output

  • 1828 Citations
  • 25 h-Index
  • 58 Article
2020

Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents

Dinavahi, S. S., Gowda, R., Bazewicz, C. G., Battu, M. B., Lin, J. M., Chitren, R. J., Pandey, M. K., Amin, S., Robertson, G. P. & Gowda, K., Feb 1 2020, In : European Journal of Medicinal Chemistry. 187, 111962.

Research output: Contribution to journalArticle

Development of a Novel Multi-Isoform ALDH Inhibitor Effective as an Antimelanoma Agent

Dinavahi, S. S., Gowda, R., Gowda, K., Bazewicz, C. G., Chirasani, V. R., Battu, M. B., Berg, A., Dokholyan, N. V., Amin, S. & Robertson, G. P., Feb 1 2020, In : Molecular cancer therapeutics. 19, 2, p. 447-459 13 p.

Research output: Contribution to journalArticle

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

Muku, G. E., Kusnadi, A., Kuzu, G., Tanos, R., Murray, I. A., Gowda, K., Amin, S. & Perdew, G. H., Feb 1 2020, In : Laboratory Investigation. 100, 2, p. 250-264 15 p.

Research output: Contribution to journalArticle

2019

Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline

Hubbard, T. D., Liu, Q., Murray, I. A., Dong, F., Miller, C., Smith, P. B., Gowda, K., Lin, J. M., Amin, S., Patterson, A. D. & Perdew, G. H., Apr 5 2019, In : Journal of Proteome Research. 18, 4, p. 1715-1724 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018
1 Scopus citations
2 Scopus citations

Effects of Black Raspberry on Dibenzo[a,l]Pyrene Diol Epoxide Induced DNAAdducts, Mutagenesis, and Tumorigenesis in the Mouse Oral Cavity

Chen, K. M., Guttenplan, J. B., Sun, Y. W., Cooper, T., Shalaby, N. A. E., Kosinska, W., Benitez, G., Aliaga, C., Zhu, J., Liao, J., Gowda, K., Amin, S., Stoner, G. & El-Bayoumy, K., Mar 2018, In : Cancer Prevention Research. 11, 3, p. 157-164 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin

Smith, K. J., Boyer, J. A., Muku, G. E., Murray, I. A., Gowda, K., Desai, D., Amin, S. G., Glick, A. B. & Perdew, G. H., Jan 1 2017, In : Toxicological Sciences. 160, 1, p. 83-94 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

A novel dual inhibitor of microtubule and Bruton's tyrosine kinase inhibits survival of multiple myeloma and osteoclastogenesis

Pandey, M. K., Gowda, K., Sung, S. S., Abraham, T., Budak-Alpdogan, T., Talamo, G., Dovat, S. & Amin, S., Sep 2017, In : Experimental Hematology. 53, p. 31-42 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Effects of Black Raspberry Extract and Berry Compounds on Repair of DNA Damage and Mutagenesis Induced by Chemical and Physical Agents in Human Oral Leukoplakia and Rat Oral Fibroblasts

Guttenplan, J. B., Chen, K. M., Sun, Y. W., Lajara, B., Shalaby, N. A. E., Kosinska, W., Benitez, G., Gowda, K., Amin, S., Stoner, G. & El-Bayoumy, K., Dec 18 2017, In : Chemical research in toxicology. 30, 12, p. 2159-2164 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
5 Scopus citations
5 Scopus citations

Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses

Muku, G. E., Lahoti, T. S., Murray, I. A., Podolsky, M. A., Smith, K. J., Hubbard, T. D., Kuzu, G., Gowda, K., Amin, S. G. & Perdew, G. H., Dec 1 2017, In : Laboratory Investigation. 97, 12, p. 1471-1487 17 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Effects of black raspberry extract and protocatechuic acid on carcinogen-DNA adducts and mutagenesis, and oxidative stress in rat and human oral cells

Guttenplan, J. B., Chen, K. M., Sun, Y. W., Kosinska, W., Zhou, Y., Kim, S. A., Sung, Y., Gowda, K., Amin, S., Stoner, G. D. & El-Bayoumy, K., Aug 2016, In : Cancer Prevention Research. 9, 8, p. 704-712 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Hubbard, T. D., Murray, I. A., Bisson, W. H., Lahoti, T. S., Gowda, K., Amin, S. G., Patterson, A. D. & Perdew, G. H., Aug 3 2015, In : Scientific reports. 5, 12689.

