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Research Output 1999 2019

  • 1757 Citations
  • 25 h-Index
  • 56 Article
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Article
2019
N'-nitrosonornicotine
Oral Leukoplakia
Tobacco
Tongue
Carcinogens
2 Citations (Scopus)

Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline

Hubbard, T. D., Liu, Q., Murray, I. A., Dong, F., Miller, C., Smith, P. B., Gowda, K., Lin, J. M., Amin, S., Patterson, A. D. & Perdew, G. H., Apr 5 2019, In : Journal of Proteome Research. 18, 4, p. 1715-1724 10 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Microbiota
Metabolism
Hydroxyquinolines
Chemical activation

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

Muku, G. E., Kusnadi, A., Kuzu, G., Tanos, R., Murray, I. A., Gowda, K., Amin, S. & Perdew, G. H., Jan 1 2019, (Accepted/In press) In : Laboratory Investigation.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 2
Aryl Hydrocarbon Receptors
Cholesterol
Ligands
Genes
2018
Metabolites
DNA Damage
Ovary
DNA
Epoxy Compounds
1 Citation (Scopus)

D1 dopamine receptors intrinsic activity and functional selectivity affect working memory in prefrontal cortex

Yang, Y., Lee, S. M., Imamura, F., Gowda, K., Amin, S. & Mailman, R., Jan 1 2018, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Arrestin
Prefrontal Cortex
Short-Term Memory
Dopamine
Adenylyl Cyclases
3 Citations (Scopus)

Effects of Black Raspberry on Dibenzo[a,l]Pyrene Diol Epoxide Induced DNAAdducts, Mutagenesis, and Tumorigenesis in the Mouse Oral Cavity

Chen, K-M., Guttenplan, J. B., Sun, Y-W., Cooper, T., Shalaby, N. A. E., Kosinska, W., Benitez, G., Aliaga, C., Zhu, J., Liao, J. J., Gowda, K., Amin, S., Stoner, G. & El-Bayoumy, K., Mar 1 2018, In : Cancer Prevention Research. 11, 3, p. 157-164 8 p.

Research output: Contribution to journalArticle

Mutagenesis
Powders
Mouth
Carcinogenesis
DNA Damage
2017
8 Citations (Scopus)

Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin

Smith, K. J., Boyer, J. A., Muku, G. E., Murray, I. A., Gowda, K., Desai, D., Amin, S. G., Glick, A. B. & Perdew, G. H., Jan 1 2017, In : Toxicological Sciences. 160, 1, p. 83-94 12 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Neutrophil Activation
Chemotactic Factors
Keratinocytes
Skin
4 Citations (Scopus)

A novel dual inhibitor of microtubule and Bruton's tyrosine kinase inhibits survival of multiple myeloma and osteoclastogenesis

Pandey, M. K., Gowda, K., Sung, S., Abraham, T., Budak-Alpdogan, T., Talamo, G., Dovat, S. & Amin, S., Sep 1 2017, In : Experimental Hematology. 53, p. 31-42 12 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Osteogenesis
Microtubules
Polymerization
Cell Survival
5 Citations (Scopus)

Effects of Black Raspberry Extract and Berry Compounds on Repair of DNA Damage and Mutagenesis Induced by Chemical and Physical Agents in Human Oral Leukoplakia and Rat Oral Fibroblasts

Guttenplan, J. B., Chen, K-M., Sun, Y-W., Lajara, B., Shalaby, N. A. E., Kosinska, W., Benitez, G., Gowda, K., Amin, S., Stoner, G. & El-Bayoumy, K., Dec 18 2017, In : Chemical Research in Toxicology. 30, 12, p. 2159-2164 6 p.

Research output: Contribution to journalArticle

Oral Leukoplakia
Mutagenesis
DNA Adducts
Fibroblasts
DNA Damage
5 Citations (Scopus)
Environmental Pollutants
Alcohol Drinking
DNA Damage
Alcohols
Carcinogenesis
5 Citations (Scopus)
Tobacco
Mouth Neoplasms
Biomarkers
carcinogens
Early Detection of Cancer
3 Citations (Scopus)

Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses

Muku, G. E., Lahoti, T. S., Murray, I. A., Podolsky, M. A., Smith, K. J., Hubbard, T. D., Kuzu, G., Gowda, K., Amin, S. G. & Perdew, G. H., Dec 1 2017, In : Laboratory Investigation. 97, 12, p. 1471-1487 17 p.

Research output: Contribution to journalArticle

Macrophages
Ligands
Uric Acid
Lipopolysaccharides
Inflammation
2016
9 Citations (Scopus)

Effects of black raspberry extract and protocatechuic acid on carcinogen-DNA adducts and mutagenesis, and oxidative stress in rat and human oral cells

Guttenplan, J. B., Chen, K-M., Sun, Y-W., Kosinska, W., Zhou, Y., Kim, S. A., Sung, Y., Gowda, K., Amin, S., Stoner, G. D. & El-Bayoumy, K., Aug 1 2016, In : Cancer Prevention Research. 9, 8, p. 704-712 9 p.

