Mack Ruffin, MD, MPH

    • 6149 Citations
    • 41 h-Index
    1988 …2020

    Research output per year

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    Personal profile

    Research interests

    Dr. Mack Ruffin’s research has focused on cancer prevention and control with emphasis on cervical, colorectal and pancreatic cancer. His research spans rural community trials, practice transformation, individual patient clinical trials, early detection biomarkers discovery and validation trials and dissemination studies. He is currently focused on stool microbiome as a screening strategy for colorectal cancer; community and practice intervention to promotion HPV vaccine series initiation and completion; HPV self-sampling as a new strategy to get women to engage in checking for cervical cancer; and validation of new blood, urine and stool markers for screening for colorectal cancer.

    Teaching and educational interests

    Dr. Mack Ruffin is interested in teaching on any topic related to health promotion and disease prevention. He has worked with adolescents, teenagers, young adults, senior adults, healthcare trainees and workers and community organizations. He is particularly interested in working with community organizations devoted to rural or underserved minority populations.

    Clinical interests

    Dr. Mack Ruffin's current clinical interests include discovery and validation of new markers for the early detection of colorectal cancer, especially those linked to stool, saliva and microbiome. His goal is to replace the current non-invasive screening strategies (stool testing) and invasive testing (colonoscopy) for colorectal cancer with better-performing and patient-acceptable non-invasive screening tests.

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    Research Output

    A multi-level model to understand cervical cancer disparities in appalachia

    Paskett, E. D., Pennell, M. L., Ruffin, M. T., Weghorst, C. M., Lu, B., Hade, E. M., Peng, J., Bernardo, B. M. & Wewers, M. E., Jan 1 2020, In : Cancer Prevention Research. 13, 3, p. 223-228 6 p.

    Research output: Contribution to journalReview article

    Open Access
  • 1 Scopus citations

    Enteric Virome and Carcinogenesis in the Gut

    Emlet, C., Ruffin, M. & Lamendella, R., Mar 1 2020, In : Digestive Diseases and Sciences. 65, 3, p. 852-864 13 p.

    Research output: Contribution to journalReview article

    Open Access
  • Fecal short-chain fatty acids are not predictive of colonic tumor status and cannot be predicted based on bacterial community structure

    Sze, M. A., Topçuoğlu, B. D., Lesniak, N. A., Ruffin, M. T. & Schloss, P. D., Jul 1 2019, In : mBio. 10, 4, e01454-19.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Increases in colonic bacterial diversity after ω-3 fatty acid supplementation predict decreased colonic prostaglandin E2 concentrations in healthy adults

    Djuric, Z., Bassis, C. M., Plegue, M. A., Sen, A., Turgeon, D. K., Herman, K., Young, V. B., Brenner, D. E. & Ruffin, M. T., Jan 1 2019, In : Journal of Nutrition. 149, 7, p. 1170-1179 10 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Inherited alterations of TGF beta signaling components in Appalachian cervical cancers

    Knobloch, T. J., Peng, J., Hade, E. M., Cohn, D. E., Ruffin, M. T., Schiano, M. A., Calhoun, B. C., McBee, W. C., Lesnock, J. L., Gallion, H. H., Pollock, J., Lu, B., Oghumu, S., Zhang, Z., Sears, M. T., Ogbemudia, B. E., Perrault, J. T., Weghorst, L. C., Strawser, E., DeGraffinreid, C. R. & 2 others, Paskett, E. D. & Weghorst, C. M., Oct 1 2019, In : Cancer Causes and Control. 30, 10, p. 1087-1100 14 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations