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Research Output 1987 2019

  • 2855 Citations
  • 32 h-Index
  • 59 Article
  • 8 Review article
  • 2 Editorial
  • 1 Chapter
2019

DNA polymerases as chemotherapy targets: Promise and challenges

Eckert, K. & Barnes, R. P., Jan 1 2019, In : Oncotarget. 10, 6, p. 620-621 2 p.

Research output: Contribution to journalEditorial

DNA-Directed DNA Polymerase
Drug Therapy

Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D

Kaushal, S., Wollmuth, C. E., Das, K., Hile, S. E., Regan, S. B., Barnes, R. P., Haouzi, A., Lee, S. M., House, N. C. M., Guyumdzhyan, M., Eckert, K. & Freudenreich, C. H., Apr 23 2019, In : Cell Reports. 27, 4, p. 1151-1164.e5

Research output: Contribution to journalArticle

Open Access
Cells
Endonucleases
Human Chromosomes
Metaphase
Chromosomes
2018
1 Citation (Scopus)
oncogenes
DNA-Directed DNA Polymerase
DNA Replication
Oncogenes
DNA
4 Citations (Scopus)

DNA polymerase eta prevents tumor cell-cycle arrest and cell death during recovery from replication stress

Barnes, R. P., Tsao, W. C., Moldovan, G-L. & Eckert, K., Dec 1 2018, In : Cancer Research. 78, 23, p. 6549-6560 12 p.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Cell Death
Neoplasms
Genomic Instability
Cell Survival
10 Citations (Scopus)

Genome-wide Identification of Structure-Forming Repeats as Principal Sites of Fork Collapse upon ATR Inhibition

Shastri, N., Tsai, Y. C., Hile, S., Jordan, D., Powell, B., Chen, J., Maloney, D., Dose, M., Lo, Y., Anastassiadis, T., Rivera, O., Kim, T., Shah, S., Borole, P., Asija, K., Wang, X., Smith, K. D., Finn, D., Schug, J., Casellas, R. & 3 others, Yatsunyk, L. A., Eckert, K. & Brown, E. J., Oct 18 2018, In : Molecular cell. 72, 2, p. 222-238.e11

Research output: Contribution to journalArticle

Replication Protein A
Retroelements
DNA Replication
Microsatellite Repeats
Genome
2 Citations (Scopus)

Long-read sequencing technology indicates genome-wide effects of non-B DNA on polymerization speed and error rate

Guiblet, W. M., Cremona, M., Cechova, M., Harris, R. S., Kejnovská, I., Kejnovsky, E., Eckert, K., Chiaromonte, F. & Makova, K. D., Dec 1 2018, In : Genome research. 28, 12, p. 1767-1778 12 p.

Research output: Contribution to journalArticle

Polymerization
Genome
Technology
DNA
G-Quadruplexes
2017
12 Citations (Scopus)

DNA polymerases eta and kappa exchange with the polymerase delta holoenzyme to complete common fragile site synthesis

Barnes, R. P., Hile, S. E., Lee, M. Y. & Eckert, K., Sep 1 2017, In : DNA Repair. 57, p. 1-11 11 p.

Research output: Contribution to journalArticle

Holoenzymes
Proliferating Cell Nuclear Antigen
Aphidicolin
Tumors
Genes
15 Citations (Scopus)
DNA-Directed DNA Polymerase
Maintenance
Genome
Genomic Instability
Recombinational DNA Repair
2016
3 Citations (Scopus)

Reverse Transcription Errors and RNA-DNA Differences at Short Tandem Repeats

Fungtammasan, A., Hoover, M., Campos-Sánchez, R., Eckert, K., DeGiorgio, M. & Makova, K. D., Oct 1 2016, In : Molecular biology and evolution. 33, 10, p. 2744-2758 15 p.

Research output: Contribution to journalArticle

reverse transcription
Microsatellite Repeats
Reverse Transcription
RNA
microsatellite repeats
2015
33 Citations (Scopus)

Accurate typing of short tandem repeats from genome-wide sequencing data and its applications

Fungtammasan, A., Ananda, G., Hile, S. E., Su, M. S. W., Sun, C., Harris, R. S., Medvedev, P., Eckert, K. & Makova, K. D., May 1 2015, In : Genome research. 125, 5, p. 736-749 14 p.