Research output: Contribution to journalArticle

DNA Adducts
Mutagenesis
Carcinogens
Oxidative Stress
Carcinogenesis
2015
82 Citations (Scopus)

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Hubbard, T. D., Murray, I. A., Bisson, W. H., Lahoti, T. S., Gowda, K., Amin, S., Patterson, A. D. & Perdew, G. H., Aug 3 2015, In : Scientific reports. 5, 12689.

Research output: Contribution to journalArticle

Indoles
Microbiota
Hydrocarbons
Ligands
Gastrointestinal Tract
29 Citations (Scopus)
Aryl Hydrocarbon Receptors
Dioxins
Response Elements
Xenobiotics
Cell Differentiation
29 Citations (Scopus)

Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation

Van Den Bogaard, E. H., Podolsky, M. A., Smits, J. P., Cui, X., John, C., Gowda, K., Desai, D., Amin, S., Schalkwijk, J., Perdew, G. H. & Glick, A. B., May 22 2015, In : Journal of Investigative Dermatology. 135, 5, p. 1320-1328 9 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Keratinocytes
Pharmacology
Skin
Dermatology
25 Citations (Scopus)

Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner

Varadarajan, S., Poornima, P., Milani, M., Gowda, K., Amin, S., Wang, H-G. & Cohen, G. M., Jan 1 2015, In : Oncotarget. 6, 14, p. 12668-12681 14 p.

Research output: Contribution to journalArticle

Apoptosis
Reactive Oxygen Species
Down-Regulation
Electron Transport Complex I
Caspase 9
45 Citations (Scopus)

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia

Song, C., Gowda, C., Pan, X., Ding, Y., Tong, Y., Tan, B., Wang, H., Muthusami, S., Ge, Z., Sachdev, M., Amin, S., Desai, D., Gowda, K., Gowda, R., Robertson, G., Schjerven, H., Muschen, M., Payne, K. J. & Dovat, S., Oct 8 2015, In : Blood. 126, 15, p. 1813-1822 10 p.

Research output: Contribution to journalArticle

Casein Kinase II
Tumors
Leukemia
Phosphatidylinositol 3-Kinase
Genes
6 Citations (Scopus)
Environmental Pollutants
Pharmacokinetics
Tissue Distribution
Ovary
Liver
2014
28 Citations (Scopus)
Aryl Hydrocarbon Receptors
Rheumatoid Arthritis
Intercellular Signaling Peptides and Proteins
Fibroblasts
Cytokines
16 Citations (Scopus)

In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract

Fang, Z. Z., Krausz, K. W., Nagaoka, K., Tanaka, N., Gowda, K., Amin, S., Perdew, G. H. & Gonzalez, F. J., Apr 1 2014, In : British Journal of Pharmacology. 171, 7, p. 1735-1746 12 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Oral Administration
Gastrointestinal Tract
Intestines
N-(2-(3H-indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)purin-6-amine
21 Citations (Scopus)

Maritoclax induces apoptosis in acute myeloid leukemia cells with elevated Mcl-1 expression

Doi, K., Liu, Q., Gowda, K., Barth, B. M., Claxton, D., Amin, S., Loughran, T. P. & Wang, H-G., Jan 1 2014, In : Cancer Biology and Therapy. 15, 8, p. 1077-1086 10 p.

Research output: Contribution to journalArticle

Myeloid Cells
Acute Myeloid Leukemia
Apoptosis
Daunorubicin
Nude Mice
12 Citations (Scopus)

Oxidized derivative of docosahexaenoic acid preferentially inhibit cell proliferation in triple negative over luminal breast cancer cells

Pogash, T. J., El-Bayoumy, K., Amin, S., Gowda, K., de Cicco, R. L., Barton, M., Su, Y., Russo, I. H., Himmelberger, J. A., Slifker, M., Manni, A. & Russo, J., Jan 1 2014, In : In Vitro Cellular and Developmental Biology - Animal. 51, 2, p. 121-127 7 p.

Research output: Contribution to journalArticle

Docosahexaenoic Acids
Cell Proliferation
Breast Neoplasms
Cell Line
Triple Negative Breast Neoplasms
5 Citations (Scopus)

Pyoluteorin derivatives induce Mcl-1 degradation and apoptosis in hematological cancer cells

Doi, K., Gowda, K., Liu, Q., Lin, J. M., Sung, S., Dower, C., Claxton, D., Loughran, T. P., Amin, S. & Wang, H-G., Dec 1 2014, In : Cancer Biology and Therapy. 15, 12, p. 1688-1699 12 p.

