Leonard "Jim" Jefferson, PhD

    • 18056 Citations
    • 75 h-Index
    1966 …2020

    Research output per year

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    Research Output

    2020

    A time course for markers of protein synthesis and degradation with hindlimb unloading and the accompanying anabolic resistance to refeeding

    Roberson, P. A., Shimkus, K. L., Welles, J. E., Xu, D., Whitsell, A. L., Kimball, E. M., Jefferson, L. S. & Kimball, S. R., Jul 1 2020, In : Journal of applied physiology (Bethesda, Md. : 1985). 129, 1, p. 36-46 11 p.

    Research output: Contribution to journalArticle

    2019

    Evidence for a role for sestrin1 in mediating leucine-induced activation of mtorc1 in skeletal muscle

    Xu, D., Shimkus, K. L., Lacko, H. A., Kutzler, L., Jefferson, L. S. & Kimball, S. R., May 2019, In : American Journal of Physiology - Endocrinology and Metabolism. 316, 5, p. E817-E828

    Research output: Contribution to journalArticle

    8 Scopus citations

    O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1 dependent mitochondrial dysfunction in the retina

    Dierschke, S. K., Miller, W. P., Favate, J. S., Shah, P., Kawasawa, Y. I., Salzberg, A. C., Kimball, S. R., Jefferson, L. S. & Dennis, M. D., Apr 5 2019, In : Journal of Biological Chemistry. 294, 14, p. 5508-5520 13 p.

    Research output: Contribution to journalArticle

    1 Scopus citations
    2018

    Repressors of mTORC1 act to blunt the anabolic response to feeding in the soleus muscle of a cast-immobilized mouse hindlimb

    Shimkus, K. L., Jefferson, L. S., Gordon, B. S. & Kimball, S. R., Oct 2018, In : Physiological reports. 6, 20, e13891.

    Research output: Contribution to journalArticle

    2 Scopus citations
    2017

    Dietary fat quantity and type induce transcriptome-wide effects on alternative splicing of pre-mRNA in rat Skeletal Muscle

    Black, A. J., Ravi, S., Jefferson, L. S., Kimball, S. R. & Schilder, R. J., Sep 1 2017, In : Journal of Nutrition. 147, 9, p. 1648-1657 10 p.

    Research output: Contribution to journalArticle

    7 Scopus citations
    2016

    Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation

    Kimball, S. R., Gordon, B. S., Moyer, J. E., Dennis, M. D. & Jefferson, L. S., Aug 1 2016, In : Cellular Signalling. 28, 8, p. 896-906 11 p.

    Research output: Contribution to journalArticle

    30 Scopus citations

    Loss of REDD1 augments the rate of the overload-induced increase in muscle mass

    Gordon, B. S., Liu, C., Steiner, J. L., Nader, G. A., Jefferson, L. S. & Kimball, S. R., Jan 1 2016, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 311, 3, p. R545-R557

    Research output: Contribution to journalArticle

    12 Scopus citations

    Regulation of protein and mRNA expression of the mTORC1 repressor REDD1 in response to leucine and serum

    Black, A. J., Gordon, B. S., Dennis, M. D., Jefferson, L. S. & Kimball, S. R., Dec 1 2016, In : Biochemistry and Biophysics Reports. 8, p. 296-301 6 p.

    Research output: Contribution to journalArticle

    2 Scopus citations

    The translational repressor 4E-BP1 contributes to diabetes-induced visual dysfunction

    Miller, W. P., Mihailescu, M. L., Yang, C., Barber, A. J., Kimball, S. R., Jefferson, L. S. & Dennis, M. D., Mar 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 3, p. 1327-1337 11 p.

    Research output: Contribution to journalArticle

    9 Scopus citations
    2015

    ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis

    Wang, L., Liu, X., Nie, J., Zhang, J., Kimball, S. R., Zhang, H., Zhang, W. J., Jefferson, L. S., Cheng, Z., Ji, Q. & Shi, Y., Feb 1 2015, In : Hepatology. 61, 2, p. 486-496 11 p.

    Research output: Contribution to journalArticle

    34 Scopus citations

    Amino acid-induced activation of mTORC1 in rat liver is attenuated by short-term consumption of a high-fat diet

    Kimball, S. R., Ravi, S., Gordon, B. S., Dennis, M. D. & Jefferson, L. S., 2015, In : Journal of Nutrition. 145, 11, p. 2496-2502 7 p.

    Research output: Contribution to journalArticle

    12 Scopus citations
    33 Scopus citations
    15 Scopus citations
    27 Scopus citations
    2014
    21 Scopus citations

    MTORC1-independent reduction of retinal protein synthesis in type 1 diabetes

    Fort, P. E., Losiewicz, M. K., Pennathur, S., Jefferson, L. S., Kimball, S. R., Abcouwer, S. F. & Gardner, T. W., Sep 2014, In : Diabetes. 63, 9, p. 3077-3090 14 p.

    Research output: Contribution to journalArticle

    11 Scopus citations
    69 Scopus citations
    23 Scopus citations

    RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells

    Gordon, B. S., Kazi, A., Coleman, C., Dennis, M., Chau, V., Jefferson, L. J. & Kimball, S., Mar 1 2014, In : Cellular Signalling. 26, 3, p. 461-467 7 p.