Research output: Contribution to journalArticle

Microsatellite Repeats
Genome
Alleles
Polymerase Chain Reaction
Oncogenic Viruses
5 Citations (Scopus)

Genetic evidence that both dNTP-stabilized and strand slippage mechanisms may dictate DNA polymerase errors within mononucleotide microsatellites

Baptiste, B. A., Jacob, K. D. & Eckert, K., May 1 2015, In : DNA Repair. 29, p. 91-100 10 p.

Research output: Contribution to journalArticle

DNA-Directed DNA Polymerase
Microsatellite Repeats
Mutagenesis
Tandem Repeat Sequences
Base Pairing
36 Citations (Scopus)

Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins

Guilliam, T. A., Jozwiakowski, S. K., Ehlinger, A., Barnes, R. P., Rudd, S. G., Bailey, L. J., Skehel, J. M., Eckert, K., Chazin, W. J. & Doherty, A. J., Jan 30 2015, In : Nucleic acids research. 43, 2, p. 1056-1068 13 p.

Research output: Contribution to journalArticle

DNA Primase
Proliferating Cell Nuclear Antigen
DNA-Binding Proteins
DNA Replication
Mitochondrial DNA
2014
60 Citations (Scopus)

Interplay between DNA repair and inflammation, and the link to cancer

Kidane, D., Chae, W. J., Czochor, J., Eckert, K., Glazer, P. M., Bothwell, A. L. M. & Sweasy, J. B., Jan 1 2014, In : Critical Reviews in Biochemistry and Molecular Biology. 49, 2, p. 116-139 24 p.

Research output: Contribution to journalReview article

DNA Repair
DNA Damage
Repair
Inflammation
DNA
13 Citations (Scopus)

Microsatellite Interruptions Stabilize Primate Genomes and Exist as Population-Specific Single Nucleotide Polymorphisms within Individual Human Genomes

Ananda, G., Hile, S. E., Breski, A., Wang, Y., Kelkar, Y., Makova, K. D. & Eckert, K., Jan 1 2014, In : PLoS genetics. 10, 7, e1004498.

Research output: Contribution to journalArticle

Human Genome
primate
Microsatellite Repeats
Primates
single nucleotide polymorphism
2013
29 Citations (Scopus)

Distinct mutational behaviors differentiate short tandem repeats from micro satellites in the human genome

Ananda, G., Walsh, E., Jacob, K. D., Krasilnikova, M., Eckert, K., Chiaromonte, F. & Makova, K. D., Apr 29 2013, In : Genome Biology and Evolution. 5, 3, p. 606-620 15 p.

Research output: Contribution to journalArticle

Tandem Repeat Sequences
tandem repeat sequences
Human Genome
Microsatellite Repeats
polymorphism
93 Citations (Scopus)

DNA synthesis by pol η promotes fragile site stability by preventing under-replicated DNA in mitosis

Bergoglio, V., Boyer, A. S., Walsh, E., Naim, V., Legube, G., Lee, M. Y. W. T., Rey, L., Rosselli, F., Cazaux, C., Eckert, K. & Hoffmann, J. S., Jan 1 2013, In : Journal of Cell Biology. 201, 3, p. 395-408 14 p.

Research output: Contribution to journalArticle

DNA-Directed DNA Polymerase
Mitosis
DNA
S Phase
Carcinogenesis
10 Citations (Scopus)

Mature microsatellites: Mechanisms underlying dinucleotide microsatellite mutational biases in human cells

Baptiste, B. A., Ananda, G., Strubczewski, N., Lutzkanin, A., Khoo, S. J., Srikanth, A., Kim, N., Makova, K. D., Krasilnikova, M. & Eckert, K., Jan 1 2013, In : G3: Genes, Genomes, Genetics. 3, 3, p. 451-463 13 p.

Research output: Contribution to journalArticle

Microsatellite Repeats
DNA Mismatch Repair
DNA-Directed DNA Polymerase
Mutation
Genomic Instability
30 Citations (Scopus)

Mechanism of replicative DNA polymerase delta pausing and a potential role for DNA polymerase kappa in common fragile site replication

Walsh, E., Wang, X., Lee, M. Y. & Eckert, K., Jan 23 2013, In : Journal of Molecular Biology. 425, 2, p. 232-243 12 p.

