Mack Ruffin, MD, MPH

    • 5946 Citations
    • 40 h-Index
    1977 …2021
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    Personal profile

    Research interests

    Dr. Mack Ruffin’s research has focused on cancer prevention and control with emphasis on cervical, colorectal and pancreatic cancer. His research spans rural community trials, practice transformation, individual patient clinical trials, early detection biomarkers discovery and validation trials and dissemination studies. He is currently focused on stool microbiome as a screening strategy for colorectal cancer; community and practice intervention to promotion HPV vaccine series initiation and completion; HPV self-sampling as a new strategy to get women to engage in checking for cervical cancer; and validation of new blood, urine and stool markers for screening for colorectal cancer.

    Teaching and educational interests

    Dr. Mack Ruffin is interested in teaching on any topic related to health promotion and disease prevention. He has worked with adolescents, teenagers, young adults, senior adults, healthcare trainees and workers and community organizations. He is particularly interested in working with community organizations devoted to rural or underserved minority populations.

    Clinical interests

    Dr. Mack Ruffin's current clinical interests include discovery and validation of new markers for the early detection of colorectal cancer, especially those linked to stool, saliva and microbiome. His goal is to replace the current non-invasive screening strategies (stool testing) and invasive testing (colonoscopy) for colorectal cancer with better-performing and patient-acceptable non-invasive screening tests.

    Fingerprint Dive into the research topics where Mack Ruffin is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

    • 7 Similar Profiles
    Colorectal Neoplasms Medicine & Life Sciences
    Early Detection of Cancer Medicine & Life Sciences
    Uterine Cervical Neoplasms Medicine & Life Sciences
    Primary Health Care Medicine & Life Sciences
    Papanicolaou Test Medicine & Life Sciences
    Biomarkers Medicine & Life Sciences
    Neoplasms Medicine & Life Sciences
    Papillomavirus Vaccines Medicine & Life Sciences

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    Projects 1977 2021

    Colorectal Neoplasms

    P1 - Omega-3 fatty acids and Colorectal Cancer Prevention

    Ruffin, M., Taylor, J., Lawrence, T., Gruber, S., Giordano, T., Fearon, E. R., Smith, W. A., Taylor, J. M. G., Brenner, D. E. & Simeone, D.

    National Institutes of Health


    Project: Research project

    Pancreatic Neoplasms
    Chronic Pancreatitis

    Reducing Cervical Cancer in Appalachia

    Ruffin, M., Jewell, S. D., Paskett, E. D., Weghorst, C., Jewell, S., Slater, M. D. & Wewers, M. E.

    National Institutes of Health


    Project: Research project

    Human papillomavirus 11
    Human papillomavirus 6
    Psychological Stress
    Research Personnel
    Retinoid X Receptors
    Retinoic Acid Receptors

    Research Output 1988 2019

    1 Citation (Scopus)

    Fecal short-chain fatty acids are not predictive of colonic tumor status and cannot be predicted based on bacterial community structure

    Sze, M. A., Topçuoğlu, B. D., Lesniak, N. A., Ruffin, M. T. & Schloss, P. D., Jul 1 2019, In : mBio. 10, 4, e01454-19.

    Research output: Contribution to journalArticle

    Open Access
    Bacterial Structures
    Volatile Fatty Acids
    Colorectal Neoplasms
    2 Citations (Scopus)

    Increases in colonic bacterial diversity after ω-3 fatty acid supplementation predict decreased colonic prostaglandin E2 concentrations in healthy adults

    Djuric, Z., Bassis, C. M., Plegue, M. A., Sen, A., Turgeon, D. K., Herman, K., Young, V. B., Brenner, D. E. & Ruffin, M. T., Jan 1 2019, In : Journal of Nutrition. 149, 7, p. 1170-1179 10 p.

    Research output: Contribution to journalArticle

    Fatty Acids
    Dietary Supplements

    Inherited alterations of TGF beta signaling components in Appalachian cervical cancers

    Knobloch, T. J., Peng, J., Hade, E. M., Cohn, D. E., Ruffin, M. T., Schiano, M. A., Calhoun, B. C., McBee, W. C., Lesnock, J. L., Gallion, H. H., Pollock, J., Lu, B., Oghumu, S., Zhang, Z., Sears, M. T., Ogbemudia, B. E., Perrault, J. T., Weghorst, L. C., Strawser, E., DeGraffinreid, C. R. & 2 others, Paskett, E. D. & Weghorst, C. M., Oct 1 2019, In : Cancer Causes and Control. 30, 10, p. 1087-1100 14 p.

    Research output: Contribution to journalArticle

    Uterine Cervical Neoplasms
    Transforming Growth Factor beta
    Logistic Models

    Interactivity in a Decision Aid: Findings From a Decision Aid to Technologically Enhance Shared Decision Making RCT

    Jimbo, M., Sen, A., Plegue, M. A., Hawley, S., Kelly-Blake, K., Rapai, M., Zhang, M., Zhang, Y., Xie, X. & Ruffin, M. T., Jul 2019, In : American Journal of Preventive Medicine. 57, 1, p. 77-86 10 p.

    Research output: Contribution to journalArticle

    Decision Support Techniques
    Early Detection of Cancer
    Colorectal Neoplasms
    Decision Making
    Office Visits

    Results of a Pilot Study of a Mail-Based Human Papillomavirus Self-Testing Program for Underscreened Women from Appalachian Ohio

    Reiter, P. L., Shoben, A. B., McDonough, D., Ruffin, M., Steinau, M., Unger, E. R., Paskett, E. D. & Katz, M. L., Mar 1 2019, In : Sexually transmitted diseases. 46, 3, p. 185-190 6 p.

    Research output: Contribution to journalArticle

    Postal Service
    Papanicolaou Test
    Uterine Cervical Neoplasms
    Control Groups