Research output: Contribution to journalArticle

91 Scopus citations
32 Scopus citations

Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation

Van Den Bogaard, E. H., Podolsky, M. A., Smits, J. P., Cui, X., John, C., Gowda, K., Desai, D., Amin, S. G., Schalkwijk, J., Perdew, G. H. & Glick, A. B., May 22 2015, In : Journal of Investigative Dermatology. 135, 5, p. 1320-1328 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner

Varadarajan, S., Poornima, P., Milani, M., Gowda, K., Amin, S., Wang, H. G. & Cohen, G. M., Jan 1 2015, In : Oncotarget. 6, 14, p. 12668-12681 14 p.

Research output: Contribution to journalArticle

26 Scopus citations

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia

Song, C., Gowda, C., Pan, X., Ding, Y., Tong, Y., Tan, B. H., Wang, H., Muthusami, S., Ge, Z., Sachdev, M., Amin, S. G., Desai, D., Gowda, K., Gowda, R., Robertson, G. P., Schjerven, H., Muschen, M., Payne, K. J. & Dovat, S., Oct 8 2015, In : Blood. 126, 15, p. 1813-1822 10 p.

Research output: Contribution to journalArticle

48 Scopus citations
8 Scopus citations
2014
28 Scopus citations

In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract

Fang, Z. Z., Krausz, K. W., Nagaoka, K., Tanaka, N., Gowda, K., Amin, S. G., Perdew, G. H. & Gonzalez, F. J., Apr 1 2014, In : British Journal of Pharmacology. 171, 7, p. 1735-1746 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Maritoclax induces apoptosis in acute myeloid leukemia cells with elevated Mcl-1 expression

Doi, K., Liu, Q., Gowda, K., Barth, B. M., Claxton, D., Amin, S., Loughran, T. P. & Wang, H. G., Aug 2014, In : Cancer Biology and Therapy. 15, 8, p. 1077-1086 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Oxidized derivative of docosahexaenoic acid preferentially inhibit cell proliferation in triple negative over luminal breast cancer cells

Pogash, T. J., El-Bayoumy, K., Amin, S., Gowda, K., de Cicco, R. L., Barton, M., Su, Y., Russo, I. H., Himmelberger, J. A., Slifker, M., Manni, A. & Russo, J., Jan 1 2014, In : In Vitro Cellular and Developmental Biology - Animal. 51, 2, p. 121-127 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Pyoluteorin derivatives induce Mcl-1 degradation and apoptosis in hematological cancer cells

Doi, K., Gowda, K., Liu, Q., Lin, J. M., Sung, S., Dower, C., Claxton, D., Loughran, T. P., Amin, S. & Wang, H-G., Dec 1 2014, In : Cancer Biology and Therapy. 15, 12, p. 1688-1699 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2013

Aryl hydrocarbon receptor antagonism mitigates cytokine-mediated inflammatory signalling in primary human fibroblast-like synoviocytes

Lahoti, T. S., John, K., Hughes, J. M., Kusnadi, A., Murray, I. A., Krishnegowda, G., Amin, S. & Perdew, G. H., Oct 1 2013, In : Annals of the Rheumatic Diseases. 72, 10, p. 1708-1716 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Proteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the efficacy of ABT-737 in melanoma cells

Pandey, M. K., Gowda, K., Doi, K., Sharma, A. K., Wang, H. G. & Amin, S., Nov 4 2013, In : PloS one. 8, 11, e78570.

Research output: Contribution to journalArticle

27 Scopus citations
2012

Ah receptor antagonism represses head and neck tumor cell aggressive phenotype

DiNatale, B. C., Smith, K., John, K., Krishnegowda, G., Amin, S. G. & Perdew, G. H., Oct 1 2012, In : Molecular Cancer Research. 10, 10, p. 1369-1379 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation

Doi, K., Li, R., Sung, S. S., Wu, H., Liu, Y., Manieri, W., Krishnegowda, G., Awwad, A., Dewey, A., Liu, X., Amin, S., Cheng, C., Qin, Y., Schonbrunn, E., Daughdrill, G., Loughran, T. P., Sebti, S. & Wang, H. G., Mar 23 2012, In : Journal of Biological Chemistry. 287, 13, p. 10224-10235 12 p.