Research output: Contribution to journalArticle

DNA Polymerase III
DNA-Directed DNA Polymerase
Inverted Repeat Sequences
DNA
Microsatellite Repeats
18 Citations (Scopus)

Tumor-specific microsatellite instability: Do distinct mechanisms underlie the MSI-L and EMAST phenotypes?

Hile, S. E., Shabashev, S. & Eckert, K., Mar 1 2013, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 743-744, p. 67-77 11 p.

Research output: Contribution to journalReview article

Microsatellite Instability
Phenotype
Neoplasms
Microsatellite Repeats
N-methylsuccinimide
2012
71 Citations (Scopus)

A genome-wide analysis of common fragile sites: What features determine chromosomal instability in the human genome?

Fungtammasan, A., Walsh, E., Chiaromonte, F., Eckert, K. & Makova, K. D., Jun 1 2012, In : Genome Research. 22, 6, p. 993-1005 13 p.

Research output: Contribution to journalArticle

Aphidicolin
Chromosomal Instability
Human Genome
Genome
Logistic Models
34 Citations (Scopus)

Beyond translesion synthesis: Polymerase κ fidelity as a potential determinant of microsatellite stability

Hile, S. E., Wang, X., Lee, M. Y. W. T. & Eckert, K., Feb 1 2012, In : Nucleic acids research. 40, 4, p. 1636-1647 12 p.

Research output: Contribution to journalArticle

Microsatellite Repeats
DNA-Directed DNA Polymerase
Holoenzymes
Nucleic Acid Repetitive Sequences
Human Genome
19 Citations (Scopus)

DNA polymerase kappa microsatellite synthesis: Two distinct mechanisms of slippage-mediated errors

Baptiste, B. A. & Eckert, K., Dec 1 2012, In : Environmental and Molecular Mutagenesis. 53, 9, p. 787-796 10 p.

Research output: Contribution to journalArticle

DNA-Directed DNA Polymerase
Microsatellite Repeats
Dinucleotide Repeats
Nucleotides
Alleles
2 Citations (Scopus)

Dna polymerases and their role in genomic stability

Eckert, K. & Sweasy, J. B., Dec 1 2012, In : Environmental and Molecular Mutagenesis. 53, 9, p. 643-644 2 p.

Research output: Contribution to journalEditorial

Genomic Instability
DNA-Directed DNA Polymerase
DNA Damage
21 Citations (Scopus)

Down-regulation of HtrA1 activates the Epithelial-Mesenchymal transition and ATM DNA damage response pathways

Wang, N., Eckert, K., Zomorrodi, A. R., Xin, P., Pan, W., Shearer, D. A., Weisz, J., Maranas, C. D. & Clawson, G., Jun 26 2012, In : PloS one. 7, 6, e39446.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Automatic teller machines
DNA damage
DNA Damage
Down-Regulation
15 Citations (Scopus)

The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation

Donigan, K. A., Hile, S. E., Eckert, K. & Sweasy, J. B., Apr 1 2012, In : DNA Repair. 11, 4, p. 381-390 10 p.

Research output: Contribution to journalArticle

DNA-Directed DNA Polymerase
Stomach Neoplasms
Tumors
Mutation
Neoplasms
2011
38 Citations (Scopus)

A matter of life or death: How microsatellites emerge in and vanish from the human genome

Kelkar, Y. D., Eckert, K., Chiaromonte, F. & Makova, K. D., Dec 1 2011, In : Genome research. 21, 12, p. 2038-2048 11 p.

Research output: Contribution to journalArticle

Human Genome
Microsatellite Repeats
Parturition
DNA Transposable Elements
Life Cycle Stages
20 Citations (Scopus)

The in vitro fidelity of yeast DNA polymerase δ and polymerase e{open} holoenzymes during dinucleotide microsatellite DNA synthesis

Abdulovic, A. L., Hile, S. E., Kunkel, T. A. & Eckert, K., May 5 2011, In : DNA Repair. 10, 5, p. 497-505 9 p.

Research output: Contribution to journalArticle

Holoenzymes
DNA-Directed DNA Polymerase
Microsatellite Repeats
Yeast
Yeasts
2010
77 Citations (Scopus)

Defective mismatch repair, microsatellite mutation bias, and variability in clinical cancer phenotypes

Shah, S. N., Hile, S. E. & Eckert, K., Jan 15 2010, In : Cancer Research. 70, 2, p. 431-435 5 p.

