• 17579 Citations
  • 74 h-Index
1966 …2022
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Fingerprint Dive into the research topics where Leonard "Jim" Jefferson is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 10 Similar Profiles
Skeletal Muscle Medicine & Life Sciences
Proteins Medicine & Life Sciences
Rats Chemical Compounds
Insulin Medicine & Life Sciences
Eukaryotic Initiation Factor-2B Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
Liver Medicine & Life Sciences
Amino Acids Medicine & Life Sciences

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Projects 1977 2022

Skeletal Muscle
Proteins
skeletal muscle
Protein Biosynthesis
Sirolimus
Physiological Adaptation
Students
Education
Research
Precision Medicine

RESEARCH TRAINING IN PHYSIOLOGICAL ADAPTATIONS TO STRESS

Jefferson, L. "., Evans, W. & Farrell, P.

National Institutes of Health

7/1/966/30/06

Project: Research project

training program
graduate
physiology
student
minority
Skeletal Muscle
Peptides
Proteolysis
Amino Acids
Ribosomal RNA

Research Output 1966 2019

2 Citations (Scopus)

Evidence for a role for sestrin1 in mediating leucine-induced activation of mtorc1 in skeletal muscle

Xu, D., Shimkus, K. L., Lacko, H. A., Kutzler, L., Jefferson, L. J. & Kimball, S., May 1 2019, In : American Journal of Physiology - Endocrinology and Metabolism. 316, 5, p. E817-E828

Research output: Contribution to journalArticle

Leucine
Skeletal Muscle
Cell Culture Techniques
Amino Acids
Oral Administration

O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1 dependent mitochondrial dysfunction in the retina

Dierschke, S. K., Miller, W. P., Favate, J. S., Shah, P., Imamura, Y., Salzberg, A. C., Kimball, S., Jefferson, L. J. & Dennis, M., Jan 1 2019, In : Journal of Biological Chemistry. 294, 14, p. 5508-5520 13 p.

Research output: Contribution to journalArticle

Protein Biosynthesis
Retina
Messenger RNA
Ribosomes
Eukaryotic Initiation Factors
1 Citation (Scopus)

Repressors of mTORC1 act to blunt the anabolic response to feeding in the soleus muscle of a cast-immobilized mouse hindlimb

Shimkus, K. L., Jefferson, L. J., Gordon, B. S. & Kimball, S., Oct 1 2018, In : Physiological reports. 6, 20, e13891.

Research output: Contribution to journalArticle

Hindlimb
Skeletal Muscle
Extremities
Immobilization
Proteins
7 Citations (Scopus)

Dietary fat quantity and type induce transcriptome-wide effects on alternative splicing of pre-mRNA in rat Skeletal Muscle

Black, A. J., Ravi, S., Jefferson, L. J., Kimball, S. & Schilder, R. J., Sep 1 2017, In : Journal of Nutrition. 147, 9, p. 1648-1657 10 p.

Research output: Contribution to journalArticle

Dietary Fats
RNA Precursors
Alternative Splicing
Transcriptome
Skeletal Muscle
16 Citations (Scopus)

Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation

Kimball, S., Gordon, B. S., Moyer, J. E., Dennis, M. & Jefferson, L. J., Aug 1 2016, In : Cellular Signalling. 28, 8, p. 896-906 11 p.

Research output: Contribution to journalArticle

Leucine
Phosphorylation
Amino Acids
Essential Amino Acids
mechanistic target of rapamycin complex 1