Research output: Contribution to journalArticle

Apoptosis
Neoplasms
K562 Cells
Structure-Activity Relationship
Biological Products
2013
23 Citations (Scopus)

Aryl hydrocarbon receptor antagonism mitigates cytokine-mediated inflammatory signalling in primary human fibroblast-like synoviocytes

Lahoti, T. S., John, K., Hughes, J. M., Kusnadi, A., Murray, I. A., Krishnegowda, G., Amin, S. & Perdew, G. H., Oct 1 2013, In : Annals of the Rheumatic Diseases. 72, 10, p. 1708-1716 9 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Fibroblasts
Cytokines
Rheumatoid Arthritis
Interleukin-6
25 Citations (Scopus)

Proteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the efficacy of ABT-737 in melanoma cells

Pandey, M. K., Gowda, K., Doi, K., Sharma, A., Wang, H-G. & Amin, S., Nov 4 2013, In : PloS one. 8, 11, e78570.

Research output: Contribution to journalArticle

melanoma
Melanoma
apoptosis
Apoptosis
Degradation
2012
29 Citations (Scopus)

Ah receptor antagonism represses head and neck tumor cell aggressive phenotype

DiNatale, B. C., Smith, K., John, K., Gowda, K., Amin, S. & Perdew, G. H., Oct 1 2012, In : Molecular Cancer Research. 10, 10, p. 1369-1379 11 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Neck
Head
Phenotype
Neoplasms
101 Citations (Scopus)

Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation

Doi, K., Li, R., Sung, S., Wu, H., Liu, Y., Manieri, W., Gowda, K., Awwad, A., Dewey, A., Liu, X., Amin, S., Cheng, C., Qin, Y., Schonbrunn, E., Daughdrill, G., Loughran, T. P., Sebti, S. & Wang, H-G., Mar 23 2012, In : Journal of Biological Chemistry. 287, 13, p. 10224-10235 12 p.

Research output: Contribution to journalArticle

Degradation
Videocassette recorders
Oncology
Hematologic Neoplasms
Proteasome Endopeptidase Complex
15 Citations (Scopus)

Induction of ovarian cancer and DNA adducts by dibenzo[a,l]pyrene in the mouse

Chen, K-M., Zhang, S. M., Aliaga, C., Sun, Y-W., Cooper, T., Gowda, K., Zhu, J., Amin, S. & El-Bayoumy, K., Feb 20 2012, In : Chemical Research in Toxicology. 25, 2, p. 374-380 7 p.

Research output: Contribution to journalArticle

DNA Adducts
Ovarian Neoplasms
Tobacco
Tumors
Ovary
15 Citations (Scopus)
Nitrosamines
Tobacco
DNA-Directed DNA Polymerase
DNA Polymerase I
Base Pairing
10 Citations (Scopus)
Aryl Hydrocarbon Receptors
Cytokines
Response Elements
Complement C3-C5 Convertases
Complement Membrane Attack Complex
2011
6 Citations (Scopus)
Nitrosamines
Tobacco
Oligodeoxyribonucleotides
Oligomers
N'-nitrosonornicotine
20 Citations (Scopus)

Preliminary physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents

Crowell, S. R., Amin, S., Anderson, K. A., Gowda, K., Sharma, A., Soelberg, J. J., Williams, D. E. & Corley, R. A., Dec 15 2011, In : Toxicology and Applied Pharmacology. 257, 3, p. 365-376 12 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Benzo(a)pyrene
Polycyclic Aromatic Hydrocarbons
Rodentia
Metabolites
36 Citations (Scopus)
Toll-Like Receptor 2
Glycosylphosphatidylinositols
Plasmodium falciparum
Fatty Acids
Macrophages
42 Citations (Scopus)

Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway

Gowda, K., Prakasha Gowda, A. S., Tagaram, H. R. S., Carroll, K. F. S. O., Irby, R., Sharma, A. & Amin, S., Oct 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 20, p. 6006-6014 9 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Isatin
Phosphorylation
Vinblastine
Cells
2010
54 Citations (Scopus)

Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties

Murray, I. A., Gowda, K., Dinatale, B. C., Flaveny, C., Chiaro, C., Lin, J. M., Sharma, A., Amin, S. & Perdew, G. H., May 17 2010, In : Chemical Research in Toxicology. 23, 5, p. 955-966 12 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Modulators
Anti-Inflammatory Agents
Tetradecanoylphorbol Acetate
Gene expression
61 Citations (Scopus)

Evidence for ligand-mediated selective modulation of aryl hydrocarbon receptor activity

