Projects per year
Personal profile
Professional information
Fellow, Association of American Medical Colleges Council of Deans (2018)
Fellow, American Association for the Advancement of Science (2017)
Fellow, American Academy of Microbiology (2014)
Fellow, American College of Physicians (2012)
Fellow, Infectious Diseases Society of America (2009)
Diplomate, Subspecialty of Infectious Diseases, American Board of Internal Medicine (1996; recertified through 2024)
Diplomate, American Board of Internal Medicine (1990)
Research interests
Dr. Leslie Parent's research focuses on understanding the molecular mechanisms underlying the assembly of retrovirus particles. Her laboratory members uses genetic, biochemical, biophysical and live-cell imaging approaches to dissect the viral and cellular factors that mediate the trafficking of retroviral proteins and genomic RNA complexes in infected cells. Their investigation of the host factors involved in transport of retroviral proteins and RNAs throughout the cell is at the interface of virology and cellular biology.
Recent work in Dr. Parent's laboratory has focused on studying the mechanism by which retroviruses recognize their RNA genomes and select them for incorporation into virions. She has adopted a comparative retrovirology approach by comparing and contrasting the replication strategies of Rous sarcoma virus, mouse mammary tumor virus and human immunodeficiency virus. Members of her laboratory discovered that the Gag protein of Rous sarcoma virus undergoes nuclear trafficking, which is required for efficient incorporation of genomic RNA into virions. This work challenges the current dogma of how retroviruses select and incorporate their genomic RNA into virus particles.
In addition to her research, Dr. Parent is a standing member of the NIH study section HVCD (HIV Molecular Virology, Cell Biology and Drug Discovery).
Teaching and educational interests
Dr. Leslie Parent participates in the training of medical students, residents and fellows in clinical infectious diseases. She is co-director of Penn State College of Medicine's MD/PhD Medical Scientist Training Program (MSTP), where she is involved in mentoring the next generation of physician-scientists.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Executive Leadership in Academic Medicine (ELAM) Program, Drexel University College of Medicine
… → 2016
Retrovirology, Research Fellowship, Penn State Health Milton S. Hershey Medical Center
1992 → 1997
Infectious Disease, Fellowship, Penn State Health Milton S. Hershey Medical Center
1991 → 1994
Internal Medicine, Residency, Duke University
1987 → 1991
MD, Duke University
… → 1987
External positions
Associate Editor, Retrovirology
2019 → …
Editorial Board Member, Journal of Virology
2004 → …
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Projects
- 1 Finished
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Liquid-liquid phase separation of nucleocapsid proteins during SARS-CoV-2 and HIV-1 replication
Chau, B. A., Chen, V., Cochrane, A. W., Parent, L. J. & Mouland, A. J., Jan 31 2023, In: Cell Reports. 42, 1, 111968.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Clinician-Scientist Faculty Mentoring Program (FAME) – A New Inclusive Training Model at Penn State Increases Scholarly Productivity and Extramural Grant Funding
Dovat, S., Gowda, C., Mailman, R. B., Parent, L. J. & Huang, X., 2022, In: Advances in Medical Education and Practice. 13, p. 1039-1050 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency
Dahal, S., Clayton, K., Been, T., Fernet-Brochu, R., Ocando, A. V., Balachandran, A., Poirier, M., Maldonado, R. K., Shkreta, L., Boligan, K. F., Guvenc, F., Rahman, F., Branch, D., Bell, B., Chabot, B., Gray-Owen, S. D., Parent, L. J. & Cochrane, A., Dec 2022, In: Retrovirology. 19, 1, 18.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
SARS-CoV-2 vaccine effectiveness against infection, symptomatic and severe COVID-19: a systematic review and meta-analysis
Ssentongo, P., Ssentongo, A. E., Voleti, N., Groff, D., Sun, A., Ba, D. M., Nunez, J., Parent, L. J., Chinchilli, V. M. & Paules, C. I., Dec 2022, In: BMC Infectious Diseases. 22, 1, 439.Research output: Contribution to journal › Article › peer-review
Open Access35 Citations (SciVal) -
Building a System to Engage and Sustain Research Careers for Physicians
Huang, X., Dovat, S., Mailman, R. B., Thiboutot, D. M., Berini, D. & Parent, L. J., Apr 1 2021, In: Academic Medicine. 96, 4, p. 490-494 5 p.Research output: Contribution to journal › Review article › peer-review
Open Access5 Scopus citations
Prizes
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Dean's Award for Excellence in Teaching
Parent, Leslie (Recipient), Reid, J. Spence (Recipient), Krok, Karen (Recipient), Lubin, Jeffrey (Recipient), Acharya, Jayant (Recipient) & Felix, Todd (Recipient), 2014
Prize
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