    Research output: Contribution to journalArticle

    31 Scopus citations
    2013

    Hyperglycemia mediates a shift from cap-Dependent to cap-Independent translation Via a 4E-BP1-Dependent mechanism

    Dennis, M. D., Shenberger, J. S., Stanley, B. A., Kimball, S. R. & Jefferson, L. S., Jul 1 2013, In : Diabetes. 62, 7, p. 2204-2214 11 p.

    Research output: Contribution to journalArticle

    15 Scopus citations
    3 Scopus citations

    Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells

    Cheng, Y., Ren, X., Zhang, Y., Shan, Y., Huber-Keener, K. J., Zhang, L., Kimball, S. R., Harvey, H., Jefferson, L. S. & Yang, J. M., Jan 1 2013, In : Autophagy. 9, 2, p. 208-219 12 p.

    Research output: Contribution to journalArticle

    37 Scopus citations
    25 Scopus citations
    51 Scopus citations

    SAD-A kinase controls islet β-cell size and function as a mediator of mTORC1 signaling

    Nie, J., Liu, X., Lilley, B. N., Zhang, H., Pan, Y. A., Kimball, S. R., Zhang, J., Zhang, W., Wang, L., Jefferson, L. S., Sanes, J. R., Han, X. & Shi, Y., Aug 28 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 34, p. 13857-13862 6 p.

    Research output: Contribution to journalArticle

    23 Scopus citations
    61 Scopus citations
    2012
    9 Scopus citations
    18 Scopus citations
    79 Scopus citations
    2011
    14 Scopus citations

    Circulating sphingolipid biomarkers in models of type 1 diabetes

    Fox, T. E., Bewley, M. C., Unrath, K. A., Pedersen, M. M., Anderson, R. E., Jung, D. Y., Jefferson, L. S., Kim, J. K., Bronson, S. K., Flanagan, J. M. & Kester, M., Mar 1 2011, In : Journal of Lipid Research. 52, 3, p. 509-517 9 p.

    Research output: Contribution to journalArticle

    85 Scopus citations
    61 Scopus citations
    15 Scopus citations

    Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids

    Dennis, M. D., Baum, J. I., Kimball, S. R. & Jefferson, L. S., Mar 11 2011, In : Journal of Biological Chemistry. 286, 10, p. 8287-8296 10 p.

    Research output: Contribution to journalArticle

    69 Scopus citations
    22 Scopus citations
    16 Scopus citations
    2010

    Ablation of 4E-BP1/2 prevents hyperglycemia-mediated induction of VEGF expression in the rodent retina and in Müller cells in culture

    Schrufer, T. L., Antonetti, D. A., Sonenberg, N., Kimball, S. R., Gardner, T. W. & Jefferson, L. S., Sep 2010, In : Diabetes. 59, 9, p. 2107-2116 10 p.

    Research output: Contribution to journalArticle

    30 Scopus citations

    Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity

    Li, J., Romestaing, C., Han, X., Li, Y., Hao, X., Wu, Y., Sun, C., Liu, X., Jefferson, L. S., Xiong, J., Lanoue, K. F., Chang, Z., Lynch, C. J., Wang, H. & Shi, Y., Aug 4 2010, In : Cell Metabolism. 12, 2, p. 154-165 12 p.

    Research output: Contribution to journalArticle

    139 Scopus citations
    82 Scopus citations
    11 Scopus citations

    Maintaining adequate nutrition, not probiotic administration, prevents growth stunting and maintains skeletal muscle protein synthesis rates in a piglet model of colitis

    Harding, S. V., Adegoke, O. A. J., Fraser, K. G., Marliss, E. B., Chevalier, S., Kimball, S. R., Jefferson, L. S. & Wykes, L. J., Mar 1 2010, In : Pediatric Research. 67, 3, p. 268-273 6 p.

    Research output: Contribution to journalArticle

    7 Scopus citations

    Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway

    Winter, J. N., Fox, T. E., Kester, M., Jefferson, L. S. & Kimball, S. R., Aug 1 2010, In : American Journal of Physiology - Cell Physiology. 299, 2, p. C335-C344

    Research output: Contribution to journalArticle

    52 Scopus citations
    2009

    ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression

    Whitney, M. L., Jefferson, L. S. & Kimball, S. R., Feb 6 2009, In : Biochemical and Biophysical Research Communications. 379, 2, p. 451-455 5 p.

    Research output: Contribution to journalArticle

    101 Scopus citations
    47 Scopus citations
    60 Scopus citations

    Fed-state clamp stimulates cellular mechanisms of muscle protein anabolism and modulates glucose disposal in normal men

    Adegoke, O. A. J., Chevalier, S., Morais, J. A., Gougeon, R., Kimball, S. R., Jefferson, L. S., Wing, S. S. & Marliss, E. B., Jan 2009, In : American Journal of Physiology - Endocrinology and Metabolism. 296, 1, p. E105-E113

    Research output: Contribution to journalArticle

    19 Scopus citations
    14 Scopus citations

    Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1

    Zhang, L., Kimball, S. R., Jefferson, L. S. & Shenberger, J. S., Jun 1 2009, In : Free Radical Biology and Medicine. 46, 11, p. 1500-1509 10 p.

    Research output: Contribution to journalArticle

    28 Scopus citations