Murray, I. A., Morales, J. L., Flaveny, C. A., DiNatale, B. C., Chiaro, C., Gowda, K., Amin, S. & Perdew, G. H., Feb 1 2010, In : Molecular Pharmacology. 77, 2, p. 247-254 8 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Ligands
Response Elements
Dioxins
Selective Estrogen Receptor Modulators
30 Citations (Scopus)
Selenium
Sulfur
Antineoplastic Agents
Colonic Neoplasms
Substitution reactions
2009
28 Citations (Scopus)

MAPK-activated protein kinase 2 differentially regulates plasmodium falciparum glycosylphosphatidylinositol-inducedproduction of tumor necrosis Factor-α and interleukin-12 in macrophages

Zhu, J., Wu, X., Goel, S., Gowda, N. M., Kumar, S., Gowda, K., Mishra, G., Weinberg, R., Li, G., Gaestel, M., Muta, T. & Gowda, C., Jun 5 2009, In : Journal of Biological Chemistry. 284, 23, p. 15756-15761 6 p.

Research output: Contribution to journalArticle

Glycosylphosphatidylinositols
Macrophages
Plasmodium falciparum
Interleukin-12
Protein Kinases
2008
3 Citations (Scopus)
Environmental Pollutants
Metabolites
Microsomes
Metabolism
Estuaries
2007
25 Citations (Scopus)
Boronic Acids
Microwave irradiation
Polycyclic Aromatic Hydrocarbons
Palladium
Metabolites
7 Citations (Scopus)

Plasmodium falciparum GPI mannosyltransferase-III has novel signature sequence and is functional

Basagoudanavar, S. H., Feng, X., Gowda, K., Muthusamy, A. & Gowda, C., Dec 28 2007, In : Biochemical and Biophysical Research Communications. 364, 4, p. 748-754 7 p.

Research output: Contribution to journalArticle

Mannosyltransferases
Glycosylphosphatidylinositols
Plasmodium falciparum
Parasites
Biosynthesis
48 Citations (Scopus)

Src-family kinase-dependent disruption of endothelial barrier function by Plasmodium falciparum merozoite proteins

Gillrie, M. R., Krishnegowda, G., Lee, K., Buret, A. G., Robbins, S. M., Looareesuwan, S., Gowda, D. C. & Ho, M., Nov 1 2007, In : Blood. 110, 9, p. 3426-3435 10 p.

Research output: Contribution to journalArticle

Merozoites
src-Family Kinases
Plasmodium falciparum
Claudin-5
Falciparum Malaria
2006
42 Citations (Scopus)

Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model

Lu, Z., Serghides, L., Patel, S. N., Degousee, N., Rubin, B. B., Krishnegowda, G., Gowda, D. C., Karin, M. & Kain, K. C., Nov 1 2006, In : Journal of Immunology. 177, 9, p. 6344-6352 9 p.

Research output: Contribution to journalArticle

Cerebral Malaria
Glycosylphosphatidylinositols
Plasmodium falciparum
Cytokines
Macrophages
20 Citations (Scopus)
Glycosylphosphatidylinositols
Plasmodium falciparum
Polysaccharides
Antibodies
Anti-Idiotypic Antibodies
8 Citations (Scopus)

Serum antibody levels to glycosylphosphatidylinositols in specimens derived from matched Malian children with severe or uncomplicated Plasmodium falciparum malaria and healthy controls

Cissoko, Y., Daou, M., Lyke, K. E., Dicko, A., Diarra, I., Kone, A., Guindo, A., Traore, K., Gowda, K., Diallo, D. A., Doumbo, O. K., Plowe, C. V., Gowda, C. & Sztein, M. B., 2006, In : American Journal of Tropical Medicine and Hygiene. 75, 2, p. 199-204 6 p.

Research output: Contribution to journalArticle

Glycosylphosphatidylinositols
Falciparum Malaria
Malaria
Antibodies
Immunoglobulin G
2005
27 Citations (Scopus)

Differential antibody responses to Plasmodium falciparum glycosylphosphatidylinositol anchors in patients with cerebral and mild malaria

Perraut, R., Diatta, B., Marrama, L., Garraud, O., Jambou, R., Longacre, S., Gowda, K., Dieye, A. & Gowda, C., Apr 1 2005, In : Microbes and Infection. 7, 4, p. 682-687 6 p.

Research output: Contribution to journalArticle

Cerebral Malaria
Glycosylphosphatidylinositols
Plasmodium falciparum
Antibody Formation
Malaria
91 Citations (Scopus)
Glycosylphosphatidylinositols
Anopheles
Plasmodium falciparum
Nitric Oxide Synthase
Parasites
354 Citations (Scopus)
Cell signaling
Glycosylphosphatidylinositols
Macrophages
Plasmodium falciparum
Phospholipases
113 Citations (Scopus)
Glycosylphosphatidylinositols
JNK Mitogen-Activated Protein Kinases
Macrophages
Extracellular Signal-Regulated MAP Kinases
Plasmodium falciparum