Research output: Contribution to journalArticle

103 Scopus citations

Induction of ovarian cancer and DNA adducts by dibenzo[a,l]pyrene in the mouse

Chen, K-M., Zhang, S. M., Aliaga, C., Sun, Y-W., Cooper, T., Gowda, K., Zhu, J., Amin, S. & El-Bayoumy, K., Feb 20 2012, In : Chemical Research in Toxicology. 25, 2, p. 374-380 7 p.

Research output: Contribution to journalArticle

16 Scopus citations
15 Scopus citations
12 Scopus citations
2011
6 Scopus citations

Preliminary physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents

Crowell, S. R., Amin, S. G., Anderson, K. A., Krishnegowda, G., Sharma, A. K., Soelberg, J. J., Williams, D. E. & Corley, R. A., Dec 15 2011, In : Toxicology and Applied Pharmacology. 257, 3, p. 365-376 12 p.

Research output: Contribution to journalArticle

21 Scopus citations
39 Scopus citations

Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway

Gowda, K., Prakasha Gowda, A. S., Tagaram, H. R. S., Carroll, K. F. S. O., Irby, R., Sharma, A. & Amin, S., Oct 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 20, p. 6006-6014 9 p.

Research output: Contribution to journalArticle

44 Scopus citations
2010
55 Scopus citations

Evidence for ligand-mediated selective modulation of aryl hydrocarbon receptor activity

Murray, I. A., Morales, J. L., Flaveny, C. A., DiNatale, B. C., Chiaro, C., Gowdahalli, K., Amin, S. & Perdew, G. H., Feb 1 2010, In : Molecular pharmacology. 77, 2, p. 247-254 8 p.

Research output: Contribution to journalArticle

62 Scopus citations
30 Scopus citations
2009

MAPK-activated protein kinase 2 differentially regulates plasmodium falciparum glycosylphosphatidylinositol-inducedproduction of tumor necrosis Factor-α and interleukin-12 in macrophages

Zhu, J., Wu, X., Goel, S., Gowda, N. M., Kumar, S., Gowda, K., Mishra, G., Weinberg, R., Li, G., Gaestel, M., Muta, T. & Gowda, C., Jun 5 2009, In : Journal of Biological Chemistry. 284, 23, p. 15756-15761 6 p.

Research output: Contribution to journalArticle

29 Scopus citations
2008
4 Scopus citations
2007
25 Scopus citations

Plasmodium falciparum GPI mannosyltransferase-III has novel signature sequence and is functional

Basagoudanavar, S. H., Feng, X., Krishnegowda, G., Muthusamy, A. & Gowda, D. C., Dec 28 2007, In : Biochemical and Biophysical Research Communications. 364, 4, p. 748-754 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Src-family kinase-dependent disruption of endothelial barrier function by Plasmodium falciparum merozoite proteins

Gillrie, M. R., Krishnegowda, G., Lee, K., Buret, A. G., Robbins, S. M., Looareesuwan, S., Gowda, D. C. & Ho, M., Nov 1 2007, In : Blood. 110, 9, p. 3426-3435 10 p.

Research output: Contribution to journalArticle

48 Scopus citations
2006

Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model

Lu, Z., Serghides, L., Patel, S. N., Degousee, N., Rubin, B. B., Krishnegowda, G., Gowda, D. C., Karin, M. & Kain, K. C., Nov 1 2006, In : Journal of Immunology. 177, 9, p. 6344-6352 9 p.

Research output: Contribution to journalArticle

42 Scopus citations
22 Scopus citations

Serum antibody levels to glycosylphosphatidylinositols in specimens derived from matched Malian children with severe or uncomplicated Plasmodium falciparum malaria and healthy controls

Cissoko, Y., Daou, M., Lyke, K. E., Dicko, A., Diarra, I., Kone, A., Guindo, A., Traore, K., Krishnegowda, G., Diallo, D. A., Doumbo, O. K., Plowe, C. V., Gowda, D. C. & Sztein, M. B., Dec 1 2006, In : American Journal of Tropical Medicine and Hygiene. 75, 2, p. 199-204 6 p.

Research output: Contribution to journalArticle

8 Scopus citations
2005

Differential antibody responses to Plasmodium falciparum glycosylphosphatidylinositol anchors in patients with cerebral and mild malaria

Perraut, R., Diatta, B., Marrama, L., Garraud, O., Jambou, R., Longacre, S., Krishnegowda, G., Dieye, A. & Gowda, D. C., Apr 1 2005, In : Microbes and Infection. 7, 4, p. 682-687 6 p.

Research output: Contribution to journalArticle

29 Scopus citations
93 Scopus citations