Research output: Contribution to journalReview article

DNA Mismatch Repair
Microsatellite Repeats
Phenotype
Microsatellite Instability
Mutation
24 Citations (Scopus)

Incorporation of gemcitabine and cytarabine into DNA by DNA polymerase β and ligase III/XRCC1

Prakasha Gowda, A. S., Polizzi, J. M., Eckert, K. & Spratt, T., Jun 15 2010, In : Biochemistry. 49, 23, p. 4833-4840 8 p.

Research output: Contribution to journalArticle

gemcitabine
DNA Polymerase III
DNA Ligases
Cytarabine
DNA-Directed DNA Polymerase
1 Citation (Scopus)

Making Mutations is an Active Process: Methods to Examine DNA Polymerase Errors

Eckert, K. & Gestl, E. E., Mar 30 2010, The Handbook of Plant Mutation Screening: Mining of Natural and Induced Alleles. Wiley-VCH, p. 55-82 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

DNA-Directed DNA Polymerase
Mutation
Genetic Templates
DNA
Molecular Biology
9 Citations (Scopus)

Telomeric repeat mutagenicity in human somatic cells is modulated by repeat orientation and G-quadruplex stability

Damerla, R. R., Knickelbein, K. E., Kepchia, D., Jackson, A., Armitage, B. A., Eckert, K. & Opresko, P. L., Nov 10 2010, In : DNA Repair. 9, 11, p. 1119-1129 11 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Thermodynamic stability
Cells
DNA Repair Enzymes
Genetic Vectors
69 Citations (Scopus)

What is a microsatellite: A computational and experimental definition based upon repeat mutational behavior at A/T and GT/AC repeats

Kelkar, Y. D., Strubczewski, N., Hile, S. E., Chiaromonte, F., Eckert, K. & Makova, K. D., Oct 29 2010, In : Genome Biology and Evolution. 2, 1, p. 620-635 16 p.

Research output: Contribution to journalArticle

Microsatellite Repeats
microsatellite repeats
polymorphism
genetic polymorphism
genome
2009
47 Citations (Scopus)

DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D

Shah, S. N., Opresko, P. L., Meng, X., Lee, M. Y. W. T. & Eckert, K., Dec 5 2009, In : Nucleic Acids Research. 38, 4, p. 1149-1162 14 p., gkp1131.

Research output: Contribution to journalArticle

DNA Polymerase III
DNA
Proteins
Cell Extracts
Microsatellite Repeats
60 Citations (Scopus)

Every microsatellite is different: Intrinsic DNA features dictate mutagenesis of common microsatellites present in the human genome

Eckert, K. & Hile, S. E., Apr 1 2009, In : Molecular Carcinogenesis. 48, 4, p. 379-388 10 p.

Research output: Contribution to journalReview article

Human Genome
Mutagenesis
Microsatellite Repeats
DNA
Mutation Rate
11 Citations (Scopus)

Human postmeiotic segregation 2 exhibits biased repair at tetranucleotide microsatellite sequences

Shah, S. N. & Eckert, K. A., Feb 1 2009, In : Cancer Research. 69, 3, p. 1143-1149 7 p.

Research output: Contribution to journalArticle

Microsatellite Repeats
DNA Mismatch Repair
Mutation Rate
Alleles
Cell Line
11 Citations (Scopus)

Loop II of DNA polymerase beta is important for discrimination during substrate binding

Lin, G. C., Jaeger, J., Eckert, K. & Sweasy, J. B., Feb 1 2009, In : DNA Repair. 8, 2, p. 182-189 8 p.

Research output: Contribution to journalArticle

DNA Polymerase beta
Amino Acids
Substrates
Ground state
Nucleotides
4 Citations (Scopus)
Protease Inhibitors
Ketones
Phenylalanine
Uterine Cervical Neoplasms
Alanine
2008
32 Citations (Scopus)

DNA polymerase kappa produces interrupted mutations and displays polar pausing within mononucleotide microsatellite sequences

Hile, S. E. & Eckert, K., Feb 1 2008, In : Nucleic acids research. 36, 2, p. 688-696 9 p.

