Projects per year
Personal profile
Professional information
Fellow, Association of American Medical Colleges Council of Deans (2018)
Fellow, American Association for the Advancement of Science (2017)
Fellow, American Academy of Microbiology (2014)
Fellow, American College of Physicians (2012)
Fellow, Infectious Diseases Society of America (2009)
Diplomate, Subspecialty of Infectious Diseases, American Board of Internal Medicine (1996; recertified through 2024)
Diplomate, American Board of Internal Medicine (1990)
Research interests
Dr. Leslie Parent's research focuses on understanding the molecular mechanisms underlying the assembly of retrovirus particles. Her laboratory members uses genetic, biochemical, biophysical and live-cell imaging approaches to dissect the viral and cellular factors that mediate the trafficking of retroviral proteins and genomic RNA complexes in infected cells. Their investigation of the host factors involved in transport of retroviral proteins and RNAs throughout the cell is at the interface of virology and cellular biology.
Recent work in Dr. Parent's laboratory has focused on studying the mechanism by which retroviruses recognize their RNA genomes and select them for incorporation into virions. She has adopted a comparative retrovirology approach by comparing and contrasting the replication strategies of Rous sarcoma virus, mouse mammary tumor virus and human immunodeficiency virus. Members of her laboratory discovered that the Gag protein of Rous sarcoma virus undergoes nuclear trafficking, which is required for efficient incorporation of genomic RNA into virions. This work challenges the current dogma of how retroviruses select and incorporate their genomic RNA into virus particles.
In addition to her research, Dr. Parent is a standing member of the NIH study section HVCD (HIV Molecular Virology, Cell Biology and Drug Discovery).
Teaching and educational interests
Dr. Leslie Parent participates in the training of medical students, residents and fellows in clinical infectious diseases. She is co-director of Penn State College of Medicine's MD/PhD Medical Scientist Training Program (MSTP), where she is involved in mentoring the next generation of physician-scientists.
Education/Academic qualification
Executive Leadership in Academic Medicine (ELAM) Program, Drexel University College of Medicine
… → 2016
Retrovirology, Research Fellowship, Penn State Health Milton S. Hershey Medical Center
1992 → 1997
Infectious Disease, Fellowship, Penn State Health Milton S. Hershey Medical Center
1991 → 1994
Internal Medicine, Residency, Duke University
1987 → 1991
MD, Duke University
… → 1987
External positions
Associate Editor, Retrovirology
2019 → …Editorial Board Member, Journal of Virology
2004 → …Fingerprint Dive into the research topics where Leslie Parent is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Projects
- 2 Finished
ANALYSIS OF HIV-1 GAG-MEDIATED ASSEMBLY
National Institute of Allergy and Infectious Diseases
6/1/93 → 5/31/94
Project: Research project
Research Output
RNA-binding domains of heterologous viral proteins substituted for basic residues in the RSV gag NC domain restore specific packaging of genomic RNA
Rice, B. L., Lochmann, T. L. & Parent, L. J., Jan 1 2020, In : Viruses. 12, 4, 370.Research output: Contribution to journal › Article
Open Access
Rous sarcoma virus genomic RNA dimerization capability in vitro is not a prerequisite for viral infectivity
Liu, S., Maldonado, R. K., Rye-McCurdy, T., Binkley, C., Bah, A., Chen, E. C., Rice, B. L., Parent, L. J. & Musier-Forsyth, K., May 2020, In : Viruses. 12, 5, 568.Research output: Contribution to journal › Article
Open Access
Visualizing association of the retroviral gag protein with unspliced viral RNA in the nucleus
Maldonado, R. J. K., Rice, B., Chen, E. C., Tuffy, K. M., Chiari, E. F., Fahrbach, K. M., Hope, T. J. & Parent, L. J., Mar 1 2020, In : mBio. 11, 2, e00524-20.Research output: Contribution to journal › Article
Open Access
1
Scopus
citations
A trip down memory lane with Retrovirology
Benkirane, M., Berkhout, B., Borrow, P., Fassati, A., Fujii, M., Garcia-Martinez, J. V., Margolis, D., Nijhuis, M., Parent, L., Strebel, K., Venter, F., Kirchhoff, F., Lever, A., Ross, S. & Mak, J., Aug 21 2019, In : Retrovirology. 16, 1, 22.Research output: Contribution to journal › Review article
Open Access
Introduction
Parent, L., Aug 17 2018, Retrovirus-Cell Interactions. Parent, L. J. (ed.). 1 ed. Elsevier, p. xxix-xxxvResearch output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)
Open Access
Prizes
Dean's Award for Excellence in Teaching
Parent, Leslie (Recipient) & Reid, J. Spence (Recipient), 2014
Prize