Research output: Contribution to journalArticle

DNA-Directed DNA Polymerase
Microsatellite Repeats
Mutation
Alleles
DNA Primase
2007
10 Citations (Scopus)
DNA Polymerase beta
Mutagenesis
Microsatellite Repeats
Alleles
Escherichia coli
2006
82 Citations (Scopus)

Characterization of human breast epithelial cells by confocal Raman microspectroscopy

Yu, C., Gestl, E., Eckert, K., Allara, D. & Irudayaraj, J., Dec 4 2006, In : Cancer Detection and Prevention. 30, 6, p. 515-522 8 p.

Research output: Contribution to journalArticle

Cell Nucleus
Breast
Epithelial Cells
Raman Spectrum Analysis
Explosions
72 Citations (Scopus)

DNA polymerases and human diseases

Sweasy, J. B., Lauper, J. M. & Eckert, K., Nov 1 2006, In : Radiation research. 166, 5, p. 693-714 22 p.

Research output: Contribution to journalReview article

DNA-directed DNA polymerase
DNA-Directed DNA Polymerase
human diseases
deoxyribonucleic acid
genes
2005
6 Citations (Scopus)
DNA-Directed DNA Polymerase
Nucleotides
Alkylation
DNA
Substrates
6 Citations (Scopus)

Loss of DNA minor groove interactions by exonuclease-deficient Klenow polymerase inhibits O6-methylguanine and abasic site translesion synthesis

Gestl, E. E. & Eckert, K., May 10 2005, In : Biochemistry. 44, 18, p. 7059-7068 10 p.

Research output: Contribution to journalArticle

Exonucleases
DNA-Directed DNA Polymerase
DNA
Oligonucleotides
Base Pairing
61 Citations (Scopus)

Prostate-cancer-associated I260M variant of DNA polymerase β is a sequence-specific mutator

Dalal, S., Hile, S., Eckert, K., Sun, K. W., Starcevic, D. & Sweasy, J. B., Dec 6 2005, In : Biochemistry. 44, 48, p. 15664-15673 10 p.

Research output: Contribution to journalArticle

DNA-Directed DNA Polymerase
Hinges
Prostatic Neoplasms
DNA
Tumors
2004
131 Citations (Scopus)

Breast Cancer Metastasis Suppressor 1 (BRMS1) Forms Complexes with Retinoblastoma-binding Protein 1 (RBP1) and the mSin3 Histone Deacetylase Complex and Represses Transcription

Meehan, W. J., Samant, R. S., Hopper, J. E., Carrozza, M. J., Shevde, L. A., Workman, J. L., Eckert, K., Verderame, M. & Welch, D. R., Jan 9 2004, In : Journal of Biological Chemistry. 279, 2, p. 1562-1569 8 p.

Research output: Contribution to journalArticle

Retinoblastoma-Binding Protein 1
Histone Deacetylases
Transcription
Cells
Breast Neoplasms
6 Citations (Scopus)
Microsatellite Instability
Microsatellite Repeats
Thymidine Kinase
Mutation Rate
Simplexvirus
46 Citations (Scopus)
DNA Primase
DNA-Directed DNA Polymerase
Mutagenesis
Microsatellite Repeats
Alleles
2002
50 Citations (Scopus)

Misalignment-mediated DNA polymerase β mutations: Comparison of microsatellite and frame-shift error rates using a forward mutation assay

Eckert, K., Mowery, A. & Hile, S. E., Aug 20 2002, In : Biochemistry. 41, 33, p. 10490-10498 9 p.

Research output: Contribution to journalArticle

DNA-Directed DNA Polymerase
Microsatellite Repeats
Assays
Mutation
DNA
34 Citations (Scopus)

Mutation rate and specificity analysis of tetranucleotide microsatellite DNA alleles in somatic human cells

Eckert, K., Yan, G. & Hile, S. E., Jul 20 2002, In : Molecular Carcinogenesis. 34, 3, p. 140-150 11 p.

Research output: Contribution to journalArticle

Mutation Rate
Microsatellite Repeats
Alleles
DNA
Thymidine Kinase
48 Citations (Scopus)
Exonucleases
DNA-Directed DNA Polymerase
DNA
Alkylation
Exodeoxyribonucleases